GLYPHOSATE REREGISTRATION ELIGIBILITY TEAM

Office of Pesticide Programs: Special Review and Reregistration Division Eric Feris . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Reregistration Branch Health Effects Division Jane Smith . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Chemical Coordination Branch Krystyna Locke . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Toxicology Branch I Jeff Evans . . . . . . . . . . . . . . . . . . . . . . . . . . . cc!pational and Residential Expos!re Branch Randolph Perfetti . . . . . . . . . . . . . . . . . . . . . . . . . Chemistry Branch " Reregistration S!pport Biological and Economic #nalysis Division James G. Saulmon . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Biological #nalysis Branch Eric Maurer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Economic #nalysis Branch Environmental $ate and Effects Division andace !rassard . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ecological Effects Branch Kevin Poff . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Environmental $ate and %ro!ndwater Branch !ernice Slutsky . . . . . . . . . . . . . . . . . . . . . . . . . . . . Science #nalysis and Coordination Staff Registration Division Mark Perry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Registration S!pport Branch Karen P. "icks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $!ngicide"Her&icide Branch 'olicy and Special 'ro(ects Staff Jean Frane . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $ood Safety ) Reg!lation Trac*ing Section Office of General o!nsel:

'esticides and Toxic S!&stances Division #e$ra !urton . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 'esticides Branch

Office of

om"liance Monitoring:

'olicy and %rants Division !everly %pdike . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $I$R# 'olicy ) #nalysis Branch i

GLYPHOSATE RED September 1993

TABLE O#

ONTENTS

GLOSSARY O# TERMS AN$ ABBRE%IATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . vi E&E 'TI%E S'MMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . viii I( II( INTRO$' TION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . + ASE O%ER%IE) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ,
A( B( ( $( E( *emical O+er+ie, . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 'se Profile . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Estimated 'sage of Pesticide . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $ata Re-!irements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Reg!lator. Histor. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . , , . .

III(

S IEN E ASSESSMENT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
A( B( Prod!ct *emistr. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

H!man Healt* Assessment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . +/ +. Toxicology #ssessment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . +/ a. &. c. d. e. #c!te Toxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . +/ S!&chronic Toxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ++ Chronic Toxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . +, Carcinogenicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . +0 Developmental Toxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . +1

ii

GLYPHOSATE RED September 1993

f. g. h. i. (. *. ,.

Reprod!ctive Toxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . +2 3!tagenicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . +3eta&olism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . +4e!rotoxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . +5 ther Toxicological Endpoints . . . . . . . . . . . . . . . . . . . . . . . . . . . +. Reference Dose . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . +.

Expos!re #ssessment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ,/ a. &. Dietary Expos!re . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ,/ cc!pational and Residential . . . . . . . . . . . . . . . . . . . . . . . . . . . . ,+

0.

Ris* #ssessment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ,0 a. &. c. Dietary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ,0 cc!pational and Residential . . . . . . . . . . . . . . . . . . . . . . . . . . . . ,6 Dietary Expos!re References . . . . . . . . . . . . . . . . . . . . . . . . . . . . ,6

(

En+ironmental Assessment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0/ +. Environmental $ate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0/ a. &. 0,. Ecological Effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0a. &. Ecological Ha7ard . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0Ecological Effects Ris* #ssessment . . . . . . . . . . . . . . . . . . . . . . 10 Environmental $ate and Transport . . . . . . . . . . . . . . . . . . . . . . . . 0/ Environmental $ate and %ro!ndwater #ssessment . . . . . . . . . .

I%(

RIS/ MANAGEMENT AN$ REREGISTRATION $E ISION . . . . . . . . 1-

. . . . . . . . -/ 9a&eling Re:!irements for 3an!fact!ring"8se 'rod!cts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -/ A( Man!fact!ring2'se Prod!cts . . . . . . . . . . . . . . . . . . Position . . -. . 15 +. . . . . . . 1Eligi&le and Ineligi&le 8ses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -/ %( A TIONS RE1'IRE$ BY REGISTRANTS . . . . . . . . . . . . . . . . a. . . . . . . . . . . . . . . . -6 %I( APPEN$I ES . . . . . . . . . . . . . -. . . . . . . . . . . 15 B( Reg!lator. . . . . . . . . . -. . . . . . . . . . . . . . . . . . . .GLYPHOSATE RED September 1993 A( $etermination of Eligi0ilit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . B( #dditional %eneric Data Re:!irements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -+ +. . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . #:!atic . . . . . . . . . . . . . . . . 4ona:!atic . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . 15 9a&eling Rationale . . . . . . . . . . . . . . . . . .. . . #dditional 'rod!ct"Specific Data Re:!irements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ( E3isting Stoc4s . 0. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -6 8se 'atterns S!&(ect to Reregistration Ta&le of the %eneric Data Re:!irements and St!dies 8sed to 3a*e the Reregistration Decision A""endi3 A " A""endi3 B " . . . . . . . . .. . . . . . . . 1+. . . . . . . . . . . . . -+ 9a&eling Re:!irements for End"8se 'rod!cts . . . . . . . . . . . . . . . . . . . Tolerance Re"assessment . . -+ End2'se Prod!cts . . -/ +. . . . . . . . . . . . . . . . &. . . . . . . . . Eligi&ility Decision . . . -/ Endangered Species Statement . . . . . . . . .

#ttachment 1 " .GLYPHOSATE RED September 1993 A""endi3 " " Citations Considered to &e 'art of the Data Base S!pporting the Reregistration of %lyphosate A""endi3 $ 9ist of #vaila&le Related Doc!ments A""endi3 E " 'esticide Reregistration Hand&oo* A""endi3 # " %eneric and 'rod!ct"Specific Data Call"In . #ttachment 2 " . #ttachment + " . #ttachment . " Response . #ttachment . E'# #cceptance Criteria 9ist of all Registrant=s> sent this Data Call"In Cost Share?Data Compensation $orms ." Chemical Stat!s Sheet %eneric Data Call"In and 'rod!ct Specific Data Call"In $orms with Instr!ctions %eneric Data Call"In and 'rod!ct Specific Data Call"In Re:!irements Stat!s and Registrants< Response $orms with Instr!ctions E'# %ro!ping of End 8se 'rod!cts for 3eeting #c!te Data Re:!irements. #ttachment 0 " . #ttachment 6 " Toxicology .

# statistically derived concentration of a s!&stance that can &e expected to ca!se death in 1/A of test animals.g. 3edian 9ethal Dose.i. End"8se 'rod!ct 8. # statistically derived single dose that can &e expected to ca!se death in 1/A of the test animals when administered &y the ro!te indicated =oral or dermal>.g. Environmental 'rotection #gency $ederal Insecticide@ $!ngicide@ and Rodenticide #ct $ederal $ood@ Dr!g@ and Cosmetic #ct $ederal Register Highest Dose Tested 3edian 9ethal Concentration.@ mg?l or ppm. 9ethal Dose"low. The estimated pesticide concentration in an environment@ s!ch as a terrestrial ecosystem.S. It is expressed as a weight of s!&stance per !nit weight of animal@ e. C#S C$R CS$ EEC E' E'# $I$R# $$DC# $R HDT 9C1/ #ctive Ingredient Chemical #&stracts Service Code of $ederal Reg!lations Confidential Statement of $orm!la Estimated Environmental Concentration. 9owest Dose at which lethality occ!rs 9owest Effect 9evel 9D1/ 9Dlo 9E9 .@ mg?*g. It is !s!ally expressed as the weight of s!&stance per weight or vol!me of water or feed@ e.GLYPHOSATE RED September 1993 GLOSSARY O# TERMS AN$ ABBRE%IATIONS a.

GLYPHOSATE RED September 1993 3#TC 3axim!m #llowa&le Toxicant ConcentrationB # range at which the pesticide ca!ses no effect =4 E9> and the lowest dose at which an effect was o&served =9 E9>. Cor*er 'rotection Standard vii . 4ot #pplica&le 4ational 'oll!tant Discharge Elimination System 4o &served Effect 9evel 3' 3'I 3RID 4?# 4'DES 4 E9 '' '#DI ppm REI RfD RS TD TC effect. T3RC C'S ffice of 'esticide 'rograms 'rovisional #ccepta&le Daily Inta*e 'arts 'er 3illion Restricted Entry Interval Reference Dose Registration Standard Toxic Dose. 3an!fact!ring"8se 'rod!ct 3axim!m 'ermissi&le Inta*e 3aster Record Identification =n!m&er>. Toxic Concentration. The dose at which a s!&stance prod!ces a toxic effect. E'#<s system of recording and trac*ing st!dies s!&mitted. The dose at which a s!&stance prod!ces a toxic Theoretical 3axim!m Resid!e Contri&!tion.

# Reference Dose of . The #gency has classified glyphosate as a %ro!p E carcinogen =signifies evidence of non"carcinogenicity in h!mans>. # re"assessment of tolerances is incl!ded in this doc!ment and there are no ma(or changes in the previo!sly"esta&lished tolerances.52@ the #gency iss!ed the doc!ment DRegistration Standard for 'esticide 'rod!cts Containing %lyphosate as the #ctive IngredientD =4TIS F'B5-"+/0.+6>. St!dies show that glyphosate is no more than slightly toxic to &irds and is practically non"toxic to fish and honey&ees. The isopropylamine salt of glyphosate@ the active ingredient in 10 of these registrations@ is !sed as a her&icide to control a n!m&er of &roadleaf weeds and grasses. There are also a n!m&er of non"food !se sites incl!ding ornamental@ t!rf@ forestry@ and ind!strial rights"of"way. This proposal is &ased on a maternal 4 E9 of +-1 mg?*g?day from a ra&&it developmental toxicity st!dy and an !ncertainty factor of +//. The dietary ris* assessment is &ased on a worst"case scenario@ ass!ming treatment of +//A of acreage and highest legal resid!e val!es which li*ely res!lt in an overestimation of expos!re and ris*. In E!ne +. The Registration Standard re:!ired scientific st!dies in the areas of phytotoxicity@ environmental fate@ toxicology@ prod!ct chemistry@ and resid!e chemistry. #fter completing its review for reregistration@ the #gency now concl!des that the data &ase on glyphosate is s!&stantially complete. Except where explicitly noted otherwise@ the term Dglyphosate@D when !sed in this doc!ment@ refers to either the technical acid or the isoproplyamine and sodi!m salts of glyphosate. However@ the monoammoni!m salt is incl!ded in the tolerance expression. However@ a toxic inert in glyphosate end !se prod!cts necessitates the la&elling of some . In addition there are seven her&icide?plant reg!lation prod!cts containing the monoammoni!m salt of glyphosate which were registered s!&se:!ent to the development of 9ist # and are not a s!&(ect of this RED. tolerances for processed food and animal feed and animal tolerances. There are 20 glyphosate"containing prod!cts registered for !se in the 8nited States.GLYPHOSATE RED September 1993 E&E 'TI%E S'MMARY This doc!ment addresses the reregistration eligi&ility of the pesticide glyphosate. Two registrations contain the sodi!m salt of glyphosate and are !sed in s!garcane fields. There are 51 tolerances esta&lished for vario!s crops and crop gro!ps as well as $ederal $ood@ Dr!g@ and Cosmetic #ct G6/. Based on the res!lts of its reregistration review@ E'# has concl!ded that all registered !ses of glyphosate are eligi&le for reregistration. Even with these val!es@ however@ dietary expos!re is expected to &e minimal. Cith the exception of a few waived st!dies@ all of the data re:!ired have &een s!&mitted. The principal food !se sites incl!de corn@ wheat@ sorgh!m@ citr!s and stone fr!its@ potatoes and onions@ asparag!s@ coffee@ pean!ts@ and pineapples. mg?*g?day has &een recommended. #vaila&le data have &een s!fficient to allow re"assessment of existing tolerances@ which incl!des the monoammoni!m salt of glyphosate.

GLYPHOSATE RED September 1993 prod!cts Dtoxic to fishD since some glyphosate prod!cts are applied directly to a:!atic environments. Before reregistering each prod!ct@ the #gency is re:!iring that prod!ct specific data in the areas of prod!ct chemistry and ac!te toxicology@ revised Confidential Statements of $orm!la@ and revised la&eling &e s!&mitted within eight =5> months of the iss!ance of this doc!ment. #fter reviewing these data and the revised la&els@ the #gency will determine whether to re"register a prod!ct &ased on whether or not that prod!ct meets the re:!irements in Section 0=c>=1> of $I$R#. . The #gency does have concerns regarding the potential ha7ard to endangered plant species and the Ho!ston toad. End !se prod!cts containing glyphosate in com&ination with other active ingredients will not &e re"registered !ntil the Reregistration Eligi&ility Decisions for all active ingredients contained in that prod!ct are iss!ed and all the active ingredients contained in the prod!ct are also eligi&le for reregistration. However@ the #gency is not re:!iring any modification of !se or la&el changes in this doc!ment. However@ prod!ct specific data for these prod!cts are &eing called in at this time. Spray drift st!dies are re:!ired as is a Tier II Hegetative Higor st!dy. In an effort to red!ce the time@ reso!rces@ and n!m&er of animals needed to f!lfill the ac!te toxicology data re:!irements for glyphosate"containing end !se prod!cts@ the #gency has D&atchedD prod!cts considered to &e similar with respect to ac!te toxicity testing re:!irements. # $ederal Register 4otice on the Endangered Species 'rotection 'lan and s!&se:!ent g!idance to registrants will impose appropriate expos!re mitigation meas!res for areas where endangered plant species and the Ho!ston toad may &e enco!ntered. In addition@ there have &een a n!m&er of reported incidents of spray drift damage to non"target crops. These st!dies are not part of the target data &ase for reregistration of glyphosate.

$inally@ Section HI is the #ppendices which s!pport this Reregistration Eligi&ility Doc!ment. '' ' . #dditional details concerning the #gency<s review of applica&le data are availa&le on re:!est.S. Section H disc!sses the reregistration re:!irements for glyphosate./62/.56.55@ the $ederal Insecticide@ $!ngicide@ and Rodenticide #ct =$I$R#> was amended to accelerate the reregistration of prod!cts with active ingredients registered prior to 4ovem&er +@ +. Section IH presents the reregistration decision for glyphosate. The p!rpose of the #gency<s review is to reassess the potential ha7ards arising from the c!rrently registered !ses of the pesticideI to determine the need for additional data on health and environmental effectsI and to determine whether the pesticide meets the Dno !nreasona&le adverse effectsD criterion of $I$R#. The doc!ment consists of six sections. Environmental 'rotection #gency =referred to as Dthe #gencyD> of all data s!&mitted to s!pport reregistration.D Th!s@ reregistration involves a thoro!gh review of the scientific data &ase !nderlying a pesticide<s registration. There are five phases to the reregistration process. Section III disc!sses the h!man health and environmental assessment &ased on the data availa&le to the #gency. This doc!ment presents the #gency<s decision regarding the reregistration eligi&ility of the registered !ses of the isopropylamine salt and the sodi!m salt form!lations of glyphosate. Except where explicitly noted otherwise@ the term Dglyphosate@D when !sed in this doc!ment@ refers to either the technical acid or the isoproplyamine and sodi!m salts of glyphosate &!t does not cover the monoammoni!m salt prod!cts since the compo!nd was not incl!ded in the $ederal Register p!&lication of 9ist #.+ + $ield E'#<s reviews of data on the set of registered !ses considered for E'#<s analysis may &e o&tained from the perations Division =H-1/2C>@ ffice of 'esticide 'rograms@ E'#@ Cashington@ DC . The first fo!r phases of the process foc!s on identification of data re:!irements to s!pport the reregistration of an active ingredient and the generation and s!&mission of data to f!lfill the re:!irements. The fifth phase is a review &y the 8. The amended #ct provides a sched!le for the reregistration process to &e completed in nine years. Section I is the introd!ction.GLYPHOSATE RED September 1993 I( INTRO$' TION In +.>=#> states that in 'hase 1 Dthe #dministrator shall determine whether pesticides containing s!ch active ingredient are eligi&le for registrationD &efore calling in data on prod!cts and either re"registering prod!cts or ta*ing Dother appropriate reg!latory action. Section II descri&es glyphosate@ its !ses@ data re:!irements and reg!latory history. $I$R# Section 6=g>=.

6"/ +/02/+ =isopropylamine salt> +/02/0 =sodi!m salt> C0 H5 4 1 ' Ro!nd!p@ Rodeo@ Shac*le Basic 3an!fact!rerB 3onsanto Company 5// 4. St. 9o!is@ 3 20+2B( 'se Profile The following is information on the c!rrent registered !ses with an overview of !se sites and application methods. . The following active ingredient=s> are covered &y this Reregistration Eligi&ility Doc!mentB Common 4ameB Chemical 4ameB C#S Registry 4!m&erB '' Chemical CodesB Empirical $orm!laB Trade 4amesB glyphosate 4"phosphonomethyl glycine 0526+". # detailed ta&le of the !ses of glyphosate is given in #ppendix #. 9ind&ergh Blvd. ChemicalB glyphosate@ isopropylamine salt her&icide =+/02/+> Type of ChemicalB 3echanism of #ctionB not *nown at this time@ &!t it appears to inhi&it the aromatic amino acid &iosynthesis pathway and may inhi&it or repress chlorismate m!tase and?or prephenate hydratase.GLYPHOSATE RED September 1993 II( ASE O%ER%IE) A( *emical O+er+ie.

o!tdoor TERRESTI#9 $EED CR 'B alfalfa@ &arley@ &eans@ &!c*wheat@ corn@ grass forage?fodder?hay@ lentils@ millet =proso>@ nongrass forage?fodder?straw?hay@ oats@ past!res@ rye@ sorgh!m@ wheat. TERRESTRI#9 $ D CR 'B acerola =Cest Indies Cherry>@ apricot@ articho*e =Eer!salem>@ asparag!s@ atemoya@ avocado@ &anana@ &eech n!t@ &eets@ &lac*&erry@ &l!e&erry@ &oysen&erry@ &ra7il n!t@ &readfr!it =&readn!t>@ &roccoli@ &r!ssels spro!ts@ &!ttern!t@ ca&&age@ ca&&age =Chinese>@ caram&ola =(alea>@ carrot =incl!ding tops>@ cashew@ ca!liflower@ celery@ chard =swiss>@ cherimoya@ cherry@ chestn!t@ chicory@ cocoa@ coffee@ collards@ cran&erry@ cress =water>@ c!c!m&er@ c!rrant@ date@ dew&erry@ eggfr!it tree =canistel>@ eggplant@ elder&erry@ endive =escarole>@ fig@ fil&ert =ha7eln!t>@ garlic@ goose&erry@ go!rds@ gro!ndcherry =straw&erry . %REE4H 8SE $ D CR 'B greenho!ses"in !se. #J8#TIC 4 4"$ D I4D8STRI#9B a:!atic areas?water@ drainage systems@ systems.GLYPHOSATE RED September 1993 8se sitesB gro!ps and #J8#TIC $ D CR 'B agric!lt!ral drainage systems@ irrigation systems@ la*es?ponds?reservoirs =with h!man or wildlife !se>@ streams?rivers?channeled water. 8TD R RESIDE4TI#9B ho!sehold?domestic dwellings premises. I4D R 4 4"$ DB greenho!se"empty. #J8#TIC 4 4"$ D a:!atic areas?water 8TD RB sewage $ RESTRKB conifer release@ forest plantings =reforestation programs>@ forest trees =all or !nspecified>.

GLYPHOSATE RED September 1993 tomato?tomatillo>@ g!ava@ hic*ory n!t@ horseradish@ h!c*le&erry@ (a&otica&a@ (ac*fr!it@ *ale@ *item&illa =ceylon goose&erry>@ *iwi fr!it@ *ohlra&i@ lee*@ lett!ce@ litchi n!t@ logan&erry@ longan@ lo:!at@ macadamia n!t .

