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Homeopathy and Acupuncture as Bioinformatics Sciences : A Proposal for the Recognition of the Existence of a Law of Nature –The Law

of Therapeutic Neuromodulation
Author: Andrés Amado Zuno Arce and Carlos Haubi-Segura
Hpathy Ezine, March, 2013

The authors propose a Law of Therapeutic Neuromodulation to explain the mechanism of homeopathy and acupuncture.
ABSTRACT The brain and CNS are an organs similar to a computer and is the ultimate director of the body. This means that organs, tissues and cells are under its control and that these parts of the body do not control what happens to them. If the brain is functioning properly, we have health; and if it works wrongly a disease will show. Acting on the brain by neuromodulation, by means of acupuncture, homeopathy or even allopathic drugs can produce a therapeutic response. The purpose of this paper is to recognize this effect and propose the recognition that there is a Law of Cure which explains how several medical systems work. In this theory, homeopathy and acupuncture work by stimulating peripheral sensory receptors and transmitting information to the brain which in turn will trigger a curative response to the affected organ. In this sense, acupuncture is an informaticscybernetic system for a biological system, and therefore it could be considered part of the informatics sciences, in the same way that the brain is a living computer which has inputs and outputs and controls all processes inside the body. In this paper we present the basis for this theory. Keywords- homeopathy, acupuncture, bioinformatics, Central Nervous System, computer, brain, therapeutic, neuromodulation, Law of Nature INTRODUCTION A brief introduction to Science and the Laws of Nature Science is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the natural world. Science also is about synthesis, confronting thesis and antithesis in a dialectic fashion, creating new theories based on apparently conflicting ideas. Eventually, some theories are elevated to the status of laws of nature, as they become a theoretical principle deduced from particular facts, applicable to a defined group or class of phenomena, and expressible by the statement that a particular phenomenon always occurs if certain conditions be present [1]. In physics, chemistry and mathematics we have several laws (i.e. laws of motion, of electromagnetism and gravitation, the laws of energy (thermodynamics) and heat transfer, the gas laws and the laws of aerodynamics [2]). There are several Laws that apply to physiology, for example, the Law of Facilitation, Arndt-Schultz Law, Davis’ Law, Reciprocal Inhibition, All or Non, Weber’s Law, Pflugger’s Law, etc. However, in medicine, very few Laws of Cure have been proposed. In fact, western (orthodox) medicine does not recognize a single law other than the laws of nature previously discussed. On the other hand, complementary and alternative medicine (CAM) has a series of laws that direct the actions of the physician, both during diagnosis and treatment. In homeopathic medicine the Law of Similars ( similia similibus curentur, proposed by Samuel Hahnemann in 1810, states that any substance that can produce a

For example. in rats [17]. disease is perceived as a disharmony (or imbalance) in the functions and interactions of yin and yang and a reduction in the qi [7]. vitamins or herbal extracts [11]. although there is insufficient evidence to determine whether acupuncture is beneficial in other conditions [12]. Stimulation of a group of acupoints can in turn stimulate the CNS to trigger a positive feedback mechanism that will reactivate the organ. (2006). such as moxibustion. neoplasia). two basic types of reactions can be expected. This law is also used by acupuncturists. it should be also true that “health is a CNS function―. which states that: (1) symptoms will reverse in chronological order to how symptoms originally appeared. According to Traditional Chinese Medicine (TCM). or burning mugwort herb. about the progression of disease and of the healing processes. and only very lately. Therapeutic Bioinformatics and Neuromodulation Although bioinformatics is generally regarded as the use of computer science to facilitate research in molecular biology. auscultation and olfaction. [18]. processes it and reacts accordingly. (2) symptoms will reverse from above to below and from the inside to the outside. nausea and vomiting. When we stimulate a specific acupoint. norepinephrine or GABA [16]. to stimulate specific acupoints [9]. According to scientific research. was presented by Constantine Hering in 1833 [4]. like “touching the screen― or “clicking in the mouse―. and specifically about the neuromodulation of disease. disease. and predicts the progression of the healing process accompanied by a therapeutic aggravation. synthesized in this document. Yoshimoto et al. as one does in computers. The informatics-cybernetic conceptualization applied to medicine. LASER and heat) to produce an input of information. Of special interest is the input of sensory stimuli. no histological or physiological structures correlate to these principles [14]. Acupuncture therapy is generally complemented by other therapies. which receives the impulse. Stimulation of the acupoints is performed either through variable influences of the needles or by electroacupuncture as well as by injection of drugs. Another Law of Cure. The insertion of the needles is performed rapidly through the superficial layers of the skin with very little pain. uses the “acupoints― in a way that resembles the way we handle information and correlate media in the mechanical-electronic-brain