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UTTARAKHAND TECHNICAL UNIVERSITY DEHRADUN STUDY AND EVALUATION SCHEME [Effective from the session: 2009-10] Course: B.

Pharm.
Year – IV Semester - VII T.A. – Teacher Assessment, ESE – End Semester Examination, CT – Cumulative Test
Subject Name Theory 1 2 3 4 5 PHR- 701 PHR- 702 PHR- 703 PHR- 704 PHR- 705 Pharmaceutical Management Pharmaceutical Bio-pharmaceutics & Pharmacokinetics Medicinal Chemistry-III Pharmacology-III Pharmacognosy -IV Period (Hours) L 3 3 3 3 3 P 0 0 0 0 0 CT 15 15 15 15 15 Sessional TA 05 05 05 05 05 Total 20 20 20 20 20 Exam ESE 80 80 80 80 80 100 100 100 100 100 3 3 3 3 3 Subject Total Credits

S.N.

Course Code

Practical Day to Day Evaluation 6 7 8 9 PHR- 702P PHR- 704P PHR- 705P PHR- 706P Pharmaceutical Bio-pharmaceutics & Pharmacokinetics Pharmacology-III Pharmacognosy -IV Report on Industrial Visit 15 12 --160 640 0 0 0 4 4 4 ------20 20 20 80 80 80 100 100 100 100 900 2 2 2

Note: - Duration in Theory & Practical of ESE shall be 3 (three) hours and 4 (four) hours respectively 0.6 Credits – Sessional 2.4 Credits - ESE

4 Credits – ESE .N.Pharmaceutical Packaging Or (E). Quality Assurance & Validation Or (G). Pharm.Novel Drug Delivery Systems Or (F)-GMP.805P 15 12 -- -- 160 640 800 - Note: . ESE – End Semester Examination.801 PHR.805 4 0 15 05 20 80 100 4 Practical Day to Day Evaluation 6 7 PHR-803P Pharmaceutical Analysis Elective (A).Duration in Theory & Practical of ESE shall be 3 (three) hours and 4 (four) hours respectively 0.Standardization of Herbal Drugs and Cosmetics Or (B). Year – IV Semester – VIII T.Advanced Pharmacology Or (I).804 Environment and Ecology Clinical Pharmacy& Drug Interaction Pharmaceutical Analysis-III Pharmacopoeial Standards Elective (A). CT – Cumulative Test Course Code Subject Name Theory 1 2 3 4 PHR.Novel Drug Delivery Systems Or (F)-GMP. 5 PHR.UTTARAKHAND TECHNICAL UNIVERSITY DEHRADUN STUDY AND EVALUATION SCHEME [Effective from the session: 2009-10] Course: B.A.Pharmaceutical Packaging Or (E).Standardization of Herbal Drugs and Cosmetics Or (B).Pharmaceutical Marketing Or (D).803 PHR.Pharmaceutical Entrepreneurship L 3 3 3 3 Period (Hours) P 0 0 0 0 CT 15 15 15 15 Sessional TA 05 05 05 05 Total 20 20 20 20 Exam ESE 80 80 80 80 100 100 100 100 3 3 3 3 Subject Total Credits S. – Teacher Assessment.Hospital Pharmacy Or (H).6 Credits – Sessional 2.Hospital Pharmacy Or (H).Pharmaceutical Marketing Or (D).Drug Design Or (C).Advanced Pharmacology Or (I).Pharmaceutical Entrepreneurship 0 4 --20 80 100 2 0 8 -- -- 40 160 200 4 PHR. Quality Assurance & Validation Or (G).Drug Design Or (C).802 PHR.

2. Marketing.Pharm IV (VII Semester) PHR. procedure of exporting and importing goods. Koontz H. Sterling Publishers. Materials. [08] Unit-III Economics: Principles of economics with special reference to the Laws of demand and supply. Organizing Staffing Directing and Controlling).R. Datta A. Delegation of Authority / Responsibility. general principles of insurance and inland and foreign trade. Communication. Bank reconciliation statement. transportation. Pharma Book Syndicate 4. Chadwick Leslie. Margin/ Morale) [08] Unit-II Principles of Management (Coordination. evaluation. Receipt. Issuance.N. Production. Quality control. Barthwal R. Weihrich H. demand schedule. treatment of cheques bills of exchange. profits and loss account. 7. retail. Material Management / PHI. Ledger posting and book entries preparation of trial balance. balance sheet. promissory notes and bundles documentary bills. columns of a cash book. DPCO Act: Cost Accounting. Formulation record rules [10] Unit-IV Pharmaceutical Marketing: Functions. 6. Joseph Essentials of Management / PHI. Decision making. rectification of errors. 3. literature.701 PHARMACEUTICAL INDUSTRIAL MANAGEMENT Unit-I Concept of Management: Administrative Management (Planning. demand curves labor welfare. Industrial Economics –/ New Age International. Identification of key points to give maximum thrust for development and perfection. ethics of sales. storage financed feedback information. Pharmaceutical Selling. Operative Management (Personnel. purchase. merchandising. Approval. Vidya sagar Pharmaceutical Industrial Management.B. Recruitment. buying. leadership. multiple shop and mail order business. Accountancy: Principles of Accountancy. Essentials of Management. Massie L. keeping and pricing of stocks. Production. Record Keeping). [08] Unit-V Supply Chain Management: Procurement. 8. selling. . department store. Time/space. Motivation. wholesale. advertising.K. Distribution & Marketing [06] BOOKS RECOMMENDED: 1. Entrepreneurship development. detailing. Production and Operative Management / Tata Mc Graw Hill. Salesmanship: Principle of sales promotion.. Financial. channels of distribution. training. Innovation Creativity. 5. Mukopadhyay Sekhar. Tata Mc Graw Hill. The essence of management accounting / PHI. Analysis. Chary S. compensation to the pharmacist.