TERRESTRI#9 $ D L $EED CR 'B agric!lt!ral fallow?idleland@ almond@ apple@ &arley@ &eans@ &eets =!nspecified>@ &!c*wheat@ calamondin@ citron =citr!s>@ citr!s hy&rids other than tangelo@ corn =!nspecified>@ corn =field>@ cotton =!nspecified>@ grapefr!it@ grapes@ *!m:!at@ lemon@ lentils@ lime@ millet proso =&roomcorn>@ m!stard@ oats@ orange@ parsnip@ pean!ts =!nspecified>@ peas =!nspecified>@ pineapple@ potato =white?irish>@ p!mmelo =shaddoc*>@ rape@ rice@ rice =wild>@ rye@ sorgh!m@ soy&eans =!nspecified>@ s!gar &eet@ s!garcane@ tangelo@ tangerines@ tomato@ triticale@ t!rnip@ wheat.GLYPHOSATE RED September 1993 =&!shn!t>@ mamey =mammee apple>@ mango@ marmalade&ox =genipapo>@ mayhaw =hawthorn>@ melons@ melons =cantalo!pe>@ melons =honeydew>@ melons =mango>@ m e l o n s = m ! s * > @ m e l o n s = w a t e r > @ m e l o n s w i n t e r =casa&a?crenshaw?honeydew?persian>@ m!stard@ nectarine@ o*ra@ olive@ onion@ papaya@ parsley@ passion fr!it@ peach@ pear@ pecan@ pepper@ persimmon@ pistachio@ plantain@ pl!m@ pomegranate@ pr!ne@ p!mp*in@ :!ince@ radish@ rasp&erry =&lac*@ red>@ rh!&ar&@ r!ta&aga@ sapodilla@ sapota =white>@ so!rsop@ spinach@ s:!ash =s!mmer>@ s:!ash =winter>@ s!gar apple =c!stard apple>@ sweet potato@ tamarind@ taro@ tea@ waln!t =English?&lac*>@ yam. . TERRESTRI#9 4 4"$ D CR 'B agric!lt!ral fallow?idleland@ agric!lt!ral rights"of"way?fencerows?hedgerows@ agric!lt!ral !nc!ltivated areas@ airports?landing fields@ christmas tree plantations@ golf co!rse t!rf@ ind!strial areas =o!tdoor>@ nonagric!lt!ral o!tdoor &!ildings?str!ct!res@ nonagric!lt!ral rights"of"way?fencerows?hedgerows@ nonagric!lt!ral!nc!ltivated areas?soils@ ornamental and?or shade trees@ ornamental lawns and t!rf@ ornamental woody sh!&s and vines@ paths?patios@ paved areas =private roads?sidewal*s>@ recreational areas@ !r&an areas. TERRESTRI#9 L %REE4H 8SE 4 4"$ D CR 'B ornamental and?or shade trees@ ornamental woody shr!&s and vines. TERRESTRI#9 4 4"$ DL 8TD R RESIDE4TI#9B ornamental and?or shade trees@ ornamental her&aceo!s plants@ ornamental lawns and t!rf@ ornamental woody sh!&s and vines.

// A glyphosate@ isopropylamine salt .2 A glyphosate@ isopropylamine salt /.// A glyphosate@ isopropylamine salt 1../ A glyphosate@ isopropylamine salt -.// A glyphosate@ isopropylamine salt /..1/ A glyphosate@ isopropylamine salt 3an!fact!ring 8se .// A glyphosate@ isopropylamine salt $orm 4ot Identified?Solid -2.0..+/ A glyphosate@ isopropylamine salt +5.// A glyphosate@ isopropylamine salt +/..// A glyphosate@ isopropylamine salt 'ress!ri7ed 9i:!id /.1/ A glyphosate@ isopropylamine salt 6+.5/ A glyphosate@ isopropylamine salt +.GLYPHOSATE RED September 1993 'estsB many &roadleaf and grass weeds $orm!lation types registeredB SI4%9E #CTIHE I4%REDIE4TB $orm 4ot Identified?9i:!id 10.-1 A glyphosate@ isopropylamine salt Sol!&le Concentrate?9i:!id 2.1/ A glyphosate@ isopropylamine salt 2/.// A glyphosate@ isopropylamine salt 'elleted?Ta&leted 50.2 A glyphosate@ isopropylamine salt /.0/ A glyphosate@ isopropylamine salt +1.-/ A glyphosate@ isopropylamine salt +5.2/ A glyphosate@ isopropylamine salt ..2 A glyphosate@ isopropylamine salt .1/ A glyphosate@ isopropylamine salt 6+.// A glyphosate@ isopropylamine salt 10.// A glyphosate@ isopropylamine salt 5.5.6.// A glyphosate@ isopropylamine salt 9i:!id"Ready to 8se +.5/ A glyphosate@ isopropylamine salt 6+.// A glyphosate@ isopropylamine salt Sol!&le Concentrate?Solid ..1.

I.1/ A glyphosate@ isopropylamine salt L + other #.GLYPHOSATE RED September 1993 389TI'9E #CTIHE I4%REDIE4TB 9i:!id"Ready to 8se +./ A glyphosate@ isopropylamine salt L + other #./5 l& ae?#I 'elleted?Ta&leted " applied as a spot treatment@ for example from a hand held sprayerI 'ress!ri7ed 9i:!id " applied as a spot treatment@ for example from an aerosol canI Sol!&le Concentrate?9i:!id " applied at rate of -. gal ae?#I ChemicalB glyphosate@ sodi!m salt plant reg!lator =+/02/0> Type of ChemicalB 3echanism of #ctionB modifies plant growthI hastens fr!it ripening .. Sol!&le Concentrate?9i:!id +2./.I. +0. /.?. -.1 l& ae?#I Sol!&le Concentrate?Solid " applied at rates of /.I.?.I..0/ A glyphosate@ isopropylamine salt L + other #.5/ A glyphosate@ isopropylamine salt L + other #..1/ A glyphosate@ isopropylamine salt L + other #. /.-/ A glyphosate@ isopropylamine salt L + other #.6/ A glyphosate@ isopropylamine salt L + other #..1 A glyphosate@ isopropylamine salt L + other #.I. +6.I.0I 9i:!id"Ready to 8se " applied at rate of 0.I. +. 3ethods and rates of application =%iven in maxim!m active =acid e:!ivalent =ae>> rates@ except as otherwise noted>B Broadcast or sprayI for example as neededB $orm 4ot Identified?9i:!id " rates were not specified in #ppendix # dated 5?+.I.0I $orm 4ot Identified?Solid " rates were not specified in #ppendix # dated 5?+.

GLYPHOSATE RED September 1993 8se %ro!ps and SitesB TERRESTRI#9 $ D L $EED CR 'B pean!ts =!nspecified>I s!garcane $orm!lation Types RegisteredB SI4%9E #CTIHE I4%REDIE4TB sol!&le concentrate?solid -1.1 l& a.i. The data@ reported on an aggregate and site =crop> &asis@ reflect ann!al fl!ct!ations in !se patterns as well as the varia&ility in !sing data from vario!s information so!rces. The ta&le &elow s!mmari7es glyphosate !seage &y site.+ days preharvest intervalI pean!ts " 56 days preharvest interval.i./A glyphosate@ sodi!m salt 3ethods and Rates of #pplicationB sol!&le concentrate?solid " applied as gro!nd spray at pean!t &loom stage at /. These estimates are derived from a variety of p!&lished and proprietary so!rces availa&le to the #gency.?# in 1 gal water. Glyphosate Usage Site Multiple Acres Treated (x1000) unknown 350-390 Pounds AI (x1000) 3000-7000 500-550 non-ag areas almonds .1. Do not apply this prod!ct thro!gh any type of irrigation system. 8se 9imitationsB s!garcane " .?# in +/ gal waterI sol!&le concentrate?solid " applied as aerial spray at s!garcane ratoon stage at /./0-1 l& a. ( Estimated 'sage of Pesticide This section s!mmari7es the &est estimates availa&le for the pesticide !ses of glyphosate.

150 65-200 275-325 20-125 1.100-1.300 10-110 5-10 15-65 5-150 5-#0 25-30 100-150 2.500-1.500 300-600 10-150 10-30 15-50 5-300 5-$0 30-55 #50-550 2.$00 200-225 10-70 20-#0 60-70 10-30 30-#0 20-#0 150-175 350-1.000-1.200 225-375 1.000-3.#00 50-60 5-35 25-30 25-#0 5-15 15-30 5-20 100-125 250-#50 .500 650-1. ield co!!on hay"pas!ure dry edible beans"peas grape rui! grapes lemons o!her ag si!es oranges peaches peanu!s pears pecans plums"prunes rice sorghum soybeans spring whea! sugarcane po!a!oes sun lowers swee! corn !oma!oes green beans"peas walnu!s win!er whea! 75-275 550-600 15-95 1.700 20 1$3-375 25-265 10-70 1.600-#.GLYPHOSATE RED September 1993 apples barley cherries corn.200-2.500 50 70-1#0 #5-550 5-75 3.000-3.300-1.700 300-1.000 3.

These data were re:!ired to s!pport the !ses listed in the Registration Standard. #ppendix B incl!des all data re:!irements identified &y the #gency for c!rrently registered !ses needed to s!pport reregistration. %lyphosate is registered in the 8nited States for !se as a her&icide.. ./ million acre treatments were made with +5.52 Registration Standard for glyphosate incl!de st!dies on prod!ct chemistry@ ecological effects@ environmental fate@ toxicology@ and resid!e chemistry. III( S IEN E ASSESSMENT A( Prod!ct *emistr./A>@ soy&eans =.+@ approximately +0". Hay?past!re =.52 Registration Standard eval!ated the st!dies c!rrently on file at the #gency and re:!ired s!&mission of f!rther data. This Reregistration Eligi&ility Doc!ment reflects an assessment of all data which were s!&mitted in response to the Registration Standard. Histor.5. 4on" agric!lt!ral areas =00A>@ soy&eans =+1A>@ hay?past!re =++A>@ and corn =5A> comprise 2-A of the total po!nds of active ingredient applied.A>@ and other agric!lt!ral areas =.GLYPHOSATE RED September 1993 TOTA 1!"#$%&!0"!$0 11"'#$&1$"()% In a typical year &etween +. $( $ata Re-!irements Data re:!ired in the E!ne +.million po!nds active ingredient.. and +. E( Reg!lator. The E!ne +./A> comprise -+A of the total acreage treated with glyphosate./A>@ field corn =.

B C 0 H5 4 1 ' +2. The ac!te inhalation st!dy was waived &y the #gency since glyphosate technical is a nonvolatile solid and ade:!ate inhalation st!dies were cond!cted on the end"!se prod!ct form!lations.GLYPHOSATE RED September 1993 Empirical $orm!laB 3olec!lar CeightB C#S Registry 4o./-*+ 00067039 *esult ) #320 mg"kg ) 2 g"kg . . Toxicology #ssessment The toxicological data &ase on glyphosate is ade:!ate and will s!pport reregistration eligi&ility."% The following ta&le is derived from 3's considered toxicologically similar to glyphosate technical.//EC and a &!l* density of +.6"/ +/02/+ =isopropylamine salt@ I'#> +/02/0 =sodi!m salt> The glyphosate =4"phosphonomethyl glycine> salts are nonselective her&icides and plant growth reg!lators.-6 l&?ft0. a./0526+"..uired +ategory *** *** . #c!te Toxicity The ta&le &elow s!mmari7es the toxicity res!lts and categories for technical grade glyphosate. It is +A sol!&le in water at .o! -e. B( H!man Healt* Assessment +. The technical isopropylamine salt =I'#> is a white crystalline solid with a melting point of . The technical sodi!m salt is a white crystalline solid which decomposes at +6/EC with a &!l* density of 0/ l&?ft0 .B Sha!ghnessy 4o. Acute Toxicity Test %cu!e &ral 'ra!( '1( %cu!e +ermal 'rabbi!('1( %cu!e *nhala!ion '1( 1 .1EC and insol!&le in ethanol@ acetone@ or &en7ene.

These doses were e:!ivalent to /@ 20@ 0+. Body weight gains of the high"dose males and females were a&o!t .6A and +5A lower@ respectively@ than those of the controls. =3RIDs 6/11.1/@ 1// or .//// ppm of glyphosate for three months."% 1 .2.05-.mg?*g?day@ respectively =males> and /@ 56@ 6/6 and +2.1// mg?*g?day of glyphosate for three months./"day feeding st!dy Sprag!e"Dawley rats were fed diets containing /@ +///@ 1/// or . Based on the red!ced .6/+@ and ///.> increased ser!m gl!cose in the mid"dose and high" dose malesI =0> increased &lood !rea nitrogen =B84> and ser!m al*aline phosphatase in the high"dose malesI and =6> occ!rrence of pancreatic lesions in the high"dose males =pancreas was not examined in the low"dose and mid"dose gro!ps>. clears in 7 days sligh! irri!a!ion nega!ive +ategory *** *1 . 00137139. Based on these findings@ the systemic 4 E9 is M +/// ppm =not determined definitively> for &oth sexes. They are accepta&le for reregistration =3RIDs 6+6//2/+@ and 6+6//2/.> In a second ./"day feeding st!dy CD"+ mice were fed diets containing /@ .0 mg?*g?day@ respectively =females>. Body weight gains of the low"dose and mid"dose gro!ps were compara&le to those of the controls. 0013713$. 001371#0 ther st!dies s!&mitted to the #gency give similar res!lts.GLYPHOSATE RED September 1993 Acute Toxicity Test 0ye *rri!a!ion '1( +ermal *rri!a!ion '2( 2kin 2ensi!i3a!ion '3( *esult mild irri!a!ion.and +. The following findings were regarded as possi&ly treatment"relatedB =+> increased ser!m phosphor!s and potassi!m in all treated gro!ps@ males and femalesI =.> &./-*+s 00137137./-*+ #1#0060# 3 ./-*+ #1#00603 2 . S!&chronic Toxicity In a .

2 months. or .1// mg?*g.562/> The re:!ired . Treatment"related effects o&served only in the high dose gro!ps incl!dedB =+> very slight erythema and edema in intact and a&raded s*in of &oth sexesI =.> decreased food cons!mption in malesI and =0> decreased ser!m lactic dehydrogenase in &oth sexes. These levels were e:!ivalent to /@ 0@ +/ and 0+ mg of glyphosate?*g?day@ respectively@ for the males and /@ 0@ ++ and 06 mg of glyphosate?*g?day@ respectively@ for the females./"day feeding st!dy in dogs is satisfied &y the one"year dog feeding st!dy. =3RID ///025/0> In a .05-. There were no effects &ased on any of the parameters examined =toxic signs@ mortality@ &ody weights@ food cons!mption@ hematology@ clinical chemistry@ !rinalysis@ organ weights and organ?tiss!e pathology>. =3RID ///. The ra&&its were exposed for three consec!tive wee*s@ 2 ho!rs?day@ 1 days?wee*. The levels of glyphosate tested were +/@ +/// or 1/// mg?*g?day.or ++50 . years. =3RID ///.GLYPHOSATE RED September 1993 &ody weight gains in &oth sexes@ the 4 E9 for systemic toxicity is 1// mg?*g and the 9 E9 is .> # second chronic feeding?carcinogenicity st!dy was cond!cted !sing male and female Sprag!e"Dawley rats which were fed diets containing /@ .6/ mg?*g?day@ respectively@ for the males and /@ ++0@ 61. Based on these effects@ the 4 E9 for males and females is +/// mg?*g?day and the 9 E9 is 1/// mg?*g?day.+"day dermal st!dy glyphosate was applied to the s*in of 4ew Nealand white ra&&its !sing +/ ra&&its?sex?dose =1 with intact and 1 with a&raded s*in>.//// ppm of glyphosate for .@ 02. Therefore@ the 4 E9 for systemic toxicity is $ 0// ppm =HDTI malesB 0+ mg?*g?day and femalesB 06 mg?*g?day>. Chronic Toxicity # chronic feeding?carcinogenicity st!dy was cond!cted !sing male and female Sprag!e"Dawley rats which were fed diets containing /@ 0/@ +// or 0// ppm of glyphosate for . These levels were e:!ivalent to /@ 5.///@ 5/// or . =3RID //+100-6> c.

GLYPHOSATE RED September 1993 mg?*g?day@ respectively@ for the females.> In the malesB increased incidence of cataracts and lens a&normalities@ decreased !rinary . Treatment"related effects o&served only in the high"dose gro!p incl!dedB =+> In the femalesB decreased &ody weight gainsI and =.

=3RID //+100-6> d.or ++50 mg?*g?day> for . Therefore@ the 4 E9 for systemic toxicity is $ 1// mg?*g?day@ for &oth sexes. mg?*g?day and femalesB 61mg?*g?day> and the 9 E9 is . There were no effects &ased on all parameters examined@ in all gro!ps.2 months. The #gency also concl!ded that this st!dy was not cond!cted at high eno!gh dose levels for an ade:!ate negative carcinogenicity. Therefore@ the 4 E9 for systemic toxicity is 5/// ppm =malesB 02.GLYPHOSATE RED September 1993 pH@ increased a&sol!te liver weight and increased liver weight?&rain weight ratio =relative liver weight>.> # chronic feeding?carcinogenicity st!dy was cond!cted !sing Sprag!e"Dawley rats fed diets containing glyphosate =malesB /@ 5.//// ppm =HDTI malesB .@ 02. However@ the #gency concl!ded that these neoplasms were not treatment"related and glyphosate was not considered to &e carcinogenic in this st!dy &eca!se the incidence of thyroid carcinomas was not statistically significant and the incidence of testic!lar t!mors was within the historical incidence. years.> hepatocell!lar =liver> adenomas in the low"dose and high" dose malesI and =0> thyroid C"cells .6/ mg?*g?day and femalesB /@ ++0@ 61./@ +// or 1// mg?*g?day for one year.6/ mg?*g?day and femalesB ++50 mg?*g?day>.05-. 4o significant systemic effects were o&served in the low"dose and mid"dose male and female gro!ps. Carcinogenicity # chronic feeding?carcinogenicity st!dy was cond!cted !sing Sprag!e"Dawley rats which were fed diets containing glyphosate =malesB /@ 0@ +/ or 0+ mg?*g?day and femalesB /@ 0@ ++ or 06 mg?*g?day> for . or . The st!dy showed a slightly increased incidence of =+> pancreatic islet cells adenomas in the low"dose and high"dose malesI =. =3RID 6+2605/+> # chronic st!dy was cond!cted !sing male and female &eagle dogs which were given glyphosate in gelatin caps!les containing /@ . The following findings were o&served in the high"dose gro!ps when compared with the conc!rrent controlsB =+> increased incidence of thyroid C"cell carcinomas in femalesI and =. =3RID ///.> increased incidence of interstitial cell =9eydig cell> testic!lar t!mors.

GLYPHOSATE RED September 1993

adenomas in the mid"dose and high"dose males and females. The #gency concl!ded that these

GLYPHOSATE RED September 1993

adenomas were not treatment"related and glyphosate was not considered to &e carcinogenic in this st!dy. Cith respect to pancreatic islet cells adenomas@ there was no statistically significant positive dose"related trend in their occ!rrenceI there was no progression to carcinomasI and the incidence of pancreatic hyperplasia =non"neoplastic lesion> was not dose" related. Cith respect to hepatocell!lar adenomas@ the increased incidence of these neoplasms was not statistically significant in comparison with the controlsI the incidence was within the historical control rangeI there was no progression to carcinomasI and the incidence of hyperplasia was not compo!nd"related. Cith respect to thyroid C" cell adenomas@ there was no statistically significant dose"related trend in their occ!rrenceI the increased incidence was not statistically significantI there was no progression to carcinomasI and there was no significant dose"related increase in severity or incidence of hyperplasia in either sex. =3RID 6+2605/+> # carcinogenicity st!dy in mice was cond!cted with CD"+ mice fed diets containing /@ +1/@ -1/ or 61// mg?*g?day of glyphosate for +5 months. 4o effects were o&served in the low" dose and mid"dose gro!ps. The following findings were o&served in the high"dose gro!pB =+> decreased &ody weight gain in males and femalesI =,> increased incidence of hepatocell!lar hypertrophy@ hepatocell!lar necrosis and interstitial nephritis in malesI =0> increased incidence of proximal t!&!le epithelial &asophilia and hypertrophy in femalesI and =6> slightly increased incidence of renal t!&!lar adenomas@ a rare t!mor@ in males. Based on these effects@ the systemic 4 E9 and 9 E9 were -1/ mg?*g?day and 61// mg?*g?day@ respectively. The #gency concl!ded that the occ!rrence of these adenomas was spontaneo!s rather than compo!nd"ind!ced &eca!se the incidence of renal t!&!lar adenomas in males was not statistically significant when compared with the conc!rrent controls. #n independent gro!p of pathologists and &iometricians also cond!cted extensive eval!ations of these adenomas and reached the same concl!sion. Therefore@ glyphosate was not considered to &e carcinogenic in this st!dy. =3RIDs //+0/6/2@ and //+1/126> n E!ne ,2@ +..+@ the #gency classified glyphosate in %ro!p E =evidence of non"carcinogenicity for h!mans>@ &ased on a lac* of convincing evidence of carcinogenicity in ade:!ate

GLYPHOSATE RED September 1993

st!dies with two animal species@ rat and mo!se.

