You are on page 1of 9

Volume 2 Issue: 5 (May 2013) | Page: 36 - 43

ISSN 2278 4500

A monthly research awareness e-Journal by

Chief Editor Dr. Saurav Arora Editorial Advisory Board Dr. Jos Eizayaga (Argentina) Dr. Silvia Waisse (Brazil) Dr. Leoni Bonamin (Brazil) Dr. Shivang Swaminarayan (India)

IPRH proudly publishes

Visit www.jcshom.com for more details!

IPRH is an Advertisement free portal


IPRH receives no money from government or corporations and entirely depends upon your contribution. You may consider making donations for this initiative. Any donation you make, big or small is a valuable support for this work to continue. Please note that contributions to IPRH are not tax deductible. For making donations please log on to http://www.audesapere.in/support/donate.html www.facebook.com/audesapere.in www.twitter.com/drsauravarora in.linkedin.com/in/drsauravarora

CONTACT: www.audesapere.in/contact FEEDBACK : www.audesapere.in/feedback.html

35
Licensed under a Creative Commons Attribution Non Commercial Share Alike 3.0 Unported License.

Table of Contents
Studies you may like to read ....................................................................................................................37 Clinical Research .........................................................................................................................................37
1. An Open Label Pilot Study Testing The Role Of Classical Homeopathy In Chronic

Allergic Rhinitis ................................................................................................................. 37 severe depression in peri- and postmenopausal women (HOMDEP-MENOP): study protocol for a randomized, double-dummy, double-blind, placebo-controlled trial... 37 randomized double-blind controlled study .................................................................... 38 interventional study .......................................................................................................... 39

2. Efficacy of individualized homeopathic treatment and fluoxetine for moderate to

3. Accelerating the healing of bone fracture using homeopathy: a prospective,

4. Evidence based homoeopathy in treating condyloma acuminatum a prospective and

Drug Standardization ................................................................................................................................39


1. Acalypha indica L - an Important Medicinal Plant: a Review of Its Traditional Uses,

and Pharmacological Properties ...................................................................................... 39

2. Regulatory Standards on Homoeopathic Drugs: Indian Perspective ........................... 39 3. Homeopathic drug proving of Okoubaka aubrevillei: a randomised placebo-controlled

trial ..................................................................................................................................... 40

4. Chelidonium majus l. - a review on pharmacological activities and clinical effects .... 41

Veterinary Research...................................................................................................................................41
1. Homeopathic studies in veterinary medicine A collection by Gaby Rottler ................. 41

Public Health ................................................................................................................................................41


2. Unification of Indian Systems of Medicine and Homoeopathy Policy and National

Health Policy in India-Stakeholders' Perspective........................................................... 41

News ................................................................................................................................................................42 Events..............................................................................................................................................................42

36

Studies you may like to read Clinical Research


An Open Label Pilot Study Testing The Role Of Classical Homeopathy In Chronic Allergic Rhinitis Shubhamoy Ghosh*, Satadal Das, Malay Mundle, Dishari Sengupta, Sk. Intaj Hossain, Munmun Koley and Subhranil Saha IJPSR, 2013; Vol. 4(4): 1475-1484.

Free Text Available Purpose: The prevalence of allergic rhinitis (AR) is increasing at an alarming rate throughout the world. India has an estimated number of 15-20 million patients with allergic bronchial asthma and 30-80% of these suffer from AR. So, AR is considered as a major chronic respiratory disease due to its prevalence, impact on quality of life (QoL), work/school performance and productivity, economic burden and links with asthma. This research aims at testing the role of classical homeopathy in bringing changes in serum immunoglobulin E (IgE) level and absolute eosinophil count (primary outcome measures) and symptoms score and WHOQOL-BREF score related to AR (secondary outcome measures) by comparing the pre-trial and post-trial data. Method: An open label, single arm, experimental, prospective, non-randomized, non-controlled, before and after comparison pilot study was carried on 34 participants suffering from chronic AR. Institutional ethical clearance was obtained; then thirty four consenting patients were enrolled after screening of 58 patients by eligibility criteria and were allocated to classical

homeopathic treatment. Four cases were dropouts; thirty cases were regular. Outcome measures were assessed and analyzed after one year. Results: After one year of homeopathic treatment, lowering of serum IgE level (1006.83395.17 vs 336.5126.96; P = 0.0000), absolute eosinophil count of blood (600.33103.61 vs 302.582.21; P = 0.0000) and AR symptoms score (30.275.12 vs 12.832.72; P = 0.0000) and increase in WHOQOL-BREF scores of AR (587.01 vs 87.76.18; P = 0.0000) were statistically highly significant. No adverse effects and/or complications were observed. Most commonly used constitutional and acute remedies were Natrum muriaticum and Histamine hydrochloride respectively in different centesimal potencies. Conclusion: Data suggest that classical homeopathic treatment may be a useful measure for the patients suffering from chronic AR. However, multi-centric randomized controlled trials with larger sample size should be undertaken for making firm recommendations. Efficacy of individualized homeopathic treatment and fluoxetine for moderate to severe depression in peri- and postmenopausal women (HOMDEP-MENOP): study protocol for a randomized, doubledummy, double-blind, placebo-controlled trial. Trials 2013, 14:105 Emma del Carmen Macas-Corts, Leopoldo Aguilar-Faisal, Juan Asbun-Bojalil

