You are on page 1of 63
BioMEMS Enabling Killer Apps in Healthcare & Lifestyle
BioMEMS
Enabling Killer Apps in
Healthcare & Lifestyle

BioMEMS

Enabling Killer Apps

in

Healthcare & Lifestyle

Chris Van Hoof, imec, Belgium

LAST MONTH

LAST MONTH

I LEARNED ABOUT MY HEALTH RISKS

I LEARNED ABOUT MY HEALTH RISKS

HEALTH •   Chronic diseases stem in large part = Genetics from lifestyle related risk factors

HEALTH

Chronic diseases stem in large part

=

Genetics

from lifestyle related risk factors

Bill Davenhall, geo-medicine guru, ESRI

LANDSCAPE OF POC D X No compelling solutions on Well-serviced Solutions exist the market yet Type
LANDSCAPE OF POC D X
No
compelling
solutions on
Well-serviced
Solutions exist
the market
yet
Type
Benchtop
Portable
Smartphone
Where?
Clinical lab
Clinical lab or Dr’s
office
Home or Dr’s office
What?
Expensive and dedicated
instrument, low-cost
disposable
Lower cost dedicated
instrument, low-cost
disposable
No instrument. More
functions integrated into
disposable. Data processing
in smartphone or cloud.
Instrument cost
Disposable cost
$10-100k
$5-20k
$0
$10-200
$10-200
$0.50-10
smart phone iLab TECHNICAL CONCEPT ONE PLATFORM - MANY MARKERS   DNA/RNA   Mutations   miRNA:

smart

phone

iLab

smart phone iLab TECHNICAL CONCEPT ONE PLATFORM - MANY MARKERS   DNA/RNA   Mutations   miRNA:
smart phone iLab TECHNICAL CONCEPT ONE PLATFORM - MANY MARKERS   DNA/RNA   Mutations   miRNA:

TECHNICAL CONCEPT

ONE PLATFORM - MANY MARKERS

DNA/RNA

Mutations miRNA: marker for cancer and other diseases Pathogen DNA/RNA: infectious diseases (HepC, HIV, et.)

Proteins

health

tracking

app +

web

services

Wireless link

smart phone iLab TECHNICAL CONCEPT ONE PLATFORM - MANY MARKERS   DNA/RNA   Mutations   miRNA:
disposable microfabricated test flexible: blood, saliva, urine
disposable
microfabricated
test
flexible:
blood,
saliva,
urine

Biomarkers for disease (cancer, Alzheimer’s,

infectious diseases, heart disease, etc.)

Small molecules and metabolites

Metabolic information (e.g. cholesterol)

Microscopy

Blood cell count (e.g. HIV CD4+) Blood disorders (e.g. sickle cell anemia)

smart phone iLab TECHNICAL CONCEPT ~1 cm Exploded view PCB with radio, power, control Detection chip

smart

phone

iLab

smart phone iLab TECHNICAL CONCEPT ~1 cm Exploded view PCB with radio, power, control Detection chip
smart phone iLab TECHNICAL CONCEPT ~1 cm Exploded view PCB with radio, power, control Detection chip

TECHNICAL CONCEPT

~1 cm
~1 cm

Exploded view

PCB with radio, power, control Detection chip Fluidics chip Package 2-4 cm
PCB with
radio,
power,
control
Detection chip
Fluidics chip
Package
2-4 cm

health

tracking

app +

smart phone iLab TECHNICAL CONCEPT ~1 cm Exploded view PCB with radio, power, control Detection chip

web

services

Wireless link

disposable microfabricated test flexible: blood, saliva, urine
disposable
microfabricated
test
flexible:
blood,
saliva,
urine
200MM BIOMEMS WAFER

200MM BIOMEMS WAFER

200MM BIOMEMS WAFER
MICRO-PILLAR ARRAY FILTER inlets outlet distributor Injection volume micro- pillars 200µm 50µm 5µm supply channel injection