2. Gibaldi. Absorption studies – in vitro.Y. R. N. In vitro evaluation of different dosage forms for drug release. 4. metabolism and excretion [08] Unit-II: Pharmacokinetics: § Significance of plasma drug concentration measurement. § Clinical Pharmacokinetics: Definition and scope [08] Unit-IV: (A) Dosage adjustment in patients with and without renal and hepatic failure. facilitated diffusion and pinocytosis). BOOKS RECOMMENDED: 1. Loo-Reigelman method. (B) Review of regulatory requirements for conduction of bioequivalent studies. Fundamentals of Clinical Pharmacokinetics. N. 3.N. G. Notari. § Compartment kinetics – One compartment and Preliminary information of multicompartment models. . 2. 5. Clinical Pharmacokinetics. 5. 7. and area under the curve (AUC). 3. (B) Pharmacokinetic drug interactions and their significance in combination therapy. [08] Unit-V: Bioavailability and Bioequivalence: (A) Measures of bioavailability. Drugs Intelligence Publishers. Milo’ Biopharmaceutics & Clinical pharcokinatics. and Tozer T. Definition and Scope § (C) Pharmacokinetics of drug absorption – zero order and first order absorption rate constant using Wagner – Nelson. Bioavailability and Bioequivalence studies Permeability studies Protein binding Statistical treatment of pharmaceutical data. 4. Wagner J. Biopharmaceuitcal Classification System § Passage of drugs across biological barrier (passive diffusion.Wagner.PHR– 702 PHARMACEUTICS -VIII (BIOPHARMACEUTICS & PHARMACOKINETICS) Unit-1: Introduction to Biopharmaceutics and Pharmacokinetics.G. Hamilton. 6. 1. active transport. Determination of pharmacokinetic parameters from plasma and urine data after drug administration by intravascular and oral route.E. § Compartment model and Non-compartment model. Lea and Febriger. § (B) Factors influencing absorption § (C) Distribution.” Pharmacokinetics for the Pharmaceutical Scientist’. John. C-max. [08] Unit-III: § Volume of distribution and distribution coefficient. [08] PHR-702P PHARMACEUTICS-VIII (BIOPHARMACEUTICS & PHARMACOKINETICS) PRACTICAL Experiments designed for the estimation of various pharmacokinetic parameters with given data. Rowland M.Y. Biopharmaceutics and Pharmacokinetics – An introduction Marcel Dekker Inc.

[08] BOOKS RECOMMENDED: 1. Ed. Levothyroxine. Philadelphia. Burger’s Medicinal Chemistry. Methicilin. Stereochemistry (A) Androgens and Anabolic steroids – Testosterone. Ministry of Health.Insulin Chlorpropamide. Carboprost. Zalcitabine.Saquinavir. Tetracyclines. New York. Prostaglandins – Misoprostol. Foye W C. Principles of Medicinal Chemistry. [08] Unit-IV: Introduction. Chloramphenicol. Mode of action. Anti. structure-activity relationship of the following classes of drug (Synthetic procedures of individually mentioned drugs only). structure-activity relationship of the following classes of drug (Synthetic procedures of individually mentioned drugs only). Thyroid and Antithyroids – Carbimazole. Propylthiouracil.HIV agents-Zidovudine.Chlorambucil. (D) Anti-Fertility Drugs [08] Unit-II: Introduction. Betamethasone. Sulphacetamide. Estradiol.. Antibiotics. Delhi. of India.Mebendazole Antifungals: Griseofulvin.K. uses. Anti-cancer drugs Alkylating Agents. Wolff ME. Clavulanic acid Antimycobacterial Agents: PAS. 3. Govt. Isoniazid. CBS Publication. Sulphadiazine. Streptomycin. Delagado J N and Remers W A R. Singh Harkrishan and Kapoor. Oxford University Press NY 6. 8. Vallabh Prakashan. Antimalarials: Cholroquine. Mode of action. V. Lamivudine. Classification.. Diloxanide Antiseptics & Disinfectants – Benzalkonium chloride Anthelmintics. Classification. Dexamethasone. Medicinal Chemistry. 4.. J. Antivirals – Amantadine.K. structure-activity relationship of the following classes of drug (Synthetic procedures of individually mentioned drugs only). (C) Adrenocorticoids – Prednisolone. Vardanayan R. uses. Stanazolol. Tolbutamide. Cephalosporins. structure-activity relationship of the following classes of drug (Synthetic procedures of individually mentioned drugs only). Steroids and related drugs: Special emphasis on Nomenclature. Pharmacopoeia of India.III) Unit-I: Introduction. Primaquine. New Delhi . Acyclovir.PHR –703 PHARMACEUTICAL CHEMISTRY –VIII (MEDICINAL CHEMISTRY . structure-activity relationship of the following classes of drug (Synthetic procedures of individually mentioned drugs only). Classification. Patrick G L. 5. Lea & Febiger. Classification. uses. Classification. John Wiley & Sons. Razdan B. Mode of action. uses. Medicinal Chemistry. Philadelphia. Norfloxacin [08] Unit-III: Introduction. Mode of action.Penicillin. Organic Pharmaceutical Chemistry. Methimazole. Metformin. uses. Carmustine Antimetabolites. (B) Estrogens and Progestogens – Progesterone. Mode of action. Eds. Dapsone Quinolones: Nalidixic acid. Clotrimazole Amphotericin B Antibacterials – Sulphamethoxazole. Acacdemic press an imprint of Elsevier 7. Amoxicillin. Gentamycin. Lippincott Co. Ethambutol. Hypoglycaemics .Glibenclamide. Synthesis of Essential Drugs. 2. Wilson And Giswold’s Text book of Organic Medicinal and Pharmaceutical Chemistry. Tinidazole. Artemesinin Antiamoebics: Metronidazole.Methotrexate 6-Mercaptopurine 5-Fluorouracil [08] Unit-V: Introduction.