computers with the keyboard or by means of tactile media. Most of these theories and counter-theories are based on the premise that cure is produced at a local level. or. palpation and examination of tongue and pulse [8]. however. Several theories about the mechanisms underlying pain relief are related to an increased release of endorphins. digital pressure and energies (photonic energy. which can be roughly simplified as “it will get worse before it gets better― [5]. Placebo effect in humans is a common controversy but it should be ruled out in veterinary acupuncture. inquiring. the stimulation of these points can correct imbalances in the flow of energy (qi) through specific channels (meridians)[6]. have emerged. Previous publications of the author describing the CNS as a cybernetic. Acupuncture uses insertion of needles. Diagnosis is based on inspection.. and (3) from the most important to the least important organ. In this context. on the other hand. serotonin. “disease is a CNS dysfunction― but then. Acupuncture. an organ similar to a computer. which is the use of moxa. in making the CNS react with its various methods and media. have raised interest and expectations in the medical and scientific community [19]. According to the type of disease treated. and cure are from a purely physiologic point of view. as systematic review of clinical trials shows no compelling evidence to reject or recommend acupunctural treatment in domestic animals [13].disease in a healthy individual will cure a person presenting the same symptoms when given in a potentized form [3]. for example. Therapeutic uses of acupuncture which have been approved by the World Health Organization include pain relief. a broader view of bioinformatics should include the use of information and systems theory to understand health and disease. data processing and output of biological responses coordinated by the CNS. it is a subject of serious research by governmental agencies [15]. new theories about the role of the Central Nervous System (CNS). a nervous impulse is transmitted towards the CNS. is a simplification of the understanding of what health.In TCM. but not dopamine. in charge of both controlling health and disease. self-regulatory system. another group of acupoints . as can be observed during acupuncture treatment of veterinary patients [10]. fertility and childbirth. discovered that acupuncture stimulates the release of serotonin. either due to a reduction in its metabolism or to a degenerative disease or an increase in the metabolic activity of an organ (inflammation. Acupuncture and Traditional Chinese Medicine Acupuncture is an alternative medicine system originated in ancient China that treats patients by manipulating thin solid needles which are inserted into acupuncture points in the skin (acupoints).

. cells can be regarded as babies who need to be provided everything they need and eliminate what is harmful to them. acupuncture. through neuromodulation. And for the liver to function correctly it needs a number of variables that are only controlled by the brain and in no way by the liver itself. rather than to inhibit. as we just saw. disease is a reflex of a dysfunction of the brain. does not have any control command. The CNS is Responsible for Sickness The conclusion of this series of events is that the organs are not responsible for their disease and that this issue resides in the brain. acupuncture can heal organs. the inflammatory response by stimulating it via the CNS. In fact. and not only locally. it is the brain. we may call it bioinformatics. producing changes in conduct and psychosomatic manifestations. the process of health was controlled by the CNS and was not a local. pathogens. DISCUSSION The CNS is Responsible for Health There is common consensus in the scientific community that the CNS is responsible for running the organism as a whole. homeopathy and herbal treatments. If we look at this from another point of view. Antithesis and Synthesis As an antithesis to previous medical paradigms. tissue or cell. the elements that require chemical energy for muscle function. In understanding acupuncture in this way. In both cases. Consider any other organ and it will be the same picture. and this is an exclusive task of the CNS. For example. regulating the excessive reactivity of an organ or system. and that is what acupuncture does. keeping the economy properly functioning. by virtue of her staple constituent of tissues and organs. disease and cure. where the CNS controls only homeostasis but not disease. synthesized by the liver. psychotherapy. For example. neither the heart nor the liver or any other organs are the architects of their own destiny. Also we see that each and every health science that is based on cybernetics-informatics systems of the living organisms are bioinformatics. This means that health. Although it is correctly regarded as part of the healing process. are carried by the circulatory system. which tries to modify the workings of the mind (a CNS function) through reprocessing of a person’s thoughts. Prahlad and Morimoto (2011) found that neuronal cells of C. Synthesis of both theories suggests that the CNS is responsible for health. The CNS is Responsible for the Healing Process In this context we can suggest that the healing process is also the responsibility of the CNS and not an independent process of each organ. Also. elegans respond differently to acute stress such as heat shock and chronic stress caused by the expression of misfolded proteins. their health. suggesting that neuronal signaling determines the course of cellular proteotoxicity [20]. Acting on the brain. our personal point of view is that