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Pt. B. D. SHARMA UNIVERSITY OF HEALTH SCIENCES, ROHTAK SCHEME OF EXAMINATION B.

Pharmacy - First Year
S. No. 1. 2. 3. 4. 5. 6. 7. 8. S. No. 9. 10. 11. 12. 13. 14. Code Subject (Theory Course) BPH : 101 Pharm. Chem. – I (Inorganic Chemistry) 102 Pharm. Chem. – II (Organic Chemistry) 103 Pharmaceutics – I (Introduction to Dosage Forms) 104 Pharmaceutics-II (Forensic Pharmacy) 105 106 107 108 Cod e BPH : 109 110 111 112 113 114 Pharmacognosy-I Pharmacology-I (Anatomy, Physiology & Health Education) Pharmaceutics – III (Drug Store and Hospital Pharmacy) Pharmaceutical Biology Subject (Practical Course) Hrs/ wee k 2 3 2 2 2 3 2 2 Hrs/ wee k 3 3 3 3 3 3 Total

Pharm. Chem. – I (Inorganic Chemistry) Pharm. Chem. – II (Organic Chemistry) Pharmaceutics – I (Introduction to Dosage Forms) Pharmacognosy-I Pharmacology-I (Anatomy, Physiology & Health Education) Pharmaceutical Biology

Pt. B. D. SHARMA UNIVERSITY OF HEALTH SCIENCES, ROHTAK SCHEME OF EXAMINATION B. Pharmacy – Second Year
S. No. 1. 2. 3. Code Subject (Theory Course) BPH : 201 Pharm. Chem. – III (Physical Chemistry) 202 Pharm. Chem. – IV (Pharmaceutical Analysis-I) 203 Pharm. Chem. – V (Pharmaceutical Biochemistry) Hrs/ wee k 2 3 2 1

SYLLABUS FOR SESSION 2009-13

4. 5. 6. 7. 8. S. No.

204 205 206 207 208

Pharmaceutics – IV (Pharmaceutical Microbiology) Pharmaceutics – V (Pharmaceutical Engineering-I) Pharmacognosy-II Computers in Pharmacy Pharmaceutical Mathematics

2 2 2 2 3 Hrs/ wee k 3 3 3 3 3 3 3 Exter nal Asses smen t Intern al Asses sment Total

Code Subject (Practical Course) BPH : 209 Pharm. Chem. – III (Physical Chemistry) Pharm. Chem. – IV (Pharmaceutical Analysis-I) Pharm. Chem. – V (Pharmaceutical Biochemistry) Pharmaceutics – IV (Pharmaceutical Microbiology) Pharmaceutics – VI (Engineering Drawing) Pharmacognosy-II Computers in Pharmacy

9.

10. 210 11. 211 12. 212 13. 213 14. 214 15. 215

SYLLABUS FOR SESSION 2009-13

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Pt. B. D. SHARMA UNIVERSITY OF HEALTH SCIENCES, ROHTAK SCHEME OF EXAMINATION B. Pharmacy - Third Year
S. No. Code Subject (Theory Course) BPH :
301 302 303 304 305 306 307 308 309 PHARMACEUTICAL CHEM.-VI (Medicinal chemistry-I) PHARMACEUTICAL CHEMISTRY-VII (Heterocyclics, Carbohydrates, Proteins and Nucleic acids) PHARMACEUTICS -VII (Physical Pharmacy) PHARMACEUTICS-VIII (Pharmaceutical Engineering-II) PHARMACEUTICS-IX (Pharmaceutical Technology-I) PHARMACOLOGY- II PHARMACOGNOSY-III PHARMACOLOGY- III (Pharmaceutical Animal Biotechnology)

Hrs/ wee k
2 2 2 2 2 3 2 2 2

Exter nal Asses smen t

Intern al Asses sment

Total

1. 2. 3. 4. 5. 6. 7. 8. 9.

Environmental Sciences

S. No.

Code Subject (Practical Course) BPH : 310 311 312 313 314 315
PHARMACEUTICAL CHEM.-VI (Medicinal chemistry-I) PHARMACEUTICS -VII (Physical Pharmacy) PHARMACEUTICS-VIII (Pharmaceutical Engineering-II) PHARMACEUTICS-IX (Pharmaceutical Technology-I) PHARMACOLOGY- II PHARMACOGNOSY-III

Hrs/ wee k 3 3 3 3 3 3

Exter nal Asses smen t

Intern al Asses sment

Total

10. 11. 12. 13. 14. 15.

B. Pharmacy Part – IV (Revised Scheme) 2003-04 Course of study for B.Pharmacy Part –IV (Revised Scheme) S.N. Subject to be taught Teaching Load Theory (hours/week) Teaching Load Practical (hours/we ek) 04 03 -3

mdu

26. 27. 28.

PHARMACEUTICS-X 02 (Biopharmaceutics and Pharmacokinetics) PHARMACEUTICS-XI 03 (Pharmaceutical Technology) PHARMACEUTICS-XII 02 (Pharmaceutical Management) SYLLABUS FOR SESSION 2009-13

31.29. 33. 30. PHARMACEUTICS-XIII (Packaging Technology) PHARMACEUTICAL CHEMISTRY-VIII (Medicinal Chemistry-II) PHARMACOLOGY.IV PHARMACEUTICAL CHEMISTRY-IX (Pharmaceutical Analysis-II) PHARMACOGNOSY-IV Total 02 03 02 03 02 19 -03 04 03 03 20 SYLLABUS FOR SESSION 2009-13 4 . 32.

Gases and Vapours: Oxygen. Major Intra and Extra-cellular Electrolytes: Physiological ions. ii. carbon black. dimercaprol. Astringents (Alum. sources of impurities. Sodium potassium tartrate and antimony potassium tartrate).BPH-101: PHARMACEUTICAL CHEMISTRY – I (INORGANIC CHEMISTRY) THEORY Max. Chlorinated lime. Povidone iodine Hydrogen peroxide. electrolytes used for replacement therapy. (14) 3.Zinc sulphate) and Anti-infective (Iodine. its preparations and radiopaque contrast media. poisons and antidotes (heavy metal and cyanide poisoning: sodium nitrite injection. Zinc oxide. i. (4) 4. Aluminum phosphate. (8) SYLLABUS FOR SESSION 2009-13 5 . Magnesium carbonate . ethylene diamine tetra acetate salts. diluents (calcium sulphate. arsenic. including limit tests for iron. sodium benzoate). bentonite). Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. uses. charcoal). Boric acid ). colorants (red ferric oxide.life period. Cationic and anionic components of inorganic drugs useful for systemic effects. An outline of methods of preparation. preservatives (sulphur dioxide. Dental Products: Dentifrices. chloride. sodium fluoride). Cathartics (Magnesium sulphate). Anaesthetics and Respiratory stimulants (ammonium carbonate). sedatives (potassium bromide and lithium carbonate). keiselguhr. Emetics (Copper sulphate. radioactive determination. isotopes. use of radioisotopes in basic research. diagnostic applications of isotopes. (2) 2. Inorganic radio-pharmaceuticals: Nuclear composition. mineral supplements. penicillamine). Potassium permanganate. Review of electronic structure of atom. artificial radioactivity. lead. sodium tetradecyl sulfate injection). etc. Pharmaceutical Aids: Anti-Oxidants (sodium metabisulphide. expectorants (Ammonium chloride and potassium iodide). radiopharmaceuticals. hypophosphorus acid). (7) 9. periodic classification and group properties of elements. therapeutic applications of isotopes. combination preparations). Essential and Trace Elements: Transition elements and their compounds of pharmaceutical importance. Protectives and Adsorbents. tests for purity and identity. half. (3) 8. heavy metals. measurement of radioactivity. Acids and Bases: Buffers. Anti-caries agents (Stanous fluoride. (4) 5. Topical Agents : Protectives (Calamine. 1. Silver nitrate. sodium thiosulphate injection. Antacids (Aluminum hydroxide gel. Titanium dioxide). acid-base balance and combination therapy. Talc. sulphate and special tests if any. filter aids (purified talc. natural colors) etc. Magnesium trisilicate. Gastrointestinal Agents: Acidifying agents (Dil HCl). modes of decay. (4) 7. nitrogen. Water. Iron and haematinics. suspending agents (sodium lauryl sulphate. colloidal silicon dioxide). of the following classes of inorganic pharmaceuticals included in Indian Pharmacopoeia. forces and stability. Miscellaneous Agents: Sclerosing agents (Morrfurate sodium injection. (4) 6. adsorbents.

Wilson. 2. E. Oxford University Press.. 3.M.O. NOTE: ANY OTHER EXPERIMENT (S) MAY BE INCLUDED IN SUPPORT OF THEORETICAL ASPECTS OF THE COURSE. Pharmacopoeia of India. Ministry of Health. Block. Lea & Febiger. Roche.H. Stenlake. J. Philadelphia.BPH-109: PHARMACEUTICAL CHEMISTRY – I (INORGANIC CHEMISTRY) Max. Marks: 80 1. Identification and purification of selected Inorganic Pharmaceutical Substances. Bentley and Drivers. Soine and C. 2. PRACTICAL Total Hours: 75 (3hrs/week) The background and systematic qualitative analysis of inorganic mixtures containing up to 4 radicals. "Inorganic Medicinal and Pharmaceutical Chemistry". 3rd edition. Beckett and J. L.O. Books Recommended (Latest edition): 1. Govt. S& Ed. Part I. Artherden. T.B. 3. A. 4. "Textbook of Pharmaceutical Chemistry". SYLLABUS FOR SESSION 2009-13 6 . Delhi. "Practical Pharmaceutical Chemistry". of India.H. Limit tests for impurities in Pharmaceutical compounds.

polarity of bonds. Michael. D/L and R/S nomenclature. Grignard. Tautomerism. Geometrical isomerism. effects. Identifications of simple organic compound and preparation of suitable derivatives. dienes. Marks: 80 Total Hours: 75 (3hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five.BPH-102: PHARMACEUTICAL CHEMISTRY – II (ORGANIC CHEMISTRY) THEORY Max. Structure. Demonstration of Stereochemistry using Ball and stick model NOTE: ANY OTHER EXPERIMENT (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Hyperconjugation. sublimation. delocalized chemical bonding. amines. Bond lengths. Simple organic preparations involving acetylation. oxidation and reduction reactions. Catalysis by transition metal complexes. functional derivatives of carboxylic acid. Diastereomers. polarity of molecules. Reformatsky. Bonzoin condensations and benzilic acid rearrangements. sigmatrophic reactions. Stereoselective and Stereospecific reactions. 4. distillation. Witting and Perkin reactions. nucleophilic and free radicals addition to carbon-carbon multiple bonds. benzylation. recrystallization. Mannich. 3. Structure and properties: Covalent bonding. carboxylic acids. (19) Active methylene compunds: Ethyl acetoacetate and diethyl malonate synthesis and applications in organic synthesis. Aldol. Optical activity. Chirality. alcohols. phenols. preparation and reactions of Alkane. Electronegativity. 1. orientation and stereochemistry. substitutions. cycloalkanes. Introduction to various laboratory techniques viz. 6. Knoevengal. Nomenclature. SYLLABUS FOR SESSION 2009-13 7 . 4. (4) 2. 5. 2. (30) Stereochemistry (Basic Concepts): Isomerism. benzene. neighbouring gp. Hybridization. Conformations in open chain systems. Marks: 80 1. (8) Electro cyclic reactions. sulphonation. etc. Inductive and field effects. BPH-110: PHARMACEUTICAL CHEMISTRY – II (ORGANIC CHEMISTRY) PRACTICAL Total Hours: 75 (3hrs/week) Max. bond angles and bond energies. Multiple bonds. Enantiomers. Intermolecular forces. alkyl halides. (10) Addition to carbon/carbon and carbon/hetero multiple bonds: Electrophilic. Relative and absolute configuration. (4) 3. aldehydes and ketones. alkene. E/Z system of nomenclature. Racemic mixture and resolution. alkyne.

Books Recommended (Latest edition): 1. R.T. Morrison and R.N. Boyd. Organic Chemistry, Allyl and Bacon, Inc., Boston, USA. 2. Organic Chemistry: Vols.I-III, S.M. Mukherji, S.P. Singh, R.P. Kapoor and R. Dass, New Age International (P) Ltd. , Publishers, Ansari road, Second edition, New Delhi-110002. 3. I. L. Finar, Organic Chemistry, Vol. I and II, The English Language Book Society. 4. P.Sykes, A Guidebook to Machanisms in Organic Chemistry, Orient Longman, New Delhi. 5. J. March, Advanced Organic Chemistry, Reaction, Mechanisms and Structure, Wiley Eastern : New Delhi. 6. S. Pine, Organic Chemistry, McGraw Hill, 1987.

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BPH-103: PHARMACEUTICS-I (INTRODUCTION TO DOSAGE FORMS) THEORY Max. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. 1. Introduction: Importance and classification of Pharmaceutical dosage forms, Sources of information required for Pharmacists. (2) 2. Prescription: Definition, various parts of prescription and their functions, handling of prescription, sources of error and care required in dispensing prescriptions, special labelling instructions for different pharmaceutical dosage forms. Pharmaceutical Latin terms used in prescriptions and their translation into English. (4) 3. Incompatibilities: Definition, types of incompatibility-physical, chemical and therapeutic, study of examples of prescription containing incompatibility, their correction and dispensing methods. (4) 4. Additives: Colours, flavours, sweeteners, surfactants, hydrocolloids, vehicles, stabilizers and other additives used in prescriptions. (5) 5. Solid dosage forms: Powders-Definition, advantages, disadvantages, cachets, tablet triturates, preparation of different types and problems encountered in dispensing of powders, effervescent granules, lozenges. (5) 6. Monophasic liquid dosage forms: Definition, brief description and formulation of mixtures, syrups, elixirs, aromatic waters, linctuses, liniments, lotions, collodions, gargles, mouthwashes, throat paints, douches, enemas, ear drops, eye drops and nasal drops. (8) 7. Biphasic liquid dosage forms: Suspensions and emulsions: Definition, advantages, disadvantages, classification, formulation, methods of preparation, stability and evaluation. (5) 8. Semisolid dosage forms: Ointments, pastes, jellies, poultices, suppositories and pessaries: Definition, advantages, classification, types of ointment and suppository bases, factors governing selection of ideal ointment and suppository base, methods of preparation and evaluation. (7) 9. Ophthalmic products: Definition, classification, essential characteristics, administration and precautions while handling, formulation additives, preparation of eye drops, contact lenses and lens care products. (3) 10. Posology: Definition, factors affecting dose selection, calculation of children and infant doses. (2) 11. Pharmaceutical Calculations: Metric and imperial system of weights and measures, percentage calculations, enlarging and reducing recipes, isotonic solutions, alcohol dilutions, allegation methods, proof spirits, displacement value. (5) BPH-111: PHARMACEUTICS-I (INTRODUCTION TO DOSAGE FORMS) PRACTICAL Max. Marks: 80 Total Hours: 75 (3hrs/week) Dispensing of prescriptions covering following dosage forms: 1. Solid dosage forms including simple powders, compound powders, dusting powders, bulk and divided powders for oral use. 2. Monophasic dosage forms including simple mixtures, mixtures containing diffusible and indiffusible solids, liniments, lotions, enemas syrups, elixirs, aromatic waters, gargles, mouthwashes, throat paints, ear drops. SYLLABUS FOR SESSION 2009-13 9

3. Biphasic dosage forms including suspensions and emulsions for internal use. 4. Semisolid dosage forms including ointments, pastes, poultices and suppositories. 5. Ophthalmic products including eye drops. 6. Prescriptions related to pharmaceutical incompatibilities. NOTE: ANY OTHER EXPERIMENT (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Books Recommended (Latest edition): 1. Remington, The Science and Practice of Pharmacy, Mack Publishing Co., U.S.A. (Latest Edition.). 2. J. W. Cooper and G. Gunn, Tutorial Pharmacy, 1st edition, 1956, Pitman Books Ltd., London, U.K. 3. S. J. Carter, Dispensing for Pharmaceutical Students, 11th and 12th edition, 1967 and 1975, Pitman Books Ltd., London, U.K. 4. E. W.. Martin, Dispensing of Medication, 7th and 8th edition, 1971 and 1982, Marek Publishing Co., Pennsylvania, U.S.A. 5. L. Lachman, H.A. Liebennan and J.L. Kanig, The Theory and Practice of Industrial Pharmacy, Lea and Febiger, Philadelphia, U.S.A. (Latest Edition). 6. H. S. Ansel and N.G. Popovich, Pharmaceutical Dosage Forms and Drug Delivery Systems, Baltimore, Md: Lippincott Williams & Wilkins (Latest edition). 7. E.A. Rowlins, Bentley's Textbook of Pharmaceutics, Bailliere Tindall and Cox, London, Latest Edition. 8. J. B. Sprowls, Prescription Pharmacy, J. B. Lippincott Company, Philadelphia.