opioids. Tripathi. three point assay & four point assay. 6. New Delhi. Riter JM. Fungal infections. Insulin. Jay Pee Publishers.J. Hardman. organophosphorous & atropine poisoning. 10.III PRACTICAL 1.K. 9.Ghosh M. 2. 3. Le Limbird. Principles of Pharmacology. Kulkarni S. 5. RW Ruddon & AG Gil. Prentice Hall. Tetracyclines. Popular Prakashan Pvt. Parathormone. . CBS Publishers. Thyroid hormones & Thyroid Drugs. Antibiotics – Penicillins. Multi-drug resistance [10] Unit-V: A.PHR– 704 PHARMACOLOGY –III Unit-I: Pharmacology of Endocrine System Hypothalamic & pituitary hormones. Vallabh Prakashan. [08] Unit-III: Chemotherapy General Principles of Chemotherapy. 4. Churchill Livingstone. Heavy metal Anatagonists. L. Basic & Clinical Pharmacology. Principles of Toxicology Definition of poison. bracketing assay. Dale MM. oral hypoglycemic agents & glucagon.K : Text Book of Pharmacology. [07] Unit-II: ACTH & Corticosteroids.D. All experiments will be conducted using software wherever possible. 3. Cephalosporins.. Drugs acting on uterus. Progesterone & Oral Contraceptives. Scientific Book Agency. Rang MP. Introduction to Immunomodulators and Chemotherapy of Cancer.S. Editors:. Quinolones.K.G. Pergamon Press. To calculate the pA2 value of Atropine & chlorpheniramine. The Pharmacological basis of Therapeutics. Barar F. Malaria. Bioassay of Ach. Ltd. DR & Bennet PN. Experiments in Pharmacy & Pharmacology. Bioassay of histamine and acetylcholine using matching and interpolation method on rat guinea pig . BOOKS RECOMMENDED: 1. Pergamon Press. 2. Bioassay of oxytocin and acetylcholine [07] PHR-704P PHARMACOLOGY. New Delhi. histamine & oxytocin on suitable isolated preparations using matching assay. PB Molinoss. Macrolides. Chloramphenicol. Pharmacology Churchill Livingstone.. International. [08] Unit-IV: Chemotherapy of Parasitic infections. Androgens & anabolic steroids. Grover J. New Delhi. Cotrimoxazole. Laurene. Bombay. K.. B. Satoskar & Bhandarkar: Pharmacology & Pharmacotheropeutics. Fundamentals of Experimental Pharmacology. Estrogens. Katzung. Essentials of Medical Pharmacology. Clinical Pharmacology. 7. B. Calcutta. Leprosy.G. Paul. Goodman & Gilman. Sulfonamides. Calcitonin & Vitamin D. 11. Bioassays. general principles of treatment of poisoning with particular reference to barbiturates.N.Basic Principles. Hand Book of Experimental Pharmacology. Chapman and Hall.. Delhi. Tuberculosis. 8. Viral diseases. Interprint.

Some preliminary experiments in plant tissue culture. collection. Chemical evaluation of powdered drugs & Enzymes. Cultivation & Utilization of Medicinal Plants. substitute’s adulterants. Street H. Tyler V. growth & their maintenance. 12. Coffee & Tea Vasaka Biosynthesis. Cultivation of Medicinal Plants. Ipecac. 10.E. Delhi. 13. 7. uses. London. Isolation of some phytoconstituents 5. 6. BOOKS RECOMMENDED: 1. preparation. (B) Role of Medicinal & aromatic plants in National Economy. “Pharmacognosy” Bailliere Tindall East Bourne. Digitalis. J&A Churchill Ltd.K. Identification of crude drugs listed above. cultivation. 5. Rauwolfia. Diosgenin. Penicillinase. & plant laxatives. Datura.C. commercial varieties. E. Utilization & production of phytoconstituents such as– Tropane. Tissue Culture & Plant Science. Application of plant tissue culture in pharmacognosy. Coca & Withania Cinchona. RRL. Clarke ECG. Springer Verlog. London. Saskatchewan. 2. The Plant Alkaloids. . diagnostic macroscopic& microscopic features & specific chemical tests of following alkaloid containing drugs included in Ayurvedic Pharmacopoeia Tobacco. Hyalluronidase. Microscopic study of characters of any 8 selected drugs given in theory in entire and powder form. Nirali Prakashan. [08] PHR-705P PHARMACOGNOSY -IV PRACTICAL 1. Berlin. Isolation & Identification of drugs. etal Pharmacognosy. G. Gokhale SB. Rauwolfia. McGraw Hill. C. London. Jammu. [08] Unit-IV Biological sources. Belladona. The Pharmaceutical Press. Systematic study of source.K.E. Kokate.E. Ipecac & Opium Ergot. Indian Pharmacopoeia. Thin Layer Chromatography. Plant Tissue Culture Methods. Wallis T. 9. processing. Streptokinase. W. 2. Unit-V: Historical development of plant tissue culture. Solanum. 3. Academic Press. & Evans. 11. 3. Ephedra & Colchicum. Areca & Lobelia. Stahl. Plant Bitters & Sweeteners. Quinoline Opium and Indole alkaloids. Cinchona. Taxol. Nutritional requirement. 4. Liquorice. Hyoscyamus. Vallabh Prakashan. New York. Aloe. U. [08] Unit-II: Pilocarpus. Text book of Pharmacognosy” J&A Churchill Ltd. National Research Council of Canada. Henry TA. chemical constituents. 6. Tropane alkaloids containing drugs. Practical Pharmacognosy. Atal & Kapur. Analytical Microscopy. Techniques employed in elucidation of biosynthetic pathways [10] Unit-III (A) World wide trade in Medicinal plants & derived product. Veratrum & Kurchi.K. Identification tests and uses of following enzymes – [08] Diastase. Valerian. A laboratory handbook. Trease. Ganborg & Wetter.E. type of culture. Lea & Febiger Phjadelphia. Kokate. C. Catharanthus & Nux-vomica.E. Chromatographic studies of some herbal constituents. Wallis T.PHR-705 PHARMACOGNOSY-IV Unit-1: 1. papain. 4. Papain. 8. London. Gokhale AS. Ginseng.

