You are on page 1of 16

The Clinical and Translational Science Ontology Affinity Group

William R. Hogan, MD, MS


March 19, 2013 AMIA Translational Bioinformatics Summit
1

What is it?
Technically speaking, an affinity group of the Informatics Key Function Committee of the CTSA Consortium
A group of people interested in pursuing answers to the question how can ontologies best enable translational science?

4/4/2013

ONE NEED NOT BE A CTSA CONSORTIUM MEMBER TO PARTICIPATE


3

History
October 2010
Hogan and Scheuermann hatch idea at dinner during IKFC meeting

Spring 2011
Initial proposal takes shape, distributed to folks for feedback

Winter (of discontent) 2011-2012


Proposal submitted to Operations Committee of IKFC and returned with questions and request for revisions and clarification
4/4/2013

History (continued)
April 2012
First Clinical and Translational Science Ontology Workshop held in Baltimore, MD Participants enthusiastic about forming ontologyrelated AG in IKFC Given takeover of CTSA Consortium support by C4, old AG proposal forms no longer in use Proposal split into elevator pitch and operations documents

July 2012
Elevator pitch and operations documents submitted to IKFC Operations Committee
4/4/2013

History (continued)
November 2012
C4 and IKFC Operations Committee member inform Hogan that the Clinical and Translational Science Ontology Affinity Group (CTSO-AG) is approved!

December 2012
C4 sets up infrastructure for CTSO-AG on ctsacentral.org CTSO-AG keeps Google Group for inclusion of members outside Consortium
4/4/2013

History (continued)
January 2013
First CTSO-AG monthly call held

February 2013
Second Clinical and Translational Science Ontology Workshop held in Orlando, Florida (sponsored by Translational Research Institute of UAMS and cosponsored by NCBO)

March 2013
Second CTSO-AG call held
4/4/2013

Current Activities
Defining subject matter of the AG
Ontology in support of CTSA evaluation Identifying and cataloging projects, software, research studies, etc. that use ontologies and the ontologies they employ Generating a tutorial on ontology targeted at junior translational science investigators
4/4/2013

Definition Activity
Are we interested in any type of controlled vocabulary, thesaurus, taxonomy, classification, etc.? If not, what are the distinctions and why do they matter? White paper is currently on v6 and very close to distribution to entire CTSO-AG Lead: Mathias Brochhausen
4/4/2013

Evaluation Activity
Collaboration with evaluation KFC Representing key metrics for interoperability of evaluation data Has links to CTSAConnect project to deliver investigator data (e.g., grants, pubs) data into the process Two-page proposal distributed for feedback, with ultimate goal of obtaining buy in from leadership of Evaluation KFC Lead: Dagobert Soergel
4/4/2013

10

Catalog Activity
If we are going to understand how ontologies enable translational science, then we need to track their use and associated outcomes Setting up Wiki site Made initial decisions for organization of site Lead: William Hogan

4/4/2013

11

Tutorial Activity
Initial goal is deck of ~60 PowerPoint slides Currently collecting folks existing tutorials, slides, videos, Wikis, etc. Leads: He, Brochhausen, Soergel, Hogan

4/4/2013

12

Where to Find Stuff


Google group
http://groups.google.com/group/ctsa-ontology ctsa-ontology@googlegroups.com

C4 site
https://ctsacentral.org/committee/ikfc-clinical-and-translationalscience-affinity-group-ctso-ag list.kfc.informatics.ontology@ctsacentral.org

CTSO Workshops
First: http://www.bioontology.org/wiki/index.php/Clinical_and_Trans lational_Science_Ontology_Workshop Second: http://ncorwiki.buffalo.edu/index.php/CTSA_Ontology_Worksh op
4/4/2013

13

Where to Find (continued)


Elevator pitch and operations documents
https://groups.google.com/forum/?fromgroups=#!t opic/ctsa-ontology/BysA64zEKzc

Dropbox for tutorial effort (send request to join to Hogan)

4/4/2013

14

How to Participate in CTSO-AG


Email JLBufford@uams.edu with:
The email address you want to subscribe Whether you are with member institution of CTSA Consortium and signed up to IKFC Whether email address above is the one subscribed to IKFC

Join monthly calls (details emailed to both Google Group and C4 listservs)
Second Tuesday of the month at 2p ET Next one is Tuesday, April 9 at 2p ET

Engage one of the current activities and drive it forward!


4/4/2013

15

Acknowledgements
Those instrumental to formation of group:
Richard Scheuermann Barry Smith Warren Kibbe Lindsay Cowell Melissa Haendel Jesse Tennenbaum Mathias Brochhausen Dagobert Soergel JENNIFER BUFFORD! And the remainder of the 37 participants of the first Workshop who self-identified as being interested in participating

IKFC Operations Committee for their valuable criticisms, suggestions, recommendations, etc. Award UL1TR000039 from NCATS
4/4/2013

16