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Minerals are basic elements on which life is built. Scientific investigations regularly bring proofs of their vital importance for any form of life1. Lately proof was made that boron is an essential element for human health2, and as well for animals and plants3, 4, 5. The ideal daily amount of boron we need is not known6; nevertheless, it was estimated that 2 to 3 milligrams of elemental boron per day for an adult is a minimum requirement7, 8. Investigations showed a chronic boron deficiency in the people living in western countries; the western food brings about 1 milligram or less of boron per day9, 10. This deficiency is mainly due to the use of chemical fertilizers—phosphorus and potash used as chemical fertilizers inhibit the uptake of boron by plant roots. We know that boron is necessary for the stabilisation of cellular membranes and for the transportation of toxic elements. For example, boron dislodges fluorine11, and aluminum, and to a lesser extent cadmium, led and mercury, and helps actively the fixation in the body of magnesium and calcium12 – without boron, magnesium and calcium cannot be fixed in the body13, 14. Boron is distributed throughout the body with the highest concentration in the parathyroid glands, followed by bones and dental enamel. It is essential for healthy bone and joint function, regulating the absorption and metabolism of calcium, magnesium and phosphorus through its influence on the parathyroid glands. This effect is done in synergy with 17‐ estradiol15. It seems that boron is for the parathyroids what iodine is for the thyroid. Boron deficiency causes the parathyroids to become overactive, releasing too much parathyroid hormone which raises the blood level of calcium by taking out calcium from bones and teeth. This leads to osteoarthritis and other forms of arthritis, osteoporosis and tooth decay. High blood levels of calcium lead to calcification of soft tissues causing muscle contractions and stiffness, calcification of endocrine glands, especially of the pineal gland and the ovaries, arteriosclerosis, kidney stones, and calcification of the kidneys, and ultimately to kidney failure. Boron deficiency combined with magnesium deficiency is especially damaging to the bones
1 Naghii MR., Samman S. Prog Food Nutr Sci 1993 Oct;17(4):331-349 The role of boron in nutrition and metabolism. Prog Food Nutr Sci 1993 Oct;17(4):331-349.
Penland, J.G., The importance of boron nutrition for brain and psychological function, Biol. Tr. Elem. Res.,1998; 66: 299–317. 3 Moseman RF. Chemical disposition of boron in animals and humans. Environ Health Perspect . 1994, 102:113-117). 4 Nielsen FH. Boron in human and animal nutrition. Plant soil. 1997, 193:199-208. 5 Hu H, Penn SG, Lebrilla CB, Brown PH. Isolation and characterization of soluble boron complexes in higher plants. The mechanism of phloem mobility of boron. Plant Physiol 1997, 113:649–655.
Sutherland, B., Strong, P., and King, J.C., Determining human dietary requirements for boron, Biol. Tr.Elem. Res., 1998; 66: 193–204. 7 Nielsen FH. Environ Health Biochemical and physiologic consequences of boron deprivation in humans. Perspect 1994 Nov;102 Suppl 7:59-63. 8 Korkmaz M, Sayl U, Sayl BS, Bakirdere S, Titretir S, Yavuz Ataman O, Keskin S. Estimation of human daily boron exposure in a boron-rich area. Brit J Nutr 2007, 98:571–575. 9 Rainey CJ, Nyquist LA, Christensen RE et al. Daily intake of boron from the American diet. J Amer Dietetic Assoc , 99:335-341. 10 Rainey CJ, Nyquist LA, Christensen RE, Strong PL, Culver BD, Coughlin JR. Daily boron intake from the American diet. J Am Diet Assoc. 1999 Mar;99(3):335-40. 11 J. Elsair, R. Merad, R. Denine, M. Reggabi, S. Benali, M. Zaaouz, K. Khelfat and M. Tabet Aoul, Boron as an Antidote in Acute Fluoride Intoxication in Rabbits: Its Action on the Fluoride and Calcium-Phosphorous Metabolism. Fluoride 1980, V 13, Nr.1.
Nielsen FH Studies on the relationship between boron and magnesium which possibly affects the formation and maintenance of bones. Magnes Trace Elem, 1990, 9:2, 61-9 13 Volpe SL, Taper LJ, Meacham S. The relationship between boron and magnesium status and bone mineral density in the human: a review. Magnes Res. 1993 Sep;6(3):291-6.