Soil. 1974 [08] Unit-V Environmental Protection Act -1986 Noise Pollution Hazardous Wastes Hazardous Chemical Hazardous Microorganism Biomedical Waste Solid waste disposal Provisions as applicable to drugs and cosmetics. Pharma Book Syndicate. Hyderabad. Desert and Aquatic.Introduction causes and control measures. Compliances & Standards Vol. Thermal. of India with latest amendments.Natural Resources – renewable & non renewable C.Forest Grassland. I &II.B. [08] Unit IV Law related to Environmental Protection Air (Prevention and Control of pollution )Act 1987 Water prevention & Control of Pollution Act.Definition.. [08] BOOKS RECOMMENDED: 1.. Mineral resources. Reddy. Marine. 2. Land resources. Trivedy R. utilization. Noise. Relevant Acts & Rules published by Govt. M. types features & functions of difference ecosystems. ‘ Text Book of Environmental Sciences & Technology”. B. Introduction.Anji .801: ENVIRONMENT & ECOLOGY Unit-I Environment studies A. [08] Unit-II Ecosystems A. Latest edition . scope & importance B.Use.Equitable use of resources for sustainable life style. Energy resources. D. Manoharachary C. Jyaranama Reddy P. Water.K. Guidelines. 4. [08] Unit-III Environmental pollution. 5. Pharma Book Syndiacte. Acts. Principles of Environmental Studies. Nuclear.Pharm IV (VIII Semester) PHR.Air. Water resources. role of an individual in conservation. exploitation and associated problems of forests. Hyderabad 3. National Formulary of India. Handbook of Environmental Laws. Biodiversity & its conservation with special reference to India. Food resources.

Basic skills in interpreting laboratory data. Liver function. TDM pharmacist interventions. Risk factors. Herfindal E. Davisson’s Pranciples and Practice of Medicine. renal function. and Hirashman J. [08] Unit. Categories of Phase IV studies.C. ELBS/Churchill Livingstone. 1997. 5. Adverse drug reactionEpidemiology. Monitoring a detecting adverse drug reactions.. Various phases of clinical trials. 3. Nahata M. Williams and Wilkins Publication.hypertension. John g. Reporting adverse drug reactions. Assessing causality. 2. hepatic dysfunction. [06] BOKS RECOMMENDED: 1.Scott LT.The Society of Hospital Pharmacists of Australia. clinical review. geriatric and paediatric patients. 6. classifications of the disease. [10] Unit-II DAILY ACTIVITIES OF CLINICAL PHARMACISTS Drug therapy monitoring (Medication chart view.. Communication skills including patient medication history interview. Tests associated with cardiac disorders. Nyfort-Hansen K. Hematological. congestive cardiac failure. Dose adjustment in renal failure. treatment and parameters to monitor the therapy of following systems/diseases Cardiovascular systems..T. Clinical Pharmacokinetics-Rowland and Tozer.Wagner. Calculation of loading and maintenance doses. its structure and use in evaluation of drug therapy. Renal and non-renal clearance. Quality assurance of clinical Pharmacy services. Classification. 8. development and scope PATIENT DATA ANALYSIS The patient’s case history. Biopharmaceutics and Applied Pharmacokinetics-Leon Shargel.” Pharmacokinetics for the Pharmaceutical Scientist”. ischemic heart disease Renal system.IV CONCEPT OF ESSENTIAL DRUGS AND RATIONAL USE OF DRUGS Definition. Prentice Hall publication. Orient Longman.802 CLINICAL PHARMACY AND DRUG INTERACTIONS Unit-I INTRODUCTION TO CLINICAL PHARMACY Definition. Guidelines for good clinical research practice and ethical requirements.Research support including planning and execution of clinical trials. symptoms. American Society of Health System Pharmacists. Estimation and determinants of bioavailability. USA. A Text book of Clinical Pharmacy Practice –Essential Concepts and Skills.acute and chronic renal failure GI diseases [08] Unit-V RESEARCH DESIGN AND CONDUCT OF CLINICAL TRIALS.L. 4. Practice Standrds and Definitions. 7. Relevant review articles from recent medical and pharmaceutical literature. Inc. patient counseling. . Drug utilization evaluation (DUE) and review (DRU).PHR. Clinical Pharmacy and Therapeutics Williams and Wilkins 9. Parthasarthi G. Prescription auditing and medication errors and monitoring [08] Unit-III CLINICAL PHARMACOKINETICS Physiological determinants of drug clearance and volumes of distribution.