Therefore@ the 4 E9 and 9 E9 for maternal toxicity are +/// mg?*g?day and 01// mg?*g?day@ respectively. =3RID ///6202. =3RID ///62020> f. Treatment"related effects o&served only in the high" dose dams incl!dedB =+> diarrheaI =.> nasal dischargeI and =0> death =+/?+2 or 2.> decreased mean &ody weight gainI =0> &reathing rattlesI =6> inactivityI =1> red matter aro!nd the nose and mo!th@ and on forelim&s and dorsal headI =2> decreases in total implantations?dam and invia&le fet!ses?damI and =-> deaths =2?. Therefore@ the 4 E9 and 9 E9 for maternal toxicity are +-1 mg?*g?day and 01/ mg?*g?day@ respectively..1A of does died &y gestation day . Treatment"related developmental effects o&served only in the high"dose gro!p incl!dedB =+> increased n!m&er of litters and fet!ses with !nossified sterne&raeI and =. D!e to high maternal mortality at the 01/ mg?*g?day dose level@ too few litters =only 2> were availa&le to assess ade:!ately developmental toxicity at that level.GLYPHOSATE RED September 1993 e.> In a second st!dy@ pregnant D!tch Belted ra&&its were administered /@ -1@ +-1 or 01/ mg?*g?day of glyphosate &y gavage d!ring gestation days 2 thro!gh .1 or .> decreased mean fetal &ody weights.+>.-.. The 4 E9 and 9 E9 for developmental toxicity are +/// mg?*g?day and 01// mg?*g?day@ respectively. Treatment"related findings were o&served only in the high"dose gro!p and incl!dedB =+> diarrheaI =. The only effect o&served was an increased incidence of focal t!&!lar dilation of the *idney =&oth !nilateral and &ilateral com&ined> in the high"dose male $ 0& p!ps.6A of the gro!p>. Developmental toxicity was not o&served at any dose tested. Therefore@ the 4 E9 for systemic and reprod!ctive toxicity . The 4 E9 for developmental toxicity is $ +-1 mg?*g?day. Developmental Toxicity # developmental toxicity st!dy was cond!cted with pregnant Charles River C BS CD rats which were administered /@ 0//@ +/// or 01// mg?*g?day of glyphosate &y gavage d!ring gestation days 2 thro!gh +. Reprod!ctive Toxicity # reprod!ction st!dy was cond!cted with male and female Sprag!e"Dawley rats which were administered /@ 0@ +/ or 0/ mg?*g?day of glyphosate contin!o!sly in the diet for three s!ccessive generations.

GLYPHOSATE RED September 1993 is $ 0/ mg?*g?day =HDT>. The .

Treatment"related effects o&served only in the high" dose gro!p incl!dedB =+> soft stools@ very fre:!ent@ in the $ o and $ + males and femalesI =. Based on the a&ove findings@ the systemic 4 E9 and 9 E9 are +//// ppm =1// mg?*g?day> and 0//// ppm =+1// mg?*g?day>@ respectively.> decreased food cons!mption and &ody weight gain of the $ o and $+ males and females d!ring the growth =premating> periodI and =0> decreased &ody weight gain of the $ +a@ $. The reprod!ctive 4 E9 is 0//// ppm =+1// mg?*g?dayI HDT>I and the developmental 4 E9 and 9 E9 are +//// ppm =1// mg?*g?day> and 0//// ppm =+1// mg?*g?day>@ respectively. .1> #nother reprod!ction st!dy was cond!cted with Sprag!e" Dawley rats which were administered /@ +//@ 1// or +1// mg?*g?day of glyphosate contin!o!sly in the diet for two s!ccessive generations....1>@ the #gency concl!ded that the latter was a sp!rio!s rather than glyphosate"related effect.+1/+> Since the focal t!&!lar dilation of the *idneys was not o&served at the +1// mg?*g?day level =HDT> in the .GLYPHOSATE RED September 1993 4 E9 and 9 E9 for developmental toxicity are +/ mg?*g?day and 0/ mg?*g?day@ respectively.a and $. =3RID 6+2."generation rat reprod!ction st!dy &!t was o&served at the 0/ mg?*g?day level =HDT> in the 0"generation rat reprod!ction st!dy =//+/1.1>@ was not o&served at any dose level in this st!dy. $ocal t!&!lar dilation of the *idneys@ o&served in the previo!s st!dy =//+/1. =3RID //+/1.& male and female p!ps d!ring the second and third wee*s of lactation.

su$tilis H+. hc r and Salmonella typhimurium strains T#./> # gene m!tation assay in mammalian cells was cond!cted !sing glyphosate in the Chinese hamster ovary =CH > cells?hypoxanthine " g!anine "phosphori&osyl transferase =H%'RT> assay@ with and witho!t meta&olic activation. The strains of Salmonella typhimurium !sed were T#.5@ T#+//@ T#+101 and T#+10-. #mino methyl phosphonic acid =#3'#> was the only meta&olite fo!nd in !rine =/..250> In a fo!rth st!dy@ glyphosate was tested in two assaysB the rec"assay !sing !. In the first st!dy@ single or repeated doses of radiola&eled +6C"glyphosate were administered orally to male and female Sprag!e"Dawley rats.25+> # Str!ct!ral Chromosomal #&erration #ssay was cond!cted !sing a single dose of glyphosate administered intraperitoneally =i. .5@ T#+//@ T#+101@ T#+10and T#+105@ with and witho!t meta&olic activation.0A of the . 4o increases in reverse m!tations were o&served at any concentration. =3RID //+0. 4o m!tagenic response was o&served either with or witho!t meta&olic activation !p to the limit of cytotoxicity =+/ mg?3l>. 4inety"seven point five percent of the administered dose was excreted in the !rine and feces as the parent compo!nd@ glyphosate.> to male and female Sprag!e"Dawley rats. coli C'. =3RID ///-52+.> h.-A of the dose was eliminated as C .GLYPHOSATE RED September 1993 g. The dose !sed was + g?*g of &ody weight and the &one marrow cells were examined for clastogenic =chromosome"damaging> effect."/. 4o increases in m!tations were o&served in either st!dy. =3RID ///-52. =3RID //+0. 3eta&olism Two meta&olism st!dies with rats are availa&le. $ollowing a single oral dose of +6 C"glyphosate@ 0/ to 02A of the dose was a&sor&ed and less than /.p.=recL> and 361 =rec">I and the reverse m!tation assays !sing E. 4o significant clastogenic effects were o&served. 3!tagenicity # %ene m!tation assay in an #mes Test was cond!cted !sing glyphosate@ &oth with and witho!t meta&olic activation..

GLYPHOSATE RED September 1993 administered dose> and feces =/. 9ess than +."/.6A of the administered dose>./A of the ..

The dose level of glyphosate !sed for male and female rats was ++1/ mg?*g.1@ 6@ or +/ ho!rs after in(ection. $emoral &one marrow samples were collected from one third of the male and female rats sacrificed at /. =3RIDs 6/-2-+/+@ and 6/-2-+/. Thirty min!tes after in(ection of glyphosate@ the concentration of radioactivity in the &one marrow of male and female rats was e:!ivalent to /. Similarly@ the half"lives of the radioactivity in plasma were approximately + ho!r for &oth sexes. =3RID //+0.. ho!rs for males and females@ respectively. .1/@ +@ .GLYPHOSATE RED September 1993 a&sor&ed dose remained in tiss!es and organs@ primarily in &one tiss!e.A@ respectively@ of the administered dose./"day ne!rotoxicity screening &attery in the rat =g!idelines 5+"5"SS@ 5.//-.1@ /. Blood samples were collected /..251> i. 4e!rotoxicity The ac!te and .@ 6@ 2 and +/ ho!rs after in(ection. #ss!ming first order *inetics@ the decrease in radioactivity in &one marrow occ!rred with a half"life of -. Repeated dosing at +/ mg?*g did not significantly change the meta&olism@ distri&!tion or excretion of glyphosate.2 and 6. These findings indicate that very little glyphosate reaches &one marrow@ that it is rapidly eliminated from &one marrow and that it is even more rapidly eliminated from plasma."-> is not &eing re:!ired since there was no evidence of ne!rotoxicity seen in any of the existing st!dies at very high doses and this chemical lac*s a leaving gro!pI therefore@ it wo!ld not seem li*ely to inhi&it esterases =the pres!mptive ne!rotoxic mechanism of concern for all organophosphates>.//66A and /.> In a second st!dy@ male and female Sprag!e"Dawley rats received single intraperitoneal in(ections of radiola&eled +6C" glyphosate.

. *.52@ the Eoint $ood and #gric!lt!ral rgani7ation of the 8nited 4ations =$# >?Corld Health rgani7ation =CH > on 'esticides Resid!es OE3'RP proposed an #llowa&le Daily Inta*e =#DI> of /.@ the #gency<s ffice of 'esticide 'rograms Reference Dose =RfD> 'eer Review Committee recommended that the RfD for glyphosate &e esta&lished at . The #DI was &ased on a .A of the individ!al technical glyphosate samples contained less than +.. Domestic #nimal Safety St!dies =52"+> are not &eing re:!ired for the !se patterns of glyphosate =a plant growth reg!lator and her&icide>. Technical grade glyphosate contains 4"nitrosoglyphosate =44%> as a contaminant.2" month st!dy whereas maternal mortality was o&served in the developmental ra&&it st!dy in the high dose gro!p. #nalyses showed that greater than ..2"month feeding st!dy in the rat yielding a 4 E9 of Q 0+ mg?*g &ody weight per day and and !ncertainty factor of +//. The #gency places more importance on the developmental ra&&it st!dy since no effect was o&served in the .GLYPHOSATE RED September 1993 (./ ppm 44%.> with technical grade glyphosate is not &eing re:!ired &eca!se there are no toxicological endpoints to indicate this st!dy is necessary. mg?*g?day.-@ +. In Septem&er of +. This RfD has not yet &een confirmed &y the #gency RfD Cor* %ro!p. The #gency concl!ded that the 44% content of glyphosate was not toxicologically significant.0 mg?*g &ody weight for glyphosate per se. This val!e was &ased on the maternal 4 E9 of +-1 mg?*g?day from the ra&&it developmental toxicity st!dy =///62020> and an !ncertainty factor =8$> of +//. ther Toxicological Endpoints # dermal penetration st!dy =g!ideline 51". E3'R . Carcinogenicity testing of nitroso contaminants is normally re:!ired only in those cases in which the level of nitroso compo!nds exceeds +. Reference Dose n #!g!st ./ ppm.

St!dies with lactating goats and laying hens fed a mixt!re of glyphosate and #3'# indicate that the primary ro!te of elimination was &y excretion =!rine and feces>. 3eta&olism via 4" methylation yields 4"methylated glycines and phosphonic acids. . ppm for #3'#.. The :!alitative nat!re of the resid!e in animals is ade:!ately !nderstood. St!dies with a variety of plants incl!ding corn@ cotton@ soy&eans@ and wheat indicate that the !pta*e of glyphosate or its meta&olite@ aminomethyl phosphonic acid =#3'#>@ from soil is limited. These res!lts are consistent with meta&olism st!dies in rats@ ra&&its@ and cows. Dietary Expos!re The :!alitative nat!re of the resid!e in plants is ade:!ately !nderstood./+. The terminal resid!es in eggs@ mil*@ and animal tiss!es are glyphosate and its meta&olite #3'#I there was no evidence of f!rther meta&olism. This method !tili7es %9C =3ethod I of '#3 Hol. The material which is ta*en !p is readily translocated. Expos!re #ssessment a.+1 ppm> along with resid!es &elow the level of detection =M/. 3!ch of the resid!e data for crops reflects a detecta&le resid!e of parent =/./1 ppm> of #3'#./1 " /./+ ppm for glyphosate and /. . The terminal resid!e to &e reg!lated in livestoc* is glyphosate per se.2"month rat st!dy. $or the most part@ the ratio of glyphosate to #3'# is . III limit of detection is /. $oliarly applied glyphosate is readily a&sor&ed and translocated thro!gho!t the trees or vines to the fr!it of apples@ coffee@ dwarf citr!s =calamondin>@ pears and grapes.GLYPHOSATE RED September 1993 ac*nowledged that there is no effect at the highest dose tested in the . to + &!t can approach + to + in a few cases =e.g. #n ade:!ate enforcement method is availa&le for analysis of resid!es of glyphosate and its meta&olite #3'# in or on plant commodities and in water. The terminal resid!e to &e reg!lated in plants is glyphosate per se. $or enforcement of tolerances in animal commodities@ an H'9C method with fl!orescence detection is availa&leI the reported limits of detection are /.@ soy&eans and carrots>./1 ppm>.

In addition@ glyphosate is poorly a&sor&ed dermally. &.6. %lyphosate@ when applied at lower rates@ is also a plant growth reg!lator. =$or these . The ac!te inhalation toxicity st!dy for the technical material was waived &eca!se glyphosate is non"volatile and &eca!se there were ade:!ate inhalation st!dies with end"!se prod!cts showing low toxicity. #ll data re:!irements for magnit!de of the resid!e in plants have &een eval!ated and deemed ade:!ate.e carcinogenicity> occ!pational and residential expos!re data are not re:!ired. cc!pational and Residential cc!pational and residential expos!re can &e expected &ased on the c!rrently registered !ses of prod!cts containing glyphosate. # list of resid!e chemistry st!dy references is provided on page . #c!te oral and dermal toxicity data for the technical material are in Toxicity Category III and IH. Therefore@ occ!pational and residential expos!re data are not re:!ired to s!pport the reregistration of glyphosate. #dditional potato processing data are &eing generated.GLYPHOSATE RED September 1993 The availa&le storage sta&ility data indicate that resid!es of glyphosate and its meta&olite #3'# are sta&le !nder fro7en storage conditions =". 4o additional storage sta&ility data are needed. years@ and in water for + year. %lyphosate is a non"selective her&icide applied to terrestrial food and non"food crops@ t!rf@ greenho!se crops@ and non" crop areas where total vegetation control is desired. #ltho!gh glyphosate meets the #gency<s expos!re criteria for post"application?reentry and?or mixer?loader?applicator expos!re monitoring data@ glyphosate does not meet the #gency<s toxicity criteria for these data re:!irements./EC>B in or on plant commodities for a period of + year@ in animal commodities for . However@ d!e to the low toxicity =ac!te category III> of glyphosate and the lac* of other toxicological concerns =i. 4o additional data are re:!ired for magnit!de of the resid!e in animals@ pota&le water@ and fish. #ll data re:!irements for magnit!de of the resid!e in plants as a res!lt of irrigation with glyphosate"treated water have also &een s!&mitted and are ade:!ate to s!pport registered !se and applica&le tolerances.

> The following information is prod!ct"specific related@ &!t is presented here for informational p!rposes. In reports iss!ed &y California since then =+.5and +. Some glyphosate end" !se prod!cts are in Toxicity Category I and II &ased on primary eye irritation or dermal irritation. The #gency did not re:!ire personal protective e:!ipment for !sers of DhomeownerD prod!cts =containing !p to +/A glyphosate> &eca!se of the low concentration of glyphosate and &eca!se the prod!cts are Dready"to"!seD@ re:!iring no mixingI therefore@ the potential for eye or dermal expos!re is minimi7ed. The #gency@ at this time@ is not adding any additional personal protective e:!ipment re:!irements to the la&els of end" !se prod!ctsI however@ any existing personal protective e:!ipment on those la&els m!st &e retained. The #gency has determined that the +. The Cor*er 'rotection Standard =C'S> for #gric!lt!ral 'esticides "" 6/ C$R 'arts +12 and +-/ "" esta&lished an interim restricted entry interval =REI> of +. #t that time@ it was determined that mixer?loaders were at ris* of eye or s*in in(!ry from splashes d!ring mixing and loading. These mixer?loader?applicator reported incidents consisted of eye and s*in irritation."ho!r REI for all C'S sites sho!ld &e retained as a pr!dent meas!re to mitigate ris* to wor*ers entering treated areas after application.GLYPHOSATE RED September 1993 same reasons@ these data were not re:!ired in the +.52 Registration Standard.55>@ glyphosate contin!ed to &e a leading ca!se of illnesses or in(!ries =primarily eye and s*in irritation>. $!rthermore@ given the *nown irritation" effects concerns for glyphosate@ the #gency considers the additional protections offered &y the re:!irements in the C'S essential to its decision that a +.5/ and +. In the +.52 Registration Standard@ the #gency recommended personal protective e:!ipment@ incl!ding protective eyewear for mixer?loader?applicators !sing end"!se prod!cts that co!ld ca!se eye or s*in irritation. ho!rs for glyphosate &eca!se the ac!te toxicity categories of glyphosate for ac!te dermal toxicity@ s*in irritation potential@ and eye irritation potential are Toxicity Category III or IH."ho!r REI for this chemical will .1 leading ca!ses of illnesses or in(!ry d!e to pesticides !sed &etween +.56. In California@ where physicians are re:!ired to report pesticide poisonings@ glyphosate was ran*ed third o!t of the .

.GLYPHOSATE RED September 1993 offer s!fficient ris* mitigation to wor*ers.

1 mg?*g &wt?day@ which represents +. 0. The incl!sion of recommended tolerances for reregistration as well as tolerances recommended for revocationI the !se of the highest existing@ pending@ or recommended resid!e val!e for each commodityI and the ass!mptions of tolerance level resid!es and treatment of +// percent of the crops for every commodity considered res!lt in an overestimation of expos!re and ris* val!es for glyphosate =tho!gh there is some .. pop!lation s!&gro!ps. The predicted fre:!ency@ d!ration@ and degree of expos!re d!e to post"application as the res!lt of s!ch !ses sho!ld not warrant the ris* mitigation meas!res &eing re:!ired for persons engaged in the prod!ction of agric!lt!ral plants for commercial or research p!rposes./.. pop!lation from food !ses of glyphosate is /. pop!lation and .S. This analysis was meant to &e a Dworst caseD scenario of ris*.A of the RfD. Dietary The chronic dietary ris* analysis !sed tolerance level resid!es and ass!med all acreage@ of the crops considered@ was treated with glyphosate to estimate the Theoretical 3axim!m Resid!e Contri&!tion =T3RC> for the overall 8.. These expos!res =T3RCs> were then compared to the RfD for glyphosate to estimate chronic dietary ris*.A of the RfD. The calc!lated T3RC for the overall 8. The s!&gro!p most highly exposed@ non"n!rsing infants less than one year old@ has a T3RC of /.. ver one third of the dietary expos!re and ris* from glyphosate is d!e to the proposed tolerances on wheat.S. Ris* #ssessment a./15 mg?*g &wt?day@ or .GLYPHOSATE RED September 1993 Therefore@ d!ring the REI the #gency will allow wor*ers to enter areas treated with glyphosate d!ring the REI only in the few narrow exceptions allowed in the C'S. The #gency has determined that@ at this time@ the entry restrictions disc!ssed in this section need not apply to !ses of glyphosate o!side the scope of the Cor*er 'rotection Standard for #gric!lt!ral Chemicals@ incl!ding o!t"of"scope commercial !ses and homeowner !ses.

