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BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE, PILANI HYDERABAD CAMPUS INSTRUCTION DIVISION, FIRST SEMESTER 2013-2014 Course Handout

Date: 01-08-2013

Course number Course title Instructor-in-charge Team of instructors

: BIO F111 : General Biology : SUMAN KAPUR : Vidya Rajesh, P Sankar Ganesh, Debashree Bandyopadhyay, Sridev Mohapatra, Palash Mandal, S Swaminathan, Jayati Ray Dutta

Course description

Living System and their properties, major biological compounds, basic biochemical and physiological processes, introduction to genetics and recombinant DNA technology. Scope and objectives :

The course is aimed at providing the introduction of biological system with respect to nature, behavior and functioning of the cell. The intricate relationship of the living organism with its environment at the molecular level is highlighted so that the impact of the modern biological researches can be understood and appreciated. Text book : T1: Eldon D. Enger, Frederick C. Ross and David B. Bailey, Concepts in Biology, 14th Edition (BITS Pilani Custom Edition) Tata McGraw Hill Publishing Company Limited, 2010. Reference books : R1: Peter H.Raven, George B. Johnson, Jonathan B. Losos, Susan R. Singer Biology, 7th Edition. WBC McGraw Hill, 2005. R2: C. Starr, Biology: Concept and application, 6th Edition, Thomson Learning. Suggested reading : S1: Campbell, N.A., Reece J.B., Biology, 7th Edition, Pearson Education Inc, 2009. S2: Campbell, N.A., et. al. Essential Biology with Physiology, 2nd Edition Pearson Education Inc, 2009.

Course plan: Lecture No. 1-2 3 4 5 6 7 8 Enzymes 9 10 11 12 13 14 15 16 17 18 19 20 21 Recombinant DNA technology DNA & RNA: Structure and function relationship Taxonomy Cell structure and functions Learning objectives Introduction The chemistry of life: Biomolecules Reference Chap/Sec (Books) 1 (T1) 3 (T1) 3 (T1) 4 (T1) 4 (T1) 4 (T1) 5 (T1) 5 (T1) 6 (T1) 6 (T1) 6 (T1) 7 (T1) 7 (T1) 20 (T1) 20 (T1) 8 (T1) 8 (T1) 8 (T1) 11 (T1) 11 (T1) 11 (T1)

Topics to be covered Brief introduction to all aspects of biology (Section 1.4 onwards of T-1) Carbohydrate and lipids Proteins and nucleic acids Cell theory, cell membrane and transport Membranous organelles Non-membranous organelles, Nuclear components and major cell types Nomenclature Bio-catalysis: Hypotheses Environmental factors, co-enzymes, enzyme activation and inhibition Introduction Cellular respiration: Glycolysis

Biochemical pathways

TCA cycle, ETS, ATP calculation and fermentation Protein and fat metabolism, Photosynthesis Photosynthesis continued: C4 Pathway The classification and Evolution of Organisms A brief survey of the domains; Acellular infectious particles Central Dogma, molecular structures, duplex DNA and DNA replication. Gene expression: Transcription and translation Mutation and mutagenesis, Introduction to rDNA Introduction Tools: Vectors and endonucleases Gene cloning and expression: Illustration (Dolly) Applications: Healthcare, agriculture and industry

Lecture number 22 23 24 25 26 27 28 29 30 Self Study 31

Learning objectives Cell division: Mitosis (Cell copying process)

Topics to be covered Cell cycle: The stages of mitosis Abnormal cell division: Basis of oncology Introduction Mechanisms I & II and crossing over Nondisjunction, sex determination and comparison of mitosis & meiosis Introduction, Inheritance patterns and laws

Reference Chapter (Books) 9(T1) 9 (T1) 9 (T1) 9 (T1) 10 (T1) 10 (T1) 12.1-12.4 13.1-13.5 (T1) 13.9 (T1) 15.1 to 15.3 (T1) 24(T1)

Cell division: Meiosis (Sex cell formation)

Mendelian genetics (Concepts and problems)

Multiple allelism, Sex linked inheritance Pleiotropy, polygenic inheritance and Environmental Influence Speciation, gene pool concept, Hardy-Weinberg equilibrium and its applications Ecosystem Dynamics: The flow of energy matter Basic principle Blood circulation: Pulmonary & Systemic Nature of blood and role of heart

Genetic diversity within species

Ecology

32

Material exchange in the body

33 Self Study 34 35 36 37 38 39 Sex and reproduction 40 Bodys Control Mechanism - II Bodys control mechanism - I Nutrition

Gas exchange: Respiratory anatomy and lung function Mechanical processing of food Chemical processing of food and waste disposal: Digestive system Kidney structure & function Food and Diet Nervous system: Nerve impulse, events at the synapse and CNS organization Endocrine system, sensory input (Chem & Ear), sensory input (Eye & skin) and output coordination Immune system and defense mechanisms Humoral and cell-mediated immune responses, Blood typing and AIDS Chromosomal determination of sex, male and female foetal development, hormonal control of fertility, fertilization, pregnancy and contraception

24 (T1)

24 (T1) 25 (T1) 26(T1)

26 (T1) 26 (T1) 26 (T1)

27(T1)

Evaluation scheme: EC No. 1. Date and time 30/9, 3.30 -4.30 PM 9/11, 3.30 -4.30 PM Tutorial hours 11/12 ,9.00 12.00 PM

Evaluation component

Duration

Marks

Remarks*

Test 1

60 min

60

CB

2.

Test 2

60 min

60

OB

3.

Surprise tutorial tests

Diverse

60

CB CB+OB

4.

Comprehensive examination

3 hrs

120

* OB: Open book, CB: Closed book Chamber consultation hour: Will be announced by the section instructor. Notices: All notices regarding this course will be displayed on the notice board of biological sciences group, located on the 1st floor of A-Block. Grading policy: Award of grades will be guided in general by the histogram of marks. Decision on border line cases will be taken based on individuals sincerity, attendance in classes, and the section instructors assessment of the student. Make-up policy: As per Clause 4.07 of BITS academic regulations booklet. Only in case of medical emergency and hospitalization

Instructor-in-charge BIO F111