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v. v. Introduction: (5) i.a brief reviews. IPR studies. Poisons Act 1919. Relevant information for marketing the Pharmaceutical products in other countries. International documentation: New drug application. B. vi. iv.BPH-104: PHARMACEUTICS –II (FORENSIC PHARMACY) THEORY Max. National Book Centre. iii. Govt of India. States shops and establishments Act and Rules. iv. Insecticides Act 1968. vii. iii. Minimum Wages Act 1948 & Rules 1950. L. Medicinal and Toilet preparations (Excise duties) Act 1955. 2.a brief reviews. Sundari Mohan Avenue. vi. Prevention of cruelty to Animal Act 1960. 1940 and all amendments. Patents Act 1970 and Rules 1972 4. Drug laws by P. SYLLABUS FOR SESSION 2009-13 11 . Narcotic Drugs and Psychotropic Substances Act 1985 and Rules. ii. M. viii. Mithal. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. Drug and cosmetics Act 1940 and rules 1945. Medical termination of Pregnancy Act 1970 and Rules 1975. Drugs and Cosemetics Act. 1. Pharmacy Act 1948 iii. A brief study of the following with special reference to the main provisions (with amendments): (25) i. 4. Dr. ix. (5) Books Recommended (Latest editions) 1. 3. Pharmaceutical legislation. Procedure of filling patent (National & International). Drug and Magic remedies (objectionable advertisements) Act 1954. AICTE Act 1987. 3. An elaborate (practical oriented) study of the following: (15) i. Pharmaceutical Ethics ii. Relevant Acts & Rules published by the Government of India. Price Control Act 1995.a brief reviews. Drug and Pharmaceutical Industry. Text Book of Forensic Pharmacy. Malik. Calcutta 700014. ii. 2. Pharmaceutical education.

Shark liver oil and wool fat. Determination of leaf constants such as stomatal index. citronella. Ginger. Pectin. An introduction to active constituents of drugs: their isolation. Cod-liver oil. Gum Acacia. Marks: 80 BPH-105: PHARMACOGNOSY-I THEORY Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. mutation and hybridization with reference to medicinal plants. (2) 2. chenopodium. stomatal number. kokum butter. decoction. scope and development of Pharmacognosy. Systematic pharmacognostic study of the following: (10) (a) Carbohydrates and derived products: Agar. classification and properties. lemon peel. Balsam of peru. taxonomical pharmacological. eucalyptus. castor oil. Pest management and natural pest control agents. Asafoetida. cardamom. Benzoin. (7) 11. 9. Microscopic measurements of cells and cell contents: starch grains. (3) 7. Balsam of tolu. chemical and biological methods of evaluation. SYLLABUS FOR SESSION 2009-13 12 . Classification of drugs: Alphabetical. NOTE: ANY OTHER EXPERIMENT (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. (b) Lipids: Bees wax. Quality control of crude drugs: Adulteration of crude drugs and their detection by organoleptic. clove fennel. for concentrated preparations. (4) 3. Polyploidy. Honey. (4) 6. and natural colorants. Identification of crude drugs mentioned in theory. history. nutmeg. Sources of drugs: Biological. cinnamon. vein-islet number. percolation (various types including processes for concentrated preparations. 2. Study of the drugs containing resins and resin combinations: Colophony. Morphological characteristics of plant families mentioned in the theory. calcium oxalate crystals and phloem fibres. Introduction: Definition. Volatile oils: General methods of obtaining volatile oils from plants. musk and sandalwood. caraway. Study of volatile oils of mentha. Lard. gelatin. 4. Starch and Tragacanth. (3) 8. Isabgol. collection. (5) 5. Cultivation. marine. orange peel. continuous hot percolation). maceration (various types including processes for organized and unorganized drugs. Linseed oil. diatomite. Podophyllum. 1. cumin. Cocoa butter. Myrrh. cassia. (3) BPH-112: PHARMACOGNOSY-I PRACTICAL Max.Max. 3. Cannabis. valerian. (6) 10. (3) 4. vein termination number and palisade ratio. geographical and plant tissue cultures. Turmeric. kaolin. microscopic. Guar gum. physical. double and triple maceration processes) and factors affecting choice of extraction process. Extraction: Various methods of extraction of crude drugs namely infusion. lemon grass. Marks: 80 Total Hours: 75 (3hrs/week) 1. Study of pharmaceutical aids like talc. Plant hormones and their applications. bentonite. chemical and others with their merits and demerits. Rice bran oil. Types of soils and fertilizers of common use. coriander. morphological. processing and storage of crude drugs : factors influencing cultivation of medicinal plants.

Trease and Evans Pharmacognosy (15th Ed. Brady & J. 1957. M.. Robbers. Jackson & D. 2002. 3. London. Hickey and C.Books Recommended (Latest edition): 1.M. 1967. Trease. E. Bombay. SYLLABUS FOR SESSION 2009-13 13 . Stanley Thomes Ltd. V. Saunders Limited. Powdered Vegetable Drugs. London. Snowdon. India. E. Pharmacognosy (9th Edition). C. 2. 4. 6. B. B. Bailliere Tindall. 1974. R. W. P. G. 1988. Varghese Company. A Textbook of Pharmacognosy (7th Edition). Evans. L.. 1988. King. Trevor Robbinson. 100 Families of FIowering Plants. W. W. Tylor.. The Organic Constituent of Higher Plants. 2nd Edn. E. K. Burge Publishing Co. 5.). Cambridge University Press.

tuberculosis. Lung volumes. (5) 7. Functions of cerebrum. Scope of Anatomy. (3) 15. types of joints and their disorders. poliomyelitis. burns. taste and skin. diphtheria. poisoning. Mountain sickness and Caisson’s disease. Central Nervous System: Structure and function of brain and spinal cord. Mechanism of respiration. olfaction. ECG and heart sounds. blood circulation. electrophysiology of muscles. tetanus. (4) 10. Physiology of urine formation and acid base balance. Vital centers of medulla oblongata. filariasis. Disease causing agents and prevention of disease. bleeding and clotting disorders. their types and characteristics. mechanism of coagulation.T. (2) 16. coitus and fertilization. Digestion. Sex hormones. 1. Bones and Joints: Structure and function of skeleton. (6) 13. Physiology and Divisions of ANS. (4) 12. Reticulo-endothelial system and its function. modes of transmission and prevention of chicken pox. Reproductive system: Structure and function of Male and Female reproductive systems. and its physiology with special reference to liver. second messengers. Connective. Nutrition: Balanced diet. pancreas and stomach. physiology of menstruation. Muscular and Nervous tissues. Blood grouping and its significance. (3) SYLLABUS FOR SESSION 2009-13 14 . (4) 9. (2) 2. (2) 17. Autonomic Nervous System: Anatomy. Formation of lymph and its composition. (5) 5. PHYSIOLOGY. Respiratory system: Anatomy of respiratory tract. Urinary System: Structure and functions of Kidney and Urinary Tract. Parathyroid.I. signal transduction. cerebellum. Basic anatomy and physiology of Pituitary. cardiac cycle. Pregnancy and parturition. Spermatogenesis and Oogenesis. Communicable diseases: The causative agents. audition. Deficiency disorders of various nutrients. absorption. (4) 3. cerebral ventricles. fractures and resuscitation methods. Thyroid. their prevention and treatment. Physiology and basic terminology. Sense organs: Physiology of vision. Motor and sensory pathways. Cardiovascular system: Anatomy and physiology of heart. Health education: Concepts of health and disease. (6) 6. STD and AIDS. Marks: 80 Total Hours: 75 (3hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five.BPH-106: PHARMACOLOGY-I (ANATOMY. movements of intestine and disorders of digestive system. malaria. Blood and Lymph: Composition and functions of blood including their disorders. rabies. First Aid: Emergency treatment of shock. (6) 18. blood pressure. cranial nerves and their functions. Tissues: Epithelial. (3) 14. Disorders like Cyanosis. measles. heart rate. Digestive system: Gross anatomy of the G. (6) 8. (5) 11. cell stimulation and neuronal functions. AND HEALTH EDUCATION) THEORY Max. Structure and functions of cell: Ion channels. Adrenal and Pancreatic hormones and disorders of these glands. Transport of oxygen and carbon dioxide. (5) 4. snakebite.

S. CBS Publishers. heart rate and blood pressure recording.S. Text book of Anatomy and Physiology for Health professionals by Indu Khurana. 1995. J. McGraw Hill International Book Company. on arrangement with W. A. Marks: 80 Total Hours: 75 (3hrs/week) 1. J. F. SYLLABUS FOR SESSION 2009-13 15 . Principles of Internal Medicine. 3. Livingstone. blood group determination. Haemoglobin estimation. U. W. 4. Gray's Anatomy. E.BPH-113: PHARMACOLOGY-I (ANATOMY. 10. Romanes. 5. Neil and N. A. published by Oxford University Press. Review of Medical Physiology. PHYSIOLOGY. Martin. B. Books Recommended (Latest edition): 1. Fauei. S.L.E. Sherman and D. AND HEALTH EDUCATION) PRACTICAL Max. Williams & R. Text Book of Medical Physiology published in India by Prism Books Ltd. published by Oxford University Press. published by Appleton & Lange. J. 2. published by Churchill 6. H.B. 7. ESR. 1998. 9.L. Vander. K. 4. Saunders Company. J. Eleventh Edition. A. Guyton & J. S. bleeding and clotting time. 38th Edition. 14th Ed. Blood experiments: Enumeration of RBC and WBC. Cunningham's Textbook of Anatomy.E. 3. edited by G. Hall. Determination of vital capacity. C. Ganong. Warwick. Study of different systems with the help of models. Microscopic study of different tissues.J. edited by P. Jools.. U. Health education – charts for various communicable diseases. E. 5. D. Wilson Harrison. Human Physiology. Keele. 8. A. 1982. Isslbucher. Samson Wright'sltpplied physiology. Identification of bones and points of identification. 6. NOTE: ANY OTHER EXPERIMENT (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Thirteenth Edition. Kasper. J. 2. Braunwald. Thirteenth Edition. Luciano.

Satellite pharmacy services. Requirements and abilities required for Hospital pharmacists. (4) 2) Drug House Management: Selection of Site. inventory carrying cost. SYLLABUS FOR SESSION 2009-13 16 . (2) Books Recommended (Latest editions): 1. 4. (4) 5) Recruitment. composition. requirements. DRUG STORE MANAGEMENT 1) Introduction: Trade. 4) Manufacturing (Sterile and Non-Sterile): Economical considerations. Non-sterile manufacture –Liquid orals. Forms of Business Organizations. (4) 4) Sales Promotion. (4) 2) Hospital Pharmacy: Definition. Codification. Personnel and facilities requirements including equipments based on individual and basic needs.T. testing of raw materials. 3. In-patient services: types of services. Industry and Commerce. VED analysis. Market Research. Salesmanship. India . 2. Location. Remington Pharmaceutical Sciences. the lead time. credit information. facilities. training. detailed discussion of unit Dose system. layout production planning. scrap and surplus disposal.BPH-107: PHARMACEUTICS-III DRUG STORE MANAGEMENT & HOSPITAL PHARMACY THEORY Max. minimum and maximum stock levels.C (Pharmacy Therapeutic Committee). demand estimation. Importance and objectives of Purchasing. Functions and objectives of Hospital Pharmaceutical services. Hospital Pharmacy. Classifications based on various criteria. Smith Loa & Febiger. Channels of Distribution. modern techniques like ABC. estimation of demand. Prentice Hall. Advertising and Window Display. Function. (10) 5) Procurement of stores. externals-bulk concentrates. Management and Health delivery system in India. man-power requirements. Principles and methods of Pharmacy management. Hassan Lippincott. Introduction of Elements of Economics and Management. Central sterile services. safety stock. Functions and subdivision of Commerce. Lippincott. (4) 3) Drug Distribution system in Hospitals: (4) i. Floor ward stock system. organization. (2) 6) P. (2) 8) Long-term care facilities. functioning. contracts and price determination and legal requirements thereto. evaluation and compensation of the pharmacist. handling of drug stores and other hospital supplies. (3) HOSPITAL PHARMACY 1) Hospitals: Definition. tenders. Sterile manufacture-large and small volume parenterals. Layout. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. Philadelphia. Materials Manegemnet by Gopalkrishna. Out –patient services ii. Space Lay-out and legal requirements. Hospital Formulary System and their organisation. Bed Side Pharmacy. Flow chart of material and men. (2) 7) Drug Information service and Drug Information Bulletin. qualities of a salesman. selection of suppliers. Harrg A. economic order quantity. (5) 3) Inventory Control: objects and importance.

taenia and ascaris. Anatomy of stem. Liliaceae. functions and cell inclusions. Structure and life history of parasites as illustrated by amoeba. Rubiaceae. Respiration. Methods of classification of plants: Artificial. Mitosis and meiosis. root and leaf of monocot and dicot plants. flower. (5) 3. C. N. Mosquito and Silkworm. Evidence and theories of evolution. Umbelliferae. Study of life history of insects: Housefly. Knowledge of Physiological process: Transpiration. Botany 2. fruit and seed. Solanaceae. root and leaf. entamoeba. use and type of microscope. Gross identification of slides of structure and life cycle of lower plants/animals mentioned in theory. Classification and general characters of invertebrates and vertebrates up to class with important examples. plasmodium. (4) BPH-114: PHARMACEUTICAL BIOLOGY PRACTICAL Max. Care. Microscopic examination 'of stem. root and leaf and their modifications. 1. Invertebrates. 3. Apocynaceae. Natural and Phyllogenetic. 4. Cruciferae. Mendel's laws. Knowledge of heredity and variation. Graminae. Rutaceae. Study of tissues: Meristematic and Permanent tissues. (6) 9. Botany SYLLABUS FOR SESSION 2009-13 17 . Plant taxonomy: Families. Growth and growth regulators. 3. Datta. trypanosoma. Dhami & Dhami. Study of plant cell. K. Books Recommended: 1. Leguminosae. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. Structure of human parasites mentioned in theory with the help of specimen. (3) 2.Ranunculaceae. NOTE: ANY OTHER EXPERIMENT (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. (7) 7. 4. (3) (3) 5. chromosomal theory of inheritance. 5. Bhatia.BPH-108: PHARMACEUTICAL BIOLOGY THEORY Max. 2. Description of flowers related to families mentioned in theory. Morphology of plant parts indicated in theory. Morphology of the stem. (7) 6. Marks: 80 Total Hours: 75 (3hrs/week) 1. Labiate. (5) 10. Papavaraceae. 6. Photosynthesis. its organelles. A. (3) 8. (4) 11.

coefficient of thermal expansion and compressibility. concept of spontaneity. liquid crystalline state. two and three miscible pairs). geometry and symmetry of crystals. state etc. equations of state.Membrane Equilibrium and drug absorption. wt. Phase Equilibrium: Phase component. solutes distributing in immiscible solvents. ionic and free-radical reactions. molar refraction. determination of rate and order. Kirchhoff’s equation and numericals for exercises. ideal and real gases. energy and enthalpy changes. Free Energy and Equilibrium: Helmholtz and Gibb’s free energy. application in mol. Swarm theory of liquid crystals. deduction of phase rule. degrees of freedom. smectic and nematic liquid crystals. Phase diagrams for one component system. chemical equilibrium. DebyeHuckel theory and its use in protein purification. critical constant and its determination. half. Thermo. equilibrium between phases and cooling curves. determination. (a) (b) (c) 4. Liquids: Intensive and extensive properties.life time. surface tension. Thermodynamics: (13) Energy and First Law of Thermodynamics: Preliminaries and definitions. parallel and opposing reactions. (a) Non. Crystal diffraction. (Collision. consecutive. entropy changes for phase changes and chemical reactions. Solution of gases in liquids.chemical equations. triangular plots and partially miscible three liquid systems (formation of one. partition. Miller indices. optical activity and their importance in structure elucidation. molecular interpretation of entropy. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. reversibility. physical properties of crystals. critical phenomena. Second and Third Law of Thermodynamics: Carnot Cycle. Additive and constitutive properties. a) Reaction Rates: Rate and rate constant. zero. parachor. Mol. Three-component systems. order and molecularity. temperature and pressure. point defects. (6) Kinetics and Adsorption: (11) (b) 3. second and third order reactions. applications. Applications. Theories and reaction Kinetics. effect of temperature. expressions for equilibrium constant.Electrolyte Solutions: Concentration scales. heat capacities and their relationship for ideal gas. (a) States of Matter: (12) Gaseous: Brief introduction to the behavior of gases. ideal and real solutions. Electrolyte Solutions: Arrhenius theory of electrolytic dissociation. colligative properties. types of crystals. first. 5. effect of volume. Donnan. Heats of reaction. Ionic equilibrium in blood. irreversible process. determination.coefficient and its importance. Deviation from ideal behavior. Lindman and Transition state Theory) SYLLABUS FOR SESSION 2009-13 18 .BPH-201: PHARMACEUTICAL CHEMISTRY – III (PHYSICAL CHEMISTRY) THEORY Max. wt. isothermal and adiabatic processes involving ideal gases. molar volume. Solutions: (8) (b) (c) 2. entropy calculations for ideal gas systems. absolute entropy. Solids: Amorphous and crystalline solids. Bragg’s equation. 1. for two component systems involving eutectics.