GLYPHOSATE RED September 1993 !nderestimation d!e to the lac* of cons!mption information for some of the commodities to which .

c. 0007$$2#. 0010$1#0. 00036222. 0010$099. 000###23. 000376$$. 00067#25. 0010$231. 000519$0. 000519$2. 0010$100. 0010$101. #19#0701 6171-# 'b(7 %nimal /e!abolism 6171-# 'c( and 'd(7 -esidue %naly!ical /e!hods 6171-# 'e(7 2!orage 2!abili!y . &. 00061555. 0010$1##. 000391#1. 00036231. 0010$116. 0010$1#9. 0010$175. 00053002. #0502601. #05#130# 000391#2. 00159#19. 0010$151. 0010$1$6. 00065752. 0007$$23. 0010$129. 00061559. 00061553. 0006371#. 00065753. 000519$3. #0502605. 00076$05. 000#00$3. 0010$176. 0010$097. 0010$151. cc!pational and Residential #s disc!ssed a&ove in the occ!pational expos!re assessment@ expos!re to h!mans from proper application of glyphosate to terrestrial food and non"food crops as well as greenho!ses@ t!rf@ and non"crop areas can res!lt in in(!ry =primarily eye and s*in irritation> from splashes d!ring mixing and loading. #053200#. 4uideline"5ommodi!y 6171-# 'a(7 8lan! /e!abolism -e erences 1 0003$771. 0003$770. 0016#729. 0010$099. 0010$09$. 00122715. 00065751. The #gency contin!es to recommend protective clothing =incl!ding protective eye wear> for mixer?loader?applicators !sing end"!se prod!cts that may &e in toxicity category I or II for primary eye and dermal irritation. 0006010$. 0010$200. 00053002. 001119#5 0009#971. 4onetheless@ given the ris* val!es arrived at &y this analysis@ E'# concl!des that the chronic dietary ris* posed &y this pesticide on these food !ses is minimal. 00053005.GLYPHOSATE RED September 1993 glyphosate is expected to &e applied>. Dietary Expos!re References This ta&le references the resid!e data !sed to s!pport the reregistration of glyphosate and incl!des the commodities eligi&le for reregistration. 0003$979. #05#1301-#05#130# 0002$$53. 001119#5. 0010$133. 0010$133. 0010$129. 001119#9. 00036223. 0010$132.

#19#7001 0010$159 ."% #07$3101 .ulb 1ege!ables 4roup . 0010$151 #0$35201 .ee!s."% .5arro!s . 0010$151 0010$151 #0$35201 -e erences 1 .8arsnips .rassica( 4roup .."% 000393$1."% 0010$159 ."% ."% 0010$159 0010$159 .2ugar bee!s .%r!ichokes.GLYPHOSATE RED September 1993 4uideline"5ommodi!y 6171-# 'k( 'l(7 /agni!ude o !he -esidue in 8lan!s -oo! and 9uber 1ege!ables 4roup .5hicory .9urnips =eaves o -oo! and 9uber 1ege!ables 4roup .."% .ee!s.4arlic .8o!a!oes ."% .-adish .5hicory leaves .2pinach . garden .<orseradish . :erusalem .-u!abagas .9urnip !ops ."% 000393$1.2wee! po!a!o .2ugar bee! !ops ."% . greens .5elery .=e!!uce 'head and lea ( ."% 0010$151.2alsi y .&nions 'green and dry bulb( =ea y 1ege!ables 'e>cep! .

#0$02$01 0010$159 .5abbage . 0010$203 00061555. 00015762. 0003$90$..2oybean orage and hay 0010$159 0010$159 00015759. #0$02$01 -e erences 1 00015759. 00015761. 0003$90$.5auli lower . 00015765. 00015760. 00015762. 000#00$#.. 00015763. 0010$153. 00156793 'processed commodi!ies( @oliage o =egume 1ege!ables '2ucculen!"+ried( 4roup . 0003395#.8ea vines and s!raw .=en!il orage and hay .eans 'succulen! and dried( . 00015767. 0003395#. 0010$153.GLYPHOSATE RED September 1993 4uideline"5ommodi!y ."% #0$02$01. 00015761./us!ard greens =egume 1ege!ables '2ucculen!"+ried( 4roup . 00015767. 0001576#. 00015760."% . 0002#503.roccoli . 00015766.?ale . 00015766.ean vines and hay .=en!ils . 00061555.. 0010$153. 0010$203 @rui!ing 1ege!ables 4roup 5ucurbi! 1ege!ables 4roup 5i!rus @rui!s 4roup 'processed commodi!ies( 8ome @rui!s 4roup 2!one @rui!s 4roup 000391#2 #0159#01 0010$129 001119#9 . 00061555. 000#00$#. 00015765. 00015763.2oybeans 0010$159 0010$159 0010$159 #0$02$01.rassica =ea y 1ege!ables 4roup .8eas 'succulen! and dried( . 0001576#.

4rapes 'processed commodi!ies( .arley 'processed commodi!ies( .. 000#00$7. #1#7$101 0003$90$. 000###22. 000###22."% ."% 00023336. 00023512. 000###22."% 0003$90$.5ranberries .. 00109271.8lums ' resh prunes( 001119#9 -e erences 1 2mall @rui!s and . 000#00$7. #1#$#301 00150$35 001119#5 001119#5 00053002 0003$770.Ahea! 'processed commodi!ies( @orage. 0010$203 .. 000#00$7.. 000###22.&a!s 'processed commodi!ies( .u!s 4roup . #0502602 #050260#."% . 00122715. hay.-ice 'processed commodi!ies( . 000376$7."% 0003$90$.GLYPHOSATE RED September 1993 4uideline"5ommodi!y .-aspberries 9ree . @odder. 000#00$7. 0010$203. 000#00$6. 000#00$5.erries 4roup .arley orage. 000###22 . 000#00$7. 0010$203 0003$90$. 000#$2$#.2orghum 'processed commodi!ies( . 0010$203. 000###26. 0003$90$. #0502601 #0502603 0003$90$.5orn ' ield and resh( 'processed commodi!ies( .lueberries .%lmond hulls 5ereal 4rains 4roup .lackberries . 0010$203. 0010$132 #07$5303 . and 2!raw o 5ereal .-ye 'processed commodi!ies( . and s!raw 4rains 4roup 0003$90$. 0010$203 .

000376$7.-ice s!raw ."% 0003$90$. 0010$176. 0010$203. 000#00$7.%vocados . s!raw. #0502601 0003$90$.4enip .on-grass %nimal @eeds ' orage.read rui! .%sparagus . 00023512. 000###22 .@igs .:ack rui! 00059050 #01#9#01 #01#9#01 000519$0. 00122715 00076$05.5orn orage and odder .%!emoya .%l al a seed /iscellaneous 5ommodi!ies . 0010$153.Ahea! orage and s!raw 4rass @orage. 000###26.GLYPHOSATE RED September 1993 4uideline"5ommodi!y . 0010$203 0003$90$. 000519$1 0010$1##. and <ay 4roup . #06#2#01 0010$1#9 0010$175 #01#9#01 #01#9#01 -e erences 1 00023336. 000#00$7.4uavas .:abo!icaba . 0010$203 00061553.2orghum orage and odder .5oconu! .5arambola . 0010$176.. 000###22. hay. 0010$203. @odder.ananas . 0010$1#7 00076$05.5o!!on 'processed commodi!ies( . #0502602 0003$90$. and hay( 4roup . 000#00$7.%cerola .-ye orage and s!raw .5ocoa beans . 0010$203. 0010$153 #01#9#01 ..5anis!el . 000###22. and s!raw . 0010$1#7 #05#130# 00060103.&a! orage.+a!es . 000#00$6. 00109271. odder. 0003$90$.5o ee beans . 00061553. 000#00$5. 000#$2$#.5herimoya .

2ugar apple . 00155120 . #239$#01 -e erences 1 0010$115. 0002$$52 #01#9#01 . #0532001-03 00036229.?iwi rui! ."% 000393$1. 0007$$2# .8alm oil . 00076#91. and 0ggs 6171-# 'g(7 /agni!ude o !he -esidue in @ish 0010$1#0 0010$16$ #01#9#01 0007$$23.GLYPHOSATE RED September 1993 4uideline"5ommodi!y .8ineapple ./amey 2apo!e '/ammee %pple( .=i!chi .8ersimmons ."% 001119#5 00063713 #05$0#01 . #05#1305 #01#9#01 #01#9#01 001##3#1.&kra .=ongan .9ea . #239$#01 0010$175.2oursop . /ilk. 0015#311.2apodilla .9amarind .8assion @rui! .8apayas .8eanu!s 'processed commodi!ies( .Aa!ercress 6171-# 'h(7 /agni!ude o !he -esidue in 8lan!s -esul!ing rom !he Bse o *rriga!ion Aa!er 6171-# 'C(7 /agni!ude o !he -esidue in /ea!. 0002$$52 001##3#1.8is!achio .&lives 'processed commodi!ies( ./angoes .2ugarcane 'processed commodi!ies( ."% 0010$175. 8oul!ry.2apo!e 'black and whi!e( .u! '=ychee( .

00077229.> 'hotodegradation in Cater %lyphosate is sta&le to photodegradation in pH 1@ -@ and . 6171-# 'i(7 /agni!ude o !he -esidue in @ood <andling 0s!ablishmen! 6171-57 -educ!ion o -esidues 1 .a!ure and /agni!ude !he -esidue in +rinking and *rriga!ion Aa!er -e erences 1 00039377. 00077232. at 1 and 01EC. =#ccession //+/5+..+/+> =0> 'hotodegradation on Soil %lyphosate is sta&le to photodegradation on soil. Environmental $ate a. Environmental $ate and Transport =+> Hydrolysis %lyphosate is sta&le at pH 0@ 2@ .> =. 00077233. 00077236. 00077231. 5hemis!ry . 0007723#. 00077301. 0010$173.-2E 10665( in !he <eal!h 0 ec!s +ivision da!ed 10"27"92 !hrough @&*D ( En+ironmental Assessment +.ranch -eregis!ra!ion 2uppor! '5. 0007722$. 0007723$. addi!ional re erence in orma!ion can be provided rom 9able % in !he 8roduc! and -esidue 5hemis!ry 5hap!ers by -D. 00077237. 00077235. =3RID 6+001+/+> =6> #ero&ic Soil 3eta&olism .D 8er e!!i. 000393$1."% means no! available by /-*+ numberD 9hose guidelines"commodi!ies which do no! lis! a /-*+ re erence number. &!ffered sol!tions !nder nat!ral s!nlight.GLYPHOSATE RED September 1993 4uideline"5ommodi!y 6171-# ' (7 . 00077230. 00077227. =3RID 6+25.

..0-. #minomethyl phosphonic acid =#3'#> was the ma(or degradate. ./2 days in Ric*apoo sandy loam and D!po silt loam respectively. =3RID 6.days in flooded silty clay loam sediment that was inc!&ated in the dar* at .> =2> #ero&ic #:!atic 3eta&olism %lyphosate has a half"life of .+ days in anaero&ic =flooded pl!s nitrogen atmosphere> silty clay loam sediment. =3RID 6.@ . Some of the data from the individ!al field sites are deficientI however@ the #gency may !se the data from the eight field sites together to satisfy the terrestrial field dissipation +26"+ data re:!irement.1/.51 and .GLYPHOSATE RED September 1993 Data indicate half"life val!es of +.0-.1/0> =-> 9eaching?#dsorption?Desorption Rd val!es of 2. #3'# was the ma(or degradate.@ ///-26./@ -/@ . =3RID 6.1/+> =1> #naero&ic #:!atic 3eta&olism %lyphosate has a half"life of 5./D of water@ the recovered radioactivity in the soils was .soils with .0-.1C for 0/ days.0"+//A of the applied material. #fter =aged> leaching .@ and +-1 were reported for Dr!mmer silty clay loam@ Ray silt@ Spin*s sandy loam@ 9intonia sandy loam@ and Cattail Swamp sediment respectively.0@ //+/5+6/> =5> Terrestrial $ield Dissipation The #gency has received an interim report on a terrestrial field dissipation st!dy in progress &y 3onsanto Company.2 S /..2/-1/+> This report contains data from eight different field sites. #3'# was the ma(or degradate. =3RID 6. =#ccessions //+/5+.6.

inch layer in 3innesota@ 4ew Kor* and Texas@ and glyphosate was detected at generally M/. In #ri7ona at .6 inch soil layer. #ccepta&le aero&ic soil@ aero&ic a:!atic and anaero&ic a:!atic meta&olism st!dies demonstrate that !nder those conditions at ./+ to /.+ ppm and /.GLYPHOSATE RED September 1993 The interim report res!lts from the first +.?acre> was +0.5@ and +6/.+ D#T the average glyphosate resid!es were /.2 days respectively indicating that glyphosate resid!es in the field are somewhat more persistent in cooler climates as opposed to milder ones =%eorgia@ California@ #ri7ona@ hio@ and Texas>..../1 ppm at the other 1 field sites =2"+. Soil core contamination was attri&!ted to these detections since movement of resid!es to this depth on the first day of sampling is !nli*ely."+5 and +5" . inch depth>. days with a range of ."+5 inch soil layer in .. The reported half"lives =DT1/> from the field st!dies cond!cted in the coldest climates@ ie./2@ in the +5".2 =Texas> to +6/.2 =Iowa> days. In California@ at / D#T@ average glyphosate resid!es were /./+ ppm in the 2"+.-. inch depth. %lyphosate =as well as #3'#> was shown to remain predominantly in the /"2 inch soil layer thro!gho!t the d!ration of the st!dy at all field sites. There were a n!m&er of detections from /..l& a.6 inch soil hori7ons respectively.-@ +.i.?acre@ +/.@ .5.1EC in the la&oratory glyphosate degrades rapidly with half"lives of approximately . or +. %lyphosate was detected at three different sites &elow +. 3innesota@ 4ew Kor* and Iowa@ were the longest at .and 5 days respectively.1 l& a.e. ppm in the 2" +. There were no glyphosate resid!es in the 2"+. months of &aregro!nd field dissipation trials from eight sites show that the median half"life =DT1/> for glyphosate applied at maxim!m ann!al !se rates =-. Iowa was the individ!al test site to have average glyphosate resid!es@ at all sampling times@ greater than /.+/ ppm in the +. inches./.

inches which may indicate a pro&lem with sampling techni:!e./ D#T@ and . Since there were no glyphosate resid!es detected in the 2"+.GLYPHOSATE RED September 1993 #ri7ona on . inch soil layer at +./1 ppm in the +./ D#T the average glyphosate resid!es were /.+ D#T and in s!&se:!ent samples &elow +. In Iowa at +."+5 inch soil layer.

#3'# levels were detected at /. The #3'# levels at those sites had decreased to /.6 inch soil layer on . and .+.5 days respectively. In all samples &!t three@ #3'# resid!e levels were M/. months after treatment. The half"lives for the dissipation of #3'# for seven of the eight test sites wereB .15 =California> days. The maxim!m average #3'# levels fo!nd in the /"2 inch soil layer were /.2 and +./ and +5/ D#T respectively in 4ew Kor*./1 ppm in the 2"+.+ D#T in #ri7ona and /.66 ppm at +. = hio> to .6/ days with a range of ++. In 4ew Kor* at +6 and 0/ D#T average resid!es were detected at /. inch soil layer. D#T sample average #3'# resid!es were /. and /./2 ppm in the +5" . In Iowa at the ./0 ppm in the +. Iowa and 4ew Kor* also exhi&ited 1/A dissipation times of +6/./5 ppm./2 ppm. #3'# was also shown to remain predominantly in the /"2 inch soil layer. The #3'# levels generally reached a maxim!m &etween day +6 and day 0/. # final report on the terrestrial field dissipation st!dy showed the median half"life =DT1/ > =of eight sites> of #3'# was ./6 and /. Chere the field half"lives were longer =Iowa@ 3innesota@ 4ew Kor*>@ the maxim!m average #3'# levels occ!rred &etween 2.2 ppm and occ!rred in hio and %eorgia at .-.1 D#T. #ri7ona +6.."+5 inch soil layer at . #3'# was fo!nd at every test site on Day / samples indicating the rapid degradation of parent glyphosate.+ D#T and 2+ D#T respectively. days .GLYPHOSATE RED September 1993 the lac* of a significant amo!nt of rainfall &etween sampling intervals in com&ination with the amo!nt of time &etween sampling intervals and the high adsorptive characteristics of glyphosate give an indication that there may have &een a pro&lem with sampling techni:!e.

.GLYPHOSATE RED September 1993 . days . California %eorgia 3innesota .15 days 5.2 days 0/. .

-0 ppm in tree foliage immediately posttreatment. 4ew Kor* .6/ days hio ++.5/+> =+/> $orestry Dissipation Chen aerially applied at 0.> #:!atic $ield Dissipation %lyphosate dissipated from water =irrigation so!rce> with a calc!lated half"life of -. The forestry dissipation st!dy res!lts demonstrate that when !sed !nder normal silvic!lt!re practices according to la&el directions@ the maxim!m com&ined . . It then declined rapidly with half"lives of M+ day at the 3ichigan and %eorgia sites and M+6 days at the regon site. #3'# was shown to remain predominantly in the /"2 inch soil layer thro!gho!t the d!ration of the st!dy at all eight field sites.GLYPHOSATE RED September 1993 ./ days from the sediment of the farm pond in 3isso!ri.1 days and +. The three detections were attri&!ted to contamination d!ring sampling rather than vertical mo&ility.-1 l&?# to forested sites in 3ichigan@ regon@ and %eorgia@ glyphosate averaged 21. %lyphosate acc!m!lated in the pond sediment@ and to a lesser extent in the stream sedimentsI glyphosate was present in pond sediment at $+ ppm in 3ichigan and regon at approximately + year posttreatment./1 ppm> at depths greater than +. =3RID 6/55+2/+> In 3ichigan@ %eorgia and regon pond and stream water@ the maxim!m glyphosate concentrations were meas!red immediately posttreatment and dissipated rapidly. . =. days Texas +0+ days Iowa was not calc!lated &eca!se recharging of #3'# resid!es was greater than degradation. inches. #3'# was detected three times =at a concentration greater than /. =3RID 6+11." +.

%lyphosate and #3'# resid!es in soil dissipate with time. The average half"life for the dissipation of glyphosate was +// days@ and .GLYPHOSATE RED September 1993 glyphosate and #3'# resid!e level in soil is less than 1 ppm.

ppm in carrot tops and roots@ respectively@ and /.GLYPHOSATE RED September 1993 ranged from 01 to +15 days. The average half"life for the dissipation of #3'# was ++5 days@ and ranged from -+ days to +21 days./.5 and 65 days postplanting@ O+6CPresid!es were /. In immat!re lett!ce harvested at .ppm in lett!ce@ /./12 ppm in &arley grain and straw@ respectively. =3RID 6+11./+ and 6+160.growing season with glyphosate treated water .ppm in lett!ce@ /./1. In immat!re lett!ce harvested at 01 and 2+ days postplanting@ O+6 CPresid!es were /. In crops planted at ++.5/+> =++> #cc!m!lation in Confined Rotational Crops %lyphosate resid!es =expressed as fresh weight> acc!m!lated in lett!ce@ carrots@ and &arley planted 0/@ ++./0./. days posttreatment@ O+6 CPresid!es at harvest were /./+./1./12 ppm.> #cc!m!lation in Irrigated Crops #lfalfa@ corn =grain and forage>@ grass =fesc!e or s!dan> and lett!ce were irrigated five to eight times d!ring the +.+-1 ppm in &arley grain and straw@ respectively./65 ppm@ respectively.5.> =+.ppm in carrot tops and roots@ respectively@ and /.-+ l& ai?#./11 ppm@ respectively./-5 and /. and /./. In immat!re lett!ce harvested at 6/ and 2/ days postplanting@ O+6 CPresid!es were /./2+ ppm in &arley grain and straw@ respectively.5 and /./+5 and /. In crops planted at 0/ days@ posttreatment@ O+6 CPresid!es at harvest were /.and /. =3RID 6+160.+55 and /./0.//./1+ and /. In crops planted at 026 days posttreatment@ O+6CPresid!es at harvest were /. #cc!m!lation decreased as the length of the rotation increased.5 ppm in lett!ce@ /././60 ppm@ respectivelyI in &arley forage harvested at 65 days postplanting@ O+6 CPresid!es were /./6.+/5 and /.and /.@ and 026 days after sandy loam soil was treated with glyphosate at 0.2 ppm in carrot tops and roots@ respectively@ and /.

