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Beauty comes from within. Stability too.
Clinical routine shows that stability plays an important role during the early stages of implantology
treatment. The quicker and more intensive the osseointegration process, the higher the implant stability. Dexabone
is an incomparably stable, highly purified, and well established spongiosa bone graft material of bovine origin. It
goes further towards satisfying the requirements for increased safety and better predictability. The material is used
for oral guided bone regeneration (GBR) in the management of simple and complicated defects to build up the bone
bed. The mineral composition, the crystalline structure, and the spongiosa structure of Dexabone are very similar to
those in the human body. Therefore, Dexabone achieves the same elasticity, strength and stability in the patient’s
jaw after integration as the body’s own jaw bone.

Dexabone is eminently suitable for all augmentation techniques for building up a strong implant bed and
treating periodontal defects. Dexabone is the material of choice for functional and aesthetic reconstructions for
natural, reliable, simple and economic bone regeneration. In combination with autologous bone and other bone graft
materials as well. Thanks to the particularly high degree of purity of the hydroxyapatite of bovine origin and the
physiological pH of 8.2, the outstanding homogeneity of the hydroxyapatite structure and the interconnecting
macropores of the natural bone, Dexabone is superior to other hydroxyapatite ceramics.
Table:

Mechanical properties Dexabone block Dexabone block


20x20x40mm3 20x20x40mm3

Compressive force [N] 1670 +/- 120 4510 +/- 770

Compressive strength [N/cm2] 420 +/- 32 564 +/- 96

Shear force [N/cm2] 124 +/- 35 338 +/- 200

Mechanical properties of Dexabone

Stability with Dexabone

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Perfection is rare. Purity too.
The development of a single-phase hydroxyapatite such as Dexabone was prompted by the trend towards
increased safety and better predictability. The focus on the body’s biological healing processes demanded a material
that does not contaminate the healing process in the body with phase impurities. The phase content of Dexabone as
measured by X-ray diffractograms shows phase pure hydroxyapatite. Dexabone is pure and 100% safe (BSE) and
100% protein-free. Thus Dexabone does not contain any phase constituents that impair the healing process. This
means better clinical safety for therapist and patient alike. In this way, Dexabone exploits the natural and perfect
healing potential of the human body right from the start.

Diffraction pattern of natural bone; Dexabone; HA of algae and Tricalcium phosphate

Scanning electron microscope pictures

A natural bone B Dexabone

C HA of algae D TCP

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Therapies need acceptance. Performance too.

Dexabone – Biofunctionality

The excellent acceptance and biocompatibility of hydroxyapatite and Dexabone spring from its material
properties. The other properties of Dexabone are based on the open interconnecting pore structure. This is identical
to the biological characteristics of the bovine starting material and arises from the physiological structure of the
human body. Dexabone’s macroporous structure is ideal in its osteoconductive function and promotes the ingrowth
of blood vessels and nerves. The adhesion and spread of osteoblasts over the Dexabone surface creates an open,
interconnecting pore structure, which prompts a bioactive reaction with bone tissue formation, bone tissue
strengthening and bone tissue interlinking leading to the restoration of the bone and its function. The
osteoconductive properties of hydroxyapatite ceramic have been demonstrated without doubt by biopsies.

Dexabone – Long-term success

The very good acceptance of Dexabone is seen in its efficacy. Hydroxyapatite of bovine origin has been
successfully used in clinical medicine since 1989. Radiological follow-ups after 3 and 6 months showed
consolidation of the defects that was consistent with the healing phase. Biopsies retrieved from clinical grafts
showed that the ceramic had almost completely been surrounded by bone and that newly formed bone had also been
deposited inside the ceramic pores. The long-term results were also confirmed by a large number of studies and
clinical applications.

Dexabone – Tolerability

The bone graft material Dexabone is extremely well tolerated. Its pH of 8.2 matches the physiological levels,
which is particularly important during the early stages of implantation. Dexabone does not contain any
pharmacologically active constituents. Large patient populations have confirmed the good biocompatibility of
hydroxyapatite ceramic. Not one single rejection reaction has been reported to date.

Dexabone – Administration

The Dexabone material is very hydrophilic and can easily be mixed with the patient’s blood before insertion.
The Dexabone/blood mixture demonstrates excellent coagulation properties and can be taken off the spatula
confidently and applied with pinpoint accuracy. Bone regeneration can be promoted in combination with autologous
blood and bone.

Dexabone is supplied in double sterile bottles ready for use :

Pack Sizes Granule Sizes


0.5 gr 0.5 – 1.0 mm / 1.0 – 2.0 mm
1.0 gr 0.5 – 1.0 mm / 1.0 – 2.0 mm
3.0 gr 0.5 – 1.0 mm / 1.0 – 2.0 mm
5.0 gr 0.5 – 1.0 mm / 1.0 – 2.0 mm

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Dexabone solubility

a
The good integrated HA-ceramic
fragments are visible macroscopically.

b
Staining with toluidin blue.
Well structured trabecular bone
with numerous osteoblasts on the
trabecular and ceramic surface

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Clinical Cases

X-ray of dental cyst, maxilla lt. situation before Cystectomy situation after Cystectomy

defect augmentation utilizing defect augmentation utilizing defect augmentation utilizing


Dexabone Dexabone & Hyprosorb membrane Dexabone & Hyprosorb membrane

Courtesy of prof.Dr.med.dent.N.Watted, Center for Dentistry & Esthetics

Lateral sinus window Situation of perforated sinus Application of Hyprosorb


membrane Membrane by perforated

Dexabone filling of the sinus Hyprosorb membrane before Situation after bilateral flap closure
sinus window closing

Courtesy of Dr.med.dent.Ph.D. Fahim Atamni


Hyprosorb membrane x-ray dental cyst, maxilla lt. situation before Cystectomy
&Dexabone

situation after Cystectomy x-ray after bone augmentation


defect augmentation utilizing
utilizing Dexabone
Dexabone & Hyprosorb membrane

Courtesy of prof.Dr.med.dent.N.Watted, Center for Dentistry & Esthetics

Clinical Cases

Courtesy of prof.Dr.med.dent.N.Watted, Center for Dentistry & Esthetics


Efficacy makes sense. Safety too.
The clinical application of Dexabone guarantees the highest possible safety and predictability. The
spongiosa bone graft material of bovine origin Dexabone covers a broad spectrum of indications and offers so many
options for effective and safe prognoses in everyday clinical routine.

Dexabone is produced by a specially developed method under clean-room conditions using a validated
production process. aap Biomaterials GmbH & Co. KG satisfies the requirements of a quality management system
in accordance with EN ISO 13485:2003 and EN ISO 9001:2000. The product Dexabone fulfils the requirements
laid down in Annex II.4 of Directive 93/42/EEC and Directive 2003/32/EC.

Dexabone – Safety
The unique manufacturing process with a two-stage heating process removes unwanted fractions such as fat,
cells, antigen structures and inactivated pathogens. The specific retrieval of bovine donor spongiosa is the reason for
the balanced ratio of porosity and density of Dexabone and offers an incomparably firm bond between the ceramic
crystals and unique mechanical strength. The controlled further processing with wide-ranging chemical purification
processes and specific high-temperature stages inactivates all organic elements and eliminates all immunological
processes: Dexabone is 100% safe (BSE), 100% protein-free.

Dexabone is a hydroxyapatite ceramic that consists entirely of inorganic material which is available as
granules of various sizes or pre-formed shapes.

Dexabone is superior to other hydroxyapatite ceramics due to its particularly high degree of purity,
the physiological pH, the homogeneity of the hydroxyapatite structure and the interconnecting macropores.

Literature
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