Hunt CD; Herbel JL; Nielsen FH. Metabolic responses of postmenopausal women to supplemental dietary boron and aluminum during usual and low magnesium intake: boron, calcium, and magnesium absorption and retention and blood mineral concentrations. Am J Clin Nutr, 1997 Mar, 65:3, 803-13. 15 Sheng MH, Taper LJ, Veit H, Thomas EA, Ritchey SJ, Lau KH. Dietary boron supplementation enhances the effects of estrogen on bone mineral balance in ovariectomized rats. Biol Trace Elem Res. 2001 Jul;81(1):29-45.
Environ Health Perspect 1994. A. Samman S The effect of boron supplementation on its urinary excretion and selected cardiovascular risk factors in healthy male subjects. Christopher T. 1994. Dietary boron decreases peak pancreatic in situ insulin release in chicks and plasma insulin concentrations in rats regardless of vitamin D or magnesium status. 1996 Feb. C.7 Macrophages. a greater than twofold increase in testosterone concentrations (from 0. 27 Hunt CD. 2002. Scorei. Mitran. Elem. Boron exhibits anti‐inflammatory16.. Biol Trace Elem Res V 135. S3(1):205-226). 334-344. 27-37. . Bone. and Maurizio Trevisan.102 Suppl 7:49-53. 26 Armstrong TA.143(3):1223-38. Scorei. R. and the normalization of progesterone and oestrogen avoids not only hot flashes or night sweats. Boron is the key for membrane integrity as remedy to 16 Scorei RI.R. 17 R. Williams L. 51:162–169. 273-86. Relation of boron to the composition and mechanical properties of bone. without exogenous hormone therapy. and for better controlling obesity. Oncol Rep. The effect of boron supplementation on its urinary excretion and selected cardiovascular risk factors in healthy male subjects. Ion. and a significant increase in calcium retention. 79:1549–1556. R.and teeth. Biol Trace Elem Res 2011 Dec. Anticancer Agents Med Chem. Iancu. 2010 May. Dorn. Richard P. 21 Touillaud M. Boron helps our vasculature to stay healthy. sexual hormones production is increased with boron supplementation. Nr 1-3 (2010). 2004. 18:2. B. 20 Newnham RE. Epub 2011 Jan 28. 25 Tiejian Wu. Klenerman L. and Samman. Thus. Naghii MR. M. Number 1 (2007). 24 Bakken NA. 1994 Feb. Clark R. This is particularly interesting for people suffering of diabetes type 2 and 3. In Vitro Effects of Calcium Fructoborate upon Production of Inflammatory Mediators by LPS-stimulated RAW 264. growth. Calcium fructoborate—potential anti-inflammatory agent. Popa R Jr. and it was found to be efficient for fighting breast21. in men testosterone may increase naturally as much as 30 to 50% over the basic level and in women progesterone and oestrogen are also increased28. and this happens in both sexes. some people questioned the safety of taking boron for breast. Nr 1. Dietary boron intake and prostate cancer risk. Inflammatory response. Elemental analysis of femoral bone from patients with fractured neck of femur or osteoarthrosis. 1997a. Boron supplementation resulted in a twofold increase in 17‐estradiol levels. Biol Trace Elem Res V 118. Associations of Serum C-reactive Protein with Fasting Insulin. Herbel JL. it participates not only to the health of bones but of the joints as well20. but more importantly the cardiovascular complications29 and osteoporosis30. J Anim Sci 2001. Res. it becomes easy to understand that boron is a key element for the prevention and remedy of osteoporosis. et al. Galateanu. Kelly SA. Haines J. These hormones may be increased in women at menopause. 17.83 ng/mL). Iordachescu. Spears JW. 56: 273–286 32 Helliwell TR. Sempos. S. and Glycosylated Hemoglobin. Jakovljevic J. uterus and lung cancers23. Glucose. 11:887–892. 151-7. 2003 Nov. Roberts NB. Joan P. 23 Scorei RI. In Vitro Effects of Calcium Fructoborate on fMLP-stimulated Human Neutrophil Granulocytes. C. thus avoiding coronary heart diseases32. Boron acts also on the enzymes implicated in the synthesis of hormones26. Cimpean. Front Biosci 2011. D. Tr. Pillow P.9(2):171-82. Biol. prostate22. 31 29 Naghii. Donahue. Zhang ZF. V. Orrell R. Calcium fructoborate: plant-based dietary boron as potential medicine for cancer therapy. 1 02(Suppl 7):59-63. Hunt CD. Because boron increases the serum sex hormones. Nutr Cancer. et al. Ciofrangeanu. 2005. particularly steroid hormones and vitamin D. and thyroid hormone concentrations are affected by long-term boron supplementation in gilts. Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. Boron is necessary to normalize the production of insulin in the pancreas and its release in the blood24. J Nutr. Rotaru P. Biochemical and Physiologic Consequences of Boron Deprivation in Humans. and our boron deficiency explains why this disease is so common in the western world. Irwin A. American Journal of Epidemiology. Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer. 1997 Mar. Boron-containing compounds as preventive and chemotherapeutic agents for cancer. Biol Trace Elem Res. D.. Kenney MA. 155. Walsh HP. 28 Nielsen Forrest H. 18 R I. Montgomery C. Winton M. which is of high importance in postmenopausal women. The testosterone increase participates to the maintenance of the muscular mass and strength. 19 Scorei RI. 56:3. Lloyd KE. Mitran. A. Ciubar. This is because they missed the fact that all cancers start with disruption of the membranes integrity. 18 and anti‐cancer activities19. 31. Iordachescu. and inflammatory processes through reduction of C‐reactive protein25. prostate and uterus cancers. Environ Health Prospect.31 to 0. Idso JP.133(11):3577-83. 30 McCoy H. 22 Cui Y. Cimpean. 10(4):346-51. 102(7):83–85. Essentiality of boron for healthy bones and joints. V. Environ Health Perspect 1994 Nov. Vol. J Bone Miner Res.27 Thus.
