Brand Name: Decilone Generic name: Dexamethasone Indications: rheumatoid arthritis, systemic lupus, acute gouty arthritis, psoriatic
arthritis, ulcerative colitis, and Crohn's disease. Severe allergic conditions: bronchial asthma, allergic rhinitis, drug-induced dermatitis, and contact and atopic dermatitis. Chronic skin conditions: dermatitis herpetiformis, pemphigus, severe psoriasis and severe seborrheic dermatitis. Chronic allergic and inflammatory conditions of the uvea, iris, conjunctiva and optic nerves of the eyes Blood cell cancers (leukemias), and lymph gland cancers (lymphomas). Blood diseases: idiopathic thrombocytopenia purpura ; autoimmune hemolytic anemia. Drug Classification: Synthetic adrenal corticosteroid; glucocorticoid type. Mechanism of Action: Corticosteroids are natural substances produced by the adrenal glands located adjacent to the kidneys. Corticosteroids have potent antiinflammatory properties by preventing phospholipid release, decreasing eosinophil action and a number of other mechanisms. Dexamethasone, a corticosteroid, is similar to a natural hormone produced by your adrenal glands.
It often used to replace this chemical when your body does not make enough of it. Dosage PO: initial, 0.75-9 mg/day; maintenance, gradually reduce to minimum effective dose (0.5-3 mg/day) Special precaution: Tell your doctor and pharmacist if you are allergic to dexamethasone, if you're taking in anti- coagulants, and if you are pregnant. Pregnancy risk: Dexamethasone can be used in pregnancy, but is generally avoided. Adverse reaction: stomach irritation,vomiting,headache,dizziness, insomnia, restlessness, depression anxiety, acne, increased hair growth, easy bruising,irregular or absent menstrual periods, skin rash swollen face, lower legs, or ankles vision problems, cold or infection that lasts a long time, muscle weakness, black or tarry stool. Contraindications: Infection, peptic ulcer, acute glumerulonephritis Form: Tablet Nursing Responsibility: Assess patients on long term therapy have blood tests to determine glucose levels an electrolyte balance Assess patients muscles for weakness and wasting
(continuation Decilone) Assess for signs and symptoms of other diseases because adrecocorticoids mask the severity of most illnesses. Monitor BP at least 2 times daily unil the patient is stabilized on a maintenance dose. Report increase in BP. Assess for GI bleeding when patient is on a long term therapy Teach patient or family to take medication with food, to be careful to avoid falls because steroids makes the bones more usceptible to fractures, the need to slowly withdrawing the drug when therapy is completed so that the patients own adrenal cortex will gradually be reactivated to take over the productions of hormone, the need to maintain general hygiene to prevent infection because antibody productin is decreased by adrenocorticosteroids.