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Opportunities for Medical Ceramics
Nano-655

NanoMarkets, LC
October 2013

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ABOUT NANOMARKETS
• NanoMarkets provides industry analysis of advanced materials and their application in upstream markets • Our work includes market, company and technology analysis, market forecasting and due diligence • Offerings include reports, custom consulting, seminars/webinars and in-house training. NanoMarkets is based in U.S., with extensive contacts all over the world

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ABOUT THE REPORT
In the past, medical ceramics were represented by ceramic and clay implants that remained inert in the host and acted as scaffolds or supports. Today the scenario has changed remarkably due to the introduction of an entirely new generation of bioceramics. These implants are, amazingly, structurally and functionally compatible with living tissue in the human body and contribute to the development of new tissue. Over the past two decades, there has been tremendous improvement in the performance of these bioceramics, and technology advances have created a very huge market for ceramics in the medical sector. Although there are a few risks and ambiguities regarding the use of implants and medical devices based on ceramics, NanoMarkets certainly believes that the market for implantable bioceramics will continue to grow in future. This growth can possibly be converted into profitable businesses by the companies manufacturing the medical ceramic devices and the firms that supply the necessary raw materials.

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RELATED REPORTS
Bio-Plastics Markets Worldwide Medical Polymer Markets 2013-2020

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THE MEDICAL CERAMICS MARKET
• Advancements in medical ceramics has supported areas such as medical device & implant and healthcare segments • Arrival of related products such as piezo-ceramics and nanoceramics has further boosted these sectors • Also creating opportunities for firms supplying raw materials to these segments

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OPPORTUNITIES IN MEDICAL DEVICES & IMPLANT SEGMENTS
PROSTHESES & BONE REPLACEMENTS

All-ceramic implants preferred over ceramic-metal and ceramicpolymer for small & medium bone replacements as they offer

• Better clinical trial results • Biocompatibility

• High degree of osseo integration

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ADVANCED PRODUCTION METHODS

Injection molding, engineered coatings and metal ceramic-assemblies have made complex joints and small precision instruments a reality

Improved manufacturing processes will enhance the application of medical ceramics to other medical applications

Companies like Straumann, Nobel Biocare (NB), and Zimmer adopting CAD/CAM for production of implants

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BIOACTIVE CERAMIC COATINGS

Combination mechanical & bioactive properties makes ceramic coatings on metal useful for medical applications

ACP, Glass ceramic coatings on titanium & DLC coatings are a few examples.

Development in coating process technology, making bioactive ceramic cost-effective

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PIEZO-CERAMICS & NANO-CERAMICS

Piezo-Ceramics in demand due to applicability in Piezoceramic sensors and motors in the medical diagnostic equipments • High-strength nano-composites and superior biocompatible coatings for implants, a reality because of nanometer-sized biomaterials Nano-technology and micro-technology will continue to be used in fabrication of bio-devices

• To be used for diagnosis and treatment of cancer because of healing ability and their potential as a next generation drug delivery system

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OPPORTUNITIES IN HEALTHCARE
ORTHOPEDICS & DENTISTRY

Bone scaffolding, a new technology in which medical ceramics are finding potential • Bio-ceramic hip joints are already a hit as these longer lasting joints offer patients relatively active life.

Demand is likely to come from USA, as FDA has approved ceramic-based implants • Aging global population will heavily drive demand

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SCAFFOLD-GUIDED BONE REGENERATION

Medical ceramicsare the perfect material for scaffold guided bone regeneration

• Wound healing is another application area in which many companies are active In addition to knee and hip replacements, small bone replacements are likely to see growth

• A number of regenerative solutions now being offered by companies like Zimmer

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INJECT ABLE CERAMIC & REGENERATION

Immediate pain relief, durability, full weight-bearing recovery, bone consolidation, and maintenance of the structural integrity of the bone favors injectable ceramics for reconstructive foot and back-filling procedures • Bonesupport, curasan (DE) and covalent Materials Corporation (JP) are active in this area Injectable ceramics that can be injected with minimal invasion has potential to enter bone reconstruction, drug delivery system and other medical applications • Such bone substitute solutions have trong business potential and firms that have recognized this will benefit in future

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OPPORTUNITIES FOR MATERIAL FIRMS
KEYS TO SUCCESS

Time Reduction

• Through adoption of innovative manufacturing processes

Attaining scalability

• In a cost-effective manner, without impacting biocompatibility

Reliable Process

• Adoption for manufacturing of large bone replacement implants to reduce pricing disparity

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FACTORS AFFECTING MANUFACTURERS

Clinical Trials:Result will have an influence on the demand for medical ceramics Trade Barriers:Both tariff & non-tariff barriers likely to impact this industry negatively

Environmental Regulations:By overcoming such regulations firms can get advantage Globalization:Either lead to innovative products or may allow penetration of low quality products

R & D needs:Significant amount of R & D needed in order to be innovative in this industry

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KEY FIRMS IN MEDICAL CERAMICS INDUSTRY Orthopedic Implant Manufacturers
Company
DePuy(US)

Description
Innovative product line up Regularly launching new products

Zimmer Holdings (US)

Strong distribution network Adopts acquisition strategy for growth

Stryker Corp. (US)

Dominance in the orthopedic segment particularly in cranio-maxillofacial market Strong presence in Asian market Acquisition strategy for growth Strong product portfolio

Biomet 3I (US) Well established in hip implant segment Synthes (US) Leadership in cranio-maxillofacial market particularly in Japan

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Dental Implant Manufacturers Company
Straumann (Switzerland)

Description
Soft tissue level implant is considered a benchmark in commercial and clinical applications. A large portfolio of dental products CAD/CAM based solutions Unique tip and thread design of its Nobel Active implants

Nobel Biocare (Switzerland)

Dental products based on wide variety of materials, such as acrylics, alumina, zirconia, titanium, and cobalt chromium. CAD/CAM based solutions Well established in dental space & strong product portfolio CAD/CAM based high precision manufacturing technique Comprehensive range of dental implants

Zimmer (US)

Biomet 3I (US)

Pioneered the development of biological driven implants

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Materials & Injectable Ceramics Suppliers Company
Morgan Technical Ceramics (UK) CeramTec(DE) Kyocera (JP) 3M (US) Reliable aesthetics, strength of products for dental applications CoorsTek (US) Bonesupport (Sweden) Strong presence in labware, precision instruments, and pump components Patented CERAMENT technology, that helps to remodel bone using their osteoconductive property

Description
At the forefront of several ceramic innovations Ability to customize product Strong presence in medical equipment segment Specializes in small ceramic components for implanted electronic medical devices CAD/CAM-based dental restoration solution

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SUMMARY: MARKET PREDICTION FOR 2013-2020

Global Medical Ceramics Market
© NanoMarkets 2013

Ceramic market is likely to more than double in terms of revenue US$ Millions

3,500 3,000 2,500

Growing at a CAGR of 15.54% through the forecasting period

2,000 1,500 1,000 500 0 2013 2014 2015 2016 2017 2018 2019 2020

To reach $ 3 billion in revenues by 2020

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LEADING MATERIAL SEGMENTS
Leading Material Segments
3,000 2,500

Alumina to dominate the materials segment
US$ Millions

2,000

1,500

Bioglass to grow faster than other segments

Zirconia to be the second most used material

1,000

500

0 2013 Alumina 2014 2015 Zirconia 2016 2017 2018 2019 2020 Hydroxyapatite Bioglass

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CONTACT US
Address: NanoMarkets, LC PO Box 3840 Glen Allen, VA 23058 Telephone / Fax 804-270-1718 804-360-7259

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