A. applications in pharmaceutical analysis. Assay of official formulation containing more than one ingredients using instrumental techniques. Ministry of Health.Theory. Applications in pharmacopoeial analysis [08] Unit-V Basic Principles.Chemistry. 2. Interpretation of IR . Becket A. Jr and Dean J. Applications in pharmacopoeial analysis [08] Unit-II: Fluorimetric Analysis. Instrumentation and applications. PALGRAVE NewYork 4. chemical shift.Electronic excitation. Instrumentation and Application of GLC & HPLC. deviation from Beer’s law.H. Shielding & Desheilding. BOOKS RECOMMENDED: 1. 5. Skoog V. mass spectra of some simple compounds. and Merrit L. Instrumental methods of analysis Van Nostrand Renhold. organic spectroscopy. [08] Unit-III NMR Spectroscopy. Applications in pharmacopoeial analysis [10] Unit-IV Mass Spectroscopy –Theory. Principles of Instrumental Analysis. quantitative laws. single and double beam spectrophotometry. Practical Pharmaceutical Chemistry Vol. Infra. Chatten L.G. A text book of Pharmaceutical Chemistry Vol. Silver stein RM & Webster FX. spectrophotometry. The Athlone Press of the University of London. I & II Marcel.Red spectrophotometry-Theory. Instrumentation and applications Ultra violet and Visible.. Interpretation of spectra. spin-spin splitting spectra of simple compounds.H. spin-spin coupling. Spectrometric Identification of Organic Compounds. I and II. New York. 6. Willard H. 2. [06] . Govt of India. FTIR. Applications in pharmacopoeial analysis PHR-803P PHARMACEUTICAL ANALYSIS -III PRACTICAL 1. New York.Theory of 1H.B. Instrumentation & Applications. Dekker. Kemp William. Holler-Neimen 3. spectra of simple compounds. 7. instrumentations. Pharmacopoeia of India. instrumentation. and Stenlake J. John Wiley & Sons.PHR–803 PHARMACEUTICAL ANALYSIS -III Unit-I: Colorimetric Method.NMR.

betamethasone eye drop) [8] BOOKS RECOMMENDED: 1. blood and blood related products Illustrative studies of 2 monographs each for API (paracetamol. vaccines and antisera. general monographs on dosage forms [8] Unit V General monographs of veterinary products.PHR-804 PHARMACOPOEIAL STANDARDS Unit I General notices. test methods. Indian Pharmacopoeia 2010 .Physiochemical and Pharmaceuticals methods [8] Unit III Tests on herbal products. Vaccines & Blood related products. general notices.biological and chemical [8] Unit II Test methods. excipients (lactose. general requirements for herbs and herbal products. General monographs of biotechnology products. dexamethasone). starch) and dosage forms (amoxicillin dry syrup. General tests [8] Unit IV Containers.

hair darkeners and skin care products. Tyler Varro. Tea.R. Amla.E. Chaudhary. Herbal drug industry .E. Brady Lynn. [08] Unit-II .D. Harborne Phytochemical methods of chemical analysis. Vapoorte. Mottal. 13. [08] Unit-V – Role of markers in the standardization of herbal products [08] BOOK RECOMMENDED 1. CDRI Lucknow. & Tracey MV.N.Standardization of plant material as per WHO guidelines. 6. Quality Assurance & Validation (G) Hospital Pharmacy (H) Advanced Pharmacology (I). Evans W. Wallis T. Pharmacognosy 3. (C) Pharmaceutical Marketing (D)Pharmaceutical Packaging (E) Novel Drug Delivery System (F) GMP. E. conditioners. G. Aloe vera. microscopical. Modern methods of plant analysis 11. The practical evaluation of phytopharmaceuticals 10. organoleptic. Swendson Chromatography of alkaloids.C. Robbers J.. Pharmacoepial standards for Ayurvedic formulations CCRAS. [08] Unit-III –Herbal Cosmetics: Brief study of Phytocosmetics. Herbs used for different cosmetic formulations like shampoos. 9. Glycyrrhiza.. 7. R. 12. Henna. physical & chemical evaluation of crude drugs. [08] Unit-IV -Analysis of official formulations derived from crude drugs including some ayurvedic preparations. British herbal phamacopocia. and Turner T. Pharmacognosy ELBS. Industrial significance and current status. Study of following drugs used in different cosmetic formulations: Soapnut. Indian herbal pharmacopocia.A.E. Trease..R. Dhavan B. 2.C. Basic evaluation parameters for skin care products and shampoos.R.PHR –805 ELECTIVE Any one of the following: (A) Standardization of herbal drugs and cosmetics (B) Drug design. turmeric. Peach K. 5. Hibiscus. sandalwood etc.. & Srimal R. Delhi. Clerk’s isolation & identifications of drugs 8.C.Pharmaceutical Entrepreneurship (A) STANDARDISATION OF HERBAL DRUGS and COSMETICS Unit I – Commerce and quality control of natural medicinal plants products. Brain K. The use of pharmacological techniques for evaluation of natural products.Text book of Pharmacognosy 4.