the CNS also controls disease. Thesis. or energies like electricity or heat. Thus. Even chemical drugs used as a support for psychiatric therapy use neuromodulation as a mechanism of action. or irritants. This concept does not apply in cases in which the body is affected by external agents such as toxins. The same happens with tissues and cells. Most notably the cell. event. tissues and cells. processes the information in the CNS and produces a healing or therapeutic effect (output). such responsibility is the brain’s. Inflammation is part of a complex biological response of vascular tissues to harmful stimuli. also uses the neuromodulation capacity of the organism. are used to control. isolated. because. By acting on the organism as a whole. which is the responsibility of the CNS. So.will produce a negative feedback mechanism. damaged cells. In a recent study. the placebo effect is another neuromodulation healing process where the patient takes a pill believing it has a real therapeutic effect (input). orthodox medical treatment is generally focused on suppressing it with the use of non-steroidal anti-inflammatory drugs (NSIADs) and steroids (cortisol and its derivates). is its obligation and that is what it does. we understand that the other organs are not responsible for their proper functioning.

N. B and Bala. such as fMRI. (2006) demonstrated in double-blind trials stimulation or inhibition of brain function by the use electroacupuncture [26]. 2. Paul. A.. B. 1992.. Sukul et al [[2]]: 1. which means that the homeopathic remedy acts on the brain and the hypothalamus. fatigue.P. different central manifestations were found if electroacupuncure was applied at analgesic and non-analgesic acupoints in rats [24]. The parameter “Physiological variability in human body temperature― (Vital Heat) is selected for the study. (2005) found specific fMRI patterns in human brain triggered by stimulation of special acupoints [25]. The hypothalamus controls body temperature.P. Bala. and Batuev..S. For example. 1992. N. Additional papers on acupuncture neuromodulation: can be found at several websites (i. Soc. It synthesizes and secretes neurohormones. Sukul. (2007) reviewed several neuroimaging techniques at the moment where acupuncture treatment was performed [23]. and Batuev. A.. often called hypothalamic-releasing hormones.which is definitely proven in clinical research and this is precisely the mechanism by which this therapy works. Sukul. Bhattacharyya. Woo et al. Sci. http://www. S.C. Proc. (2000) evaluated how acupuncture modulates the limbic system and subcortical gray structures of the human brain using fMRI studies in normal subjects [21]. 13. and circadian cycles.K.-Sukul. Nux vomica on alcoholic rats and their hypothalamic neurons.C. thirst. Yan et al. A. Sinha Babu.N. directly. This new theory provides a new medical and physiological paradigm: that acupuncture (and other medical therapies) actually work through neuromodulation. Paul. Prolonged cataleptogenic effects of potentized homeopathic drugs.CuIt. Zool. .equimagenes.C. 45(A): 307-310. All data points at the possibility that acupuncture works by stimulating the CNS and then it is up to the brain and other CNS structures to produce a healing process. The statistical procedures like Auto Regressive Spectrum (ARS) and Parametric Prediction and Reconstruction (PPR) are used to study the change in temperature variability. Psychopharmacology.51: 161-163.e. Effect of two potentized homeopathic drugs on the hypothalamic neurons of rats on salt diet. N. and Bhattacharyya. Proc. Homeopathic Neuromodulator Verifications Dr.C.P. and these in turn stimulate or inhibit the secretion of pituitary hormones. Nirmal C. N. Soc. S.S. 1986. There is marked change in temperature variability after applied homeopathic medicine. Kurzina. Temperature readings are taken at an interval of 1 second for 5 minutes.. The following studies were made by Dr. Acupuncture proved by neuromodulation Neuromodulation by acupuncture has been proven through experimentation using imaging technologies. Calcutta. PET and SPECT. Devendra Kumar MD from India has conducted a study [[1]] in which he found evidence that homeopathic medicines produce some change in the physiological variability. Sinha Babu. The hypothalamus is responsible for certain metabolic processes and other activities of the Autonomic Nervous System. Similar results were obtained by Kong et al. 45(A): 311-314. Hui et al. Time series spectral analysis is performed by using statistical processing software. Effect of a potentized homeopathic drag (sic). one of the regulatory fuctions of the Hypothalus. Calcutta. (2005) reviewed research involving acupuncture using brain imaging techniques in order to show the specific areas of the brain influenced when acupuncture was used [22]. S. Also. Lewith et al. however different brain networks were activated when using manual or electroacupuncture stimulation of acupoints in normal subjects [27]..K. A.php/resonanciapet-acupuntura). Influence of homeopathic drugs on neurotransmitter systems. hunger. 12. “Homeopathic medicines of 200c potency are applied orally to human subjects. The current state of knowledge regarding the effect of acupuncture therapy on humans and animals suggests that specific areas of the brain are influenced when acupuncture is used. (2002). So. Dhond et al. Zool.1985. ‘Thermoregulation in human subjects’ is understood as a primary subject to understand the action of homeopathic medicine. Sukul. ‘Physiological variability in temperature’ from skin of forearm is measured with the help of temperature data logger and water/soil temperature sensor. S. 89:338-339. N. Kurzina.com/index.

