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Increase size of tumor

Compression of nearby blood vessels Decrease tissue perfusion (Ischemia)

Compression of nerve endings Pain

Compression of Lymph Nodes Orange Peel Skin

Irregular shape mass Dimpling effects in the breast Obvious asymmetry of the breast

Tissue Necrosis

Shifting of Aerobic to Anaerobic Respiration Lactic Acid Production Irritates nerve endings Increase SGOT/AST

Presence of Discharge in the breast

Rupture of the obstructed blood vessels Bleeding Hgb=78 mg/dL Hct=23% Tachypnea Tachycardia Pale Lips, Conjunctiva, Nailbeds Poor Capillary refill 3-4seconds Easy fatigability Anemia Dizziness Weakness

Predisposing Factors: Age Gender History of Breast Ca Late Menopausal

Precipitating Factors: Diet Obesity

Etiology: Cellular Aberration

Insertion/Deletion in the DNA/RNA sequence Alteration in Chromosomes Mutation of Normal Cells

Presence of NonFunctional Benign Cells Malignant cells releases Anorexinogenic Agents Affects the satiety center Loss of appetite (anorexia) Impaired Nutrition

Presence of Malignant Cells

Mutation of the TP53

Abnormal cells escapes apoptosis Abnormal cells proliferates Increase no. of malignant cells

Body Compensates: Increase Breakdown of Carbohydrates, Fats, and Protein Decrease Muscle Mass

Deprives the nutrition of Normal cells

Weight Loss

Increase size of tumor