Parallel and Split & Mixed synthesis. New York (1975). 2. Analogous based drug design concept with suitable examples b. Market behaviour.Internal control and external control. Lippincott Co.J.Hansch method & Software’s in QSAR. Estimating current demand Geo-demo. Market analysis. Olson. Estimating industry sales. Academic Press.Major concept in demand measurement. . Marketing generic drugs. [08] Unit-III Economic and competitive aspects of pharmaceutical industry. Hospital & Government agencies. Bioisosterism. Sterochemical aspects in drug design. Selection of stockists and distributors. Interactions (Forces) involved in drug receptor complex. Marcel Dekker Inc.Perun “Computer aided Drug Design methods Applications”. Pearson Education Asia. International marketing. Burger A “A guide to chemical basis of Drug Design “John Wiley & Sons”.J. Thomas J.F. S. Prescribing habits of physician. New York. Detailing. Burger’s Medical Chemistry. Introduction to pharmaceutical marketing. Drug development and the marketing research interface.A. Market share and future demand. Ariens: Drug Design. [08] Unit-V Controls. Structure Based drug design concept with examples [08] Unit-IV Combinatorial chemistry-Introduction. Physiochemical properties in relation to biological action. [08] BOOKS RECOMMENDED 1. 3. Kotler. E. Smith. [08] BOOKS RECOMMEDED: 1. Lead Discovery. Identification of the marketing. M. Quantitative models.H. A.Advertising.graphic analysis. (C) PHARMACEUTICAL MARKETING Unit-I Principles of marketing management. Retail competition. CBS Publishers & Distributors.(B) DRUG DESIGN Unit-I Introduction to Drug Design. [08] Unit-IVDistribution channels in pharmaceutical marketing – Manufacuturer. Philadelphia. New York. Edward C “Computer Assisted Drug Design (American Chemical Society). [08] Unit-II MARKET RESEARCH: Measuring & Forecasting Market Demand . parameters. 5. Philip “Marketing Management”. Doerge. Wholesaler. John Willey and Sons. R. 6.C. Patient motivation. Sinkula and S. [08] Computer Aided Drug Design-Introduction & Softwares used in CADD Unit-V QSAR Introduction. [08] Unit-II Drug metabolism-Phase I & Phase II Metabolic Reactions. Valvani. Wilson and Gisvold’s Text Book of Organic Medicinal and Pharmaceutical Chemistry. 4. 2. Wolff. Retailer. Diversification and specialization. Mickey C. Prodrugs & Soft drug concepts [08] Unit-III a. “Principles of pharmaceutical marketing”. 7. Market segmentation & Market targeting.E. Physical Chemical Properties of Drugs. Salkovisky.

packaging materials and product mix-up. Ancillary materials used in packaging. Packaging of Cosmetics and Toiletories.. importance in therapeutics. Defects in packages. General methods of design and evaluation of C. Pharmacopoeial tests and specifications. nanoparticles. Theory of controlled release drug delivery systems.D. USP 8. 7. 4. pulmonary colonic delivery.(D) PHARMACEUTICAL PACKAGING Unit-I New concepts in pharmaceutical packaging. Packaging Engineering. 3.O. Sterilization of packaging materials. package design for international transit [08] Unit-II 3. [08] Unit-V 8. Kac Chensney. nose to brain. Barail. glass and plastics. testing of finished packs as per ICH guidelines . chemical and biomedical engineering approach to achieve controlled drug delivery. package design research. Packaging of Pharmaceuticals. Drug and cosmetic Packaging. Quality-Control of Packaging Materials in Pharmaceutical Industry. pharmacosomes and resealed-erythrocytes.S. Osmotic pumps. post-sterilization testing 9.D. Harburn. Carriers for drug delivery systems. drug immobilization techniques. [08] Unit-IV 7. 5. 6. [08] Unit-II 3. Blister and strip packaging materials. Packaging materials with special reference to polymers. Advances in drug delivery systems. Package systems.D. Packaging of Parenterals. their testing and specifications including microbiology [08] Unit-III 5. Stability of package and packaging material 7. Prodrugs. Joseph D. Implants and inserts: Types. Physical. Ophthalmics. Brien. liposomes. Testing of containers & closures. Release and diffusion of drugs from C. aerosols and testing Corrugated fiber board materials. formulation and evaluation. BIS specifications (E) NOVEL DRUG DELIVERY SYSTEM Unit-I 1. Transdermal drug delivery systems: Theory. Microencapsulation: Methods. An Introduction to buccal. 2. use of bar codes and controls on inline packing. metals. [08] Unit-III 5.S. Targeted Drug delivery systems: Concept of drug targeting. their investigations and corrective & punitive action(CAPA) [08] BOOKS RECOMMENDED: 1. transmucosal and stemceuticals [08] . Griffin. ionotophoresis. 2. Legal requirement as per D &C rules and rules of importing countries. Printing requirements. Medical Device Packaging Handbook. their design and specifications [08] Unit-IV 8. Ross. design and evaluation methods. methods in drug targeting. testing of packaging materials and their transit worthiness [08] Unit-V Mechanization of packaging operation. kinetics of drug release from microcapsules technology and applications. 6. control of packaging materials and their specifications 4. 4.D. niosomes. label and leaflets preparation. 6. ocular.