The cells don’t handle what it takes for them to swell or not to swell. Obviously he did not say “the central nervous system― because it is understood when he says “the whole nervous system― I have no doubt that he did understand that the influence was on the CNS [[6]]. irrevocably. microbes and cells. and in like manner. it no more remains local…The nerve which was first affected by the miasma has already communicated it in an invisible manner to the nerves of the rest of the body…― Master Hahnemann understands that the vital force is in the nerves: “which then. 52. in the moment when it has taken effect. 15. Taking into account Hahnemann’s genius I cannot think that he have missed the leadership role of the CNS and therefore the influence of homeopathic medicine. virtual) alterative powers of the serviceable medicines acting upon our spirit-like vital force. We may apply in the joint an injection of cortisone and the cells of the area will cease to be inflamed.K. dynamically communicates the disease to the vital force (to the whole nervous system) in the same moment― Page #49 of the same book: “As soon as the miasma of Itch. and BHATTACHARYYA. thus happens in the moment when in vaccination the morbid fluid in the body scratch of the skin comes in contact with the exposed nerve. Physiol. 1987. dynamically communicates the disease to the vital force (to the whole nervous system) in the same moment. g. N. K 1985. S. which perceives them through the medium of the sentient faculty of the nerves everywhere present in the organism…― Hahnemann’s “ Chronic Diseases― [[5]] Page #45: “When the smallpox or the cowpox catches.& Cult. S. S. but rather in the surface. Sci. Sinha Babu. a true curing one. Env Ecol. B. C. It is about a different interpretation of the theories of the possible direct influence of the remedies in the misbalanced vital energy. irrevocably. Master Hahnemann knew that the homeopathic influence reaches the CNS Now a series of observations are made to show that the informatics-cybernetic interpretation is Hahnemannian. SUKUL. SUKUL. 49(1): 52-58.C.C.  It is fundamental in the understanding of his concept of how does remedies operate. Br. but if something fails. 84(1): 6-11 38. Sukul. as a spirit-like dynamis. A. The improvement is not deep. 51: 161-163. N.14. which then.P. Cataleptogenic effect of a homoeopathic drug mediated only through the alimentary tract.J. BALA. . because without that neuronal influence.1995. is working. It is important to see this is a transcendental and fundamental matter in the Hahnemannian homeopathic conception. all such morbid derangements (diseases) cannot be removed from it by the physician in any other way than by the spirit-like (dynamic. J. touches the hand. 5(3): 411-415. Let’s imagine arthritis in a hand finger joint. the CNS. B. the swelling will come back because it does not change the way the control centre. Ind. because their action is on the brain. Anticataleptic effect of Agaricus muscarius at ultra high dilutions. cannot be attacked and affected by injurious influences on the healthy organism caused by the external inimical forces that disturb the harmonious play of life. their health is good. Hom. Healing only cells is not enough if the CNS is improperly functioning. those cellular actions are useless and have not a deep effect. If cells get from their environment what they need.    e. N. This equilibrium is reached through an influence in the nervous system. N. Influence of homeopathic drugs on neurotransmitter systems. BHATTACHARYYA. not only in the cell. Acupuncture and homeopathy do make a deep action. Allied. and BALA. Organon [[3]] Paragraph § 16 Fifth Edition [[4]] “Our vital force. But at the time the cortisone effect passes on.. S. 1995. But there are profound differences between them and if the CNS is not properly functioning.C. and Ghosh. Sukul. Homeopathic Cellular Influence Homeopathic medicine acts on beings with no CNS such as plants. This is a CNS job. Haloperidol-induced catalepsy in mice and rats suppressed by orally pre-administered potentized Agaricus.. Homeopathic medicines do not directly produce energy equilibrium. Sci. Paul. otherwise than in a spirit-like (dynamic) way. they do not operate.

