Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

1.

Basic Human Pathology Lecture #5 Acute Inflammation / Wound ...

2.

Overview: Tissue Responses to Damage

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 1

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

3.

Acute Inflammatory Response

4.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

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Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

5.

Acute Inflammatory Response

6.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

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Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

7.

Formation of Acute Inflammatory Exudate

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Formation of an Acute Inflammatory Exudate

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

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Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

9.

Clinical Effects of Acute Inflammation

10.

“4 + 1” Cardinal Signs of Inflammation

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 5

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

11.

Acute Inflammatory Response

12.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 6

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

13.

Acute Inflammatory Response

14.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 7

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

15.

Acute Inflammatory Response

16.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 8

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

17.

Acute Inflammatory Response

18.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 9

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

19.

Acute Inflammatory Response

20.

Key Facts - Neutrophils

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 10

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

21.

Acute Inflammatory Response

22.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 11

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

23.

Acute Inflammatory Response

24.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 12

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

25.

Acute Inflammatory Response

26.

Neutrophil Granules and Their Contents

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 13

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

27.

Acute Inflammatory Response

28.

Neutrophilic phagocytosis - cont’d

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 14

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

29.

Acute Inflammatory Response

30.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 15

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

31.

Acute Inflammatory Response

32.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 16

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

33.

White Blood Cells (a.k.a. leukocytes or WBC’s)

34.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 17

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

35.

Parulis (gum boil; abscess on the gingiva) = localized accum...

36.

Pus draining from a fistula of an abscessed tooth

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 18

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

37.

Fibrinous Exudate – Pericardium

38.

Purulent Exudate of the Brain

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 19

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

39.

Abscess in the Skin = Localized Accumulation of Neutrophils...

40.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 20

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

41.

Acute Inflammatory Response

42.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 21

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

43.

Acute Inflammatory Response

44.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 22

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

45.

Acute Inflammatory Response

46.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 23

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

47.

Cell Membrane Phospholipids

48.

Endogenous Mediators:

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 24

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

49.

Acute Inflammatory Response

50.

Biosynthesis of Leukotrienes and Lipoxins

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 25

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

51.

Acute Inflammation Mechanisms

52.

Acute Inflammation Mechanisms

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 26

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

53.

Acute Inflammation Mechanisms

54.

Acute Inflammation Mechanisms

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 27

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

55.

Acute Inflammation Mechanisms

56.

Acute Inflammation Mechanisms

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 28

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

57.

Acute Inflammation Mechanisms

58.

Acute Inflammation Mechanisms

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 29

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

59.

Acute Inflammation Mechanisms

60.

Acute Inflammation Mechanisms

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 30

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

61.

Acute Inflammation Mechanisms

62.

Acute Inflammation Mechanisms

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 31

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

63.

Acute Inflammation Mechanisms

64.

Acute Inflammation Mechanisms

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 32

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

65.

Acute Inflammation Mechanisms

66.

Acute Inflammation Mechanisms

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 33

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

67.

Overview of the Complement System

68.

Acute Inflammation Mechanisms

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 34

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

69.

Acute Inflammation Mechanisms

70.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 35

Tufts OpenCourseWare Acute Inflammation/Wound Healing and Repair I

© 2008 Tufts University

71.

Acute Inflammatory Response

OCW: Basic Human Pathology: Parts I and II (M. Kahn)

Page - 36

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