(F) GMP. Chien. Sources and control of quality variation. Robinson. finished products and packaging materials Internal audits. systems. New Delhi 12. 7.P. Sampling and operating characteristics curves -raw materials. Pharmaceutical Process Validation. containers. Sharma P. 8. equipment. Quality assurance systems.U. Potdar. Julian. C. out of specifications (OOS) [08] BOOKS RECOMMEDED: 1. United States Pharmacopoeia. USFDA. Preparation of documents for new drug approval and export registration (schedule L1 & Y) [08] Unit-III 4.H.P1. Building management systems [08] Unit-V 6. Deasy. IPQC problems in pharmaceutical industries. British Pharmacopoeia. Documentation. 3. 2. Cleaning. 6. Drug Delivery Systems. IPC. Polymers in Controlled Drug Delivery. Basic concept of quality assurance. WHO guidelines and ISO 9000 series. environment etc [08] Unit-IV Facility design. T. & ICH [08] Unit-II 2.Willing. Premamoy “ Polymer Science & Technology”. process. 8. validation of product. 5. D&C Act 15. Novel Drug Delivery Systems. OPPI. 7.M. ICH guidelines . 3. validation master plan.P. Requirements of GMP. Controlled Drug Delivery. Quality Assurance. New Delhi 11. 6.Protocols. CGMP. Lisbeth. TRS guidelines 13. Forms and maintenance of records in Pharmaceutical industry.X 1. Garfield. Orange guide 14. Pharmacopoeial standards for dosage form and acceptance criteria.raw materials. Quality Assurance Principles for Analytical Laboratories. How to practice GMP’s . Validation in pharmaceutical industry . 7. Microencapsulation and Related Processes. Microencapsulation and Related Processes. machinery. Noxon. In process quality control tests. 9. Sustained and Conrolled Drug Delivery Systems. investigations of market complaints. 4.Concepts in validation. 9. Loftus and Nash.Sharma P. Good Manufacturing Practices for Pharmaceuticals. Ghosh. 5.BOOKS RECOMMENDED 1. 3.P. Gutcho.GMP-cGMP-CGMP with reference to Indian scenario Drugs & cosmetics rules with reference to G. personnel. Microencapsulation. GLP. Vandana Publication. Sampling plan.GMP for Pharmaceuticals. Florey. Vandana Publication. Robinson and Vincent. 10. QUALITY ASSURANCE & VALIDATION Unit-I No GMP. Manohar A. 4. Illum & Davis. 21CFR part 211 16. Tuckerman and Hitchings. Analytical Profile of Drugs (All volumes). closures. 2. Indian Pharmacopoeia.

labeling. Manufacturing records. personnel requirements. packing of materials prior to sterilization. computerized services (e. B. Master formula record . Dispensing of controlled drugs. Responsibilities of a hospital pharmacist. and Qadry J. Medication error. . demand and costing. Ahmedabad. Types of materials stocked. purchase order. [08] Unit-III: Central Sterile Supply Unit and their Management: Aseptic techniques and clean area classification. Hospital Formulary: Contents. Purchase and Inventory control: Principles. procurement of information. case on drug interaction & adverse reactions. [08] Unit-II: Drug Store Management and Inventory Control: Organization of drug.S. Hospital Pharmacy. sterilization equipments.. storage conditions. purchase procedures. Units of radioactivity. Hasan. specifications for radio-active laboratory. Merchant H. Lea & Febiger.radio-active half life. Pharmacy and therapeutic committee. Production control. [08] BOOKS RECOMMENDED: 1. [08] Unit-IV: Drug information service: Sources of information on drugs. [08] Unit-V: Drug distribution systems in Hospitals: Out-patient dispensing. various methods of inventory control. Dispensing of drugs to ambulatory patients.S. 2. procurement and stocking. Text Book of Hospital Pharmacy. manufacturing practice. Philadelphia. Radiation hazards and their prevention.(G) HOSPITAL PHARMACY Unit-I: Organization and Structure: Organization of a hospital and hospital pharmacy. Nuclear Pharmacy: Introduction to Radiopharmaceutics. Dispensing of drugs to in-patients. Records and Reports: Prescription filling drug profile.g. Budget preparation and implementation. Patient medication profile. Types of drug distribution systems Charging Policy. Shah Prakashan. treatment schedules. Types of materials for sterilization. Supply of sterile materials. preparation of radioisotopes in laboratory using radiation dosimetry. methods adopted. radio-isotope generators. Retrieval of information. preparation and revision of hospital formulary. MEDLINE). Production of radio pharmaceuticals.S. idiosyncratic cases etc. permissible radiation dose level. methods of isotonic tagging. Manufacture of Sterile and Non-sterile Products: Policy making of manufacturable items.