S. Structural determination using Atomic parachors. To determine the specific reaction rate of the acid catalysed hydrolysis of ethyl NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Nagin Chand & Co. 3. L. 9. To draw the mutual solubility curve of phenol water system. Freundlich and Langmuir adsorption isotherms. J. To determine the heat of neutralization of HCI and NaoH. 5. R. K. acid base catalysis. Books Recommended (Latest editions): 1. 10. To determine the molecular mass of naphthalene by Rast’s method. c) Adsorption: Physiosorption and Chemisorptions. Barrante. 1998. BPH-209: PHARMACEUTICAL CHEMISTRY – III (PHYSICAL CHEMISTRY) PRACTICAL Max. Marks: 80 Total Hours: 75 (3hrs/week) SUGGESTED EXPERIMENTS 1. 12. Physical Chemistry with Biological Applications. 6. Gibbs adsorption isotherm. Physical Chemistry and its Biological Applications. S.b) Catalysis: Characteristics of catalyzsed reactions. Academic Press. J. 1978. 8. To measure the surface tension of solutions of any alcohol in water at different concentrations. acetate. W. Brey. R. homogeneous and heterogeneous catalysis. To study the molecular state of benzoic acid in benzene by partition method. 4. adsorption isotherms. Shoban Lal. Pathania. Principles of Physical Chemistry. 3. 2. BET equation and its use in surface area determination. To study the phase-diagram of a two component system having eutectic temperature (diphenylamine-napthalene). Henjman. To study the adsorption of acetic acid on activated charooal. 1980. Physical Chemistry of the Life Sciences. theory of catalysis. SYLLABUS FOR SESSION 2009-13 19 .. To determine the specific reaction rate of the hydrolysis of ethyl acetate by sodium hydroxide. R. Printell (Latest Edition). Sharma and M. enzyme catalysis. 4. To determine the heat of combustion of naphthalene at constant pressure and temperature. Laidler. 11. 7. Puri. To determine the partition cofficient of Iodine between CC1 4 and water. 2.

3. Filter papers and crucibles. Column chromatography: Adsorption and Partition theory. methods of expressing concentrations. (7) 9. titanous chloride. Titrations of weak acids and weak bases. Washing of the precipitate. Warner’s coordination number and electronic structure of complex ions. standardization and titration. Co-precipitation. (3) 2. phosphoric acid system. scope. (6) 7. Marks: 80 Total Hours: 75 (3hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. metal ion indicators. Complexometirc titrations: Concept of complexation and chelation. types of solvents. precision. fundamental of volumetric analysis. Supersaturation. concept of error. lithium and sodium methoxide. accuracy. tetrabutyl ammonium hydroxide. standard oxidation potential. 2. Mohr’s method.. Miscellaneous methods: 1. limitations. barium sulphate. added acids & bases upon buffer) Henderson Hasselbalch equation. polyamine and amino acid systems. EDTA-metal ion complexes. effect of acids. adsorption indicators. Determination of hardness of water. Postprecipitation. Nernst equation. primary and secondary standards. Kjeldhal method of nitrogen estimation. Acid base indicators. iodometry.6– dichlorophenol–indophenol. Relative strength of acids. fats and waxes. SYLLABUS FOR SESSION 2009-13 20 . Analysis of oils. Karl fischer titration 5. preparation and standardization of titrant solutions. Pharmaceutical applications.BPH-202: PHARMACEUTICAL CHEMISTRY – IV (PHARMACEUTICAL ANALYSIS – I) THEORY Max. (5) 6. Role of the solvent. Standardization of perchloric acid. strong base. thermogravimeteric curves Specific examples like barium as barium sulphate aluminium as aluminium oxide: Calcium as calcium oxalate and Magnesium as Magnesium pyrophosphate: Organic precipitants. (7) 3. masking and demasking agents. types of complexometric titration. (4) 8. preparation. factors influencing the stability of complexes. Oxygen Flask combustion 4. Non-aqueous titrations: Theoretical basis. Mixed indicators. significant figure. Filtration. stability constants. Oxidation – reduction titrations: Concepts of oxidation–reduction. Argentimetric titration. preparation. standard deviation. Chromatography with Pharmaceutical applications of each category: (20) i. 1. sodium–2. theory of redox titrations. bases. (4) 4. Gravimetric analysis: Colloidal state. Buffer solution (Effect of dilution. Acid base titrations (strong acid vs. Introduction: Importance of quality control. Neutralization titrations: Acid base concept. Ignition. Volhard’s method and Fajan’s method. Precipitation titrations: Principles of precipitation titrations. potassium permanganate. neutralization curves. indicators. Distribution of acid base species with pH. procedure and methods of detection. temperature and solvent on the solubility of precipitate. redox indicators.weak acids-weak bases and mixtures of strong & weak acids) Polyprotic systems. titrations involving cerric ammonium sulphate. calibration of analytical equipments. Titration of sodium carbonate. titration curves. mercurimetric and titration involving ammonium or potassium thiocyanate. solubility product. iodimetry. Acid base dissociation constant. normal distribution curve. Digestion. Diazotisation. (5) 5. computation of analytical results.

vi. 2. polarograph. (3) 13. Calibration of analytical weights and calibration of volumetric apparatus. 4. Ceriometry. preparation. Chatten.B. Gravimetry and Complexometry.. and J. half-cells. iv. Bassett. A. Conductometric titrations: Basic concepts. Alkalimetry. Beckett and J. (4) 12. mechanism of ion exchange and column operation. 10. general procedure. Basic instrumentation. Gas Chromatography: Introduction. A Textbook of Pharmaceutical Analysis. titration curves and applications. 2. Merritt: Jr. 8. Vol. procedure and detection of compounds. H. Paper chromatography: Theory of partition. Instrumental Mehtods of Analysis. Jenkin's Quantitative Pharmaceutical Chemistry. Iodometry. Marcel Dekker. R. 5. L. conductometer.M. (3) BPH-210: PHARMACEUTICAL CHEMISTRY – IV (PHARMACEUTICAL ANALYSIS – I) PRACTICAL Max. Wiley-Interscience. Basseler. 7. Electrochemical cells. Willard. I & II. amperometer. N. G. Chromatographic analysis of some pharmaceutical products. Books Recommended (Latest edition) 1. v. principles.H. New York. H. Vols. New York. Iodimetry. Govt.A.ii. Morril.Y). 3. New York. A. 6. Dean. J. The Athlone Press of the University of London (Latest Edition). Denney.. theoretical considerations. Silverstein.C. Van Nostrand Reinhold. different types of conductometric titrations. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Permanganometry. Delhi.Spectroscopic identification of organic compounds (John Wiley and Sons. apparatus. Connors. Pharmaceutical Chemistry. McGraw-Hill Book Co. Stenlake. G. L. Medhan. different techniques employed and different grades of papers used. Vogel's Textbook of Quantitative Inorganic Analysis Including Elementary Instrumental Analysis. Digangi. 3. Preparation and standardization of volumetric solutions and assay of official compounds involving Acidimetry. quantitative and qualitative detection. New York.E. Knevel and F. Size Exclusion Chromatography. iii. electrodes. Ministry of Health.L. Potentiometric titrations: Introduction. 4. SYLLABUS FOR SESSION 2009-13 21 . Analysis of pharmaceuticals using potentiometer. apparatus used and applications in Pharmaceutical Analysis. Jeffery & J. Indian Pharmacopoeia 1996 and 2007. Polarography: Basic concept. Practical Pharmaceutical Chemistry. (4) 11. Thin layer chromatography: Theoretical consideration. Ion Exchangers: Types of exchangers. of India. general polarography analysis and applications in pharmaceutical analysis. Amperometry: Amperometric titrations with one polarized electrode.H. K.A. Marks: 80 Total Hours: 75 (3hrs/week) 1. measurement of potential and application in pharmaceutical analysis. fundamentals of column operation and detection. I and II.

Protein and amino acid metabolism: protein turn over. determination of blood and urine creatinine. composition. hypercholesterolemia). Metabolic disorders of carbohydrate metabolism (diabetes mellitus and glycogen storage diseases): Glucose. Introduction to biochemistry: Cell and its biochemical organization. Genetic code: inhibition of protein synthesis: mutation and repair mechanism.Serum bilirubin. biosynthesis of fatty acids. Enzymes: Definition: Nomenclature. hyperbilirubinemia. Isoenzymes and their therapeutic and diagnostic applications. functions. Lipid metabolism: Oxidation of saturated (β-oxidation): Ketogenesis and ketolysis. HDL cholesterol. c) Test for hepatic dysfunction-Bile pigments metabolism. DNA replication (semiconservative /onion peel models) and DNA repair mechanism. enzyme inhibition. (8) 5. urine bilirubin and urine urobilinogen. Coenzymes and their biochemical role and deficiency diseases. hormonal regulation of carbohydrate metabolism. HMP shunt. (3) 2. glycogenesis. production of bile pigments. fatty liver. (8) 8. Factor affecting enzyme activity. Energy rich compounds: ATP. Citric acid cycle (TCA cycle). LDL cholesterol and triglycerides. Galactose tolerance test and their significance. (Creatinine /urea clearance. urea and uric acid). porphoria. Glycogenolysis. Introduction to clinical chemistry: (7) a) Urine analysis (macroscopic and physical examination. nitrogen balance. SYLLABUS FOR SESSION 2009-13 22 . IUB classification. metabolism of cholesterol. 1. quantitative and semi quantitative tests). jaundice. Protein synthesis. lipids. Determination of serum lipids. e) Lipid profile tests: Lipoproteins. Carbohydrate metabolism: Glycolysis. deamination & decarboxylation). gluconeogenesis. Metabolic disorder of Amino acids. d) Test for hepatic function: test. b) Test for NPN constituents. Biological oxidation: Coenzyme system involved in Biological oxidation. transport process across the cell membranes. total cholesterol.BPH-203: PHARMACEUTICAL CHEMISTRY – V (PHARMACEUTICAL BIOCHEMISTRY) THEORY Max. Urea cycle and its metabolic disorders. Nucleic acid metabolism: Metabolism of purine and pyrimidine nucleotides. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. (8) 6. Defective metabolism of lipids (Atherosclerosis. Hormonal regulation of lipid metabolism. (3) 3. Electron transport chain (its mechanism in energy capture: regulation and inhibition): Uncouplers of ETC: Oxidative phosphorylation. (5) 4. (8) 7. Catabolism of Amino acids (Transamination. Enzyme action. Cyclic AMP and their biological significance.

Saunders Co. Inc. SYLLABUS FOR SESSION 2009-13 23 . Biochemistry. A. 2) Separation of lipids by TLC. 5.K. Lange Medical Publication (Latest Edition). Chatterjea & Rana Schinde. 7. Textbook of Biochemistry. (Latest Edition). ammonia and creatinine in urine.. L. New Delhi (Latest Edition). Books Recommended (Latest edition): 1. Lehninger. glucose. Outlines of Biochemistry. PA Mays & V.L. Worth Publisher. Mazur. 6) Estimation of blood glucose. Harpers Review of Biochemistry. Conn & P. Freeman & Company. Stryer. Vij.W. Marks: 80 Total Hours: 75 (3hrs/week) 1) Preparation of standard buffer (nitrate. 3. Martin. 7) Enzymatic hydrolysis of glycogen by α and β amylase.L. Textbook of Medical Biochemistry. 6. SGPT and SGOT activity. Philadelphia. Biochemistry. D. RE. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE.H. W. W. 5) Identification of C-terminal amino acids of proteins. CBS Publishers and Distributors (Latest Edition). carbonate and measurement of pH). New York (Latest Edition). 8) Acid hydrolysis and action of salivary amylase on starch. 2. Principles of Biochemistry.B.BPH-211: PHARMACEUTICAL CHEMISTRY – V (PHARMACEUTICAL BIOCHEMISTRY) PRACTICAL Max.N. blood cholesterol. Jintender P. 3) Quantitative estimation of amino acids. 4. John Wiley & Sons. 10) Identification of carbohydrates. A. phosphate.M. Harrow & A. proteins and fats. 11) Identification of abnormal constituents of urine. Stumpf. San Francisco (Latest Edition). 9) Estimation of chloride. M. Redwell. (Latest Edition). 4) Quantitative estimation of proteins. Lehninger.

Aerobic and anaerobic cultivation of bacteria. enriched media and selective media. Principles and methods of different microbiological assays. Isolation of mutants. Major divisions of microbial world and relationship among them. factors influencing rate of mutation. BCG vaccine). Use of mutagenic agents. Disinfectants.e. official viral vaccines(small pox vaccine. Gram’s staining.Study of disinfectants. typhus vaccine).BPH-204: PHARMACEUTICS – IV (PHARMACEUTICAL MICROBIOLOGY) THEORY Max. control of different parameters in fermentation process. (6) 4. (2) 2. growth and cultivation of bacteria and virus. Study of different important media required for the growth of aerobic and anaerobic bacteria & fungi. toxicity tests. Diphtheria antitoxins. 2. infection. Nutritional requirements. evaluation of preservatives in pharmaceutical preparations. Counting of bacteria -Total and Viable counting techniques. (5) 3. vaccines (i. Gas gangrene. Marks: 80 BPH-212: PHARMACEUTICS – IV (PHARMACEUTICAL MICROBIOLOGY) PRACTICAL Total Hours: 75 (3hrs/week) SUGGESTED EXPERIMENTS 1. diagnostic preparation. alcohol. citric acid and vitamin B12 (cyanocobalamin). TAF. Diphtheria vaccine. Botulinum. Immunology: General introduction. Detailed study of sterility testing of different pharmaceutical preparations. SYLLABUS FOR SESSION 2009-13 24 . kinds of immunity. (6) 7. bacteristatic. (08) Max. sterility tests. Standardization of vaccines and sera. rabies vaccine. potency tests and storage of immunological products. Evaluation of bactericidal. yellow fever vaccine. PTAP). poliomyelitis vaccine. influenza vaccine. 3. microbiological assay of Penicillin. Fermentation and its design. virucidal activities. Microbial culture sensitivity testing: Interpretation of results.e. measles vaccine. maintenance of lab cultures. (11) 8. Preparation and sterilization of aerobic and anaerobic media. Different methods used in isolation and identification of bacteria with emphasis to different staining techniques and biochemical reactions. fungicidal and virucidal agents factors affecting their activation and mechanism of action. Staphylococcus and Tetanus antitoxins) Brief control of immunological products-identification tests. toxoids (FT. 1. tetracyclines. Streptomycin and vitamin B2 and B12. virus immunity. APT. Sterilization methods for all pharmaceutical products. sera. Introduction to the science of microbiology. Separation of mixed cultures and maintenance of pure cultures. (5) 6. acid fast staining and hanging drop preparation. 4. antiseptics. streptomycins. Differential media. Tetanus vaccine. Detailed study of different methods of sterilization including their merits and demerits. antitoxins(i. Preparation and isolation of fermentation products with special reference to penicillins. factors influencing infection. (7) 5. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five.