MICRO-PILLAR ARRAY FILTER

inlets outlet distributor Injection volume micro- pillars 200µm 50µm 5µm supply channel
inlets
outlet
distributor
Injection volume
micro-
pillars
200µm
50µm
5µm
supply
channel
injection area distribution area
injection area
distribution area

separation area

MICRO-PILLAR ARRAY FILTER inlets outlet distributor Injection volume micro- pillars 200µm 50µm 5µm supply channel injection
MICRO-PILLAR ARRAY FILTER inlets outlet distributor Injection volume micro- pillars 200µm 50µm 5µm supply channel injection
MICRO-PILLAR ARRAY FILTER inlets outlet distributor Injection volume micro- pillars 200µm 50µm 5µm supply channel injection
MICRO-REACTOR FOR DNA AMPLIFICATION Conv. Chip- PCR PCR
MICRO-REACTOR FOR DNA
AMPLIFICATION
Conv.
Chip-
PCR
PCR
HALF CREDIT CARD SIZE BIOMEMS achieving on-chip DNA amplification and detection from whole blood sample SEPARATION

HALF CREDIT CARD SIZE BIOMEMS

achieving on-chip DNA amplification and detection from whole blood sample

SEPARATION OF 11 DNA STRANDS IN 2CM LONG CHANNEL DNA fragments are 10, 15, 20, 25,
SEPARATION OF 11 DNA STRANDS IN 2CM LONG CHANNEL
DNA fragments are 10, 15, 20, 25, 35, 50, 75, 100, 150, 200 and 300bp
Panasonic-imec result
http://www.diginfo.tv/v/13-0022-r-en.php
HEALTH •   Chronic diseases stem in large part = Genetics from lifestyle related + Lifestyle

HEALTH

Chronic diseases stem in large part

=

Genetics

from lifestyle related

+ Lifestyle

risk factors

+ Environment

Bill Davenhall, geo-medicine guru, ESRI

3 lifestyle-related RISK FACTORS

are responsible

for all chronic diseases

PREVENTION

TRACK RISK FACTORS & ADAPT LIFESTYLE

Behavioral / lifestyle risk factors

Unhealthy diet Physical inactivity Tobacco use

GENETICS

ENVIRONMENT

Raised blood pressure Raised blood glucose Overweight/obesity Abnormal blood lipids Intermediate risk factors
Raised blood pressure
Raised blood glucose
Overweight/obesity
Abnormal blood lipids
Intermediate risk factors
PREVENTION TRACK RISK FACTORS & ADAPT LIFESTYLE Behavioral / lifestyle risk factors Unhealthy diet Physical inactivity
PREVENTION TRACK RISK FACTORS & ADAPT LIFESTYLE Behavioral / lifestyle risk factors Unhealthy diet Physical inactivity
Heart disease | Stroke | Cancer | Chronic pulmonary diseases | Diabetes MAIN CHRONIC DISEASES
Heart disease | Stroke | Cancer |
Chronic pulmonary diseases | Diabetes
MAIN CHRONIC DISEASES
PREVENTION WORKS ! “REDUCING DIABETES AND HYPERTENSION PREVALENCE BY 5% WOULD SAVE APPROXIMATELY $9 BILLION ANNUALLY

PREVENTION WORKS !

“REDUCING DIABETES AND HYPERTENSION PREVALENCE

BY 5% WOULD SAVE APPROXIMATELY

$9 BILLION ANNUALLY IN THE NEAR TERM”

PREVENTION WORKS ! “REDUCING DIABETES AND HYPERTENSION PREVALENCE BY 5% WOULD SAVE APPROXIMATELY $9 BILLION ANNUALLY

Source: Woodcock et al, Int J of Epidemiology, 2010

Source : Woodcock et al, Int J of Epidemiology, 2010 PREVENTION WORKS ! Reduction in global

PREVENTION WORKS !

Reduction in global risk mortality by increasing physical activity  Review over 1M people
Reduction in global risk
mortality by increasing
physical activity
 Review over 1M people
16 14 UNITED STATES GERMANY SWITZERLAND UNITED KINGDOM 12 10 8 6 OECD ddata OECD ata
16
14
UNITED STATES
GERMANY
SWITZERLAND
UNITED KINGDOM
12
10
8
6
OECD ddata
OECD
ata
4
1970
1980
1990
2000
2008
Total expenditure on health, % GDP

Technology should

EMPOWER

people towards disease prevention

QUALITY OF DATA DESIRABLE FORMFACTOR TECHNOLOGY, ALGORITHM & DATA ANALYTICS SENSOR, CIRCUIT, SYSTEM, INTEGRATION REQUIRES RADICAL
QUALITY OF DATA
QUALITY
OF DATA
DESIRABLE FORMFACTOR
DESIRABLE
FORMFACTOR