GLYPHOSATE RED September 1993 containing a maxim!m of .62 ppm &y + day after treatment> of glyphosate. Resid!es in the sediment &eneath the treated water reached a maxim!m of 0. Resid!es .+.1 ppm at +6 days after treatment.0 ppm =on treatment day then fell to /.

ne lett!ce sample from the 3isso!ri location =the pond site> at . =3RID 6+. ppm.GLYPHOSATE RED September 1993 of glyphosate in the sprin*ler water at the pond site were the highest .days after treatment at /.05T for edi&le tiss!es@ /..50/+> . days after treatment =of water so!rce> and 1 irrigation events was fo!nd to contain /.1.+.T for whole fish.20T for nonedi&le tiss!es@ and /.. =3RID 6/16+0/1> =+0> Bioacc!m!lation in $ish 3axim!m &ioconcentration factors were /./2 ppm glyphosate.

to +-1.GLYPHOSATE RED September 1993 =+6> 9a&oratory and $ield Holatility The re:!irement of these st!dies was waived &ased on the low vapor press!re of glyphosate. Ecological Effects a. The data indicate that chemical and photochemical decomposition is not a significant pathway of degradation of glyphosate in soil and water. &. If glyphosate were to reach s!rface water it wo!ld &e resistant to hydrolysis and a:!eo!s photolysis. The mechanism of adsorption is !nclearI however@ it is spec!lated that it may &e associated with vacant phosphate sorption sites or high levels of metallic soil cations. The low octanol?water coefficient s!ggests that glyphosate will have a low tendency to acc!m!late in fish.@ altho!gh at a slower rate than parent glyphosate. Based on the low vapor press!re of glyphosate@ volatili7ation from soils will not &e an important dissipation mechanism.. Even tho!gh glyphosate is highly water sol!&le it appears that parent glyphosate and #3'# have a low potential to move to gro!nd" water d!e to their strong adsorptive characteristics demonstrated in the la&oratory and field st!dies. Environmental $ate and %ro!ndwater #ssessment In general@ the availa&le field and la&oratory data indicate glyphosate adsor&s strongly to soil and wo!ld not &e expected to move vertically &elow the 2 inch soil layer. Ecological Ha7ard . However@ glyphosate is readily degraded &y soil micro&es to aminomethyl phosphonic acid =#3'#>@ which is degraded to C . However@ glyphosate does have the potential to contaminate s!rface waters d!e to its a:!atic !se patterns and erosion via transport of resid!es adsor&ed to soil particles s!spended in r!noff water. . Based on !naged &atch e:!ili&ri!m st!dies glyphosate and glyphosate resid!es are expected to &e immo&ile with Rd=ads> val!es ranging from 2.

obwhi!e .obwhi!e . =a> #vian Single"Dose ral 9D1/ " Technical Acute Oral Toxicity .GLYPHOSATE RED September 1993 =+> Effects to 4ontarget Birds To esta&lish the toxicity of glyphosate to &irds@ tests were re:!ired !sing the technical grade material.indings Species .uail 9$D5F 9ech 9$DF 9ech no more !han sligh!ly !o>ic !o upland game birds and wa!er owl T0o su2acute dietary studies" one study on a species o1 0ater1o0l (pre1era2ly 3allard duc4) and one on an upland ga3e 2ird species (pre1era2ly a 2o20hite 5uail)" 0ere re5uired6 These data indicate that the technical glyphosate is no 3ore than slightly toxic to 2irds on a dietary 2asis6 The guideline re5uire3ent is 1ul1illed 1or 2oth studies6 (Study I.s #)1(1 and 000$7)#!) .+ ) ) 2000 mg"kg +onclusions prac!ically non-!o>ic !o upland game birds One a/ian single&dose oral study on either a 0ater1o0l species (pre1era2ly 3allard duc4) or an upland species (pre1era2ly 2o20hite 5uail) 0as re5uired6 These data indicate that technical glyphosate is practically non&toxic to an upland 2ird species on an acute oral 2asis6 The guideline re5uire3ent 1or an a/ian acute oral study is 1ul1illed6 (Study I.AI *eproducti/e I3pair3ent ) #6#0 ppm ) #6#0 ppm +onclusions /allard duck .AI $3F .uail .indings Species .%0 (#%.ietary Toxicity . !')'#%) =&> #vian Dietary " Technical A/ian Su2acute .

o e ec!s up !o 30 ppm .o e ec!s up !o 1000 ppm . The availa&le ac!te toxicity data do not indicate a re:!irement of preca!tionary la&eling for &irds on prod!cts containing glyphosate./// mg?*g was determined for &o&white :!ail given a single oral dose of technical glyphosate. .o e ec!s up !o 1000 ppm +onclusions /allard duck /allard duck .indings Species .obwhi!e .AI *eproducti/e I3pair3ent .s !'%#!)" 000'7'!$" and !'%#!)) =d> S!mmary of $indings %lyphosate is practically non"toxic to &o&white :!ail on the &asis of ac!te oral toxicity. #vian reprod!ction st!dies indicate reprod!ctive impairment wo!ld not &e expected at a dietary level of !p to +/// ppm. St!dies indicate that the 5" day dietary 9C1/ of the chemical is greater than 6/// ppm for &oth mallard d!c*s and &o&white :!ail. These data indicate that the chemical is slightly toxic to &irds.uail $3F 9ech 90D#F 9ech $3F 9ech no! e>pec!ed !o cause reproduc!ive impairmen! An a/ian reproduction test 0as re5uired to support registration o1 the end&use products o1 glyphosate since the 1ollo0ing guideline criteria ha/e 2een exceeded6 The la2eling 1or se/eral use patterns contains directions 1or use under 0hich 2irds 3ay 2e su28ect to repeated exposure to glyphosate6 The la2eling allo0s repeat application 1or certain uses" such as al1al1a" 2arley" oats" apples" cherries" and oranges6 These data indicate that technical glyphosate is not expected to cause reproducti/e i3pair3ent6 The guideline re5uire3ents 1or an a/ian reproduction study on 2oth upland ga3e 2ird and 0ater1o0l are 1ul1illed6 (Study I.GLYPHOSATE RED September 1993 =c> #vian Reprod!ction A/ian *eproduction . #n 9D1/ greater than .

luegill sun ish 96D5F $7D3F $3F $3F 96D7F 96D7F 96D7F 96D7F ranges in !o>ici!y rom sligh!ly non-!o>ic !o prac!ically non-!o>ic !o bo!h cold wa!er and warm wa!er ish The 3ini3u3 data re5uired 1or esta2lishing the acute toxicity o1 glyphosate to 1resh0ater 1ish are the results o1 t0o #7&hour studies 0ith the technical grade product6 One study 0as to 2e per1or3ed on a cold 0ater 1ish species (pre1era2ly rain2o0 trout) and one study 0as to 2e per1or3ed using a 0ar3 0ater species (pre1era2ly 2luegill sun1ish)6 The results o1 these eight studies indicate that technical glyphosate is slightly to practically nontoxic to 2oth cold 0ater and 0ar3 0ater 1ish6 The guidelines re5uire3ent 1or acute toxicity testing o1 the technical on 1resh0ater 1ish is 1ul1illed6 (Study I.ish .indings Species .AI )$&hr +%0 (#%-+ ) ) 2# mg"l $#D9 mg"l '72D9-99D3( 120 mg"l '111130( $6 mg"l '70106( 1#0 mg"l '120170( 97 mg"l '79120( 130 mg"l '110160( 1#0 mg"l '110160( +onclusions .s 0010$11!" 0010$1(1" !')'#%" 0#(771" and !)#170) .luegill sun ish @a!head /innow .GLYPHOSATE RED September 1993 =.> Effects on 4on"Target $ish =a> #c!te Toxicity to $reshwater $ish Acute Toxicity to .luegill sun ish -ainbow 9rou! -ainbow 9rou! @a!head minnow 5hannel ca! ish .resh0ater .

resh0ater .indings Species @a!head /innow .+ ) 5D$ mg"l '#D#-$D3( $D2 mg"l '6D#-9D0( 16 mg"l '9D#-26( 11 mg"l '$D7-1#( 1# mg"l '$D7-2#( 9D# mg"l '5D6-16( )1000 mg"l )1000 mg"l 120 mg"l '56-1$0( +onclusions .resh0ater .ish .or3ulated Products Species .AI (IPA salt) #1D$F #1D$F #1D36F #1D36 #1D36F #1D36F 62D#F 62D#F G#1D2F H 15D3 I%%I sur ac!an! #7&hr +%0 (#%.GLYPHOSATE RED September 1993 =&> Chronic Toxicity to $reshwater $ish +hronic Toxicity to .luegill sun ish -ainbow 9rou! ranges in !o>ici!y rom modera!ely !o>ic !o prac!ically non!o>ic !o bo!h warmwa!er and coldwa!er ish .AI $7D3F !ech *esults /%95 ) 25D7 mg"l +onclusions no e ec!s a! or below !his level .indings 1ro3 Studies using . 0010$1(1) Acute Toxicity to .ish .luegill sun ish @a!head /innow -ainbow 9rou! .ue to the a5uatic use o1 the che3ical" its presence in 0ater is li4ely to 2e continuous or recurrent regardless o1 toxicity9 there1ore" chronic testing 0as re5uired6 This 1ish 1ull li1e cycle study satis1ies the generic guideline re5uire3ent 1or chronic 1resh0ater 1ish testing6 (Study I.luegill sun ish -ainbow 9rou! 5hannel ca! ish -ainbow 9rou! .

luegill sun ish G#0D7F H 15F IAI sur ac!an! G#0D7F H 15F IAI sur ac!an! G#1D2F H 15D3F I%%I sur ac!an! 7D03F H 0D5F IJ77I 7D03FH 0D5F IJ77I 150 mg"l '100320( )100 mg"l )1$0 mg"l -ainbow 9rou! .ish .luegill sun ish 2#0 mg"l '1$0-320 mg"l( $30 mg"l '6201600( -ainbow 9rou! @a!head minnows -ainbow 9rou! . !)#1%#" 000(0$#)" .or3ulated Products -ainbow 9rou! .GLYPHOSATE RED September 1993 Acute Toxicity to .luegill sun ish -ainbow 9rou! 51F #1F #1F #1F #1F #1F #1F $D3 mg"l '7D0-9D9( 2D3 mg"l '1D9-2D$( 9D0 mg"l '7D5-11( #D3 mg"l '3D#-5D5( 13 mg"l '11-16( 5 mg"l '3D$-6D6( 1D3 mg"l '1D1-16( Testing o1 an end&use product is re5uired i1 the pesticide 0ill 2e introduced directly into an a5uatic en/iron3ent 0hen used as directed 2y the la2el6 .luegill sun ish .rainage syste3s 0ould 2e included in such a category6 There1ore" 1or3ulated product testing 0as re5uired6 According to the sur1actant selected" the 1or3ulated product toxicity ranges 1ro3 3oderately toxic to practically non&toxic6 (Study I.indings 1ro3 Studies using .resh0ater .luegill sun ish 5hannel ca! ish .

Based on these tests@ technical glyphosate ranges from slightly to practically non"toxic to freshwater fish species.+2/>.&$l$ 9ech 100F /&. Two rain&ow tro!t .&$1$ 9ech 100F /&. ppm@ and .-1@ ID F//+/5+-+ and $olmar@ Sanders@ and E!lin +.2"ho!r 9C1/s of +.+ ) 1D0 mg"l '1D21D7( 2D0 mg"l '1D52D7( 0D65 mg"l 'D5#D7$( 13 mg"l '10-17( 3D0 '2D5-3D7( 1 mg"l 'D72-1D#( +onclusions @a!head minnow -ainbow !rou! -ainbow 9rou! 5hannel 5a! ish .GLYPHOSATE RED September 1993 000(0$#%" 000(0$#(" 000(0$#7" 000($771" 000($77!" 000($7%$" 000($7%%" 000($7%7" 000($7%#" 000($77)" 000($77%" !)#170) Sur1actant Test ..&$1$ /&.AI #7&hour +%0 (#%.ppm@ respectively =3c#llister and $or&is +. In this case@ the .6.luegill sun ish .&$l$ 9ech 100F /&.060.luegill sun ish /&.indings Species .O$1$ ranges 1ro3 3oderately toxic to /ery highly toxic to 2oth cold and 0ar3 0ater 1ish a1ter #7 hour exposure6 (Study I.-5@ ID F. S!rfactant testing was performed with &oth cold water and warm water fish.2"ho!r 9C1/s provided val!es of 52 ppm and +6/ ppm.-.&$1$ 9ech 100F /&.@ ID F. !)#170) =c> S!mmary of $indings Three tests on warm water species@ one &l!egill and two with fathead minnow@ prod!ced the .&$1$ 9ech 100F ranges in !o>ici!y rom highly !o>ic !o sligh!ly !o>ic !o warmwa!er and coldwa!er ish Testing o1 the sur1actant 3ay 2e re5uired under unusual circu3stances6 :hen inerts are li4ely to 2e toxic" testing can 2e re5uired6 These data indicate that MO./ ppm@ 56.1I E% ) % Bionomics +..

GLYPHOSATE RED September 1993 initial form!lation demonstrated an application rate m!ch .

The &l!egill and rain&ow tro!t were similar in sensitivity to the form!lation containing the DCD s!rfactant with 9C1/ val!es of +1/ and Q+// mg?l@ respectively.21 mg?l for rain&ow tro!t indicating a highly toxic category =$olmar et al.5/@ ID F///-5215>.0 mg?l or moderately toxic. The s!rfactant =3 4/5+5> when tested alone prod!ced an 9C1 / val!e of /..+2/>.21 mg?l.1> s!rfactant and glyphosate=-. Based !pon availa&le data prod!cts containing 3 4 5l5 m!st incl!de the statement@ DThis pesticide is toxic to fish.6/ mg?l> nor &l!egill =9C1/ 50/ mg?l> were very sensitive to the x"--=. #lso@ neither rain&ow tro!t =9C1/ . $or fish@ the catfish appears to &e the most tolerant with an 9C1/ val!e of +0 mg?l@ and rain&ow tro!t the most sensitive with an 9C1/ val!e of /.0 percent D##D s!rfactant provided a rain&ow tro!t 9C1/ of +.@ ID F./0A>. The s!rfactant 3 4/5+5 has &een tested separately@ prod!cing an 9C1/ of +0 mg?l on hironomous indicating it is a slightly toxic material. Bl!egill are in the same category of toxicity with an even higher 9C1/ of greater than +5/ mg?l =Thompson and %riffen +. +./ mg?l@ indicating a practically non"toxic compo!nd =Thompson and %riffen +.5/@ ID F///-521. The 9C1/ for rain&ow tro!t was +.>.6. percent isopropylamine salt and +1.D . In contrast@ the form!lation of 6+.-.GLYPHOSATE RED September 1993 lower than technical glyphosate.

!)#170) .indings 1ro3 Studies using .indings Species Daphnia magna Chironomus plumosus .resh0ater In/erte2rates .AI 99D7F !ech Acute *esults Toxicity to .indings Species Daphnia magna .AI (IPA salt) )$&hr +%0 (pp3) +onclusions Daphnia magna 62D#F $69 '7031019( !o reshwa!er inver!ebra!es ranges in !o>ici!y rom modera!ely !o>ic !o prac!ically non-!o>ic .AI $3F !ech 96D7F !ech )$&hr +%0 (pp3) 7$0 55 '31-97( +onclusions ranges in !o>ici!y rom sligh!ly !o>ic !o prac!ically non-!o>ic !o reshwa!er inver!ebra!es The 3ini3u3 data re5uire3ent to esta2lish the acute toxicity o1 glyphosate to 1resh0ater in/erte2rates is a )$&hour acute study using the technical 3aterial6 Test organis3s should 2e 1irst instar Daphnia magna or early instar a3phipods" stone 1lies or 3ay1lies6 The results o1 these studies indicate that technical glyphosate is slightly toxic to Chironomus plumosus and is practically non toxic to Daphnia magna 6 The guideline re5uire3ent 1or acute testing on a 1resh0ater in/erte2rate has 2een 1ul1illed6 (Study I.ue to the a5uatic use o1 the che3ical its presence in 0ater is li4ely to 2e continuous or recurrent regardless o1 toxicity9 there1ore" chronic testing 0as re5uired6 This study satis1ies the guideline Species re5uire3ent 1or chronic 1resh0ater in/erte2rate testing6 (Study I.resh0ater In/erte2rates +onclusions .or3ulated Products /%95 ) 50 -K 96 mg"= caused reduced reproduc!ive capaci!y .GLYPHOSATE RED September 1993 =0> Effects on #:!atic Inverte&rates =a> #c!te Toxicity to $reshwater Inverte&rates Acute Toxicity to . 0010$1(!" and !)#170) =&> Chronic Toxicity to $reshwater Inverte&rates +hronic Toxicity to .resh0ater In/erte2rates .

indings 1ro3 Studies using .resh0ater In/erte2rates .GLYPHOSATE RED September 1993 Acute Toxicity to .or3ulated Products Daphnia magna #1D2F H I%%I sur ac!an! L 15D3F #0D7F /&. 2139 #1D36F #1D$3F 310 '250#00( Daphnia magna 72 '62-$3( Daphnia magna Gammarus pseudolimnaeus Chironomus plumosus Daphnia pulex Daphnia magna Gammarus pseudolimnaeus 3 '2D6-3D#( 62 '#0-9$( 1$ '9D#-32( 2#2'22#261D5( 5D3 '#D#-6D3( #1D9 '30D762( Other results Ephemerella walkeri #1F /ay ly nymphs avoided glyphosa!e a! concen!ra!io ns o 10 mg"= bu! no! a! 1D0 mg"lD .2139 H 15F IAI sur ac!an! #1F #1F #1F 51F /&.

indings 1ro3 Studies using .rainage syste3s (0et and dry) 0ould 2e included in such a category6 There1ore" 1or3ulated product testing 0as re5uired6 According to the sur1actant selected" the 1or3ulated product toxicity ranges 1ro3 3oderately toxic to practically non&toxic6 (Study I.>. bu! no! a! !he 0D02 or 0D2 mg"l levelD Testing o1 an end&use product is re5uired i1 the pesticide 0ill 2e introduced directly into an a5uatic en/iron3ent 0hen used as directed 2y the la2el6 . !)#170) =d> S!mmary of $indings # 65"ho!r 9C1/ of -5/ ppm =mg?l> was fo!nd for #aphnia ma&na exposed to technical glyphosate =3c#llister and $or&is +. The res!lts of this st!dy indicate that the chemical is practically non"toxic to a:!atic inverte&rates.resh0ater In/erte2rates .-5@ ID F//+/5+-.GLYPHOSATE RED September 1993 Acute Toxicity to . 000($77'" 000($777" 000($770" 000($7%(" !)#170" 0010$10#" 000(0$#'" and !)#1%#) Sur1actant Test .or3ulated Products Chironomus plumosus #1F 2igni ican! increases in s!ream dri ! o midge larvae was observed a !er !he 2D0 mg"l.indings Species .AI )$&hr +%0 (#%-+ ) 13 mg"= '7D1-2#( +onclusions Daphnia magna 100F /&. In addition to these ac!te st!dies@ a fish life" cycle st!dy indicates technical glyphosate has a .&$1$ sur ac!an! sligh!ly !o>ic !o reshwa!er inver!ebra!es Testing o1 the sur1actant 3ay 2e re5uired under unusual circu3stances6 One test on the sur1actant 0as recei/ed and deter3ined as accepta2le 1or use in a ris4 assess3ent6 (Study I.