Delhi-32. Prescott. 7. Microbial viable count in Pharmaceutical Formulations. Delhi. CBS. 8. 485. Preparation of injections of water. Carrying out quality control tests. M. 15.5. normal saline and oily phenol. Vol 6a. S. Wm. Test for sterility. B. Mack publishing company. London. Microbiology. L. Test for Pyrogens. 8th Edition. Harley and D. Co. Ltd. Blackwell Scientific publications. Remington’s Pharmaceutical Sciences. Russell. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Cooper and Gunn’s Tutorial Pharmacy. Kieslich (Editor). Microbiology. Klein. Particle count in water for injection. Cooper and Gunn’s dispensing for Pharmaceutical students. New Delhi. USA. Morphological characteristics of moulds and Yeasts. K. 7.A. A Practical Approach. 10. 17. W. dextrose. Hugo and A. Thermal death time studies. Turbidimetric assay of at least one drug using microbial culture. Switzerland. Brown Publishers. England. A. Saunders Company. J. 4. Reid and chan. 9. CBS Publishers & Distributors. Osal. Oxford. Industrial Microbiology. S. Publishers. 2. 10. Fundamentals of Microbiology. 12 th Edition. K. W. S. 8. pennsylvania. 9. Basel.P. Test for limit of alkalinity of glass. J. Carter. Pcelzar. Philadelphia. Pharmaceutical Microbiology. D. 6. IRL Press. C. M. 5. Presscot & Donn. 3. U. B. pitman publishing Co. J. Books Recommended (Latest edition): 1. SYLLABUS FOR SESSION 2009-13 25 . Biological assay of tetracycline and cyanocobalamin. Sixth Edition. Woodward (Editor). Production of at least one product by fermentation. 14. 13. Furbisher. Shahdara. Verlag chemic. J. TATA Mc-Graw Hill publishing. J. Bhola Nath Nager. Bio-Chemistry reactions: (a) Starch Hydrolysis (b) Gelatin liquification and (c) Haemolysis of blood 11. 12. Carter.M. (Rabbit method and LAL method) 16. 6. Immobilized Cells and Enzymes. Phenol coefficient test for disinfectant. Biotechnology.

A.e. U. N. multipass heater.. steam jet and absorption types of refrigeration cycles. 2. (4) Books Recommended (Latest edition): 1. H. (4) 6. New Age Int. (8) 4. 6th edition. Filtration: Theory. manometers and friction losses in pipes. 3. overall heat transfer coefficient. cooling towers. International Student edition (Latest edition). behavior of solids during drying. static bed dryers. Reynolds number and its Significance. 1972. dehumidification and air conditioning. Publishers. (5) 8. film evaporators. Centrifugation: theory.A. fluidizes bed dryer and pneumatic bed dryers. liquid-liquid heat interchanger/ exchanger and finned tubes heat exchangers. filter media. Introduction to Chemical Engineering. Refrigeration: Principle and equipments employed for vapor compression. sand filter. dehumidification and air conditioning: Definitions. industrial centrifuges. material and energy balance of evaporators. Flow of fluids: Introduction. Heat Transfer: Modes of heat transfer. leaf filters. McGraw Hill.J. moving bed dryers. displacement meters and dilution methods. Pitman Medical Publishing Co. Kanig. edge filter. Factors affecting evaporation. Gunn and S.. Philadelphia. natural circulation evaporators. Principles of Humidification. London. Lachman. Sambamurthy. measurement of flow rate using headmeters. humidity measurement. McGraw Hill Co. London (Latest Edition). Ultrafiltration.S. 2003.A. Pharmaceutical Engineering. L. 6. forced circulation evaporators. SYLLABUS FOR SESSION 2009-13 26 . (6) 3. (12) 2. Liberman and J. psychrometry. K. industrial filters i. applications in Pharmacy. (3) 5. (8) 7. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. McCabe and Smith. Drying: Theory. Carter and Gunn's Tutorial Pharmacy. definitions. Badger. New Delhi. The Theory and Practice of Industrial Pharmacy. 5. Different laws of heat transfer. mechanism of fluid flow. 4. filter presses. rotary drum filter. G. Unit Operations for Chemical Engineering. large scale equipment for humidification and dehumidification. Humidification. pumps and common problems like water hammer. Bernoulli's theorem. Bentley's Text Book of Pharmaceutics. Lea and Febiger.BPH-205: PHARMACEUTICS – V (PHARMACEUTICAL ENGINEERING-I) THEORY Max. filter aids. Regulation of flow using valves.L. Evaporation: Principle.Y. 3rd edition. 1. single pass heater. Rowlins. E. Bailliere Tindall and Cox. multiple effect evaporation.A.

diagnostic microscopic and macroscopic features and specific chemical tests of following group of drugs containing glycosides: (11) i. (2) 8. sterols. duboisia. categories and common uses and marketed formulations of following indigenous drugs: Amla. strophanthus and thevetia. Alkaloidal amines: ephedra and colchicum. Lehsun. Biological sources. uses. collection. Palash. flavonoids and leucoanthocyanidins. Study of the biological sources. pepsin. ix. Glycoalkaloids: solanum. Gymnema. and myrobalan. chemical constituents. iii. amino acids in plant extract. Phytochemical screening (3) i. (3) 6. Shilajit. Studies of traditional drugs. Holistic concepts of Drugs administration in traditional systems of medicine. ii. Imidazoles: pilocarpus. Pyridine-piperidine: tobacco. chemical nature of chief constituents. Ashoka. viii. (1) SYLLABUS FOR SESSION 2009-13 27 . gall. Guggal. 1. (8) 5. quassia 3. Cardio-active sterols: digitalis. polyester and asbestos. silk. (2) 9. Bhilava. Introduction to ayurvedic preparations like arishtas. anthraquinones. Arjuna. cultivation. gutikas. adulterants used. commercial varities. sarsaparilla and senega. Plant bitters and sweeteners. cyanogenetic glycosides. Quinoline and isoquinoline : Cinchona. Nagarmotha and Neem. cardenolides. diagnostic macroscopic and microscopic features and specific chemical tests of following alkaloid containing drugs: (13) i. common vernacular names. ginseng. Satavari. Methi. nux-vomica and physostigma. ii. cultivation. Apamarg. senna. Chitrak. Shankhpushpi. pharmacology. Brahmi. asavas.BPH-206: PHARMACOGNOSY-II THEORY Max. datura. ammi. iv. Anthraquinones cathartics: aloe. bufadenolides. v. Kalajira. tea and cola. iv. adulterants. trypsin and pancreatin. substituents. areca and lobelia. Bach. substitutes. lehas and bhasmas. kuruchi. tannins and polyphenols. commercial verities. Saponins: liquorice. tailas. Kantkari. collection. saponins. Study of tannins and tannin containing drugs like gambir. 2. Rasna. black catechu. Tropane: belladonna. Screening for alkaloids. coca and withania. vi. chemical constituents. processing. dioscorea. Study of fibers used in pharmacy such as cotton. churnas. gentian. Systematic study of source. saffron. ipecac. chirata. preparation. botanical sources. hyoscymous. morphology. iii. Gaduchi. rauwolfia. Tylophora. 7. catharanthus. identification test and uses of the following enzymes: Diastase. squill. Others: Psoralea. papain. Indole: ergot. Steroidal: vertrum. opium. Punarnava. (3) 4. Adusa. Gokhru. vii. Preparation of extracts. wool. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. Purines: Coffee. ii. rhubarb and cascara.

K. Jackson & D. Varghese Company. 4. Bailliere Tindall. Trease and Evans Pharmacognosy (15th Ed. Standardization of some traditional drug formulations. M. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Carica papaya Rauwolfia. Cinchona (quinine and quinidine). Evans. SYLLABUS FOR SESSION 2009-13 28 . 2002. Ipeacac (emetine) Glycyrchiza. Gineng. London. C. Chemical evaluation of powdered drugs and enzymes. 6. Powdered Vegetable Drugs. Marks: 80 1) 2) 3) 4) 5) 6) Identification of crude drugs listed in theory. 1957. 1967. E. E. 2. Brady & J. Saunders Limited.M.. Trease.. Hickey and C. 1974. Robbers. B. 1988. P. (4) BPH-214: PHARMACOGNOSY-II PRACTICAL Total Hours: 75 (3hrs/week) Max. Microscopic study of some important crude drugs as underlined above. Books Recommended (Latest edition): 1. Burge Publishing Co. isolation and characterization of natural products.10.. Tropane alkaloid contaning plants. W. King. plants containing laxatives and valerine. Snowdon. Pharmacognosy (9th Edition). V. Cambridge University Press. 1988. A Textbook of Pharmacognosy (7th Edition).). The Organic Constituent of Higher Plants. L. W. 3. Bombay. World wide trade in plant and plant derived products with special reference to dioscoreas (Diosgenin). W. Digitalis. Tylor. 5. India. Processing. extraction. R. Studies of microscopic characters of some important drugs in entire and powdered form. Trevor Robbinson. E. 2nd Edn. Stanley Thomes Ltd. 100 Families of FIowering Plants. B. G. London.

renaming etc. etc. defining variables. industries. (3) 12.. (2) 4. (3) 3. Marks: 80 Total Hours: 75 (3hrs/week) 1. Case.. CD Writing. (10) 10. use of Machine language. (5) 7. Preprocessor directives: # include. Cables. Number systems: Decimal. Problem analysis. algorithm. Operating systems: Introduction to Operating system. URL.BPH-207: COMPUTERS IN PHARMACY THEORY Max. patent sites. input and output statement in C. adverse effects. WHO. creating. program documentation. Hub. if…. Operating system: DOS. Go to. drug information and drug storage and retrieval in retail pharmacy establishments.While. moving. MAN. Classification of networking like LAN. nested for. flow chart. debugging and testing. Mother board. Demonstration of hardware. various ports and slots available with motherboard. Introduction to C: Programming rules. constants. Programming Language (Programming with C): Introduction to programming. Else. Introduction to Internet Browsers. identifiers. Hardware: Introduction to hardware. (3) 5. Hardware of networking – Modem. data type. clinical data. classification.The scanf ( ) and printf ( ) functions. coding. WINDOWS (98 & XP) & LINUX. variables. Assembly language and Higher-level languages. plants. Binary. MS Excel. (1) 11. 1. Searching directories or folders 4. Introduction to email and how to check and compose an email? Important websites related to pharmaceutical information – like sites for information regarding drugs. Storage Devices and Memory. Software: Introduction to software. copying. WAN. CPU. Computer Package: MS Word. (2) 2. # define. 2. default statement. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. Key words. Maintenance: Checking. FDA. Nested if else…. for. File manipulations: Directories / folder / files searching. (11) BPH-215: COMPUTERS IN PHARMACY PRACTICAL Max. C-Declarations: CCharacter set. break. inventory control. Arrays: One dimensional. (6) 8. (2) 6. size and use). declaring variables. Networking: Introduction to networking. loop control statement: While. execution. Operators and expression. Input devices. conversion types etc. Creating and deleting files and folders SYLLABUS FOR SESSION 2009-13 29 . medication monitoring. Decision statements: If …. deleting.. (2) 9. Octal. Computer classifications (According to generation. Two dimensional. Scanning and formatting a floppy disk. authorities. Hexadecimal and their uses in computer. WINDOWS & LINUX 3. education and in hospitals in maintenance of records. medical literature. Do ….. initializing variables. MS PowerPoint. Output devices. History: Introduction to Computer. Internet: History. use of operating system like DOS. Switch ( ) …. Power devices like UPS. Application of computers in pharmacy: Introduction to various uses of computer in pharmaceutical research and development.

Fundamentals of Computer. and paste an image. E.5. John R. 8. email. 4th Ed. Hunt & Shelly. New Delhi. 8. Pradeep Nair. BPB Publications. Create and save a document in a word processor program like MS WORD. Copying and Moving files and folders / directories Saving in floppies and CD Writing. BPB Publications. TMH. 3rd Ed.22 Instant Reference.22: An Introduction with computer fundamentals. copy and move the data. Windows 98 Instant Reference.Balguruswamy. 2nd Ed. BPB. Create and save a work sheet using MS EXCEL. Input data in cells. 3. Simple programming in C or C++: at least five programs. Latest Ed. Payal Lotia. Programming in ANSI C. 6. 11. groups) NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. 6. DOS 6 & 6. Formatting and checking by floppy disks and Bootable CD. BPB Publications. format them.Thomas. Programming in C++. 9.Sinha. Complete Reference MS. 12. make calculations. P. Create and save presentations in POWERPOINT 11.Office 10. Books Recommended (Latest edition) 1. Internet (Search Engine.K. Complete Reference Windows XP. 9. 5. 2. TMH. 4. New Delhi. Complete Reference Internet SYLLABUS FOR SESSION 2009-13 30 . plot a graph from X and Y sets of data. Computer and common sense. 7. DOS 6 & 6. Sharon Crawford & Neil J. 2nd Ed. BPB Publications. Prentice-Hall India. Salkin.Hubbard. 10. Robert M. ABCs of Windows 98. 7. Peter Dyson. Type few paragraphs.

normal distribution curve. standard error of means. sin (ax + b) or cos (ax + b) types of functions. transpose. Kurtosis and skewness. calculation of areas under normal curve and standard normal curve (Z statistic). solution of quadratic equation. mean. area of triangle. Marks: 80 Total Hours: 75 (3hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. (20) 2. transforms of elementary function (without proof) and inverse laplace transforms not involving Euler’s theorem. calculation of standard deviation from discrete and continuous frequency distributions. Partial fractions and resolution of linear and quadratic (non-repeated) partial functions. Lapalace transforms: definition. addition. quartiles. solution of simple trigonometric identities based on above concepts. Collection of primary and secondary data through experiments or surveys sampling and complete enumeration survey. solution of simultaneous equations using matrix methods. Calculus: 5. measures of dispersion. by partial fractions and by substitution. Intergral: Integration as inverse of differentiation. (5) 3. quartile deviation. straight line. slope and intercept form. coefficient of variation. adjoint reciprocal and inverse of a matrix. xm. parametric differentiation. Pharmaceutical transforms. differentiation of implicit functions. Linear differential equations of order greater than one with constant coefficients. Differential: Limits and functions. HM and weighted arithmetic mean from discrete and continuous frequency distributions. formal evaluation of definite integrals. general equation of first degree. Algebra: Solution of linear equation up to two variables only. transforms of derivatives. locus of a point. 1. (5) SYLLABUS FOR SESSION 2009-13 31 . deviations from normality. homogeneous equations. including function of a function (chain rule). elements of central limit theorem. subtraction and transformation formulae. differential coefficient. data organization including frequency distributions and tabulation. probability theorems. (6) 10. Measures of central tendency. (4) 4. Definition of various matrices up to upper triangular matrices. (8) 8.BPH-208: PHARMACEUTICAL MATHEMATICS THEORY Max. (5) 7. solutions of ordinary and simultaneous differential equations. linear equations (Liebnitz form) and differential equations reducible to these types. Differential equations: definition and formation of ordinary differential equations. elements of successive differentiation. properties of linearity and shifting. mode. graphs of frequency distributions. variable separable. solution of simple simultaneous linear differential equations. standard deviation. range. 2-D and 3-D pictographic representation. GM. pie diagrams. Pharmaceutical application of logarithms. distance between two points. (6) 6. (4) 11. Probability and events. probability distributions. logarithmic differentiation. elements of binomial and Poisson distributions. diagrammatic representation of data. Determinants and their six important properties. indefinite integrals of standard forms. sub multiple and allied angles. T. merits and limitations of various random and non-random sampling methods.ratio of multiple. differentiation of standard functions. Bayes theorem. confidence limits. arithmetic operations on matrices. Trigonometry: revision on angle measurement and T-ratios. (6) 9. normal distribution. integration by parts. complementary function and paricular integrals of ex. median. and properties. mean deviation. solutions of simultaneous equations by Cramar’s rule. equations of first order and first degree. multiple. sub-divided and floating bar diagrams. ideal characteristics. simple. Analytical plane geometry: Cartesian co-ordinates.