TECHNOLOGY, ALGORITHM & DATA ANALYTICS

SENSOR, CIRCUIT, SYSTEM, INTEGRATION

REQUIRES RADICAL INNOVATIONS

in

QUALITY OF DATA DESIRABLE FORMFACTOR TECHNOLOGY, ALGORITHM & DATA ANALYTICS SENSOR, CIRCUIT, SYSTEM, INTEGRATION REQUIRES RADICAL
COST LOW
COST
LOW
POWER LOW
POWER
LOW

KILLER APPS THAT SAVE LIVES

•   Chronic diseases stem in large part KILLER APP #1 STAY FIT from lifestyle related

Chronic diseases stem in large part

KILLER APP #1

STAY FIT

from lifestyle related

risk factors

THE ADVERSE EFFECT OF EVOLUTION 18 kcal/kg/day 4.3 kcal/kg/day

THE ADVERSE EFFECT OF EVOLUTION

THE ADVERSE EFFECT OF EVOLUTION 18 kcal/kg/day 4.3 kcal/kg/day

18 kcal/kg/day

4.3 kcal/kg/day

WITH DRAMATIC CONSEQUENCES

WITH DRAMATIC CONSEQUENCES

WITH DRAMATIC CONSEQUENCES
NEEDS A BEHAVIOR CHANGE

NEEDS A BEHAVIOR CHANGE

NEEDS A BEHAVIOR CHANGE
A MULTITUDE OF DEVICES
A MULTITUDE OF DEVICES
IMEC ’s CIRCUITS , SYSTEMS & ALGORITHMS FOR ENERGY EXPENDITURE 90% Accuracy Reliable in everyday situations

IMEC’s CIRCUITS, SYSTEMS &

ALGORITHMS FOR ENERGY EXPENDITURE

90%

Accuracy

Reliable

in everyday situations

1 month

Autonomy

IMEC ’s CIRCUITS , SYSTEMS & ALGORITHMS FOR ENERGY EXPENDITURE 90% Accuracy Reliable in everyday situations
GRAND CHALLENGE: ENERGY INTAKE imec HYPERSPECTRAL SENSOR imec PHYSIOLOGICAL SENSOR

GRAND CHALLENGE: ENERGY INTAKE

GRAND CHALLENGE: ENERGY INTAKE imec HYPERSPECTRAL SENSOR imec PHYSIOLOGICAL SENSOR

imec HYPERSPECTRAL SENSOR

GRAND CHALLENGE: ENERGY INTAKE imec HYPERSPECTRAL SENSOR imec PHYSIOLOGICAL SENSOR

imec PHYSIOLOGICAL SENSOR

GRAND CHALLENGE: ENERGY INTAKE imec HYPERSPECTRAL SENSOR imec PHYSIOLOGICAL SENSOR
GRAND CHALLENGE: ENERGY INTAKE imec HYPERSPECTRAL SENSOR imec PHYSIOLOGICAL SENSOR
CHANGING BEHAVIOR IS TOUGH
CHANGING BEHAVIOR IS TOUGH
•   Chronic diseases KILLER APP #2 MANAGE stem in large part from lifestyle related STRESS

Chronic diseases

KILLER APP #2

MANAGE

stem in large part

from lifestyle related

STRESS

risk factors

•  Stressed person
•  Stressed person
30-40% $42-300B 25%  4/10
30-40%
$42-300B
25%
 4/10
STRESS MANAGEMENT APPS

STRESS MANAGEMENT APPS

STRESS MANAGEMENT APPS
STRESS BIOMARKERS Sympathetic and Parasympathetic Autonomic Nervous System Heart rate Respiration rate Salivation Perspiration Pupil dilation
STRESS BIOMARKERS
Sympathetic
and
Parasympathetic
Autonomic
Nervous
System
Heart rate
Respiration rate
Salivation
Perspiration
Pupil dilation
EMERGING tools

EMERGING tools

EMERGING tools
EMERGING tools
  Parameters measured today   Skin conductance   3D-accelerometer   Skin temperature   Skin humidity  

Parameters measured today

Skin conductance 3D-accelerometer Skin temperature Skin humidity Ambient temperature Ambient humidity