Cellular Support and Homeopathic Action Another cellular homeopathic possible influence is a support to the Central Nervous System. Each and every part of the organism takes part in it: the liver does its chemical part. we have reported the evidence for the effectiveness of some homeopathic remedies in controlling anxiety symptoms in animals” Assays of homeopathic remedies in rodent behavioral and psychopathological model― The CNS is Responsible for the Healing Process In this context we can suggest that the healing process is also the responsibility of the CNS and not an independent process of each organ.org/wiki/Laws_of_Nature [3] Hahnemann.― I. elegans respond differently to acute stress such as heat shock and chronic stress caused by the expression of misfolded proteins.― la sal sala la salasa. and therefore it is important to recognize that it follows a Law of Cure: “Law of Therapeutic Neuromodulation―. Acupuncture and homeopathy accomplish their healing processes through an effect on the CNS. URL: http://en. We have to point out that healing is a very complex process. suggesting that neuronal signaling determines the course of cellular proteotoxicity [20]. and this is an exclusive task of the CNS.        “In this work. Another study [[7]] proves the neuromodulator effect of homeopathic action. Cannon) of the organism which is mediated by the CNS. Cybernetic and self-regulatory mechanisms (homeostasis and homeorresis) help maintain the internal milieu and restore the health of the patient. Grove Press.they get sick. (1980) The Science of Homeopathy. and the only organ in the body that can coordinate all that healing process is the brain. does not have any control command. lungs provide oxygen. In a recent study. Darie. REFERENCES [1] Wikipedia (2012). The entire organism plays its part for a new single cell to be born.wikipedia. (1810) Organon of the Medical Art. tissue or cell. Available online at: http://www.com/reference/organon/organon. with physiological signal processing (needles sending signals to the CNS) and the brain acts like a biological computer and produces a specific output. “Abstract “ The effects of Coffea cruda 30 and 200c and caffeine on the sleep pattern of rats were investigated.         Paolo Bellavite et al [[9]] from the Verona University: II. Laws of Nature. Cristea. S. by virtue of her staple constituent of tissues and organs. “Chamomilla homeopathic dilution effect on central nervous system. José Raúl Guerrero Ramos call the attention on another research [[8]] which shows neuromodulator action (sleep patterns) of homeopathic medicines. in a sense. NY . S. Teodorescu-negres and V.homeopathyhome. and that is what homeopathy and acupuncture does. Most notably the cell. and it is also on those occasions that the homeopathic medicines help the CNS to fulfill its goals. and that medium does not depend on them but from the homeostatic mechanisms (Walter B. In fact. Conclusion Homeopathy and Acupuncture are. It is obvious that there are occasions in which that system needs an exterior help. Dr. URL::http://en. cells can be regarded as babies who need to be provided with everything they need and eliminate what is harmful to them. and so on. A.org/wiki/Science [2] Wikipedia (2012). and it is in those cases that chemical drugs designed to act only on cells may be useful. Science.html [4] Vithoulkas G.wikipedia. Prahlad and Morimoto (2011) found that neuronal cells of C. bioinformatics sciences.

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Universidad Autónoma de Aguascalientes. Carlos Haubi-Segura Departamento de Disciplinas Pecuarias. México . He is author of two books about homeopathy: "HomeopatÃa e Informática" and "Acupuntura y HomeopatÃa.Andrés Amado Zuno Arce Andrés Amado Zuno Arce is Associate Professor of the "Universidad Candegabe de HomeopatÃa" Argentina. Aguascalientes. and also of the "Escuela de HomeopatÃa del Instituto Hahnemanniano Internacional" also from Argentina.