S. 1982. Higher Engineering Mathematics. scatter plots. type I and II errors. t-test (paired and unpaired).12. Differeptial Equations. (3) Books Recommended (Latest edition): 1. (3) 13. of amount of explained variance. New Delhi (Latest Edition). 2. Statistical inference. Grewal. Schaum. Pearsonian coefficients of correlation and determination. SYLLABUS FOR SESSION 2009-13 32 . method of least squares. McGraw-Hill. Singapore. Khanna Publishers. Linear correlation and regression analysis. definitions. standard error of estimate and significance of regression(F).

Conversion of orthographic projections into isometric projections/views 6. Marks: 80 Total Hours: 75 (3hrs/week) 1.e.VI (PHARMACEUTICAL ENGINEERING DRAWING) PRACTICAL Max. diagonal scale. Scales: Construction of plain scales. offset section 5. construction of drawing in both first angle and third angle. Various methods of sectioning i. drawing instruments and their uses. Methods of depicting layouts of various sections of a pharmaceutical unit. 3. e. full section.e.BPH-213: PHARMACEUTICS. Machine Drawing N. cones ) 4. comparative scale and isometric scale 3. cylinder. types. lettering and dimensioning 2. Books Recommended (Latest editions): 1. Bhatt. circles. Frechand Viorck. A Manual of Engineering drawing for students and Draftsmen. prism. partial section. Introduction: Significance of Engineering Drawing in pharmaceutical industry. triangles. N. removed section. SYLLABUS FOR SESSION 2009-13 33 . Bhatt. pyramids. Technical Drawing ciesocke Mitchell and sponcer. D. 2. lines. Orthographic projections: Theory. hexagon). Drawing of machine parts and simple pharmaceutical equipment 7. vernier scale. construction of isometric projections/views of two dimensional figures(i. isometric views and projections. quadrilateral pentagon. 4. three dimensional solids(i. Isometric projections: Theory. rectangles. D. Engineering Drawing. half section.

Cimetidine. uses and structure activity relationship of the following classes of drugs. Naphazoline. Chlorpheniramine. iv. Imipramine. Zalpidem • Hallucinogens: Mescaline. Nitrous oxide. Diethyl satilboestrol. (8) 2. Ketamine • Sedatives and hypnotics: Flurazepam. Promethazine. Hydrochlorthiazide. Paroxetine. anti-inflammatory (non-steroidal) agents: Aspirin. SYLLABUS FOR SESSION 2009-13 34 . Tropicamide. Androgens and anabolic agents. Naproxan. Phenylbutazone. Chlorthiazide. Autacoids: • Antithistamines: Diphenhydramine. 1. Cyclopentolate. Drugs acting on central nervous system: • General anesthetics: Desflurane. methacholine and Neostigmine. succinylcholine ii. Classification. Principles of drug design (Theoretical aspects). Drugs affecting uterine motility: Oxytocics (including oxytocin. Steroids and Related Drugs: General study on Steroidal nomenclature and stereochemistry. Scopolamine hydrogen bromide. Synthesis of Testosterone from Cholesterol. Phenylephrine. Salbutamol. Ranitidine. • Eicosanoids: Occurrences. Furosemide. Medicinal applications • Analgesic. Tryptamine. Carbachol. Propofol. Terbutaline. Bethanechol. Diazepam. Diclomine. Fenfluramine iii. Traditional analog (QSAR) and mechanism based approaches (Applications of Quantum mechanics. Atropine sulphate. mode of action. Tropicamide. Drugs acting on autonomic nervous system: • Cholinergics and Anticholinergics: Acetylcholine. vi. Phenobarbotol. antipyretics. geometric and bioisosterism) of drug molecules and biological action: Drug receptor interaction including transduction mechanisms. Atenolol • Antispasmodic and anti ulcer drugs: Homatropine. Diclofenac sodium. Dichlorphenamide. Basic Principles of Medical Chemistry: Physico-chemical aspects (Optical. Maprotiline. Chemical nature. synthesis of Progesterone from diosgenin. v. ergot alkaloids and prostaglandins) Their Occurrence. computer aided drug designing (CADD) and molecular modeling. Secobarbital. Chlorcyclizine. Chemical nature. Risperidone. • Adrenergic drugs and adrenergic blocking agents: Adrenaline. Hyoscyamine sulphate. Medicinal applications. Diphenhydramine. Paracetamol. Synthesis of those compounds only mentioned against each class. Estrogens and progestational agents. • Psychotherapeutic drugs: Clozapine. General study of structural formula and therapeutic uses of steroidal antinflammatory agents. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. • Stimulants: Ephedrine. • Neuromuscular blocking agents: Gallamine. Ibuprofen. Diuretics: Acetazolamide.BPH-301: PHARMACEUTICAL CHEMISTRY – VI (MEDICINAL CHEMISTRY-I) THEORY Max. Mepyramine. Spironolactone. Triamterene and Amiloride. Amitriptyline. Prazosin. (42) i. • Antidepressants: Protriptyline. Triazolam.

Pandeya. New Age International Publishers. Monographs of selected official drugs including identification tests and tests for purity. S. 4. 5. Bentley & Driver. A Text Book of Medicinal Chemistry. Lippincott Williams & Wilkins. Lippincott Williams & Wilkins. New Delhi. 2. Principles of Medicinal Chemistry. New Delhi. Medicinal Chemistry. SYLLABUS FOR SESSION 2009-13 35 . Synthesis of selected drugs and intermediates from the course content. William Foye. 3. Ashutosh Kar. SG Publisher.BPH-310: PHARMACEUTICAL CHEMISTRY – VI (MEDICINAL CHEMISTRY-I) PRACTICAL Max. Varanshi. Text Book of Pharmaceutical Chemistry. Books Recommended (Latest edition) 1. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Oxford University Press. 2.N. Marks: 80 Total Hours: 75 (3hrs/week) 1. Text Book of Organic Medicinal & Pharmaceutical Chemistry. 6. Wilson & Grisvold.

(20) 2. San Francisco. L. source. The English Language Book Society. Biochemistry. imidazole. Configuration and conformation of monosaccharides. Morrison and R. 2. Bostan. synthesis and reactions of pyrrole. mutarotation. T. SYLLABUS FOR SESSION 2009-13 36 . I and II. L. Organic chemistry. starch and gums. secondary. helical and sheet structures. H. Stryer. W. physical properties. Cyclic structures. S. Skraup Synthesis and Bischler Nepieralski Synthesis). Structure. Synthesis and reactions of indole quinoline and isoquinoline(Fischer. epimerization. Geometry of peptide linkage. Finar. I. five and six membered heterocycles. 5. peptide synthesis. Boyd. N.M. Kapoor and R. Heterocyclic ring systems containing up to two hetero atoms. vol. chemical reactions and configuration of amino acids. furan and thiophene . Purines and Pyrimidines. preparation and reactions of adenine. Nucleic Acids: Nucleotides. London..I-III. Chemistry of Heterocyclic Compounds: Nomenclature of heterocyclic compounds. zwitterion structure. Chemistry of ascorbic acid . pyrazine oxizine. Freeman and Company. aromatic charactreristic of heterocyclic compounds. Synthesis.essential amino acids. RNA and DNA General methods for the synthesis of oligonucleotides. Disaccharides and polysaccharides. Organic Chemistry: Vols. S. R. isoelectric point. cytosine. azines.primary. (10) 4. Structure determination of polypeptides and group analysis. 4. Amino acids Peptides proteins: Classification. interconversions of aldoses and ketoses. Ansari road. lactose. R. New Delhi-110002 3. uracil. Interscience Publishers. CARBHYDRATES. thymine. pyridine and piperidine. ribose and 2-deoxyribose. Glycocides. Acheon. Organic Chemistry 4th Ed. New Age International (P) Ltd.Maltose. N. of ring size. Carbohydrates: Occurrence classification interrelationship amongst monosacharides Constitution and reactions of glucose and fructose.pyridazines. Peptides and polypeptides. 1. Inc. thiazole. An Introduction to the chemistry of Hoterecyclic Compounds. essential and non. (5) Books Recommended (Latest editions) 1. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five.P. Publishers. sucrose. guanine. tertiary and quatenary structure of proteins. PROTEINS AND NUCLEIC ACIDS) THEORY Max. Mukherji.Indole Synthesis. Tautomerism. Osazone formation. Dass. (15) 3. cellulose. oxazole.P. Condensed five and six membered heterocyclics.BPH-302: PHARMACEUTICAL CHEMISTRY – VII (HETROCYCLICS. R. determination. Chain lengthening and shortening in aldoses. New York. Chemistry of pyrazole. Classification and general characteristics of proteins. Second edition. . Singh. Allyn and Bacon.

controlled flocculation. flow properties and compression properties. surface active agents and its applications. spreading coefficient. Single point and multipoint. adsorption. kinetics of protein binding. electric properties of interface. packing arrangement. Micromeretic and Powder Rheology: Applications of micromeritics in pharmacy. stability. rheological considerations. falling ball. wetting of particles. permeability. Kinetics and drug stability : Half-life determination. wetting phenomena. methods of adjusting isotonicity. determination of viscosity. thixotropy. Surface and Interfacial Phenomenon: Liquid interface. laws of flow. (6) 7. Buffers: Buffer equation and buffer capacity in general. (6) 4. settling in suspensions. HLB classification. rotational viscometers. optical microscopy. solvent. physical mechanisms behind micro-emulsions. theory of sedimentation. solubilisation. (7) 2. methods of determining surface area. chemical decomposition of drugs. sieving. particle shape. (5) SYLLABUS FOR SESSION 2009-13 37 . bulkiness. Viscosity and Rheology: Newtonian systems. physical degradation of pharmaceutical products. (6) 5. method of determining particle volume. measurement of surface and interfacial tensions. Colloidal dispersions: Definition. thixotropy in formulation. catalytic species on drug decomposition. influence of temperature. solid gas and solid-liquid interfaces. sedimentation of flocculated particles. applications of colloid in pharmacy. particle number. protective colloidal action. adsorption at liquid interfaces. derived properties of powders. accelerated stability study. buffer in pharmaceutical systems. electrical and kinetic properties of colloids. number and weight distribution. (6) 6. applications of complexation and protein binding in pharmacy. capillary. measurement. flocculation in structured vehicles. storage conditions. optical. types. specific surface. surface free energy. buffered isotonic solutions. porosity. theories and physical stability. particle size and distribution.BPH-303: PHARMACEUTICS –VII (PHYSICAL PHARMACY) THEORY Max. adsorption at solid interfaces. Emulsions: types. Application of HLB in emulsions. densities. sedimentation. purification of colloidal dispersions.preparation. Suspensions and Emulsions: Interfacial properties of suspended particles. Complexation and protein binding: Classification of complexes. detergency. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. Dispersion system i. method of preparation and analysis. effect of Brownian movement. sedimentation parameters. average particle size. (7) 3. Non Newtonian systems. kinematic viscosity. dilatent. effect of temperature. plastic. surface and interfacial tensions. pseudoplastic. 1. (7) ii. light. measurement of tonicity.

3. Accelerated stability testing. 6. Determination of surface/interfacial tension. 12. shelf life determination and expiration dating of pharmaceuticals. 13. Preparation of pharmaceutical buffers and determination of buffer capacity.. A.BPH-311: PHARMACEUTICS –VII (PHYSICAL PHARMACY) PRACTICAL Max. E. Preparation of various types of suspensions and determination of their sedimentation parameters. I. compressibility. 2. 11.. 5. To study the influence of various factors on the rate of reaction. Ltd. angle of repose etc. Vol I to 4. porosity. al. Careless. Waberly Pvt. 8. S. Beckett and J. SYLLABUS FOR SESSION 2009-13 38 . 10. Marks: 80 Total Hours: 75 (3hrs/week) 1. HLB values and critical micellar concentration of surfactants. particle size distribution and surface areas using various methods of particle size analysis. 2. Determination of particle size.. 4. H. H. Advances in Pharmaceutical Sciences. Study of rheological properties of various types of systems using different viscometers. Mack Publishing Co. A. New Delhi. Easten Ponnsylvania. Physical Pharmacy. Determination of derived properties of powders like density. Studies on different types of complexes and determination of their stability constants. 7. S. Books Recommended (Latest editions) 1. Remington’s Pharmaceutical Sciences. U. Determinations of half-life rate constant and order of reaction. Experiments involving tonicity adjustments NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. 9. Alfred Martin et. 3. B. Studies of different types of colloid and their properties. Beans. Preparation and stability studies of emulsions.

safety requirements. Crystallization: Crystal forms and habits. azeotropic mixtures.e. Screening equipment i. horizontal and inclined plane. fixed bed diffusion battery.e. adiabatic cooling (i. (4) 6. tank crystallizers. hammer mill. (3) 8. Marks: 80 Total Hours: 50 1. ball mill and its variants. Chemical. Mier's supersaturation theory. aluminium. Mixing: Theory. Screening effectiveness. Extraction: Factors affecting. elutriation and doublecone emulsifier. glass. Sedimentation and hydraulic separation i. plastics and timber. fans and blowers. continuous diffusion battery. agitated batch crystallizers and Swenson-Walker). Equipment for liquid-liquid extraction i. stationary and vibrating types.e. Solids: Intermittent and continuous methods in vertical. Krystal crystallizers). (6) 3. (7) 2. rubber. rectification.P. non-metals i. determination of number of theory plates. Fire and Dust hazards. Materials for pharmaceutical plant construction: factors affecting the selection of a material for pharmaceutical plant. (6) 7. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five.e.squirrel cage disintegrator.applications in pharmacy. (3) 10. different mills i. Emulsification equipment.e. accident records etc. uniformity index.e. energy requirements. types of distillation. Buhrstone mill. edge runner mill. boiling point diagrams.T. compressors. nickel and alloys). factors influencing selection of suitable mixer equipment for solid-solid.e. ferrous metals (i. non-ferrous metals (i. Crystallizers based on supersaturation. equilibrium diagrams. material and energy balance of a rectifying column. equipment for extraction of solids i.e. Corrosion and its prevention: Types of corrosion causes of corrosion and method for combating corrosion. fluid energy mill. Size separation: Screening. Crystal growth theories. basket extractor. Industrial hazards and safety precautions: Mechanical.e. Max.e. centrifugal mill. Mateial and energy balance of crystallizer.BPH-304: PHARMACEUTICS –VIII (PHARMACEUTICAL ENGINEERING-II) THEORY Max.e. Hole theory. (3) SYLLABUS FOR SESSION 2009-13 39 . Electrical. (9) 5. H.E. air separator and cyclone separators. by cooling (i. volatility. liquid-liquid and solid-liquid mixing. and steam distillation. Distillation: Raoult's law. slate. Transportation of materials: Gases: Ejectors. attrition mill. Air suspension methods i. tin sliver. asbestos. cast iron. Nucleation. Laws and factors influencing. rectifying columns. Rotocel extractor and Dorr agitator. Size reduction: Mechanism.e. steel and stainless steels). (6) 4. Copper and its alloys. reflux ratio. vacuum crystallizers) and evaporation (i. (3) 9. extraction towers and Podbielniak extractor.

