MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY

)

PRACTICAL PATHOLOGY 2: AMYLOIDOSIS AND BONE TUMOURS

1. Jars

Organ: Piece of skull bone Description:  The bone shows in one area small, sessile, hard bony projection with a smooth ivory-like surface. Diagnosis: Osteoma

©ACE 2013/14

MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Part of vertebrae column. Description: The dorsal part of one vertebrae shows a mass which is:      Solitary Well circumscribed Non-encapsulated Colour-brown Cut surface- honey comb appearance

Diagnosis: Cavernous hemangioma of a vertebrae.

©ACE 2013/14

MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY)

©ACE 2013/14

MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Upper hand of humerus Description: The upper hand of the humerus shows a bulky tumour mass arising at metaphyseal region.  The mass destroyed the bone cortex and extended to soft tissue producing a fusiform mass giving a ‘mutton leg’ appearance.  On section, the mass is: o Fleshy o Grayish white in colour o Focal brownish area of haemorrhage o Yellowish area of necrosis  The epiphyseal cartilage is intact.  New bone formation is noted in subperiosteal area. Diagnosis: Osteosarcoma

©ACE 2013/14

MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Lower end of femur. Description: The epiphyseal end of the femur is expended by a tumour mass and with marked thinning of the cortical bone.  Cut surface of the mass shows: o Brownish area of necrosis o Focal cystic area of degeneration.  The remnants soft bone is seen.  No new bone formation. Diagnosis: Osteoclastoma (Giant cell tumour of bone)

©ACE 2013/14

MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY)

©ACE 2013/14

MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: liver Description: A slice from an enlarged liver shows.     Surface- smooth Border- sharp Consistency- firm Cut surface o Colour – dark brown o Semitranslucent o Appearance – waxy

Description: Amyloidosis of the liver

©ACE 2013/14

MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY)

Organ: Slice of the brain Description:  The brain is swollen with flatten gyri  The meninges are o Opaque, lusterless o Covered by purulent exudative material particularly abundant in the sulci. Diagnosis: Acute suppurative meningitis.

©ACE 2013/14

MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY)

1. HISTOPATHOLOGY

©ACE 2013/14

MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY)

Osteochondroma: Tumour tissue shows: A cap of benign looking hyaline cartilage.  Underlying core of bone trabeculae enclosing mostly fatty marrow elements.

©ACE 2013/14

MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY)

Amyloidosis, Liver Section in the liver showing.  The liver architecture is preserved  Eosinophilic structureless homogenous amyloid material is deposited extracellularly in space of Disse ( the space between the hepatocyte and sinusoidal epithelial cells.  The compressed hepatocytes are atrophied.

©ACE 2013/14

MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY)

Osteoclastoma (Giant Cell tumour of bone) Tissue tumour formed of:  Numerous evenly distributed osteoclast like tumour cell showing numerous centrally clustered nuclei within abundant cytoplasm.  interverning round to spindle shaped mononuclear cells.

©ACE 2013/14

MODULE 19 – PATHOBIOLOGY MODULE (PATHOLOGY)

Chondroma Sections revealed lobulated tumour tissue formed of irregularly scattered benign looking chondrocytes of different sizes and shapes in groups embedded within abundant faint blue condroid matrix.

©ACE 2013/14

Sign up to vote on this title
UsefulNot useful