STRESS AT WORK

80% accuracy

in classifying stress from rest

STRESS PATIENTS

75% accuracy

in classifying patients from controls

STRESS AT WORK 80% accuracy in classifying stress from rest STRESS PATIENTS 75% accuracy in classifying
STRESS AT WORK 80% accuracy in classifying stress from rest STRESS PATIENTS 75% accuracy in classifying
STRESS AT WORK 80% accuracy in classifying stress from rest STRESS PATIENTS 75% accuracy in classifying
SALIVA STRESS SENSOR

SALIVA STRESS SENSOR

SALIVA STRESS SENSOR
SALIVA STRESS SENSOR
SALIVA STRESS SENSOR
•   Chronic diseases KILLER APP #3 DISPOSABLE stem in large part from lifestyle related HEALTH

Chronic diseases

KILLER APP #3

DISPOSABLE

stem in large part

from lifestyle related

HEALTH PATCH

risk factors

REDESIGN FOR ROLL-TO-ROLL MANUFACTURING
REDESIGN FOR
ROLL-TO-ROLL
MANUFACTURING
TAKE AN IMEC WIRELESS SENSOR DESIGN
TAKE
AN IMEC WIRELESS SENSOR DESIGN
ADAPT IT FOR FOIL INTEGRATION

ADAPT IT FOR FOIL INTEGRATION

ADAPT IT FOR FOIL INTEGRATION
INTEGRATE PASSIVES AND ICS
INTEGRATE PASSIVES AND ICS
LOW-COST SKIN TEMPERATURE PATCH
LOW-COST
SKIN TEMPERATURE
PATCH
HEALTH •   Chronic diseases stem in large part = Genetics from lifestyle related + Lifestyle

HEALTH

Chronic diseases stem in large part

=

Genetics

from lifestyle related

+ Lifestyle

risk factors

+ Environment

Bill Davenhall, geo-medicine guru, ESRI

KILLER APP #4 •   Chronic diseases KEEP YOUR stem in large part ENVIRONMENT IN from

KILLER APP #4

Chronic diseases

KEEP YOUR

stem in large part

ENVIRONMENT IN

from lifestyle related

CHECK

risk factors

imec ENVIRONMENTAL NO 2 SENSOR CONTINUOUS MEASUREMENT at ambient temperature in varying humidity
imec ENVIRONMENTAL NO 2 SENSOR
CONTINUOUS
MEASUREMENT
at ambient temperature
in varying humidity
EMERGING ppb NO MONITORING Parking garage Clean air in nature 0 -20 -40 -60 -80 -100

EMERGING ppb NO 2 MONITORING

EMERGING ppb NO MONITORING Parking garage Clean air in nature 0 -20 -40 -60 -80 -100
EMERGING ppb NO MONITORING Parking garage Clean air in nature 0 -20 -40 -60 -80 -100
EMERGING ppb NO MONITORING Parking garage Clean air in nature 0 -20 -40 -60 -80 -100
EMERGING ppb NO MONITORING Parking garage Clean air in nature 0 -20 -40 -60 -80 -100

Parking garage

EMERGING ppb NO MONITORING Parking garage Clean air in nature 0 -20 -40 -60 -80 -100
EMERGING ppb NO MONITORING Parking garage Clean air in nature 0 -20 -40 -60 -80 -100

Clean air in nature

0 -20 -40 -60 -80 -100 -120 12 14 16 18 20 22 Relative response (%)
0
-20
-40
-60
-80
-100
-120
12
14
16
18
20
22
Relative response (%)

Time (hours)

EMERGING environmental MONITORING

EMERGING environmental MONITORING Basic NOSE functionality: array of eNose sensors on single chip

Basic NOSE functionality: array of eNose sensors on single chip

MEDICAL QUALITY DATA IN CONSUMER HANDS
MEDICAL
QUALITY
DATA
IN
CONSUMER
HANDS

Technology

must

EMPOWER PEOPLE

towards disease prevention and towards a healthier lifestyle

ENCOURAGE & MOTIVATE
ENCOURAGE & MOTIVATE
BioMEMS Enabling Killer Apps in Healthcare & Lifestyle
BioMEMS
Enabling Killer Apps in
Healthcare & Lifestyle