Better Living Through Nanotechnology

:
Unique applications of magnetic composites 
Thompson Mefford
Materials Science and Engineering
mefford@clemson.edu
Meffordresearch.com


MRI Contrast Agents
(Relaxometry):
Multi Mode Imaging 
(MRI + Optical/PET/CT/SPECT):
NUCLIAR MIDICINI AND ßIOLOGY (2011) VoIume: 38 Issue:
6 Iages: 885-896 
Delivery:
Nano Revievs (2010) VoI 1 (0)  
Magnetic Hyperthermia or MagMED:
Examples of Magnetic Directed Self Assembly for
Structured Composite Materials 
CoIIoidaI DC IieId AssembIy
ConlroIIed ßy IoIymer ßrush and Time 
CoIIoidaI AC IieId AssembIy Wilh In
Silu IoIymerizalion of lhe Malrix 
Iauerned Magnelic IieId
Gradienl AssembIy 
®In coIIaboralion vilh Dr. Thomas Cravford
al U. Soulh CaroIina Ihysics De¡arlmenl 
Unique Ca¡abiIilies 
Polymer
Nanoparticle
Surface Ligand
Additional
Functionality
Polymer
Nanoparticle
Surface Ligand
Additional
Functionality
A wide variety of metal and metal oxide nanomaterials
are synthesized by the Me!ord Lab.
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Shape Control:
Size Control:
Polymer
Nanoparticle
Surface Ligand
Additional
Functionality
We are designing specialized surface ligands for robust
attachment on the surface of metals and metal oxides
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PEG-trinitroDOPA in H20
PEG-trinitroDOPA in PBS
PEG-trinitroDOPA in FBS
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Time (sec)
Si
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N
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OH
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O
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OH
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OH
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PEG-trinitroDOPA
Polymer
Nanoparticle
Surface Ligand
Additional
Functionality
Custom synthesis of heterobifunctional polymers provides a
framework for being able to approach multiple applications with a
central core material
Polymer
Nanoparticle
Surface Ligand
Additional
Functionality
By controlling the end group chemistry through “click” or other
methods particles can be “tuned” to specific applications
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HO
OH
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HO
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Ground state depletion image of Cy5
labeled in a Legionella biofilm  
Schematic of functionalization of iron
oxide particles with triglycerides for the
disease specific targeting of bacteria 
Our Needs:
What We Can Offer:
•  Industrial partners for:
•  Internships for students
•  Shared research objectives (sponsorship, NSF SNM,
GOALI, etc.)
•  Understanding industrial needs
•  Unique synthetic capabilities
(catalysts, processes, and equipment)
•  Synthetic challenges for new material development

•  Workforce development
•  Directed assembly of polymer nanocomposites
•  New avenues of nanomanufacturing
•  Unique nanomaterial structures
•  Robust surface modifications
•  Custom heterobifunctional polymers
•  Instrumentation and expertise for the measurement and
characterization of colloids and nanostructured materials
AcknovIedgmenls 
National Science Foundation (DMR-0907167,
CMMI-1057633, CMMI-1130819, CBET-1236041)
Thompson Mefford
Materials Science and Engineering
mefford@clemson.edu
Meffordresearch.com