Perry’s Chemical Engineering. To perform Reynold's experiment. Books Recommended (Latest editions) 1. 13. Effect of colour on radiation of heat. Marks: 80 BPH-312: PHARMACEUTICS-VII (PHARMACEUTICAL ENGINEERING) PRACTICAL Total Hours: 75 (3hrs/week) 1. 4. 12. Richardson and Coulson’s Chemical Engineering (Vol. Determination of flow rate using venturimeter. SYLLABUS FOR SESSION 2009-13 40 . 15. 11. 10. 3. Flow rate using pitot tubes. Overall efficiency of steam distillation. 6. 2. McCabe and Smith. Effect of number of balls on the grinding rate in a ball mill. Mc Graw Hill. Effect of thickness of cake on filtration rate in a filter press. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Determination of flow rate using orificemeter. Determination of fanning factor. 8. 2. Comparison of the sensitivity of various manometers. Classification by elutriation. 14. Mc Graw Hills. 5. 1-6) Butterworth/ Mc Graw Hills. 3.Max. Determination of equilibrium moisture constant. Determination of overall heat transfer coefficient. Efficiency of a centrifugal pump. 9. Heat Transfer. Use of psychrometric chart. 7.

BPH-305: PHARMACEUTICS –IX (PHARMACEUTICAL TECHNOLOGY-I) THEORY Max. Glandular. ii) ISO 9002: Quality systems: Model for quality assurance in production and installation. handy and body lotion. Preformulation studies: Study of physical properties of drug like physical form. and fixers. dissolution and organoleptic properties and their effect on formulation. hair remover (depilatories). oxidized cellulose. calcium gluconate. 1. (5) 10. tooth powders and tooth paste. (5) 6. Nail. (8) 11. human thrombin. (7) 9. recemization. human fibrinogen. preparation and evaluation of cleansing creams. particle size. Hairs.. shape. Formulation. iv) ISO 9004: Quality management and quality system elements guidelines. human plasma protein fraction. skin tonics. pancreas. ideal plasma substitute properties. liver. 7. preparation and evaluation of other cosmetics like. dried human serum. Study of chemical properties of drug like hydrolysis. Quality audit. Dextran. cleansing lotions.e. wetting dielectric constant. preparation and evaluation of shampoos. stability and bioavailability. solubility. hair colorants. Marks: 80 Total Hours: 75 (3hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. anti-perspirants and deodorants. Skin: Structure and functions of skin. dandruff preparation. Quality assurance. Herbal Cosmetics. development and process validation methods for pharmaceutical operations involved in the production of pharmaceutical products with special reference to liquid dosage forms. polymerization etc. (4) SYLLABUS FOR SESSION 2009-13 41 . oxidation. PVP. formulation. density. ICH Guidelines for stability testing protocol for various pharmaceutical products. iii) ISO 9003: Quality systems: Model for quality assurance in final inspection and test. products i. plasma substitute. face powders. sponge. (10) 2. blood and related products: Introduction. development production installation and servicing. Design. foundation creams. hair creams. lipsticks. preparation and evaluation of nail lacquer . v) Latest amendments of ISO. GMP. moisturizing creams. (7) 4. extraction methods and preparation of thyroid. reduction. Whole human blood. shaving sticks and after shave lotion. (7) 5. dried human plasma. structure and functions. (9) 8. sun preparations. Specifications of the international standards organization: (5) i) ISO 9001: Quality systems: Mode for quality assurance in design. pituitary gland. formulation. and their influence on formulation and stability of products. absorbable gelatin. (9) 3. formulation. structure and functions. cold creams. concentrated human RBC.

Wiley Interscience. New York. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. 5. 2. AlZ. 9. 3 (Cosmetics). Vol. Y.S. 2nd edition. Lachman et. Marks: 80 Total Hours: 75 (3hrs/week) 1. 4. 3. 6. Preformulation studies including drug-excipient. 1974. Wilkinson & R. Pharmaceutics: The Science of Dosage form Design By: Aulton. 2. Mack publication. GMP for various dosage forms.BPH-313: PHARMACEUTICS-IX (PHARMACEUTICAL TECHNOLOGY-I) PRACTICAL Max. Dissolution testing and data evaluation for oral solid dosage forms. Fea & Febiger. J. N. Sagarin. Poucher's perfumes. 3. Vol. 9th edition. ISO Reports. Cosmetics: Science and Technology. 8. Moore. Preparation and Evaluation of (a) cold cream (b) vanishing cream (c) Cleansing lotion and creams (d) moisturizing creams (e) skin tonics. ponnsylvania. IP/BP/USP. in dosage form design. Chemical publishing House. Harry’s Cosmeticology. Company. 1-3. Books Recommended (Latest editions) 1. Cosmetics and Soaps. Philadelphia. 1976. (f) hair creams and hair conditioners (g) shampoos (h) hair colorant (i) depilatory (j) shaving creams and sticks (k) tooth powder (l) tooth pastes (m) after shave lotions and other cosmetics as studied in theory. preservatives etc. M. Remington’s Pharmaceutical Sciences. 5. ICH Guidelines. Theory and practice of Industrial Pharmacy 2 nd Ed. B. 7. Lippincott. compatibility studies.USA (Latest Edition). USA. SYLLABUS FOR SESSION 2009-13 42 . Balsam and E. effect of stabilizers. 4. Stability evaluation of various dosage forms. J.

b. Digitalis and cardiac glycosides b. Drugs acting on the urinary system: a. factors modifying drug action. Drugs acting on the Haematopoietic system: a. Anti-arrhythmic drugs. Pharmacology of Cardiovascular system: a. Marks: 80 Total Hours: 75 (3hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. Parasympatholytics. distribution.BPH-306: PHARMACOLOGY –II THEORY Max. Sympathomimetics. 1. antimaniacs and hallucinogens) g. General pharmacology: a. Anti-anginal and vasodilator drugs d. Neuromuscular blocking agents. Introduction to pharmacology. ADME drug reactions.N. Parasympathomimetics. bioassay of drugs and biological standardization. discovery and development of new drugs. Psychopharmacological agents (Anti-psychotic. Anti-anxiety agents and centrally acting muscle relaxants f. Fluid and electrolytic balance b. Ganglion blocking and Stimulating agents c. principles of basic and clinical pharmacokinetics. 2. antidepressants. Haemitinics b.S. Anti-epileptic drugs h. General anaesthetics c. d. Local anaesthetic agents. pharmacogenetics. Neurohumoral transmission in the C. Sedative and hypnotics e. Analgesics. Narcotic analgesics and antagonists. Pharmacology of autonomic nervous system: a. mechanism of action. Fibrinolytic and Anti-platelet drugs d. Diuretics SYLLABUS FOR SESSION 2009-13 43 . vitamin K and haemostatic agents c. sources of drugs. CNS stimulants 4. combined effect of drugs. Blood and plasma volume expanders 6. tolerance and dependence. e. k. dosage forms and routes of administration. b. adverse drug reactions and treatment of poisoning. Anti-hyperlipidemic drugs f. Anti-hypertensive drugs c. Drugs used in therapy of shock 5. Alcohols and Disulfiram d. metabolism and excretion of drugs. Anti-parkinsonian drugs i. Absorption. antipyretics and anti-inflammatory agents j. Sympatholytics. Neurohumoral transmission (autonomic and somatic) b. 3. Pharmacology of Central Nervous System: a. Anticoagulants.

Autocoids: a. Experiments on Central Nervous System: i. 5. 2.D. Churchill Living Stone. Procedures for rendering animals unconscious – stunning of rodents. 3. S. Text book of Pharmacology. Lippincott William & Willans. 7. The Pharmacological Basis of Therapeutics. pentobarbitone/hexobarbitone/thiopental sodium sleeping time in mice. Pharmacology. Prasun Kumar Das. Introduction to Experimental Pharmacology. 6. Recording of spontaneous motor activity. Effects of autonomic drugs on rabbit’s eye. JAYPEE. Histamine. Anti-tussive and Expectorants c. To study the inotropic and chronotropic effects of drugs on isolated frog heart. 2. Basic & Clinical Pharmacology. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Prostaglandins. Anti-asthmatic drugs including bronchodilators b.G. Books Recommended (Latest editions) 1. bradykinin and substance P. Common Laboratory animals and their maintenance.K. 5-HT and their antagonists b. K. 4. S. Rang. Pharmacology & Parmacotherapeutics.Katzung. To study the effect of hepatic microsomal enzyme inhibitors and induction on the ii.Tripathy. SYLLABUS FOR SESSION 2009-13 44 . 4. Sethi. Pentagastrin. ii. analgesia. Goodman & Gilman. pithing of frogs. chemical anaesthesia. Dale and Ritter. 8. angiotensin. Marks: 80 1. Pharmacology. stereotypy. Essentials of Medical Pharmacology. 6. thromboxane and Leukotrienes c.7. To study the effects of drugs on normal and hypo dynamic frog heart. Pharmacology of Cardiovascular System: i. cholecystokinins. 3. Satoshkar & Bhandarkar. Mycer. B.Bhattacharya.D. Experiments on intact preparations: i. Study of different routes of administration of drugs in mice / rats. 8. Pharmacology. 7. Elsevier. Popular Publication. Respiratory stimulants BPH-314: PHARMACOLOGY –II PRACTICAL Total Hours: 75 (3hrs/week) Max. 8. Mc Graw Hill. Lange. 5. Study of commonly used instruments in experimental pharmacology. ii. Preparation of different solutions for experiments. anticonvulsant activity and muscle relaxant activity of drugs using simple experiments. Drugs acting on the respiratory system: a. Mary J. Richard A. BI Churchill Livinstone.

General technique of biosynthetic studies and basic metabolic pathways. New Delhi-110002 SYLLABUS FOR SESSION 2009-13 45 . Marks: 80 Total Hours: 75 (3hrs/week) 1. pine. (2) 3. Alkaloids: Definition. Pharmacognosy (12 Edition). Chemistry of penicillins. Terpenoids: classification. Organic Chemistry: Vols. cardamom. R. Trease & W. celery. elucidation and synthesis of anthocyanins. general methods of determining structure and chemistry of the following members: Monoterpenoids(citral geraniol.M. S. Second edition. general methods of determining structure. Limonene menthol. pyrolidine group (hygrine). Pharmacognostic study of the following drugs & yielding volatile oils: mentha. matricaria and cedarwood. extraction. pyrrolidine-pyridine group(Tabacco and coca alkaloids). Dass. Publishers. geranium. 2. pinene and camphor). Plant allergens and allergenic substances. (3) 7. Books Recommended (Latest editions) 1. rose. Mukherji. Processing. New Age International (P) Ltd.I-III. Flavonoids: Structure. flavones and isoflavones. . vertiver. Volatile Oils: General methods of obtaining volatile oils from plant. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Structure elucidation and synthesis of the following gropus: Phenylethylamine group(ephedrine. Philadaphia. isolation. (4) 2. C. Microscopic examination of diagnostic tissues in powered crude drugs. fennel. santonin) diterpenoids (phytol) and triterpenoids (squalene). 2. 8. pyridine-piperidine group (Areca nut and Hamlock alkaloids. eucalyptus. (2) (3) BPH-315: PHARMACOGNOSY –III PRACTICAL Max. Kapoor and R.P. Sesquiterpenoids (borneol. quiroline group(conchona alkalodis). dill. 1. piporine). 3. Lea & Febiger. Chemistry of medicinal important irridoids. terpinol. amphetamine). isolation. (12) 5. Evans. nutmeg. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five.P. cinnamon.BPH-307: PHARMACOGNOSY – III (NATURAL PRODUCTS) THEORY Max. Tindall London 1983. Singh. Ansari road. An introduction to biogenesis of secondary Metabolites of pharmaceutical importance. Knowledge of important volatile oils used as flavouring agents and in perfumery. isoquinoline and phenanthrene groups (opium alkaloids) and indole group(mesembrine). streptomycin and tetracyclines. juvenile hormones. (10) 6. Pharmacognostic identification of various crude drugs. sandalwood. S. (14) 4. clove. Utilization of waste of eassential oil industry. G. isolation and characterization of natural products. R.

M. Atal & B. Vol. E. 1982.V.New Delhi. Lea & Febiger. J. London. Boyd. 1967. T. 5. The Textbook of Pharmacognosy. Pharmacognosy (9th Edition). Allya and Bacon. 6. Trover Robbinson. I and II. Organic chemistry. 4. Philaephia. E.3. G. CSTR. 7. India. Satyavati and M. Wallis. Eorrison and B. 8. Ind. C. 9. J. T. E.Raina. London. Medicinal Plants of India Vol I & IC. N. The Organia constituent of higher plants. cultivation & UIC Utilization or Medicinal Plants. H. Kapur. 1988. SYLLABUS FOR SESSION 2009-13 46 . Tylon Brady.. & A Churchill. Boston. 1976 & 1987. 4th Ed. E. Finar Organic chemistry. The English Language Book society. Robbers. ICMR. V.Birgass publishing Co.K.K.

7.I. methods of gene therapy. Roitt. UK. Transgenic animals and their applications. characterization of transfected cells.E. 2.H. Design of drug delivery systems for biotechnological products. Enzymes: (6) i. interferons. Balasubramanian. 4. Oxford. applications of immobilized enzymes. University Press. W. DNA: Structure and function. Hood L. Green and Jayaraman (Eds. vaccines. ii. Biotechnology V. Oxford.H. Stem cells and Gene Therapy: (6) i. methods of immobilization. 7. Blackwell Scientific. Types of tissue culture. Kuby.Freshrey (Willy).. Sterilization of materials for tissue culture. Introduction. Dharmalingam. I. Genetic Engineering of Animal Cells: (9) i. in vitro fertilization. primary cultures and culture of cell lines. RFLP and AFLP analysis. 6. monoclonal antibodies and human and follicle stimulating growth hormone. History and scope of tissue culture. Bryce. isolation.. Wood W.erythropoietins. M. Immunology. history. ii. 1. History and introduction to stem cells and gene therapy ii. Books Recommended (Latest editions) 1. embryo transfer and ethical issues of animal cloning. Animal Tissue Culture: (8) i. 3D culture techniques. Sateesh. Applications of stem cells and gene therapy in pharmaceuticals. 1992. Study of enzymes such as hyaluronidase. Drug Delivery systems by Biotechnology: (9) i. Cancer immunotherapy vaccines iii. and Wilson J. K. Human stem cell culture (embryonic and germ cells). anticoagulant agents. repair and recombination. amylase and protease. host system and gene cloning. iii. branches and scope of biotechnology. mechanism of action.BPH-308: PHARMACOLOGY – III (PHARMACEUTICAL ANIMAL BIOTECHNOLOGY) THEORY Max. Weissman I. Biotol Series – Butterworth and Heineman. DNA replication. ii. 5. Therapeutic and pharmaceutical applications of biotechnology. ii.. Characterization and preservation of cell lines.B. iii. 6. J... Immunology.M. iv. Introduction. 5. streptokinase. Oxford. tissue culture media. SYLLABUS FOR SESSION 2009-13 47 . gene transfer techniques. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. Concepts in Biotechnology. (5) 2. isolation of DNA. Introduction to Biotechnology: Definitions. Culture of Animal Cells. ethical issues related to stem cells. Production of drugs from biotechnology. purification. RAPD. immobilized enzymes. 4.). Freeman. Benjamin Cummings. (7) 3. Essential Immunology. 3.