Free Text Available Background The perimenopausal period refers to the interval when women's menstrual cycles become irregular and is characterized by an increased

37

risk of depressive symptoms. Use of homeopathy to treat depression is widespread but there is a lack of clinical trials about its efficacy in depression in peri- and postmenopausal women. Previous trials suggest that individualized homeopathic treatments improve depression. In classical homeopathy, an individually selected homeopathic remedy is prescribed after a complete case history of the patient. The aim of this study is to assess the efficacy and safety of the homeopathic individualized treatment versus placebo or fluoxetine in periand postmenopausal women with moderate to severe depression. Methods/design A randomized, placebo-controlled, double-blind, double-dummy, three-arm trial with a six week follow-up study was designed. The study will be conducted in a public research hospital in Mexico City (Jurez de Mxico Hospital) in the outpatient service of homeopathy. One hundred eighty nine peri- and postmenopausal women diagnosed with major depression according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (moderate to severe intensity) will be included. The primary outcome is change in the mean total score among groups on the 17-item Hamilton Rating Scale for Depression after the fourth and sixth week of treatment. Secondary outcomes are: Beck Depression Inventory change in mean score, Greene's Scale change in mean score, response and remission rates and safety. Efficacy data will be analyzed in the intention-to-treat population. To determine differences in the primary and secondary outcomes among groups at baseline and weeks four and six, data will be analyzed by analysis of variance for independent measures with the Bonferroni post-hoc test.

Discussion This study is the first trial of classical homeopathy that will evaluate the efficacy of homeopathic individualized treatment using Cpotencies versus placebo or fluoxetine in periand postmenopausal women with moderate to severe depression. It is an attempt to deal with the obstacles of homeopathic research due to the need for individual prescriptions in one of the most common psychiatric diseases. Accelerating the healing of bone fracture using homeopathy: a prospective, randomized double-blind controlled study BMC Complementary and Alternative Medicine 2012, 12(Suppl 1):O61 S Sharma*, N Sharma, R Sharma

Free Text Available Purpose In clinical practice, homeopathy is widely used in the fracture-repair process, which accelerates the healing of fractures, enhances callus formation and reduces pain. But there is no anatomical or scientific evidence yet to prove that. Therefore, the current study was undertaken to test the efficacy of homoeopathy in bone fracture healing. Methods The study was conducted as a double blind randomized controlled study with 67patients with acute non-displaced lateral malleolar fracture. Patients were recruited from the Emergency Orthopaedic department, SMS Hospital, Jaipur, India during May 2007 to May 2009. Patients were randomized to either a homoeopathy treatment (n=34) or a control group (n=33). All the patients received standard orthopaedic care through 12 weeks following injury. The treatment group received

38

homoeopathic medicine on the basis of totality of symptoms and individualisation. Outcome measures include radiological assessments and functional tests for healing.Assessments were taken on 3, 6, 9 and 12 weeks. Results Faster healing was reported in the homeopathy group by week 9 following injury, including significant improvement in fracture line (p < 0.0001), fracture edge (p<0.0001), callous formation (p< 0.05) and fracture union (p< 0.0001) in comparison to placebo. There was also lower use of analgesics and less self-reported pain in the homeopathy group. Conclusion The study suggests that homoeopathy could enhance anatomical and functional fracture healing. Evidence based homoeopathy in treating condyloma acuminatum a prospective and interventional study Chandra nath das

Drug Standardization
Acalypha indica L - an Important Medicinal Plant: a Review of Its Traditional Uses, and Pharmacological Properties

Free Text Available International Journal of Research in Botany 2013; 3(1): 19-22 D.Jagatheeswari, J.Deepa, H.Sheik Jahabar Ali and P. Ranganathan* Abstract Medicinal herbs are moving from fringe to mainstream use with a greater number of people seeking remedies and health approaches free from side effects caused by synthetic chemicals. India officially recognizes over 3000 plants for their medicinal value. It is generally estimated that over 6000 plants in India are in use in traditional, folk and herbal medicine. This article aims to provide a comprehensive review on the and pharmacological aspects of Acalypha indica. It is obtained from deciduous and mixedmonsoon forests throughout greater parts of India, ascending to 1300 m in outer Himalaya, is widely used in traditional medicinal system of India has been reported to possess hepatoprotective, anti-inflammatory, antitussive, antifungal and also used to check wounds healing and antibacterial. It is known as a rich source of tannins, flavanoids and glycosides. The innumerable medicinal properties and therapeutic uses of Acalypa indica as well as its phytochemical investigations prove its importance as a valuable medicinal plant. Regulatory Standards on Homoeopathic Drugs: Indian Perspective International Journal of Advanced Pharmaceutical Science and Technology 2013,