144. 2003. Ann Nutr Metab. Recovery of rats from vitamin D-deficient mothers.. 253-263. Volpe SL. less than 10% of the population suffer from joints diseases35. 45 Spears J.. a genotoxin found in many foods such as peanuts. Baumann W. figs. 4. J. phosphorus. peanuts butter. In: Anke M. In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes. Biol Trace El. 38. Res. This is because dietary boron influences the activity of many metabolic enzymes with impact on the metabolism of steroid hormones and several micronutrients. 1998. 79-82. Groppel B. Crit Rev Food Sci Nutr. concentration. Tr. One possible role of dietary boron in higher animals and humans. Advanced Nutrition and Human Metabolism. 2010 April. Taper LJ. 65-72. The physiological effects of dietary boron. Bru¨ ckner C. 44. 45. 43 Hunt CD. M J Keenan. Volpe SL Effects of boron supplementation on bone mineral density and dietary. Hebrew University 1980. Siver F. breast and uterus cancers. Armstrong T. it is proven fact now that low boron intakes result in impaired bone health.1007/s10616-012-9454-1. Gru¨ nM. p 1106_1111. increasing of 33 R. therefore increasing the detoxification capability of tissues and organs48. Penland JG. 3rd ed. 37 J N Dupre.66(4):183-91. 41 Penland JG. Belmont.64(6):607-12. Meacham SL. Placebo-Controlled Pilot Study to Evaluate the Effect of Calcium Fructoborate on Systemic Inflammation and Dyslipidemia Markers for Middle-Aged People with Primary Osteoarthritis. SOD is a main free radical (superoxide) scavenger. Keenan MJ. corn. Leipzig and Friedrich-SchillerUniversitat. Exper. Boron reinforces the visual acuity. The importance of boron nutrition for brain and psychological function. Res. 40 34 . 48 Groff. Boric acid: a potential chemoprotective agent against aflatoxin b1 toxicity in human blood.28(3):243-55. Mitrut.cancerisation. This seems to be in connection with a more active vitamin D in presence of boron. strengthens the hair and nails and increases skin elasticity. calcium and phosphorus gained normal healthy levels in vitamin D deficiency situations37. 66: 205–225. Advances in Plant and Animal Boron Nutrition 2007. and A M Brudevold. Biol. and it protects DNA against free radicals damage and toxins such as those made by molds. Dietary boron: Evidence for a role in immune function.43(2):219-31. Biol Trace Elem Res.35(6):315-27. Environ Health Perspect. V. 47 Turkez H. Jena: Karl-Marx-Universitat. raisins. 39 Keenan MJ. Hegsted M. 6th International Trace Element Symposium 1989. vol. Part II. improving of skin thickness. Siver F. magnesium. brain function. Thus. J. balance. 1994 Nov. Nr. 2000. Boron plays a role in improving lipid profiles. Aflatoxin B1 is the most potent pulmonary and hepatic carcinogen. 38 Hegsted M. 1994 November. 1991 Mar. while in the places where boron is abundant. 16:291–306. 102(Suppl 7): 55–58.. CA: Wadsworth/Thomson Learning. prostate. It was also shown that boron protects against the damage done by aflatoxin B1 to human hepatocytes and lymphocytes47. I. Dirican E. 102 Suppl 7:. and in children its mutagenic effect is higher than in adults. Wozniak P. Wozniak P. and cognitive performance. brain function. 62(2): 157–165. Cytotechnology. Prevalence of Rheumatois Arthritis in an Israeli Population. and urinary calcium. C. 2003. 269-276. Essentiality of boron for healthy bones and joints. 39. Boron was shown to increase superoxide dismutase (SOD) in men and postmenopausal women50.42. Tatar A. 1991. editors. Dietary boron. cereals. 49 Hunt. A Double-Blind. Environ Health Perspect. 50 Nielsen FH. Effect of boron on vitamin D deficient rats. Boron increases the availability of glutathione in the body. Trace Elem. 1989. mainly in the elimination of free radicals49. Boron fights joints diseases33 – rheumatoid arthritis and osteoarthritis—and together with a healthy nutrition allows the regeneration of thorn out cartilages in the joints34. Environ Health Perspect. 35 Bentwich Z. Environ Health Perspect. blood. 2012 Dec. M Hegsted. Scorei. I. Petrisor. and immune responses43. 