Ethical Issues. London. Novel Target Sites: Physiological functions. Akt (Protein kinase B). migraine. Purinoreceptors. India. Congestive cardiac failure. London. Caspases.) Pharmacological Experiments on Isolated Preparations. schizophrenia. M.N. Calcutta.G. mood & sleep disorder. calcium and calcium binding proteins. 5. Springer Verlag. malaria.Vogel (ed). Parkinson. Peroxisome proliferator activator receptors (PPAR)-a and AMP activated protein kinases. Berlin. Drug Discovery and Evaluation-Pharmacological Assays. UNIT 5 Stem cell therapeutics Biology of stem cells. pharmacological implications. 2. Phosphodiesterases UNIT 3 Pharmacological Techniques to Evaluate the following Class of Drugs Antiepileptics Antianxiety agents and drugs used in mood and sleep disorders Antipsychotics Drugs affecting memory Skeletal muscle relaxants and neuromuscular blockers Antidiabetic agents Analgesics and drugs used in arthritis and neuropathic pain. HIV and related opportunistic infections. Angina pectoris.Laurence and A. Cannabinoid receptors. Anti-inflammatory agents Antiulcer agents Hepatoprotective agents UNIT 4 Pharmacotherapeutics Etiopathogenesis and pharmacotherapy of diseases associated with following systems/diseases: Cardiovascular System: Hypertension. helminthiasis. leprosy. Kluwer Academic Publishers. BOOKS RECOMMENDED 1. David R. 4. Pharmacology of receptors : Classification. and therapeutic potential of the following target sites:: Rho kinase (ROCK) Phosphoinositide 3-kinase (PI3K). amoebiasis.K. cellular signaling systems. U. Fundamentals of Experimental Pharmacology. U.Bacharach (eds). Poly (ADPribose) polymerase (PARP). UK 3. Myocardial infarction. Psychiatric Disorder: Anxiety. D. hyperlipidemia. Neurosteroid receptors. and pharmacology of their modulators UNIT 2. Scientific Book Agency. Potentials of stem cell in various disorders. Protein kinases. Gross. Alzheimer’s diseases. Livingstone. H.L. . 1and 2.K. Infection Diseases: Tuberculosis. Animal Models in Cardiovascular Research.(G) ADVANCED PHARMACOLOGY AND PHARMACOTHERAPEUTICS UNIT 1 Molecular Pharmacology Receptor occupancy and cellular signaling systems including G-proteins. Vol. Neurological disorder: Epilepsy. HRT osteoporosis. Endocrine System: Diabetes. Evaluation of Drug Activities: Pharmacometerics. phospholipases.GABA & Benzodiazepine Receptors.R. Thyroid diseases. Arrhythmias. and pharmacology of agonists of the following receptor types: Excitatory Amino Acid receptors. Germany. myasthenia gravis. Melatonin receptors Ion Channels and Their Modulators: Classification and biology of potassium ionic channels.Ghosh. Academic Press. cyclic nucleotides. Oral contraception. Edinburg University Pharmacology Staff (ed.

( include only relevant to working). J. Stephen L. Australia. Srivastava U. importance Entrepreneur. Englewood cliff.history & concept. imports and exports.). & Pareek U. 7. Influences. Environmental Protection Act covering air. 10. quality system and its relevance. Fauci. Anthony S. Pharmacotherapy: A Pathophysiologic Approach. Longo.Miii. 11.A. Factory Act.. Central and State Excise Act Including Vat. Dipiro.V.G.needs. Larry Jameson. L. Business language and Communication.). Types of Entrepreneurs. (schedules H.T.U. R. Ahmedabad. Harrison’s Principles of Internal Medicine.P1.K.G. (eds. Business etiquettes.P. B. F.Yee.6. IIM. wholesale.R.V.W.X. income tax and sales tax .R. market leaders and success stories of their leading brands. Avery’s Drug Treatment: Principals and Practice of Clinical Pharmacology and Therapeutics. Inc. Prentice Hall. Case studies -3 to 5 (8) Unit-III Identification of market for product and services. Hauser.L. water. ‘Developing Entrepreneurships: A Handbook’. & Jerry. Regulatory aspects. ADIS Press.T.).Herfindal and D.Y). T.L1.Drugs and Cosmetics Act and rules relevant to licensing requirements for retail. G. and Kurt J. decision making and problem solving skills.Matzke. Sydney. Dennis L. USA. solid waste disposal record keeping. The McGraw Hill Companies. Business strategies. J. (8) Unit-II Entrepreneurship in the pharmaceutical industry. Text Book of Therapeutics: Drug and Disease Management. E. (8) Unit-IV Technology Transfer considerations Funding of projects. Personality Traits And Characteristics. (I). ‘Entrepreneur’s Master Planning Guide. problems and issues Importance of communication. Dan L. T. Innovations. Talbert. How to launch a successful business’. Rao. supply chain management keeping in mind return on investments. Learning . J..Financial. Lippincott Williams & Wilkins. (need based for understanding for practical application). 3.team building and management Concept of social entrepreneurship & sustainable entrepreneurship (Growth oriented).Pharmaceutical Entrepreneurship Unit-I Entrepreneurship.Leadership Attributes. External Financing Project Management. Isselbacher. G.Michael Posey (eds. Financial Management – understanding of balance sheet and profit and loss accounts. Kasper. The McGraw Hill Companies. Financing. Implementation and Evaluation. DPCO price control and price fixation.M Speight and NHG Holford (ed. Welsh. Case studies-3 (8) Suggested Books: 1. marketing opportunities. 2.Gourley.M.Wells. Eugene Braunwald.3 (8) Unit-V Importance of hr recourses. Bootstrapping. Inc. ‘Project Planning.C. competition. SWOT analysis Formulation of strategies. Case studies .

Deakins. 12 Factory Act. Springer. 8. Publisher: Cambridge University Press. Lechter. Entrepreneurship Policy: Theory and Practice.Central Excise Tariff Act and Import Policy. Lundström. Lois (2005). 5th Edition.Systems. Entrepreneurship and Small Firms. Isobel M. Drugs and Cosmetics Act and Rules. Govt. Hisrich. D. 14 Environmental Protection Act. Pharmaceutical Industry: Innovation & Developments (Business Issues. 13 Shop and Establishment Act. M. 6. Grenada Publisher: Nova Science Publishers Inc (3 Aug 2011) 9. Freel. and DPCO. PHR-805 P Project on Elective . 2009. The Business of Healthcare Innovation [Hardcover] Lawton Robert Burns. 4. 7.. Academic Press. 2 edition 10. 15. Michael A. Anders und Stevenson. Handbook of Entrepreneurship Research: An Interdisciplinary Survey and Introduction 5. Competition and Entrepreneurship) by David A. Technology Entrepreneurship. New Delhi. of India. Duening.. McGraw Hill. (2009).Bootstrapping Your Business: Start And Grow a Successful Company With Almost No Money by Greg Gianforte. Mancuso. Robert D. Thomas N. Publisher Adams Media 2005 11... Marcus Gibson.