mg?l for Gammarus indicating a moderately toxic material for #aphnia and no more than slightly toxic for Gammarus.1.ppm.D The res!ltant 9C1/ of -. =6> Effects on 3arine?Est!arine rganisms . The -. 4o effect was o&served at the highest level tested.GLYPHOSATE RED September 1993 3#TC greater than ... # #aphnia ma&na life cycle st!dy with an 3#TC of Q1/ " M.1 percent identified as T"-. In order to determine the effect of the three s!rfactants =DCD@ D##D@ and DT"--D> on inverte&rates@ additional #aphnia st!dies were cond!cted./0 percent isopropylamine salt of glyphosate with a s!rfactant at /.percent isopropylamine and +1 percent of a s!rfactant identified as DC.res!lted in an 9C1/ of greater than +/// mg?l or practically non" toxic category for #aphnia. The second com&ination was 6+.2 ppm reported red!ced reprod!ctive capacity@ the most sensitive parameter. The 9C1/ val!es ranged from 0 mg?l for #aphnia to 2.0 percent of a s!rfactant identified as D##.. percent isopropylamine and +1. The availa&le ac!te toxicity data indicate that preca!tionary la&eling for freshwater interverte&rates is not re:!ired for prod!cts containing glyphosate. The third com&ination consisted of 6/. # glyphosate form!lation was tested several times with different inverte&rates. ppm reveals that this material is slightly toxic to #aphnia.D This 9C1/ was 0+/ ppm which wo!ld indicate it is practically non"toxic to #aphnia.

indings Species 4rass shrimp @iddler crab %!lan!ic oys!er . Acute Toxicity to <stuarine and Marine Organis3s . 3inim!m re:!irements are res!lts from testing the technical on one est!arine fish =.2 hrs shell deposition st!dy. wo!ld allow this type of expos!re to occ!r. The !se in drainage systems =wet or dry> wo!ld allow this type of expos!re. The g!idelines re:!ire est!arine and marine st!dies when expos!re of s!ch waters is li*ely.GLYPHOSATE RED September 1993 =a> #c!te Toxicity #c!te toxicity testing for est!arine and marine organisms on technical glyphosate is re:!ired.AI 96D7F !ech 96D7F !ech 96D7F !ech *esults =550 2$1 ppm '207-3$1( =550 93# ppm '555-1570( 9=50 ) 10 mg"= or #$ hours +onclusions ranges in !o>ici!y rom sligh!ly !o prac!ically non-!o>ic !o marine organisms These data on 3arine=estuarine species are accepta2le 1or use in a ris4 assess3ent6 These data indicate that technical glyphosate is practically non&toxic to grass shri3p" 1iddler cra2" and slightly toxic to the Atlantic oyster6 Acute toxicity testing on an estuarine 1ish species is nor3ally re5uired6 >o0e/er" since there is such an extensi/e data set 1or this che3ical" the Agency can deter3ine that glyphosate . Crops@ s!ch as cotton@ corn@ s!garcane@ t!rf@ citr!s@ &erries@ forestry@ sorgh!m@ watermelon@ etc. #c!te toxicity testing for est!arine and marine organisms on form!lated glyphosate may &e re:!ired when expos!re to est!arine and marine water is expected. #gain@ since there is s!ch an extensive data set for this chemical@ the #gency can determine that glyphosate demonstrates low toxicity to fish and oyster species@ and therefore is waiving the marine fish and oyster ac!te toxicity st!dies on the form!lated prod!ct.2 hrs 9C1/ > and either a 65 hrs oyster larvae st!dy or a .

2"ho!r 9C1/ is .2139 !echG5867573 36 F /&.iche . =1> Effects on 4on"Target Insects =a> #c!te Toxicity Testing Acute Toxicity to >oney2ees .GLYPHOSATE RED September 1993 de3onstrates lo0 toxicity to 1ish species" and there1ore is 0ai/ing the 3arine 1ish acute toxicity study6 (Study I. Both of these st!dies indicate technical glyphosate is practically non"toxic to grass shrimp and fiddler cra&s. In a st!dy on fiddler cra&s =%ca pu&ilator>@ it was determined that the . #n em&ryo"larvae 65"ho!r T9 1/ for #tlantic oyster greater than +/ ppm indicating glyphosate is slightly toxic.2139 *esults oral =+ 50 ) 100Mg"bee oral =+ 50 ) 100Mg"bee con!ac! =+ 50 ) 100Mg"bee con!ac! =+ 50 ) 100Mg"bee +onclusions prac!ically non-!o>ic !o honeybees on an acu!e oral and acu!e con!ac! basis G .5+ ppm was determined for grass shrimp =Palaemonetas vul&aris>.ata Species <oneybee acu!e oral <oneybee acu!e oral <oneybee acu!e con!ac! <oneybee acu!e con!ac! AI !echG5867573 36 F /&.06 ppm glyphosate. 0010$110" and 0010$111) =&> S!mmary of $indings # series of st!dies were performed on marine? est!arine species.2"ho!r 9C1/ of .o6 000!7)$#) . # .9he percen!age o ac!ive ingredien! used was no! repor!edD The guidelines re5uire acute toxicity testing to honey2ees on the technical 0hen a her2icide is registered as a general use her2icide6 Gi/en the 3ultitude o1 use patterns 1or 0hich this che3ical is registered" acute honey2ee toxicity studies are re5uired6 ?ased on these data" glyphosate (+P7(%(') is considered practically nontoxic on the 2asis o1 acute contact toxicity" as 0ell as on acute oral toxicity6 These data satis1y guideline re5uire3ents 1or nontarget insect studies 0hen glyphosate is used as a general use her2icide6 (.

Res!lts from the honey&ee ac!te contact toxicity st!dy indicates &oth technical and form!lated glyphosate are practically nontoxic to the honey &ee with 9D1/ val!es greater than +// Ug?&ee.@ consisting of 02 A active ingredient.on&Target Plant . Res!lts from the honey&ee ac!te oral toxicity st!dy indicates &oth technical and form!lated glyphosate are practically nontoxic to the honey &ee with 9D1/ val!es greater than +// Ug?&ee.indings Species Selenastrum capricornutum Navicula pelliculosa Skeletonema costatum nabaena !los" a#uae $emna gibba -AI 96D6 96D6 96D6 96D6 *esults # day 0550 N 12D5 mg"l # +ay 0550 N 39D9 mg"l # day 0550 N 0D$5 mg"l # day 0550 N 11D7 mg"l 7 day 0550 N 21D5 mg"l 96D6 ?ased on the results o1 the preceding studies" the data indicates that the ) day <+ %0 ranged 1ro3 06$% 3g=l to '#6# 3g=l 1or 1our a5uatic plant species" and a ( day <+ %0 o1 !16% 3g=l 1or one a5uatic species6 . =a> 'hytotoxicity Testing <11ects on .GLYPHOSATE RED September 1993 =&> S!mmary of $indings $o!r st!dies were cond!cted@ two on technical glyphosate and two on the form!lation 3 4.+0. =2> Effects to 4on"Target 'lants Chen a her&icide is applied as a terrestrial nonfood !se@ a:!atic nonfood !se@ or as a forestry !se@ Tier I nontarget phytotoxicity st!dies are re:!ired in order to eval!ate the effects of the her&icide on nontarget plants.

GLYPHOSATE RED September 1993 ?ased .

These three g!ideline st!dies@ Hegetative Higor@ Droplet Si7e Spectr!m@ and Drift $ield .1 A effect on the spectr!m of monocots and dicots tested. The res!lts indicate that C'"-/+0. # seed germination?seedling emergence st!dy was cond!cted on isopropylamine salt of glyphosate C'"-/+0.. The recommended la&els do not precl!de off"target movement of glyphosate &y drift. Therefore@ the #gency is re:!iring terrestrial plant test data to assess potential ris* to nontarget plants. 4or do they address the potential off"target movement via terrestrial plants as well as a:!atic plants./ l& ai?# res!lted in M./+"+> and drift field eval!ation =./.GLYPHOSATE RED September 1993 on the data su23itted" the re5uire3ents 1or Tier I and Tier II A5uatic Plant Gro0th Studies (1!!&! and 1!'&!) ha/e 2een 1ul1illed6 A seed ger3ination=seedling e3ergence study 0as conducted (M*I. In addition@ droplet si7e spectr!m =.day EC1/ of . Based on the !se patterns@ the method of application@ and the chemical properties of glyphosate@ additional st!dies are re:!ired to eval!ate the effects on nontarget plants. mg?l for fo!r a:!atic plant species@ and a .+.e11ect on the spectru3 o1 3onocots and dicots tested6 ?ased on the results o1 this study" Tier I data re5uire3ents 1or seed ger3ination=seedling e3ergence guideline re1erence 1!!&1 ha/e 2een satis1ied6 (M*I.1 mg?l for one a:!atic species. applied at a rate !p to +/.51 mg?l to 0. =Tech> 1/A acid &asis.0" +. )01%#'01) on isopropyla3ine salt o1 glyphosate +P&(01'# (Tech) %0."+> data are re:!ired. +. The data re:!ired are the Tier II Hegetative Higor %!ideline Reference 4o..acid 2asis6 The results indicate that +P&(01'# applied at a rate up to 1060 l2 ai=A resulted in @!% .s )0!'7#01" )0!'7#0!" )0!'7#0'" )0!'7#')" and )0!'7#0%) =&> S!mmary of $indings Based on the res!lts of the a:!atic plant growth st!dies which were cond!cted on 1 species@ the data indicates that the 6 day EC1/ ranged from /.

GLYPHOSATE RED September 1993 Eval!ation are not considered part of the target data &ase for reregistration. These data do not affect the .

GLYPHOSATE RED September 1993

reregistration eligi&ility of glyphosate. If@ !pon review of the data from these st!dies@ modification in !se practices and?or preca!tionary meas!res are necessary@ the #gency will re:!ire all registrants to ma*e la&el changes as appropriate. &. Ecological Effects Ris* #ssessment Based on the c!rrent data@ it has &een determined that effects to &irds@ mammals@ fish and inverte&rates are minimal. 8nder certain !se conditions@ glyphosate is expected to ca!se adverse effects to nontarget a:!atic plants. #dditional data are needed in order to f!lly eval!ate the effects of glyphosate on nontarget terrestrial plants. This incl!des res!lts from vegetative vigor testing =+,0"+>@ droplet si7e spectr!m =,/+"+>. In addition@ the drift field eval!ation =,/,"+> st!dy m!st &e s!&mitted and reviewed. Ris* red!ction meas!res cannot &e recommended !ntil data are s!&mitted and eval!ated. =+> 4on"Endangered Species =a> Terrestrial Species The ac!te oral 9D1/ fo!nd for &o&white :!ail dosed with technical glyphosate is greater than 051+ mg?*g. This indicates that the chemical is practically non"toxic to an !pland game species. n a dietary &asis@ the availa&le data indicate that@ at most@ technical glyphosate is slightly toxic to &oth mallards and &o&white =9C1/ Q 626/>. The articles of Hoerger and Renaga =+.-,> and Renaga =+.-0> were cons!lted in order to estimate the maxim!m concentration of glyphosate which may occ!r at the highest application rate for s!ch sites as@ cotton and corn. The following chart addresses the ma(or vegetation categories !pon which fa!na are expected to feed. ,eed +ategory +oncentrations (pp3) A %607!% l2s ai=A
2hor! grass 1215

GLYPHOSATE RED September 1993

=ong grass =ea y crops @orageO small insec!s 8odsO large insec!s @rui!

557 632 29# 61 35

Comparing these resid!es to the dietary data for &oth &o&white and mallards =9C1/ Q 626/I +?1th the 9C1/ Q .,5>@ higher !se rates may prod!ce potentially toxic resid!es on short grass only =ass!ming the 9C1/ is (!st over Q 626/>. Cildlife ingesting significant amo!nts of insects@ pods and?or fr!its sho!ld not &e affected &y single applications. Directions for some of the !se patterns do indicate that applications can &e repeated. 3!ltiple treatments co!ld potentially increase resid!es on dietary items within an extended time period. #lso@ the availa&le information s!ggest that glyphosate is relatively persistent. The half"life in soil is as high as ./., days. However@ avian reprod!ction st!dies demonstrated no adverse effects at the highest level tested@ +/// parts per million. Similarly@ ./"day dietary st!dies with dogs and rats indicate no significant a&normalities when the maxim!m level tested is ,/// parts per million. Based on this@ minimal ris* is expected.

GLYPHOSATE RED September 1993

=&>

#:!atic Species #:!atic organisms do not appear to &e sensitive to technical glyphosate. The most sensitive a:!atic inverte&rate tested is hironomus plumosus with a 65"hr 9C1/ of 11 ppm which is very near to the lower limit of the #aphnia chronic 3#TC of 1/ mg?l. The most sensitive fish species are fathead minnow and rain&ow tro!t which have .2"ho!r 9C1/ s of 56.. and 52 mg?l. Chronic testing for the technical with fathead minnow provided an 3#TC of Q ,1.- mg?l. Based on the toxicity and the vario!s EEC<s the #gency has determined technical glyphosate sho!ld not ca!se ac!te or chronic adverse effects to a:!atic environments. Therefore@ minimal ris* is expected to a:!atic organisms from the technical glyphosate.

=c>

Terrestrial 'lants and #:!atic 3acrophytes # seed germination?seedling emergence st!dy was cond!cted on isopropylamine salt of glyphosate C'"-/+0. =Tech> 1/A acid &asis. The res!lts indicate that C'"-/+0. applied at a rate !p to +/./ l& ai?# res!lted in M,1 A effect on the spectr!m of monocots and dicots tested. Considering the !se patterns that are terrestrial food crop and non"food crop the a&ove EEC<s were considered for eval!ating the effects to nontarget plants. The highest expos!re of /.6/6 l& a.i. =from aerial application@ mist &lower and sprin*ler irrigation> is well &elow the +/./ l& a.i.?# rate which res!lted in M ,1 A effect on the monocots and dicots tested. Therefore@ it has &een determined that the !se of glyphosate is not expected to ca!se adverse effects on seed germination?seedling emergence with the vario!s registered !se patterns. =3RID 6/+1.0/+> 4o vegetative vigor =+,0"+> plant st!dies have &een cond!cted. Based on the !se

GLYPHOSATE RED September 1993 patterns@ the method of application and the chemical properties of .

/ 9C1/ >. I%( RIS/ MANAGEMENT AN$ REREGISTRATION $E ISION . If@ !pon review of the data from these st!dies@ modification in !se practices and?or preca!tionary meas!res are necessary@ the #gency will re:!ire all registrants to ma*e la&el changes as appropriate. The a:!atic EEC from direct application of 0.-. Ris* red!ction meas!res cannot &e recommended !ntil data are s!&mitted and eval!ated.GLYPHOSATE RED September 1993 glyphosate@ additional st!dies are re:!ired to eval!ate these effects on nontarget terrestrial plants. These data are not part of the target data &ase for reregistration.> Endangered Species Based on the toxicity data and the estimated expos!re@ it is not expected that endangered terrestrial or a:!atic organisms will &e affected from the !se of glyphosate on the registered !ses since the EEC<s are well &elow the endangered species criteria =&irdsV +?+/ 9C1/@ a:!atic organismsV +?. Based on the res!lts of the a:!atic macrophyte toxicity data@ the 6 day EC1/ was reported to &e as low as /. The recommended la&eling preca!tions do not precl!de off"target movement of glyphosate &y drift. To assess potential ris* to terrestrial plants the #gency is re:!iring additional terrestrial plant test data@ incl!ding res!lts from vegetative vigor testing@ droplet si7e spectr!m testing and drift field eval!ation.51 ppm indicating that there may &e adverse effects to nontarget a:!atic plant species. In addition@ as disc!ssed in the +. ppm was !sed to estimate expos!re.52 %lyphosate Registration Standard@ it was determined that &ased on ha&itat@ the Ho!ston Toad may &e at ris* from the !se of glyphosate on alfalfa. =. However@ many endangered plants may &e at ris* from the !se of glyphosate on the registered !se patterns.

.GLYPHOSATE RED September 1993 A( $etermination of Eligi0ilit.

The #gency has previo!sly identified and re:!ired the s!&mission of the generic =i. The #gency has determined that glyphosate prod!cts@ la&eled and !sed as specified in this Reregistration Eligi&ility Doc!ment@ will not pose !nreasona&le ris*s or adverse effects to h!mans or the environment. The #gency made its reregistration eligi&ility determination &ased !pon the target data &ase re:!ired for reregistration@ the c!rrent g!idelines for cond!cting accepta&le st!dies to generate s!ch data and the data identified in #ppendix B.e.>=#> of $I$R# calls for the #gency to determine@ after s!&mission of relevant data concerning an active ingredient@ whether prod!cts containing the active ingredients are eligi&le for reregistration. The #gency therefore finds that all prod!cts containing glyphosate as the active ingredients are eligi&le for reregistration. The data identified in #ppendix B were s!fficient to allow the #gency to assess the registered !ses of glyphosate and to determine that glyphosate can &e !sed witho!t res!lting in !nreasona&le adverse effects to man and the environment. The reregistration of partic!lar prod!cts is addressed in Section H of this doc!ment. active ingredient specific> data re:!ired to s!pport reregistration of prod!cts containing glyphosate active ingredients. . The #gency concl!des that prod!cts containing glyphosate for all !ses are eligi&le for reregistration. The #gency has completed its review of these generic data@ and has determined that the data are s!fficient to s!pport reregistration of all prod!cts containing the isopropylamine and sodi!m salts of glyphosate. #ltho!gh the #gency has fo!nd that all !ses of glyphosate =isopropylamine and sodi!m salt form!lations> are eligi&le for reregistration@ it sho!ld &e !nderstood that the #gency may ta*e appropriate reg!latory action@ and?or re:!ire the s!&mission of additional data to s!pport the registration of prod!cts containing glyphosate@ if new information comes to the #gency<s attention or if the data re:!irements for registration =or the g!idelines for generating s!ch data> change.GLYPHOSATE RED September 1993 Section 6=g>=. #ppendix B identifies the generic data re:!irements that the #gency reviewed as part of its determination of reregistration eligi&ility of glyphosate@ and lists the s!&mitted st!dies that the #gency fo!nd accepta&le. +. Eligi&ility Decision Based on the reviews of the generic data for the active ingredient glyphosate@ the #gency has s!fficient information on the health effects of glyphosate and on its potential for ca!sing adverse effects in fish and wildlife and the environment.