Free Text Available Condyloma acuminatum is one of the most prevalent sexually transmitted disease in the western countries and India. It may hamper personal life of individual. Human papilloma virus ( HPV) , subtype 6 & 11 are responsible for the disease .This case study is a prospective and intervention to combat long standing condyloma acuminatum by Homoeopathy. Keywords: Condyloma Acuminatum, Homoeopathy, Prospective & Interventional Study.

39

Volume 1, Issue 1, pp. 1-20, Article ID Sci-72 Lalit Tiwari, Nitin Rai and Rajeev Kr Sharma

symptoms produced by a homeopathic drug compared with placebo. Methods This multicentre, randomised, double-blind, placebo-controlled phase 1 trial consisted of a 7day run-in period, a 5 day intervention period and a 16-day post-intervention observation period. Subjects, investigators and statisticians were blinded for intervention groups and identity of the homeopathic drug. Subjects in the intervention group received Okoubaka aubrevillei (potency C12) and subjects in the placebo group received the optically identical sucrose globules. Dosage in both groups was five globules taken five times per day over a maximum period of 5 days. Subjects documented the symptoms they experienced in a semistructured online diary. The primary outcome parameter was the number of characteristic proving symptoms compared with placebo after a period of 3 weeks. Characteristic symptoms were categorised using content analysis. Secondary outcome parameters were the qualitative differences in profiles of characteristic and proving symptoms and the total number of all proving symptoms. The number of symptoms was quantitatively analysed on an intention-to-treat basis using analyses of covariance with the subject's expectation and baseline values as covariates. Results Thirty-one subjects were included (19 Okoubaka and 12 placebo). Data for 29 participants could be analysed. No significant differences in number of characteristic symptoms in both groups were observed between Okoubaka (mean standard deviation 5.4 6.0) and placebo (4.9 5.6). The odds ratio for observation of a characteristic symptom was 1.11 (95% confidence interval 0.4 to 3.05, P = 0.843). Females and subjects expecting a higher number of symptoms at

Free Text Available The Pharmacopoeia is the official compendium of a country related to regulatory standards of drugs manufactured and practiced in the political zone of that country. The pharmacopoeial standards are experimentally established and work as yardstick to ensure the quality safety and efficacy of a drug. These are approved standards and vetted by duly constituted bodies to incorporate in a pharmacopoeia. In broad term, the pharmacopoeia is a book of standards applicable to drug substance and their dosage forms of common usage in a country. Pharmacopoeia is prepared by recognized authority appointed by the Government of a particular country with a few exceptions eg. USP. In India, Homoeopathic System of Medicines has its own pharmacopoeia titled as Homoeopathic Pharmacopoeia of India (HPI). So far, nine volumes of HPI are published from 1971 to 2006 which covers total 919 monographs of Homoeopathic single drugs. Homeopathic drug proving of Okoubaka aubrevillei: a randomised placebo-controlled trial Trials 2013, 14:96 Michael Teut, Joern Dahler, Ute Hirschberg, Rainer Luedtke, Henning Albrecht, Claudia M Witt

Free Text Available Background Homeopathic drug proving is a basic concept in homeopathy. This study aimed to record

40

baseline or feeling more sensitive to homeopathic drugs experienced more characteristic symptoms regardless of allocation. The qualitative analysis showed an intercoder reliability of 0.69 (95% confidence interval 0.62 to 0.76). The qualitative comparison of symptom profiles was inconclusive. Conclusions Combined results of qualitative and quantitative methods did not result in a significant difference of characteristic proving symptoms between O. aubrevillei C12 and placebo. The qualitative comparison of the symptom profiles leaves some open questions. The nocebo effect might be a plausible explanation for most of the phenomena observed in this trial. Chelidonium majus l. - a review on pharmacological activities and clinical effects Biswas Surjyo Jyoti

Veterinary Research
Homeopathic studies in veterinary medicine A collection by Gaby Rottler

Free Text Available

Public Health
Unification of Indian Systems of Medicine and Homoeopathy Policy and National Health Policy in India-Stakeholders' Perspective Balpreet Singh*, Amarjeet Singh and Manoj Kumar

Free Text Available AIM: India has designed National Policy on Indian systems of Medicine and Homeopathy (ISM&H Policy) in 2002 to emphasize the development of Ayurveda, Siddha, Unani, Yoga, Naturopathy and Homoeopathy due to public patronage of these systems. Currently India has two health related policies, National Health Policy and ISM&H Policy. This study proposes to look into the need of eventual fusion of these policies for better healthcare. METHODS: An online questionnaire was designed to assess the views of Public Health experts and mailed to 100 experts. The tool was tested for content validity and a pilot study was done to find out the feasibility of the study. Study period was September 2010 to May 2011. The data was analysed with the help of Microsoft Excel 2007 represented as percentages.