(3) 4. Threats to biodiversity: Habitat loss. b. Climate change. Fossil fuels: Coal. Wind. Wildlife and Forest Acts. Organic farming . vi. Consumers and decomposers. Biodiesel and fuel cells. Changes caused by agriculture and overgrazing. Water resources: Global water resources distribution. Use and over exploitation. Man induced landslides. Solar. Multidisciplinary nature of environmental studies. Floods. Environmental pollution: Definition. Industrial and nuclear accidents. (2) 2. Role of information technology in environment and human health. Role of NGO’S. Nuclear. Soil erosion and desertification. Soil pollution and noise pollution.BPH-309: ENVIRONMENTAL SCIENCES THEORY Max. Environmental studies: Definition. Scope and importance. Conflicts over water. Fertilizer-pesticide problems. iii. Food chain and food web. Environmental protection: Salient features of Environmental Protection Act. Air pollution. Turbulent mixing. (7) 7. Energy of future for transportationEthanol. Dams . (5) 5. Role of an individual in conservation of natural resources and equitable use of resources for sustainable life style. geothermal. Effects and control measures of: Water pollution (water quality standards and parameters. Use and overutilization of surface and ground water. Poaching of wild life. Petroleum and natural gas -Availability. Alternatives to fossil fuels: Hydro electric power. a.Definition and advantages. Endangered and endemic species of India. Acid rain. Air & Water Acts. Producers. Deforestation and timber extraction. Nosocomial diseases. Bio energy. Hot spots of biodiversity. Ground water quality). Forest: Benefits of forests. Natural resources: (8) i. Oxygen transfer by water bodies. (5) 6. Soil pollution and noise pollution). Current environmental issues: Population Growth. (7) 8. Water logging and salinity. Biodiversity and its conservation: Definition: Species and ecosystem diversity.their effects on forests and tribal people. Land degradation. Land resources: Land as a resource. Water quality in lakes and preservers. Environmental effects of extracting and using mineral resources. 3. Assessment of water quality. Dependency and environmental problems. Causes. Functions of Central and State Pollution Control Boards. Effects of modern agriculture. Air pollution. Energy sources-Conventional and non conventional / Renewable and non renewable. Drought. ii. Energy flow and material cycling in ecosystem. Mineral resources: Usage and exploitation. Global warming (greenhouse effect). Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. Transformation process in water bodies. Waste management: (8) SYLLABUS FOR SESSION 2009-13 48 . Conservation of biodiversity: In-situ and ex-situ conservation of biodiversity. Dams-benefits and problems. v. Man wild life conflicts. 1. Food: World food problems. Ozone layer depletion. Effect of global price of fossil fuel on nations. Ecosystem – Structure and functional components of ecosystem. Human health and urbanization. Balanced eco system. iv. Environmental education.

Environmental Engineering Irwin/McGraw Hill International Edition. K.L. hill slopes etc. Integrated waste management. Transportation and treatment of hazardous waste: incinerators. storage and transportation. Hazardous Waste Management. Hazardous waste and their generation. Design of waste water network. Conventional process. Treatment systems for hazardous waste.J. Cunningham & Cunningham (TMH. i. Principles of Environmental Engineering and Sciences. Introduction to Environmental Science. Pre-treatment of water. MSW Management.Anjaneyalu. Visit to a local area to document environmental assets – river/forest/ grassland/hill/mountain etc. i.Kiely. G. Masen. Books Recommended (Latest editions) 1. handling of treatment plant residue. Reuse and recycling. B. Inorganic waste treatment. Household waste. Davis & S. ii. SYLLABUS FOR SESSION 2009-13 49 . Study of simple ecosystems. Waste minimization. New Delhi) 3. 2004. Water treatment processes. Advanced water treatment process. Landfill. insects and birds. Medical hazardous waste. iii. Field work: equal to 5 lectures.S. McGraw Hill International Edition.properties and separation. Study of common plants. Thermal treatment.pond. 9. Waste Water Treatment: Water flow rate and characteristics.Water Treatment: Water quality standards. iv. river. Solid Waste Management: Sources classification and composition of MSW . Water sources and their quality. Activated sludge treatment: Anaerobic digestion and its application. pretreatment. Biological treatment. 1997. primary and secondary treatment of waste water. 2. Visit to a local polluted site – urban/rural/industrial/agriculture iii. Y. Principles of Environmental Science inquiring & applications. Waste water treatment process. Hyderabad 4. ii.Publication.

Models mimicking drug metabolising enzymes. Factors effecting drug metabolism. Metformine. Pyrazinamide. Busulfan. (4) 2. Prazocin. Antineoplastic agents: Chlorambucil. Mephalan. Niclosamide. Amoxycillin and Chloramphenicol. Zidovudine x. clofibrate. Nystatin. (4) 3. Miconazole. ix. alteration of drug stability. reduction in toxicity. Liothyronine. Pyrimethamine. synthesis of Methicillin. increasing chemical stability. xiii. xvi. Coumarins. vii. Amino acids: Peptide. 1. Primaquine. Cardiovascular Drugs: Clonidine. Ethambutrol. nucleotides and related drugs. xii. reduction of gastrointestinal irritability. Antiamoebic agents: Metronidazole. and allernation of drug metabolism. Ampicillin. reductive & hydrolytic) and phase-II (conjugative) reactions. Anticoagulants: Heparin. Reversal of prodrugs chemical & enzymatic. Study of synthesis of compounds mentioned against each class. Piperazine. Fluorescein sodium. Insulin. Tolazamide. Sodium diatrizoate. 5-Flurouracil. Isosorbide dinitrate. Cyclophosphomide. Phenindione derivatives. xiv. cephalexin. Methotraxate. Sulphamethoxazole. Sulphurguanidine. Antifungal agents: Griseofulvin. Sulphasalazine. Dapsone. Amphotericin B. Tolbutamide. Proguanil. Drug activation and consequences for human health. iii. SYLLABUS FOR SESSION 2009-13 50 . Methyldopa. Tinidazole. reduction of pain at injection site. Drug Metabolism: Activation of oxygen and electron transport system. Diloxanide furoate viii. Glibenclamide. Mepacrine. Phenformin. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five.BPH-401: PHARMACEUTICAL CHEMISTRY – VIII (MEDICINAL CHEMISTRY-II) THEORY Max. Anti Malarial Drugs: Chloroquine. Propythiouracil. Sulphacetamide Sodium. Antibiotics: General study including classification. prevention of presystemic metabolism. doxicyclin. Thyroid and Anti thyroid drugs: Thyroxine. Diagnostic Agents: Propyliodone. Sulphonamides: Sulphadiazine. Anthelmentics: Thiabendazole. Carbimazole xv. vi. Prodrug Approach: Basic concept. Anti-viral including anti-HIV agents: Acyclovir. prolongation of drug action. Mebendazole. ii. mode of action. Applications of prodrug approach to alter taste and odour. site specific drug delivery. Procainamide. Anti-TB and anti-leprosy Drugs: Isoniazid. Classification. i. Ketoconazole. Nifedipine. Structure of clofazimine and streptomycin. Thiotepa. Common pro-moietics. v. Role of cytochrome P-450 monoxygenases. Structure of cloxacilin. uses and structure activity relationship of the following classes of drugs. Drug metabolising reactions: phase-I (Oxidative. clavulanic acid. Albendazole. Immunosupressives and immunostimulants : To study only the general concept xi. Insulin preparations and oral hypoglycaemic agents : Chloropropamide. iv.

Lippincott Williams & Wilkins. Surendra N. New Delhi. Lippincott Williams & Wilkins. V. Wiley Publication. New Age International. 2. Fundamentals of Medicinal Chemistry. 3.Ahluwalia. Pandeya. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Ashutosh Kar. 5. Medicinal Chemistry.Thomas. Monographs of selected official drugs including identification tests and tests for purity. William Foye. SG Publisher. Wilson & Grisvold. Medicinal Chemistry. Books Recommended (Latest editions) 1. Principles of Medicinal Chemistry.BPH-409: PHARMACEUTICAL CHEMISTRY – VIII (MEDICINAL CHEMISTRY-II) PRACTICAL Max. Madhu Chopra. 2. Marks: 80 Total Hours: 75 (3hrs/week) 1. Text Book of Organic Medicinal & Pharmaceutical Chemistry. SYLLABUS FOR SESSION 2009-13 51 .K. Synthesis of selected drugs and intermediates from the course content. 4. Ane Books India. G. 6. A Text Book of Medicinal Chemistry.

viii. Denney. Validation. quality documentation and International Conference of Harmonization (ICH) on quality. and J. Books Recommended (Latest edition) 1.A. NMR and MS. Quality Assurance (12) i. Nephelometry. Flame Photometry. iv. Practical Pharmaceutical Chemistry. (56) i. SYLLABUS FOR SESSION 2009-13 52 . Electrophoresis: Principle. Vol. Instrumental Mehtods of Analysis. GLP. Dean. iii. ix. Atomic Absorption Spectroscopy. Merritt: Jr. X-ray diffraction. validation of equipment and validation of analytical procedures.. Nuclear Magnetic Resonance Spectroscopy including C -NMR. J. Jeffery & J. patents and trade marks. NDA and Intellectual Property Rights including copy right. Quality Review. 4. iii. Fluorimetry. vii. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE.C. Stenlake. Infrared Spectrophotometry.B. H. Mass Spectrometry. instrumentation and applications. spectroscopy. study of the working principles of instrument used for analysis and applications in Pharmacy. (4) 3. HPLC and HPTLC. IR of samples with different functional groups 3. ii. ii.BPH-402: PHARMACEUTICAL CHEMISTRY – IX (PHARMACEUTICAL ANALYSIS – II) THEORY Max. The Athlone Press of the University of London (Latest Edition). Marks: 80 Total Hours: 75 (3hrs/week) 1. Turbidimetry for Practical Analysis of dispersions. Medhan. IR. 1. flame photometry. Bassett.H. x. Workshop to interpret the structure of simple organic compounds using UV. basic instrumentation. TQM. Emission Spectroscopy. Beckett and J. New York. R. vi. v. quality audit. A. 13 BPH-410: PHARMACEUTICAL CHEMISTRY – IX PRACTICAL Max. Exercises involving Nephelo-turbidimeter. fluorimetry. UV and Visible Spectroscopy. Theoretical aspects.H. 2. L. (3) 2. Turbidimetry and Nephelometry: Theory of light scattering. elements of interpretation of spectra and applications of the following analytical techniques should be discussed. Vogel's Textbook of Quantitative Inorganic Analysis Including Elementary Instrumental Analysis. G. ISO. quality of equipment. I & II. Willard. 3. Marks: 80 Total Hours: 75 (3hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five.L. 2. Van Nostrand Reinhold. H.

Indian Pharmacopoeia 1996 and 2007. New York.M. SYLLABUS FOR SESSION 2009-13 53 . Basseler. 8.. Wiley-Interscience. Vols. L. Jenkin's Quantitative Pharmaceutical Chemistry. Knevel and F. N.A. of India.Spectroscopic identification of organic compounds (John Wiley and Sons.Y). K. New York. 5.E. I and II. Digangi. Connors. Marcel Dekker. McGraw-Hill Book Co. 7. A Textbook of Pharmaceutical Analysis.4. Ministry of Health. Morril. New York. G. 6. Chatten. Pharmaceutical Chemistry. Govt. Delhi. Silverstein. A.

containers. (30) 2. Capsules: Advantages. Day-Nauta granulator. production facilities. Microencapsulation by coacervation phase separation brought about by change of temperature. formulation. measurement of applied and transmitted pressure. Tabletting machinery for production of single layer. pyrogens. development. multiorifice centrifuge. double cone granulator. formulation of tablets. types of systems. Coating of tablets. 8. actuators. formulation. coating processes i.e. 6. Tablets: Advantages. air suspension technique and pan coating. chilsonator. advantages and nomenclature of aerosols. large scale production and quality control of hard and soft gelatin capsules. Formulation of hard capsules. 7. 1. electrostatic deposition. Formulation. (5) BPH-411: PHARMACEUTICS-X (PHARMACEUTICAL TECHNOLOGY-II) PRACTICAL Total Hours: 75 (3hrs/week) Max. 5. Aerosols: Definitions. formulation of aerosols. spray granulator. containers. polymerization. extructor. vacuum deposition. Granulation by slugging. Marks: 80 1. rear vented and perforated pans). Microencapsulation by coacervation phase separation brought about by addition of nonsolvent.BPH-403: PHARMACEUTICS-X (PHARMACEUTICAL TECHNOLOGY-II) THEORY Max. 4. multilayer and compression-coated tablets. distribution of forces during compression. 2. (10) 3. components of aerosol package. preparation and evaluation of paediatric tablets. complex emulsion.e. Tablet coating: Tablet coating principles. film coating . valves. materials used in film coating. large scale production of injectable grade water and quality control of parenterals. effect of applied pressure on relative volume and factors affecting strength of tablet. (10) 5. spray congealing. Film defects and specialized coating. disadvantages and various types of tablets. SYLLABUS FOR SESSION 2009-13 54 . air suspension coating and pan coating (using conventional. propellants. coacervation phase separation. Determination of BA and M/G factor. various granulation techniques including slugging and equipments i. (10) 4. Quality control of tablets. production procedures for small volume and large volume Parenterals. applications. spray drying. Parenterals: Types of parenteral products. Microencapsulation: Study of various processes employed for microencapsulation i. Design. Marks: 80 Total Hours: 75 (3hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. manufacture of pharmaceutical aerosols and quality control of aerosols. Physics of tablet making: strain gauge. production and evaluation of controlled release preparations. sugar coating. (10) 6. Evaluation of coatings. 9. Preparation and evaluation of aspirin tablets. 3.e.

(Tablatting Technology). Marcel Dekker. Pennsylvania.10. Formulation. USA. 11. Quality control of soft and hard capsules. 13. New York. al. ELBS 5. Test for pyrogen. Preparation of small volume parenterals. 1987. Controlled drug delivery. Varghese publishing House. R. 3. SYLLABUS FOR SESSION 2009-13 55 . Theory and Practice of Industrial Pharmacy. Ellis Horwood Limited. 1987. Mack publishing Company. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. 4. preparation and evaluation of aerosol. 2. Dodar. 14. Rubinstein Pharmaceutical Technology. L. H. Remington’s Pharmaceutical sSciences. 12. Bentely’s Text Book of Pharmaceutics. Bombay. Robinson & Vincent Pel-Lee. Microencapsulation by complex emulsion method. J. Lachman et. 15. Books Recommended (Latest editions) 1. Hind Rajasthan Building. Volume-1. John Wiley & Sons. M.400014. Preparation and evaluation of large volume parenteral.

hunger. smith Loa & Febiger. (7) 4. job description and job specification. qualities and functions of personnel manager: Human resource planning: Meaning and need. 29. barriers and breakdown in communication. selection procedures. Span of management. plant location and layout. (7) 6. DPCO considerations. 10.BPH-404: PHARMACEUTICAL MANAGEMENT AND PSYCHOLOGY THEORY Max. hierarchy of human needs. Employee training: Need. Promotion. Motivation: Nature and definition.E. Principles of Material Management: Scope problems cost of item. importance. Drug addiction. line and staff conflicts: Motivation: Need for recognizing motivating factors. Mental disorders: Nature. management by departmentation. vender development. Harrg A. authority and power. Introduction to Financial management: Sources of finance. relation of psychology in pharmaceutics. 30. The chemistry of behavior: Drugs and behavior. demotion. Dispatch of goods from Pharmaceutical manufacturing unit. 1. (4) (2) (3) (7) Books Recommended (Latest edition) 1. filling of central excise papers. Personnel Management: Definition. Tariff for AHC products. Nature definition and factors affecting personality development (7) 3. training methods. Flippo. functions and principles. (3) 7. centralization and decentralization. Personnel Management by Edwin B. theories X and Y: Communication: purpose. Pricing of Pharmaceutical formulations. general exemption No. objectives. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. principles of training. Psychology: Nature. importance process. causes and psychological methods of treatment. 2. management by crisis. (6) 2. classification and price list. job analysis. vendor audit (suppliers & quotations) and Ordering procedures. 9. Recruitment and selection process: Sources of manpower. definition and scope. E. recruitment policies. Techniques of management of objectives management by exception. C. General Management: Concept. Concept and components of marketing information system. Performance appraisal: Meaning. approaches and methods. loans and repayment (4) 5. record keeping and total documentation of central excise. 8. statutory records vis-à-vis schedule M requirements. making communication effective. Delegation: Concept and significance. records thereof CENVAT. Procurement of raw material and packaging material as per warehouse system. Intelligence: Nature. product line policies and stratagies. SYLLABUS FOR SESSION 2009-13 56 . Product life cycle. Tariff. transfer and separation. book keeping. production process analysis. Marketing and Production Management: Meaning. inwarding of material and goods. Production planning & control. Philadelphia. Ethical and unethical marketing of Pharmaceutical products. definition and measurement. issue of materials to production department and documentation systems thereof. Principles and methods of Pharmacy management. thrust. importance and objectives. Central Excise Act: Chapters 28. 1 C. function and problems: functions of marketing executives.

