You are on page 1of 10

Better Living Through Nanotechnology:

Unique applications of magnetic composites


Thompson Mefford
Materials Science and Engineering
mefford@clemson.edu
Meffordresearch.com


MRI Contrast Agents
(Relaxometry):
Multi Mode Imaging
(MRI + Optical/PET/CT/SPECT):
NUCLIAR MIDICINI AND IOLOGY (2011) VoIume: 38 Issue:
6 Iages: 885-896
Delivery:
Nano Revievs (2010) VoI 1 (0)
Magnetic Hyperthermia or MagMED:
Examples of Magnetic Directed Self Assembly for
Structured Composite Materials
CoIIoidaI DC IieId AssembIy
ConlroIIed y IoIymer rush and Time
CoIIoidaI AC IieId AssembIy Wilh In
Silu IoIymerizalion of lhe Malrix
Iauerned Magnelic IieId
Gradienl AssembIy
In coIIaboralion vilh Dr. Thomas Cravford
al U. Soulh CaroIina Ihysics Dearlmenl
Unique CaabiIilies
Polymer
Nanoparticle
Surface Ligand
Additional
Functionality
Polymer
Nanoparticle
Surface Ligand
Additional
Functionality
A wide variety of metal and metal oxide nanomaterials
are synthesized by the Me!ord Lab.
y = -0.1883x
2
+ S.743Sx - 18.293
k = 0.9967
0
S
10
1S
20
2S
30
0 2 4 6 8 10 12 14 16 18
D
|
a
m
e
t
e
r

(
n
m
)

Mo|ar kano (C|e|c Ac|d: Ie(acac)
3
)
D|ameter vs. Mo|ar kano
!"#$ &'#()*+ ,-".$)/- ,.$)#& #0 1,-23,&#, *--4-4 $# $.,+-$ &1-2)52 &)6- *.*#1.,$)2"-&7 8'- -,,#, 9.,& )""3&$,.$- &)6- 4)&1-,&)#* #0 $'- ,-.2$)#* 8:;
)<.+-& 2#)*2)4- ()$' -.2' &1-2)52 4.$. 1#)*$7
Shape Control:
Size Control:
Polymer
Nanoparticle
Surface Ligand
Additional
Functionality
We are designing specialized surface ligands for robust
attachment on the surface of metals and metal oxides
0
20
40
60
80
100
0 500 1000 1500
PEG-trinitroDOPA in H20
PEG-trinitroDOPA in PBS
PEG-trinitroDOPA in FBS
H
y
d
r
o
d
y
n
m
a
i
c

S
i
z
e

(
z
-
a
v
e
r
a
g
e
,

n
m
)
Time (sec)
Si
S
S
S
O
H
N
O
C
H
2
H
2
C
O
H
2
C
C
H
2
HO
n
8
O
N
H
8
O
N
H
8
OH
OH
O
2
N
HO
O
OH
OH
O
2
N
HO
O
OH
OH
O
2
N
HO
O
PEG-trinitroDOPA
Polymer
Nanoparticle
Surface Ligand
Additional
Functionality
Custom synthesis of heterobifunctional polymers provides a
framework for being able to approach multiple applications with a
central core material
Polymer
Nanoparticle
Surface Ligand
Additional
Functionality
By controlling the end group chemistry through click or other
methods particles can be tuned to specic applications
O
O
O
O
O
N3
O
O
NHAc
HO
OH
OH
OH
HO
HO
HNAc
OH
HO
NHAc
OH
HO
HO
CO2Na
+
Ground state depletion image of Cy5
labeled in a Legionella biolm
Schematic of functionalization of iron
oxide particles with triglycerides for the
disease specic targeting of bacteria
Our Needs:
What We Can Offer:
Industrial partners for:
Internships for students
Shared research objectives (sponsorship, NSF SNM,
GOALI, etc.)
Understanding industrial needs
Unique synthetic capabilities
(catalysts, processes, and equipment)
Synthetic challenges for new material development

Workforce development
Directed assembly of polymer nanocomposites
New avenues of nanomanufacturing
Unique nanomaterial structures
Robust surface modications
Custom heterobifunctional polymers
Instrumentation and expertise for the measurement and
characterization of colloids and nanostructured materials
AcknovIedgmenls
National Science Foundation (DMR-0907167,
CMMI-1057633, CMMI-1130819, CBET-1236041)
Thompson Mefford
Materials Science and Engineering
mefford@clemson.edu
Meffordresearch.com