Free Text Available Chelidonium majus L. (Papaveraceae) is a plant that has been used for centuries in treating many diseases in European and Asian countries. Crude extracts from various parts of the plant contain isoquinoline alkaloids. The alkaloids derived from C. majus have not yet much studied; however, some reports are available on toxicity studies of alkaloids of this plant. In such a scenario there is need for understanding its therapeutic potential and its toxic actions. This review summarizes scientific findings and suggests areas where further research is needed. Keywords: Chelidonium majus, alkaloids, pharmacology, antioxidant

41

RESULTS: 58 out of 100 experts responded to questionnaire. 67% of respondents favored formation of unified health policy. Most mentioned reason for unified policy was 'common goal of health' of all system followed by 'strengthening of health system' and 'equal status and growth of all health systems'. Respondents disfavoring the concept of unified health policy opined that all health systems have different principles which can be dealt by separate policy.

CONCLUSION: Majority of respondents opined that ISM& H Policy should be merged to form unified health policy as health is a complete concept in itself and should be viewed in multidisciplinary approach. Key words: India, medicine, homoeopathy policy.

News
Complementary medicines expert dismissed from homeopathy journal Homeopathy lacks any hard evidence Press council wades into medical evidence debate No doctors, infrastructure for Homeopathy hospitals Homeopathy Day celebrated Diluting the scientific method: Ars looks at homeopathy (again) Homeopathy on the NHS is 'mad' says outgoing scientific adviser Parents need to know homeopathy does not protect against measles, says MP

Events
May 2, 2013 Dr Kalathia's Systematic Approach in Homeopathy - Modern Interpretation 9:00 am 12:30 pm Webinar: 3 Hours 30 Minutes (Repeats Every 7 Days Until June 30, 2013) Module 1: An explicit explanation of the main Kingdoms in Homeopathy with their subcategories. Module 2: Scientific but artistic Case Taking, Case Analizing and Case Menagement HomeoHelp Holistic School's virtual classroom Rumen Stoychev info@homeohelp.eu May 2 May 5, 2013 BREAK THROUGH CONCEPTS- transforming patient stories and innovative case-taking techniques Speakers: Bhawisha and Shachindra Joshi Hosted & Sponsored by Stellar Seminars Contact: Sonam Kushner- sosimilar@aol.com Marina Braun- aquamarinabr@gmail.com

42

May 5, 2013 Dr. Kishore Mehta winner of best teacher award and world renowned teacher, will share his novel way to approach to Homoeopathic Materia Medica, through demonstration of NATRUM MURIATICUM. For Details and registration kindly click the link below; http://us2.campaign-archive1.com/?u=b7a07e78278262bc324cc8b90&id=3e01540784 May 13, 2013 AMCH MODERN PRACTICE 5:00 - 7:00 pm pacific time Karen Allen, Iris Bell, Miranda Castro, Jerry Kantor, Amy Lansky, Todd Rowe and Gabrielle Traub Contact: Leslie at 714-577-8853 or email whncourses@whnow.com May 15, 2013 NCH Webinar - Homeopathy as a Form of Nanomedicine: What the Latest Research Shows NCH Member Webinar Wednesday, May 15, 2013; 8-9PM EDT The homeopathic community is a-buzz with excitement about the rapidly expanding field of nanomedicine and current research into homeopathic remedies. If you are interested in learning more about the relationship between nanomedicine and homeopathy, then you won't want to miss this webinar. Join Dr. Iris Bell, a Research Professor at the University of Arizona College of Nursing and a member of the research faculty of the American Medical College of Homeopathy, for an overview of the scientific evidence indicating that homeopathic remedies contain nanoparticles of their source materials and the implications of this evidence for clinical care. As always, this webinar is free to all NCH members, but space is limited - so register today! Website: www3.gotomeeting.com/register/294732774 May 17 May 19, 2013 Prep for CHC and other Homeopathic Certification Exams Lauri Grossman, Lucy Vaughters Kenmore WA info@seattleschoolofhomeopathy.com 425-672-4485 May 19, 2013 FREE ONLINE SESSION: Nosodes - Themes and a Case by Dr. Kalathia ENROLL FOR FREE - http://homeohelp.eu/en/enroll.html Contact Skype "homeohelpeu" or school@homeohelp.eu

43