S!fficient data are availa&le to ascertain the ade:!acy of the esta&lished tolerances listed in 6/ C$R G+5/. Tolerances 9isted 8nder 6/ C$R G+5/.GLYPHOSATE RED September 1993 .026=a> forB acerolaI alfalfa@ forage@ seed@ and hayI almonds@ h!llsI articho*es@ Eer!salemI asparag!sI atemoyaI avocadosI BahiagrassI &ananasI &eets@ garden@ rootsI Berm!dagrassI &l!egrassI Brassica leafy vegeta&les gro!pI &romegrassI &!l& vegeta&les gro!pI caram&olaI carrotsI cereal grains gro!pI citr!s fr!its gro!pI coffee &eans@ greenI cloverI cotton forageI cotton hayI cottonseedI cran&erriesI c!c!r&it vegeta&les gro!pI fesc!eI figsI foliage of leg!me vegeta&les gro!pI fr!iting vegeta&les gro!pI grapesI grass forage@ fodder@ and hay gro!pI g!avasI horseradishI *iwifr!itI leafy vegeta&les gro!pI leaves of the root and t!&er vegeta&les gro!pI leg!me vegeta&les gro!pI longan fr!itI lycheeI mangoesI non" grass animal feeds gro!p@ forage and hayI orchardgrassI papayasI parsnipsI passion fr!itI pean!tsI pean!ts@ . Position The following is a s!mmary of the reg!latory positions and rationales for glyphosate. Eligi&le and Ineligi&le 8ses The #gency has determined that all !ses of glyphosate are eligi&le for reregistration..026=a> are for the com&ined resid!es of glyphosate and its meta&olite #3'# res!lting from application of the isopropylamine salt of glyphosate and?or the monoammoni!m salt of glyphosate.026=a>B The tolerances listed in 6/ C$R G+5/. B( Reg!lator. Tolerance Re"assessment The #gency has determined that aminomethyl phosphonic acid =#3'#>@ the meta&olite of glyphosate@ no longer needs to &e reg!lated and therefore this compo!nd will &e dropped from the tolerance expression. #lso@ altho!gh the monoammoni!m salt of glyphosate is not s!&(ect to reregistration@ the availa&le data are to allow re" assessment of existing tolerances for resid!es res!lting from the application of the monoammoni!m salt of glyphosate. Chere la&eling revisions are imposed@ specific lang!age is set forth in Section H of this doc!ment. +.

ppm> are inappropriate and are to &e replaced with Dleg!me vegeta&les gro!p =except soy&eans>D and Dleg!me vegeta&les gro!p@ foliage of =except soy&ean forage and hay>@D respectively. ppm> and Dseed and pod vegeta&les@ forage and hayD =/. The individ!al tolerances for cran&erries =/.. ppm> sho!ld &e revo*ed since these fr!its are covered &y the crop gro!p tolerance =/.S. ppm> for small fr!its and &erries.S.. tolerance for soy&ean hay from +1 ppm to . tolerance for leg!me vegeta&les gro!p =except soy&eans> from /... The esta&lished crop gro!p tolerances for the now"o&solete Dseed and pod vegeta&lesD =/. The tolerance for cotton hay is to &e revo*ed since this is not a raw agric!lt!ral commodity of cotton.. Certain commodity definitions of the a&ove tolerances are not in accordance with the definitions listed in Ta&le II of S!&division I see the tolerance re"assessment ta&le on page 20 for modifications in commodity definitions. ppm> and grapes =/. To achieve compati&ility with Codex 3R9s for selected commodities@ the following actions m!st &e ta*en =see the ta&le on page 25>B =i> increase 8. ppm to 1 ppmI and =ii> increase 8.. Soy&eans m!st &e excl!ded from the crop gro!p tolerances &eca!se the !se pattern for soy&eans is different from other leg!me vegeta&les@ and the esta&lished tolerance for soy&eans and soy&ean forage and hay differ &y a factor Q1x from other leg!me vegeta&les.GLYPHOSATE RED September 1993 vinesI pineappleI pistachioI pome fr!its gro!pI radishesI r!ta&agasI ryegrassI sapodillaI sapoteI small fr!its and &erries gro!pI soy&eansI soy&ean@ forageI stone fr!its gro!pI s!gar appleI s!gar &eetsI sweet potatoesI timothyI tree n!ts gro!pI t!rnip rootsI wheatgrassI and yams./ ppm. .

// ppm>@ fesc!e =. The availa&le data indicate that following registered !se@ resid!es in or on the grass forage@ fodder@ and hay gro!p will not exceed +// ppm. Concomitant with the deletion of these tolerances@ a tolerance for resid!es in on or on the grass forage@ fodder@ and hay gro!p is to &e esta&lished at +// ppm. The expression negligi&le resid!es =4> sho!ld &e deleted. These tolerances will &e revo*ed.?+2?. To achieve compati&ility with the Codex 3R9 for wheat grain@ the 8.GLYPHOSATE RED September 1993 Tolerances for wheat@ grain and wheat@ straw at 6 and 51 ppm@ respectively@ have &een proposed =''/$0521?$#'. $or a complete listing of appropriate commodity definition changes and .. ppm>@ clover =. The availa&le data from alfalfa@ lespede7a@ and trefoil will s!pport this crop gro!p tolerance. ppm>@ Bahiagrass =.// ppm>@ ryegrass =. # tolerance of .// ppm> is to &e deleted.6 ppm> sho!ld &e deleted. Individ!al tolerances exist for resid!es in or on salsify and the following tropical?s!&tropical cropsB &readfr!itI canistelI cherimoyaI cocoa &eansI cocon!tI datesI genipI (a&otica&aI (ac*fr!itI persimmonsI sapote =&lac* and white>I so!rsopI and tamarind. The esta&lished tolerances for Dforage grassesD =/.// ppm>@ timothy =. Chen these tolerances have &een esta&lished@ the tolerances for the cereal grains gro!p and the cereal grains gro!p@ forage@ fodder@ and straw sho!ld &e modified to Dcereal grains gro!p =except wheat>D and Dcereal grains gro!p@ forage@ fodder@ and straw =except wheat straw>D@ respectively. The tolerance for soy&eans@ hay sho!ld &e raised to cover this desiccant !se.// ppm>@ and forage leg!mes =except soy&eans and pean!tsI /.// ppm>@ Berm!dagrass =. The existing and conflicting tolerances for alfalfa =...// ppm>@ orchardgrass =.S. However@ this tolerance is to &e revo*ed since this is not a raw agric!lt!ral commodity of soy&eans.// ppm>@ alfalfa fresh and hay =/.// ppm>@ and wheatgrass =.-/+@ ..// ppm has recently &een esta&lished for resid!es in or on soy&ean straw =$R 6.// ppm>@ &l!egrass =.// ppm>@ &romegrass =. Concomitant with the deletion of these tolerances@ a tolerance of +// ppm for resid!es in or on the non"grass animal feeds gro!p@ forage and hay@ is to &e esta&lished. ppm>@ Dgrasses@ forageD =/. There are c!rrently no registered !ses of glyphosate on these crop sites.>.H1201>. tolerance sho!ld &e esta&lished at 1 ppm =see the ta&le on page 25>.

GLYPHOSATE RED September 1993 recommendations@ see the ta&le on page 20. .

The #gency<s ffice of Cater has esta&lished a maxim!m contaminant level =3C9> of /.01//=+> are for the com&ined resid!es of glyphosate and its meta&olite #3'# res!lting from the . S!fficient data are availa&le to ascertain the ade:!acy of the esta&lished tolerances listed in 6/ C$R G+5/. +05@ page 0+--2@ dated E!ly +-@ +..026=c> are for the com&ined resid!es of glyphosate and its meta&olite #3'# res!lting from the !se of irrigation water containing resid!es of /.GLYPHOSATE RED September 1993 Tolerances 9isted 8nder 6/ C$R G+5/.026=c>B The tolerances listed in 6/ C$R G+5/.1 ppm following applications on or aro!nd a:!atic sites@ and are esta&lished at /. 1-@ 4o..ppm for glyphosate per se in drin*ing water =$R 4oticeB Hol.+ ppm.026=&> forB liver and *idney of cattle@ goats@ hogs@ horses@ po!ltry@ and sheepI pean!tsI pean!ts@ hayI pean!ts@ h!llsI s!garcaneI fishI and shellfish.026=&> are for the com&ined resid!es of glyphosate and its meta&olite #3'# res!lting from application of the glyphosate isopropylamine salt and?or glyphosate monoammoni!m salt for her&icidal and plant growth reg!lator p!rposes and?or the sodi!m ses:!i salt for plant reg!lator p!rposes.026=&>B The tolerances listed in 6/ C$R G+5/.026=c> for the crop gro!pings Brassica leafy vegeta&les gro!pI &!l& vegeta&les gro!pI cereal grains gro!pI citr!s fr!its gro!pI c!c!r&it vegeta&les gro!pI foliage of leg!me vegeta&les gro!pI forage@ fodder@ and straw of the cereal grains gro!pI fr!iting vegeta&les gro!pI grass forage@ fodder and hay gro!pI leafy vegeta&les gro!pI leaves of the root and t!&er vegeta&les gro!pI leg!me vegeta&les gro!pI non" grass animal feeds gro!p@ forage and hayI pome fr!its gro!pI root and t!&er vegeta&les gro!pI stone fr!its gro!pI tree n!ts gro!pI and the individ!al commodities avocados@ cottonseed@ and hops.>. Tolerances 9isted 8nder 6/ C$R G+5/. See the ta&le on page 20 for modifications in commodity definitions.01//B The tolerances listed in 6/ C$R G+51. See the ta&le on page 20 for modifications in commodity definitions. Tolerances 9isted 8nder 6/ C$R G+51.. S!fficient data are availa&le to ascertain the esta&lished tolerances listed in 6/ C$R G+5/.

GLYPHOSATE RED September 1993

application of the glyphosate for her&icidal p!rposes and?or the sodi!m ses:!i salt for plant reg!lator p!rposes. S!fficient data are availa&le to ascertain the ade:!acy of the esta&lished food additive tolerances listed in 6/ C$R G+51.01//=+> for s!garcane@ molasses. See the ta&le on page 20 for modifications in commodity definitions. The tolerances listed in 6/ C$R G+51.01//=,> are for the com&ined resid!es of glyphosate and its meta&olite #3'# res!lting from the application of the isopropylamine salt of glyphosate for her&icidal p!rposes. S!fficient data are availa&le to ascertain the ade:!acy of the esta&lished food additive tolerances listed in 6/ C$R G+51.01//=,> for olives =imported>@ palm oil@ dried tea and instant tea. See the ta&le on page 20 for modifications in commodity definitions. # +,"ppm food additive tolerance for wheat milling fractions =except flo!r> has &een proposed =$#',H1201>. To achieve compati&ility with the Codex 3R9 for wheat &ran@ !nprocessed@ the 8.S. tolerance sho!ld &e esta&lished at 6/ ppm =see the ta&le on page 25>. Tolerances G+52.01//B 9isted 8nder 6/ C$R

The tolerances listed in 6/ C$R G+52.01//=a> are for the com&ined resid!es of glyphosate and its meta&olite #3'#. S!fficient data are availa&le to ascertain the ade:!acy of the esta&lished feed additive tolerances listed in 6/ C$R G+52.01//=a> for dried citr!s p!lp and soy&ean h!lls. See the ta&le on page 20 for modifications in commodity definitions. # tolerance has recently &een esta&lished at +./ ppm for the com&ined resid!es of glyphosate and #3'# in citr!s@ molasses =$R 6,-/+@ .?+2?.,>. Existing tolerances of glyphosate are c!rrently esta&lished in the

GLYPHOSATE RED September 1993

Title 6/ of the Code of $ederal Reg!lations@ G+5/.026. The reassessment of the esta&lished tolerances is set forth in the Tolerance Reassessment Ta&le as follows.

GLYPHOSATE RED September 1993

5ommodi!y

5urren! 9olerance 'ppm(

1

9olerance 2 -eassessmen! 'ppm(

5ommen!"Correct Commodit% De!inition

Tolerances listed under 1$06'7)(a)B %cerola %l al a %l al a, resh and hay 5lover @orage legumes 'e>cep! soybeans and peanu!s( %lmond hulls %r!ichokes, :erusalem %sparagus %!emoya %vocados ;ahiagrass ;ermudagrass ;luegrass ;romegrass @escue @orage grasses 4rasses, orage &rchardgrass -yegrass 9imo!hy Ahea!grass ;ananas ;ee!s ;ee!s, sugar ;read rui! 5anis!el 5arambola 5arro!s 5herimoya 5hicory 5i!rus rui!s 5ocoa beans 5oconu! 5o ee beans 5o!!on, orage 0D2 200D0 0D2 200D0 0D# 1 0D2 0D5 0D2 0D2 200D0 200D0 200D0 200D0 200D0 0D2 0D2 200D0 200D0 200D0 200D0 0D2 0D2 0D2 0D2 0D2 0D2 0D2 0D2 0D2 0D2 0D2 0D1 1 15 -evoke -evoke -evoke ,o regis!ered uses Chicor%& roots Citrus !ruits group ,o regis!ered uses ,o regis!ered uses Co!!ee beans& green -evoke -evoke 'eets& garden& roots Sugar beets ,o regis!ered uses ,o regis!ered uses -evoke and es!ablish a! Non"grass animal !eeds group& !orage and ha% 100

lmonds& hulls

-evoke and es!ablish a! Grass !orage& !odder& and ha% group 100

2ubdivision &.o! in 9able **.GLYPHOSATE RED September 1993 5ommodi!y 5o!!on.o regis!ered uses see 5ode> <armoni3a!ion 9able $ea!% vegetables )except 'rassica* group and $eaves o! root and tuber vegetables group $ongan !ruit Sapote +ree nuts group =ongan =ychee /amy sapo!e /angoes . 8%4 5overed under small rui!s and berries group .o regis!ered uses (orage& !odder& and straw o! cereal grains group )except wheat straw* Small !ruits and berries group -evoke -evoke 0D2 -evoke . hay 5o!!onseed 5ranberries +a!es @igs @orage grasses 4rasses.o regis!ered uses . orage 8ersimmons 0D2 0D2 0D2 0D2 0D2 0D2 0D2 0D2 0D2 0D5 0D2 -evoke .eanuts& vines . orage @rui!s.o regis!ered uses Cereal grains group )except wheat* -evoke 5overed under small rui!s and berries group -evoke -evoke 0D1 .o regis!ered uses .u!s &lives 8apayas 8arsnips 8assion rui! 8eanu!. small and berries 4enip 4rain crops 4rapes 4uavas <orseradish :abo!icaba :ack rui! ?iwi rui! =ea y vege!ables 5urren! 9olerance 'ppm( 15 15 0D2 0D2 0D2 0D2 0D2 0D2 0D2 0D1 0D2 0D2 0D2 0D2 0D2 0D2 0D2 1 9olerance 2 -eassessmen! 'ppm( -evoke 5ommen!"Correct Commodit% De!inition .arsnips& roots .

2ubdivision &.o! in 9able **. . 8%4 Stone !ruits group -evoke . black 2apo!e.o regis!ered uses . orage 2eed and pod vege!ables. s!raw 0D2 0D2 0D2 20 15 15 200 0D2 0D2 0D2 0D2 0D2 0D2 0D5 0D1 0D2 0D2 .ome !ruits group -adishes& root -utabagas& root -evoke -evoke -evoke 5 . lea y.istachios ."% . hay 2oursop 2oybeans 2oybeans. whi!e 2eed and pod vege!ables 5urren! 9olerance 'ppm( 0D1 0D2 0D2 0D2 0D2 0D2 0D2 0D2 0D2 0D2 0D2 1 9olerance 2 -eassessmen! 'ppm( 5ommen!"Correct Commodit% De!inition . cucurbi! 1ege!ables.o regis!ered uses see 5ode> harmoni3a!ion 9ableO $egume vegetables group )except so%beans* (oliage o! legume vegetables group )except so%bean !orage and ha%* . hay 2oybeans.o regis!ered uses ."% 0D2 -evoke 200 -evoke -aised !o cover desiccan! useD . rui!ing 'e>cep! cucurbi!s( group 1ege!ables. bulb 1ege!ables.rassica 'cole( Pams Ahea!. s!raw 2!one rui! 2ugar apple 2wee! po!a!oes 9amarind 9urnips 1ege!ables.o regis!ered uses +urnips& roots 'ulb vegetables group Cucurbit vegetables group (ruiting vegetables group 'rassica lea!% vegetables group 5D0 $5 'proposed( see 5ode> harmoni3a!ion 9able .GLYPHOSATE RED September 1993 5ommodi!y 8ineapple 8is!achio nu!s 8ome rui!s 8o!a!oes -adishes -u!abagas 2alsi y 2apodilla 2apo!e.o regis!ered uses 2eed and pod vege!ables.ineapples . orage 2oybeans. grain Ahea!.

kidney 8oul!ry. hulls 8oul!ry. kidney 2heep.eanuts& hulls 1D0 1D0 see 5ode> harmoni3a!ion 9able see 5ode> harmoni3a!ion 9able 2D0 2D0 see 5ode> harmoni3a!ion 9able see 5ode> harmoni3a!ion 9able <ops 0D1 .* C1$06'7)(2)B 5a!!le. liver 8eanu!s 8eanu!. hay 8eanu!. kidney <ogs. liver <orses.GLYPHOSATE RED September 1993 5ommodi!y 5urren! 9olerance 'ppm( 1 9olerance 2 -eassessmen! 'ppm( 5ommen!"Correct Commodit% De!inition Tolerances listed under )0 +. kidney <orses. kidney 4oa!s. liver 2heep. liver <ogs.eanuts& ha% . kidney 5a!!le. liver 2hell ish 2ugarcane 0D5 0D5 0D25 0D5 0D5 0D5 0D5 0D5 0D5 0D1 0D5 0D5 0D5 0D5 0D5 0D5 3D0 2D0 Tolerances listed under )0 +. liver @ish 4oa!s.* 1$06'7)(c)B %vocados 5i!rus 5o!!onseed 5ucurbi!s @orage grasses @orage legumes @rui!ing vege!ables 4rain crops 0D1 0D1 0D1 0D1 0D1 0D1 0D1 0D1 Cucurbit vegetables group Grass !orage& !odder& and ha% group Non"grass animal !eeds group& !orage and ha% (ruiting vegetables group Cereal grains group and (orage& !odder& and straw o! cereal grains group Citrus !ruits group .

ins!an! Ahea! milling rac!ions 'e>cep! lour( 0D1 0D1 1D0 7D0 .alm oil& re!ined . 2ubdivision &.ome !ruits group -oot and tuber vegetables group and $eaves o! root and tuber vegetables group and 'ulb vegetables group $egume vegetables group and (oliage o! legume vegetables group Stone !ruits group . 8%4 see 5ode> harmoni3a!ion 9able Tolerances listed under )0 +.u!s 8ome rui!s -oo! crop vege!ables 0D1 0D1 0D1 2eed and pod vege!ables 0D1 2!one rui! 0D1 Tolerances listed under )0 +. pulp.* C1$76'%00(a)B 5i!rus."% -evoke #0 . palm &lives. sugarcane 30D0 Tolerances listed under )0 +. dried 5i!rus molasses 2oybean hulls 1D0 1D0 100 Citrus& molasses So%beans& hulls 1 9olerances are or !he combined residues o glyphosa!e and i!s me!aboli!e %/8%D 2 9olerances are now or glyphosa!e per seD .GLYPHOSATE RED September 1993 5ommodi!y =ea y vege!ables 5urren! 9olerance 'ppm( 0D1 1 9olerance 2 -eassessmen! 'ppm( 5ommen!"Correct Commodit% De!inition $ea!% vegetables )except 'rassica* group and 'rassica )cole* lea!% vegetables group +ree nuts group . dried 9ea.* C1$%6'%00(a)(1)B /olasses. impor!ed 9ea.o! in 9able **.* C1$%6'%00(a)(!)B Sugarcane& molasses &il.