2008 Apr.66(1-3):299-317. plasma magnesium. This explains partially the efficiency of boron in the control of lungs. doi: 10. Cytotechnology. Biol Trace Elem Res. 44 Nielsen FH.. More than 70% of the population is affected by pain and joints diseases in areas with boron deficiencies. 46 Hasan Turkez and Fatime Geyikoglu. and boron in female athletes. 102 Suppl 7:. 41.L. and the short and long term memory40.S. It was also demonstrated that boron brings metabolic balance and health in situations of vitamin D deficiency. Elem. Med. etc. and Gropper. 1998 Winter. inclusively aflatoxin B146. Is boron nutritionally relevant? Nutr Rev. 1-3 (2011). Dietary boron affects variables associated with copper metabolism in humans. Geyikoğlu F. 102(Suppl 7): 83–85. Scorei. P. & Talmon Y. Mohan R. 42 Devirian TA. Dietary boron: An overview of the evidence for its role in immune function. 1994 November. Skin rejuvenating effects of fructoborate are: decreasing of wrinkles. 1994 Nov. precision.D. S. Effects of dietary boron in rats fed a vitamin D-deficient diet. 36 R E Newnham. 36. Epub 2012 Apr 18. Bra¨ unlich H. Boron is also necessary to the central nervous system – it increases the neuromuscular coordination.
etc. if not the best. which is considered to be somewhere in the vicinity of 20 to 40 grams. 2000. US Patent 6. mannose. as well as improving the skin color and decreasing the number and size of age spots.sciencelab. polyamines. Thus boron has multiple effects on human health. Do you ingest table salt? Well. Each teaspoon of FRUCTIBORE brings about 6 milligrams of elemental boron as fructoborate. Boron Compounds And Complexes As Skin-Rejuvenating Agents. condensed with aminoacids such as serine and threonine. boron is less toxic than table salt or sea salt. all depends of the amount (dose).com/msds. we may say that fructoborate is one of the best forms of boron. enriched in fructoborate. while others lost their life with lower doses. and children as well.skin hydration. this is very far below the toxic level. but also for preventing and even healing important health issues. for our cells. while boron salts do not have these adverse effects53. which is a special syrup made from raspberries and blueberries produced organically.php?msdsId=9924967 . The term "skin rejuvenating" is thus employed not only to indicate repair of damaged skin. but also to mean any improvement to the look and feel of the skin51. 51 Miljkovic et al. the question is “what is the best form of boron for our health?”. Also specifically included among the skin rejuvenating effects is increasing collagen production.27.425. We may conclude by underlining the importance of this mineral for the human health. nevertheless.com/msds. and people with kidneys problems. 52 http://www. and is associated to the positive effects raspberries and blueberries exert on our health. Nevertheless.php?msdsId=9927593 53 http://www. the delicious organic raspberries and blueberries syrup with fructoborate and other marvels for enjoying a better health and a better quality of life at any age. and 9 milligrams for a child. Jun. Some people ingested very large amounts of boron—more than one hundred grams in a single dose without much adverse effects. This is the boron linked to polyols such as fructose. Boron is mainly controlled by kidneys.080. xylitol. therefore you are invited to discover our FRUCTIBORE. glycerol. table salt has genotoxicity and can even produce birth defects52. certainly. And.sciencelab. according to the old saying “prevent is better than heal”. are more affected. NEOBIOTIKA offer FRUCTIBORE. for enjoying a better health. Is boron toxic? Everything can be toxic. The answer is—that form of boron we find in our food. which may be caused by increased incorporation of proline by the skin. the major form of boron found in fruits and vegetables is fructoborate. Consequently. softness and elasticity. The security of boron ingestion was fixed arbitrarily to 18 milligrams per day for an adult.
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