India . Butcher. New Delhi: Pearson. (1975) Introduction to Physiological Psychology. Thompson. Carson. Relevant Acts & Rules published by the Government of India. Central excise tariff.E. Boren. 8. 10. J. N. 7. Materials Manegemnet by Gopalkrishna. (2007) Psychology (Fifth Edition). Principles and practices of management Koontz/o Donnal. A. Philips Kotler. Govt. SYLLABUS FOR SESSION 2009-13 57 . and Mineka. planning and control. 4. 5. Prentice Hall. Marketing and managerial introductions. 9. J. Gandhi. R. 6. (2004) Abnormal Psychology and Modern life. S..3. Marketing Management analysis. C. New York: Harper & Row. of India publication. 11. C. Naw Delhi: Pearson. R. R.

. (4) 7. hazards encountered by the package. formulation and different types of films for flexible package. 1. evaluation of films. gravity flow systems. vacuum filling systems.V. fluid. tamper proof packaging. types of labels and labeling machinery. time fill. Brian. Cartwright. (5) 10. weighing systems.BPH-405: PHARMACEUTICS-XI (PHARMACEUTICAL PACKAGING TECHNOLOGY) THEORY Max. Evaluation of various packaging materials. (5) 4. etc. Sterile product filling and sealing machinery i. Jonathan Merrills and Jonathan Fisher. Pharmacy Law and Practice. legal requirements. 5. Matthews. Augers. Blackwell Science. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. blister packing machinery. selection and different types of closures. (4) 5. Packaging materials: Detailed study with regard to materials employed for packaging of pharmaceuticals with main emphasis on glass. Giles Calvier. 4. Liquid Formulation Packaging: Factors influencing selection of liquid filling machinery. Types of closures used for the sterile products. blister package design and evaluation of blister package. Boylan. Sterile Product Packaging: Various types of containers used for sterile products like ampoules. (5) 9. and cushioning design. Strip packaging machinery. metals rubber. types of pouch package. Films for Flexible Packages: Ideal characteristics. bottles for I. (6) 2. Inc. screw feeders. gravimetric. peristaltic and overflow liquid filling machinery. . pouch packing machinery. Aaron L Brody and Kenneth S Marsh. Inc. bar code. child resistant packaging. Rotovision SA. (5) Books Recommended (Latest editions) 1. Introduction: Definition and objectives of packaging. (5) 8. Blister Packaging: Advantages of Blister packing. plastics. Taylor & Francis Routledge. C. Strip Packing: Advantages of Strip Packing. belt feeders. Labeling: Objectives. Marcel Dekker. volumetric. selection of a suitable package. strip package design and evaluation of strip package. production of laminates. pouch package design and evaluation of pouch package. A. objectives. SYLLABUS FOR SESSION 2009-13 58 . Balanced and unbalanced constant level filling. What is packaging design. level sensing.e. bar code symbologies. Safety and Efficacy. James Swarbrick. packaging inserts. paper board. corrugated boards. vials. Dry products Filling machinery : Factors influencing selection of solid filling machinery. 3. Evaluation of the sterile product packages. John Wiley and Sons. 2. Blister packing materials. . Pouch packaging: Advantages of Pouch packing. cascade filling systems. Encyclopedia of Pharmaceutical Technology. James C. ampoule filling and sealing machine. Wiley Encyclopedia of Packaging Technology. (7) 3. production of single layer and oriented films. International Pharmaceutical Product Registration: Aspects of Quality. vibrating feeders. (4) 6.

7. enzymes and mucolytics. vi. Introduction to Clinical Pharmacy. Sulphonamides and co-trimoxazole. COPD. Antacids. protectives. ACTH and corticosteroids. Drug delivery systems and their biopharmaceutic and therapeutic considerations. schizophrenia. v. SYLLABUS FOR SESSION 2009-13 59 . Important disorders of organ system and their management: (20) i. Interpretation of clinical laboratory tests. The basics of drug interactions. general principles of treatment of poisoning with particular reference to barbiturates opoids. Marks: 80 Total Hours: 75 (3hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. laprosy. angina. iii. Insulin. betalactamas. v. Basic concepts of Pharmacotherapy: (15) i. ii. Principles of Toxicolgy: (4) i. iii. Definition of poison. Chemotherapy: (15) i. iii. cephalosporins. Miscellaneous: carminatives. 2. Drug induced disease. fungal diseases. 5. viral diseases. chloramphenical. Drug use during pregnancy. Cardiovascular disorders: hypertension. General principles of chemotherapy. iii. Thyroid hormones and antithyroid drugs. congestive heart failure. Heavy metals and heavy metal antagonsists. urinary tract infections and sexually transmitted diseases. depressions. iv. ii. v. CNS disorders: epilepsy. Pharmacology of Endocrine system: (8) i. vi. vii. iv. oral hypoglycemic agents and glucagon. parathormone calcitonin and vitamin D. viii. astringents. adsorbents. (3) 6. Appetite stimulants and supressants. tetracyclines. erythromycin. quinolones and miscellaneous antibiotics. Drugs acting on the uterus. Antibiotics. parkinsonism. digestants. Clinical Pharmacokinetics and individualisation of drug therapy. General principles of clinical toxicology. ii. organophosphorus and atropine poisoning. Androgens and anabolic steroids. v. Chemotherapy of tuberculosis. aminoglycosides. Hypothalmic and pituitary hormones ii. 4. pencillins. acute myocardial infraction and cardiac arrthymias.BPH-406: PHARMACOLOGY –IV THEORY Max. Emetics and anti-emetics. Respiratory disease: asthma. iv. Drug use during infancy and in the elderly (Paediatrics & geriatrics). 3. antisecretory and anti-ulcer drugs. ii. iv. Laxative and antidiarrhoeal drugs. demulcents. 1. ii. iii. Drugs acting on the Gastrointestinal Tract: (6) i. Chemotherapy of malignancy and Immunosuppressive agents.

D. Elsevier. 4. Churchill Living Stone. 3. To calculate the PA3 value of mepyramine or chlorpheniramine using histamine as agonist on guinea pig ileum. Joint and connective tissue disorders: rhematie disease gout and hypercurricemia. viii. 7. 8. 5HT. urinary tract infection. Basic & Clinical Pharmacology. 6.Katzung. Pharmacology of the Gastrointestinal Tract: To study the anti-secretory and anti-ulcer activity using pylorus ligated rats.) using a suitable isolated muscle preparation by-Matching Assay -Two Point Assay -Three Point Assay 5. Concept of essential drugs and rationale drug use. 9. iv. ix. Text book of Pharmacology. (2) (2) 8. K. Pharmacology. B. Acetycholine.iv. Oxytocin etc. Endocrine disorders: Diabetes Mellitus and thyroid disorders. Rang. S.G. To find out the strength of the given sample on agonist (e. Satoshkar & Bhandarkar. S. 5. To calculate the PA2 value of atropine using acetylcholine as an agonist on rat ileum preparation. Sethi. Elsevier. Mematopoietic disorders: anemias.Tripathy. v. Neoplastic disease: acute leukaemias. Mycer. JAYPEE. enteric infections. Dale and Ritter. Anti-anxiety and sedative drugs iii. Marks: 80 BPH-412: PHARMACOLOGY –IV PRACTICAL Total Hours: 75 (3hrs/week) 1. Books Recommended (Latest editions) 1. Mc Graw Hill.D. 4.g. Clinical Pharmacology: To demonstrate the effects of certain clinically useful drugs on human volunteers like:i. vii. ulcerative colitis.Bhattacharya. Max. 3. The Pharmacological Basis of Therapeutics. hepatitis and cirrhosis. Therapeutic drug monitoring. Essentials of Medical Pharmacology. Analgesics. Richard A. upper respiratory infections. Prasun Kumar Das. hodkin's disease and Carcinoma of breast. Mary J. Anti-histamines ii. Betablockers. SYLLABUS FOR SESSION 2009-13 60 . 6.K. Gastrointestinal disorders: peptic ulcer disease. Experiments on isolated preparations: 2. Lippincott William & Willans. Pharmacology. Popular Publication. Goodman & Gilman. Lange. Pharmacology. Pharmacology & Parmacotherapeutics. Histamine. vi. Infections disease: tuberculosis. 2. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE.

Pharmacokinetics of drug absorption-zero order and first order absorption rate constant using Wagner-Nelson and Loo-Riegelman method. ix. Non-linear pharmacokinetics with special reference to one compartment model after I. Overview of regulatory requirements for conduction of bio-equivalence study. b. vi. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five.V. Compartmental model: definition and scope. extraction ratio. viii. Hepatic elimination of drugs. mechanism of renal clearance. c. hepatic clearance. tmax and Area Under Curve (AUC). Drug distribution in the body.BPH-407: PHARMACEUTICS-XII (BIOPHARMACEUTICS AND PHARMACOKINETICS) THEORY Max. v. plasma protein binding. Clearance concept. Compartmental kinetics-one compartment and two compartment models. Clinical pharmacokinetics: (5) a. regression procedures. Significance of plasma drug concentration measurement. Dosage adjustment in patients with and without renal and hepatic failure. Cmax. SYLLABUS FOR SESSION 2009-13 61 . Passage of drug across biological barrier (passive diffusion. Definition and scope. Dosage regimen adjustment for repeated therapy. iii. determination of nonlinearity (saturation mechanism). physiological and pharmaceutical. facilitated diffusion and pinocytosis). iv. vii. clearance ratio. Curve fitting (method of residuals). 1. enterohepatic circulation. c. Introduction to Pharmacokinetics drug interactions and its significance in combination therapy. Design of single dose bio-equivalence study and relevant statistics. ii. determination of renal clearance. Pharmacokinetics: (30) i. Michaels Menten equation. first pass effect. Determination of pharmacokinetics parameters from plasma and urine data after drug administration by intravascular and oral route. Bioavailability and bioequivalence: (5) a. active transport. Measures of bioavailability. Biopharmaceutics: (7) a. c. b. d. 5. Factors influencing absorption-physiochemical. 3. Introduction to Biopharmaceutics and Pharmacokinetics and their role in formulation development and clinical setting. (3) 2. billiary excretion. 4. b. drug administration. Volume of distribution and distribution coefficient.

Determination of partition coefficient of hydrophilic and hydrophobic drugs in water/ octanol system 7. SYLLABUS FOR SESSION 2009-13 62 . Brahmankar & S.. D. A. In-viro evaluation of sustained release versus traditional dosage forms (capsules and tablets). Fundamentals of Clinical Pharmacoknetics. 6. Chapter Bioavailability and Bioavailability Testing. Pharmacokinetics. In-situ absorption studies of paracetamol. Determination of bioavailability of sulfonamides / any other drug. 2. 10. 4. R. Thomas Ng. 9. Lea Febiger. 8.Whitney equation. Remington’s Pharmaceutical Sciences.Notari. Hamilton. 3.BPH-413: PHARMACEUTICS-XII (BIOPHARMACEUTICS AND PHARMACOKINETICS) PRACTICAL Max. New York. 12. Marcel Dekker. 5. riboflavin). Wagnar. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE.A Treatise.B. Study of release rate of drug through various ointment bases using agarplates/ dialysis membrane. Drug Intelligence Publications. Philadeliphia. Intestinal transport of drugs including plotting of standard curve (salicylic acid. Drug Intelligence publications. Hamilton. 6. New York.M. 2.Jaiswal. Clinical Pharmacokinetics. USA. Rowland. Ponnsylvania. 3. Marks: 80 Total Hours: 75 (3hrs/week) 1. 4th Ed. Malcolm and Tozer. W. Ritschel Handbook of Basic Pharmacokinatics. Study of effect of various additives on rate of release of drugs using dialysis method. 5. Delhi. Books Recommended (Latest editions) 1.E. Vallabh Prakashan. Determination of dissolution rate constant using Noyes. Marcel Dekker. Protein binding of drugs through diffusion cell. Easten. To study acid neutralizing capacity and rapidity of action of antacid tablets. Mack publishing Co. J. Determination of urinary excretion of sulfonamides / any other drug. Determination of effect of pH on dissolution rate constant. Biopharmaceutics & Clinical Pharmacokinetics – An Introduction. 4. 11. G. Biopharmaceutics & Pharmacokinetics. – 2008.Perrier. Gibaldi & D. 7.

(3) Immobilization of cell systems for the production of plant metabolites. (3) 5. 1. Introduction: Pharmaceutical Biotechnology. 4. Technical problems in micropropagaton such as vitrification. 8. concepts and basic techniques in tissue culture and their application in Pharmaceutical Sciences. Production of Endogeneous compounds and Transformation Involving Foreign Genes. (3) Antimicrobial agents from plant cell culture. 9. (3) The use of Non-classical techniques in the production of secondary metabolites by Plant Tissue Culture: Plant cell cultures as new alternative sources of secondary natural products. 3. (5) Production of flavoring compounds through tissue culture. (3) Application of Biotechnology in Pharmacy and intellectual property rights. (4) Production of anti tumor compounds by plant cell culture. (3) Application of Bioreactors in large scale production of useful Pharmaceutical products. clinical propagation of eilite germplasm of Pharmaceutical importance. 12. explant exudation etc. 6. (6) Production and application of synthetic seeds. SYLLABUS FOR SESSION 2009-13 63 . (4) Drug Delivery Aspects of Biotechnological Products: Introduction.BPH-408: PHARMACOGNOSY –IV (PHARMACEUTICAL PLANT BIOTECHNOLOGY) THEORY Max. Stability of peptides and proteins. (4) Micropropagation: Organigenosis and somatic embryogenesis. Marks: 80 Total Hours: 50 (2hrs/week) Note: Examiner to set eight questions and the candidates are required to attempt any five. Introduction and various Biotechnological products. 13. 10. 2. Non conventional Routes of Administration. (3) The Pharmacists’ practitioner’s role in Biotechnology. 11. 14. Effect of microenvironmention micropropogation. (3) Increasing secondary metabolite production in plant cell culture with fungal elicitors. (3) Production of edible vaccines by successful expression of foreign antigens in genetically engineered plants. 7.

Production of secondary metabolites Anthrocyanin pigments and Aromatic compounds. 2. Culture organ explants and micro propagation by axillary bud proliferation and somatic embryogenesis. K. S. 3. 3. Secondary metabolism in plnat cell cultures by phillip Marris. Gambarg and G. Phillips. Synthesis of artificial seeds and study of their delivery system. 2. John M. 1994. 5. 6. Narosa Publishing House. Oxford & IEH. Aseptic techniques. and Hanri R. Media Preparation. Plant cell tissue and organ culture fundamental methods by O. 5. 4. 7. Pazzute. IV. Initiation and maintenance of callus cultures. Shargoel and That T. Biotechnology and Pharmacy. An Introduction to plant Tissue culture by M. Springer Verlag. Razdan. Cambridge University Press. Johnson. 6.Max. SYLLABUS FOR SESSION 2009-13 64 . 1996. Medicinal and arematic plants I by V. C. Alan H. Scragg. Fowlar 1986. 4. Bajaj 1988. Michael E. Angle Staff and Michael W. Biotechnological applications of plant cultures by peter D. Initiation and maintenance of plant cell suspension cultures. L. Micro droplet and single cell nurse culture. BPH-414: PHARMACOGNOSY –IV PRACTICAL Total Hours: 75 (3hrs/week) Laboratory design. Marks: 80 1. Biotechnology in Agriculture and Forestry Vol. 1994. P. Jr. Books Recommended (Latest editions) 1. NOTE: ANY OTHER EXPERIMENTS (S) MAY BE INCLUDED IN SUPPORT OF THE THEORETICAL ASPECTS OF THE COURSE. Ngo. CRC Press Inc. Manasse.