eans 'dry( 5a!!le mea! 5a!!le milk 5a!!le. edible o al 5o!!onseed 0ggs <ay or odder 'dry( o grasses ?iwi rui! /ai3e &a!s 8eas 'dry( 8ig mea! 8ig.S. Based on this determination@ the expression of the 8. e>cep! whea!( 0D2 '=egume vege!ables group. e>cep! soybeans( increase BD2D !olerance decrease BD2D !olerance 0D1 '5J=( 1 '5J=( 0D5 '<ogs. -ecommenda!ion . The #gency has determined that #3'# no longer needs to &e reg!lated and therefore will &e deleted from the tolerance expression. e>cep! whea!( 0D2 '=egume vege!ables group. tolerances =see Tolerance Reassessment Ta&le@ a&ove>. The Codex 3R9s =c!rrently expressed in terms of glyphosate per se> and applica&le 8. e>cep! soybeans( 0D1 '5J=( 0D1 '5J=( 2 '5J=( 0D5 '5a!!le. e>cep! whea!( .arley . edible o al 8oul!ry mea! -ape seed -ice 20 '5J=( 2 '5J=( 0D1 '5ereal grains group. liver Q kidney( increase BD2D !olerances 0D1 '5J=( 10 '5J=( 0D1 '5J=( 0D1 '5ereal grains group. and hay group( 0D2 0D1 0D1 '5ereal grains group. Recommendations for compati&ility are &ased on concl!sions following reassessments of 8. liver Q kidney( 15 increase BD2D !olerances 0D5 '5J=( 0D1 '5J=( 50 '5J=( 0D1 '5J=( 0D1 '5J=( 20 '5J=( 5 '5J=( 100 '4rass orage.S. odder. tolerances and the Codex 3R9s will &e harmoni7ed@ and &oth will now &e expressed in terms of glyphosate per se.5ommodi!y /-= '2!ep( 'mg"kg( BD2D 9olerance C DET H#R3 4IN#TI 4 T#B9E 'ppm( Several maxim!m resid!e limits =3R9s> for glyphosate have &een esta&lished &y Codex in vario!s commodities. tolerances.S. Codex 3R9s and applica&le 8.S. tolerances =expressed in terms of the com&ined resid!es of glyphosate and its meta&olite #3'#> are listed in the ta&le &elow.

tolerances with the Codex 3R9sB W W Compati&ility &etween the 8.S. ppm@ respectively@ have &een proposed.. unprocessed Ahea! lour Ahea! whole meal /-= '2!ep( 'mg"kg( 0D1 '5J=( 20 '2!ep $( 5 5 '2!ep $( '2!ep $( BD2D 9olerance 'ppm( 0D1 '5ereal grains group. The levels of 8.S. odder.S.+ ppm>. e>cep! whea!( 15 '2oybeans. e>cep! whea!( # 'proposed( 12 'proposed( increase BD2D !olerance proposal increase BD2D !olerance proposal #0 '2!ep 6( 0D5 '2!ep $( 5 '2!ep $( 12 'proposed( The following concl!sions can &e made regarding efforts to harmoni7e the 8.1 to +./ ppm>I and =iii> leg!me vegeta&les gro!p =except soy&eans> =from /. W W W .. tolerance sho!ld &e decreased to achieve compati&ility with the Codex 3R9s in or on *iwifr!it =from /.1 to .S. tolerances in or on the following commodities were &ased on registered !se patterns in the 8. and cannot &e lowered to achieve compati&ility with the Codex 3R9sB =i> grass forage@ fodder@ and hay gro!pI =ii> soy&eansI and =iii> soy&eans@ forage./ ppm>I =ii> liver and *idney of hogs =from /. Cheat grain and wheat &ran tolerances of 6 and +.S. to /. and s!raw o cereal grains group.5ommodi!y 2orghum 2oya bean odder 2oya bean orage 'green( 2oya bean 'dry( 2oya bean 'imma!ure seeds( 2!raw and odder 'dry( o cereal grains 2wee! corn 'corn-on-!he-cob( Ahea! Ahea! bran. To achieve compati&ility with Codex@ these tolerance levels sho!ld &e increased@ toxicological and DRES considerations permitting@ to 1 and 6/ ppm@ respectively. to 1 ppm>I The level of the 8. tolerances and permanent Codex 3R9s exists in or onB corn =field and sweet>I riceI and sorgh!m.S. e>cep! whea! s!raw( 0D1 '5ereal grains group.. tolerances sho!ld &e increased@ toxicological and DRES considerations permitting@ to achieve compati&ility with the Codex 3R9s in or on the following commoditiesB =i> liver and *idney of cattle =from /. hay( 15 '2oybeans. The 8. orage( 20 '2oybeans( -ecommenda!ion 0D2 '5J=( 100 '5J=( 0D1 '5J=( 5 '5J=( 0D2 '@orage.

Endangered Species Statement The #gency does have concerns regarding expos!re of endangered plant species to glyphosate.S. W .W Cide differences =Q1x> exist &etween the 8. tolerances existI and =ii> Codex 3R9s have &een esta&lished@ &!t 8. Beca!se a (eopardy opinion res!lted from these cons!ltations@ the agency imposed endangered species la&eling re:!irements in the Registration Standard to mitigate the ris* to endangered species. 0.S. 9a&eling Rationale Chile st!dies show that glyphosate is no more than slightly toxic to &irds and is practically non"toxic to fish and honey&ees@ a toxic inert in glyphosate end !se prod!cts necessitates the la&elling of some prod!cts Dtoxic to fishD since some glyphosate prod!cts are applied directly to a:!atic environments. The decision to harmoni7e resid!e levels in or on these commodities cannot &e made at this time. tolerances and permanent Codex 3R9s in or on the following commoditiesB &arleyI &eans =dry>I soy&eans@ hayI cottonseedI oatsI forage@ fodder@ and straw of cereal grains.. Since that time@ additional plant species have &een added to the list of endangered species. 9a&eling statements for end !se prod!cts will li*ely refer !sers to co!nty specific &!lletins specifying detailed limitations on !se to protect endangered species. 4o :!estions of compati&ility exist with respect to commodities whereB =i> no Codex 3R9s have &een esta&lished@ &!t 8.52 Registration Standard@ the #gency disc!ssed cons!ltations with the 8S $ish and Cildlife Service =$CS> on ha7ards to crops@ rangeland@ silvic!lt!ral sites@ and the Ho!ston toad which may res!lt from the !se of glyphosate. tolerances do not exist. %( A TIONS RE1'IRE$ BY REGISTRANTS This section specifies the data re:!irements and responses necessary for the reregistration of &oth man!fact!ring"!se and end"!se prod!cts. A( Man!fact!ring2'se Prod!cts . In the E!ne +. #t the present time@ E'# is wor*ing with the $CS and other federal and state agencies to develop a program to avoid (eopardi7ing the contin!ed existence of all listed species &y the !se of pesticides. Chen the Endangered Species 'rotection 'rogram is implemented and s!&se:!ent g!idance is given@ endangered species la&eling amendments may &e re:!ired on affected end"!se prod!cts.S.

+. #dditional %eneric Data Re:!irements .

$or g!idance contact yo!r State Cater Board or Regional ffice of the E'#.. =See #ppendices for the %eneric Data Call"In 4otice.>B> of $I$R# calls for the #gency to o&tain any needed prod!ct" specific data regarding the pesticide after a determination of eligi&ility .. 9a&eling Re:!irements for 3an!fact!ring"8se 'rod!cts Effl!ent Discharge 9a&eling Statement #ll man!fact!ring"!se or end"!se prod!cts that may &e contained in an effl!ent discharged to the waters of the 8nited States or m!nicipal sewer systems m!st &ear the following revised effl!ent discharge la&eling statement. These additional generic data are not part of the target data &ase for glyphosate and do not affect the reregistration eligi&ility of glyphosate.. #ll prod!cts distri&!ted or sold &y persons other than registrants or s!pplemental registrants after cto&er +@ +. B( +.The generic data &ase s!pporting the reregistration of glyphosate for the a&ove eligi&le !ses has &een reviewed and determined to &e s!&stantially complete.m!st &ear the correct la&eling.D #ll affected prod!cts distri&!ted or sold &y registrants and distri&!tors =s!pplemental registrants> m!st &ear the a&ove la&eling &y cto&er +@ +.a3e o1 Study 9ier ** 1ege!a!ive 1igor +rople! 2i3e 2pec!rum +ri ! @ield 0valua!ion Guideline . Do not discharge effl!ent containing this prod!ct to sewer systems witho!t previo!sly notifying the local sewage treatment plant a!thority..0"+/ or 6/ C$R +1.62=a>=+> for additional information. However@ the following additional generic data are re:!ired at this time.. End2'se Prod!cts #dditional 'rod!ct"Specific Data Re:!irements Section 6=g>=. Refer to 'R 4otice . DDo not discharge effl!ent containing this prod!ct into la*es@ streams@ ponds@ est!aries@ oceans or other waters !nless in accordance with the re:!irements of a 4ational 'oll!tant Discharge Elimination System =4'DES> permit and the permitting a!thority has &een notified in writing prior to discharge.u32er 123-1 201-1 202-1 .1. The #gency will &e calling in data on processed potatoes in a separate DCI.> .

has &een .

Cor*er 'rotection Standard Compliance #ny prod!ct whose la&eling reasona&ly permits !se in the commercial or research prod!ction of an agric!lt!ral plant on any farm@ forest@ n!rsery@ or greenho!se m!st comply with the la&eling re:!irements of 'R 4otice .D c.0"++@ DS!pplemental %!idance for 'R 4otice . #:!atic DDo not contaminate water when disposing of e:!ipment washwaters and rinsate. The prod!ct specific data re:!irements are listed in #ppendix %@ the 'rod!ct Specific Data Call"In 4otice. .+/ and other applica&le doc!ments. Do not contaminate water when disposing of e:!ipment washwaters and rinsate. These la&eling revisions are necessary to implement the Cor*er 'rotection Standard for #gric!lt!ral .0"-@D which reflect the re:!irements of E'#<s la&eling reg!lations for wor*er protection statements =6/ C$R part +12@ s!&part R>. If a registrant &elieves that previo!sly s!&mitted data meet c!rrent testing standards@ then st!dy 3RID n!m&ers sho!ld &e cited according to the instr!ctions in the Re:!irement Stat!s and Registrants Response $orm provided for each prod!ct. Treatment of a:!atic weeds can res!lt in oxygen loss from decomposition for dead plants. $!rthermore@ the following additional la&eling m!st &e present on glyphosate end"!se prod!ct la&els. 'lease follow the instr!ctions in the 'esticide Reregistration Hand&oo* with respect to la&els and la&eling.made. Registrants m!st review previo!s data s!&missions to ens!re that they meet c!rrent E'# acceptance criteria =#ppendix $I #ttachment E> and if not@ commit to cond!ct new st!dies. 9a&eling Re:!irements for End"8se 'rod!cts The la&els and la&eling of all prod!cts m!st comply with E'#<s c!rrent reg!lations and re:!irements as specified in 6/ C$R G+12.D &.0" -@ D9a&eling Revisions Re:!ired &y the Cor*er 'rotection Standard =C'S>@ and 'R 4otice . a. This loss can ca!se fish *ills. 4ona:!atic DDo not apply directly to water@ to areas where s!rface water is present or to intertidal areas &elow the mean high water mar*..

'esticides =6/ C$R 'art +-/> and m!st &e completed in accordance with@ and within the deadlines .

'ersonal 'rotective E:!ipment Do not add any additional personal protective e:!ipment re:!irements to the la&els of glyphosate end"!se prod!cts@ however@ any existing personal protective e:!ipment on those la&els m!st &e retained.0"++ are to &e on the prod!ct la&eling exactly as instr!cted in those notices.0"++>.0"and . This ''E sho!ld &e inserted into the standardi7ed early entry ''E statement re:!ired &y 'R 4otice . M!lti"le2acti+e2ingredient end"!se prod!cts that contain glyphosate m!st compare the entry restrictions set forth in this section to the entry restrictions on their c!rrent la&eling and retain the more protective.0"-.and ."ho!r restricted entry interval =REI> is re:!ired for all !ses within the scope of the C'S =see 'R 4otice . This REI sho!ld &e inserted into the standardi7ed REI statement re:!ired &y 'R 4otice .0"++.D .specified in@ 'R 4otices .D Sole2acti+e2ingredient end"!se prod!cts that contain glyphosate m!st &e revised to adopt the entry restrictions set forth in this section.0"++@ all prod!cts within the scope of those notices m!st &ear C'S 'R" 4otice" complying la&eling when they are distri&!ted or sold &y the primary registrant or any s!pplementally registered distri&!tor.0". #fter #pril .0"..and . 8nless otherwise specifically directed in this RED@ all statements re:!ired &y 'R 4otices .0"++@ all prod!cts within the scope of those notices m!st &ear C'S 'R" 4otice"complying la&eling when they are distri&!ted or sold &y any person. # specific time" period in ho!rs or days is considered more protective than Dsprays have driedD or Dd!sts have settled. The personal protective e:!ipment for early entry sho!ld &e the ''E re:!ired for applicators of glyphosate@ except any applicator re:!irement for an apron or respirator is waived.and .and . Entry Restrictions Prod!cts not Primaril.0"-> on all end"!se prod!cts@ except those intended primarily for home !se =see tests in 'R 4otice .0"-.. #ny conflicting entry restrictions on their c!rrent la&eling m!st &e removed.+@ +.0".0@ +.6@ except as otherwise provided in 'R 4otices . Intended for Home 'se 'ses )it*in t*e Sco"e of t*e )PS: # +. #fter cto&er .1@ except as otherwise provided in 'R 4otices .0".

0". Prod!cts Primaril.+. 'ersons other than the registrant may generally distri&!te or sell s!ch prod!cts for 1/ months from the date of the iss!ance of this RED. However@ existing stoc*s time frames will &e esta&lished case"&y"case@ depending on the n!m&er of prod!cts involved@ the n!m&er of la&el changes@ and other factors. The #gency has determined that registrants may distri&!te and sell glyphosate prod!cts &earing old la&els?la&eling for .. Intended for Home 'se: $or prod!cts primarily intended for home !se =see tests in 'R 4otice .'ses Not )it*in t*e Sco"e of t*e )PSB Do not add any additional entry restrictions for !ses not within the scope of the C'S@ however@ any entry restrictions on the c!rrent prod!ct la&eling for those !ses m!st &e retained.0"++>@ do not add any additional entry restrictions for s!ch prod!cts@ however@ any entry restrictions on the c!rrent prod!ct la&eling m!st &e retained.2 months from the date of the iss!ance of this RED. %I( APPEN$I ES .2@ +.and . +.2 months from the date of iss!ance of this RED.0@ E!ne . Refer to DExisting Stoc*s of 'esticide 'rod!ctsI State of 'olicyDI $ederal Register@ Hol!me 12@ 4o. 'ersons other than registrants may distri&!te or sell s!ch prod!cts for 1/ months from the date of iss!ance of this RED. ( E3isting Stoc4s Registrants may generally distri&!te and sell prod!cts &earing old la&els?la&eling for .

re erences were reviewed as no!edD .1D ?olded re erences were reviewed on #"26"90D Bnbolded re erences were reviewed in !he -esidue 5hemis!ry 2cience 5hap!er o !he -eregis!ra!ion 2!andard da!ed 7"15"$5D &!herwise.

#ppendix B Ta&le of %eneric Data Re:!irements and St!dies 8sed to 3a*e the Reregistration Decision .

esticide Assessment /uidelines which are available from the 0ational "echnical Information 1ervice -2. "he following letter designations are used for the given use patterns$ A B ' D E + / 9 I : . Refer to the Bibliography appendix for a complete citation of the .art %-. Data Requiremen t &'olumn %(.5 7 )4-*. "he reference numbers accompanying each test refer to the test protocols set in the . If the Agency has acceptable data in its files this column lists the identifying number of each study.ort Royal Road 1pringfield 3A 22%4% &5*6( ). 8se ... Bibliographic citatio n &'olumn 6(.atter n &'olumn 2(. "his normally is the =aster Record Identification &=RID( number but may be a !/1! number if no =RID number has been assigned. < = 0 > 6. It contains generic data requirements that apply to glyphosate in all products including data requirements for which a !typical formulation! is the test substance..G'I$E TO APPEN$I& B Appendix B contains listings of data requirements which support the reregistration for the pesticide glyphosate covered by this Reregistration Eligibility Document. "he data table is organi#ed in the following format$ %. "he data requirements are listed in the order in which they appear in )* '+R . "his column indicates the use patterns for which the data requirements apply. "errestrial food "errestrial feed "errestrial non7food Aquatic food Aquatic non7food outdoor Aquatic non7food industrial Aquatic non7food residential /reenhouse food /reenhouse non7food +orestry Residential Indoor food Indoor non7food Indoor medical Indoor residential 2.

.study.

5/@ //+/5+.2< 7..sis olor P*. Storage sta0ilit.2. 7.+6.29 7.2+/+@ //+2+000 //+2+000 //+2+000 //+2+000 //+2+000@ 6/11.ata Supporting Guideline *e5uire3ents 1or the *eregistration o1 Glyphosate RE1'IREMENT 'SE PATTERN ITATION5S6 PRO$' T 7829A 7829B 7928 7.27 7.2> 7. 7.289 7. Anal.28A 7.0/+ 6+1-02/+@ ///0.@ ///2+110@ ///6//50@ ///2+111@ ///1+.28> HEMISTRY all all all all all all all all all all all all all all all #C onstant //+2+000 //+2+000 6/6/16/+@ //+2+000 //+2+000 //+2+000 //+2+000 //+2+000 //+2+000 //+2+000 //+2+000 6+/.@ //+/5+/.2= 7.@ ///10//..2? 7.sical State Odor Melting Point Boiling Point $ensit.2@ 7.288 7. Start( Mat( : Mnfg( Process #ormation of Im"!rities Preliminar. %a"or Press!re $issociation "H Sta0ilit. Sol!0ilit.28. OctanolB)ater Partition .

.0@ ///-5222@ ///-521-@ //+./0@ +116-//+/5+-.1.@ ///-5211@ ///-5226@ ///-5212@ ///-5221@ ///-5215@ //+/5..ata Supporting Guideline *e5uire3ents 1or the *eregistration o1 Glyphosate RE1'IREMENT 'SE PATTERN ITATION5S6 E OLOGI AL E##E TS >828A >829A >829B >82. Tro!t 2 TEP #BCD$%H #BCD$%H #BCD$%H #BCD$%H #BCD% #BCD% #BCD$%H #BCD% #BCD$%H #BCD% //+/5.-25 //+/5++/ >929A >929B In+erte0rate To3icit.5@ +1.-2//+/5++..@ +1.-@ +1. ///-26..@ //+.@ %S"/+-5/. 2 TEP #BCD$%H #BCD% >92. ///-/5.-@ ///-522.5@ //+++.6-2.@ +1. In+erte0rate To3icit.-22@ +1. >82<A >82<B >928A >928B >928 >928$ Ac!te A+ian Oral 2 1!ailB$!c4 A+ian $ietar.1. //+/5.10 //+0200./1@ ///-521. 2 Moll!s4 #BCD . Bl!egill 2 TEP #is* To3icit. 2 $!c4 )ild Mammal To3icit. Bl!egill #is* To3icit./1 ///-/5.2@ +1.////020.6-2/@ %S/+-5/.. Rain0o.2/+@ +1.1@ ///-522+@ ///-/5.B Est!arineBMarine To3icit..@ //+/5. A+ian Re"rod!ction 2 1!ail A+ian Re"rod!ction 2 $!c4 #is* To3icit. Rain0o. 2 1!ail A+ian $ietar./6 //+/5+////-26.2/.1@ 1.1@ //-5220@ +1.2//@ +1..@ ///-522/@ %S/+-5/. Tro!t #is* To3icit.1 +1.

.0/+ 6/. Bee Ac!te ontact TO&I OLOGY ?828 ?829 ?82< ?827 ?928A ?929 ?.t* A-!atic Plant Gro.cle #is* 'SE PATTERN #BCD #BCD%H #BCD%H BD% BD% BD% #B%H //+/5+++ //+.02. #eeding 2 Rodent 982$a. >92<B >92= 89928A 89929 89. ITATION5S6 Seed GerminationBSeedling Emergence A-!atic Plant Gro.02.t* Hone.@ 6+6//2/+ ///2-/0.02. 2 S*rim" Life Life . $ermal 2 Ra00itBRat *ronic #eeding To3icit./0@ 6/. 2 Rat Ac!te $ermal To3icit. 2 Ra00itBRat Primar./6@ 6/.02. 2 Rodent #BCD$%H #CD$H #BCD$%H #BCD$%H ///2-/0.265.6/+ ///. 6+6//2/0@ 6+6//2/6 //+0-+0-@ //+0-+05@ //+0-+0. E.28A Ac!te Oral To3icit.02.02.02.cle In+erte0rate .05-.@ //+0-+6/ ///025/0@ 6/11./6@ 6/.@ 6/.562/@ ///.02.29 8<828 Est!arineBMarine To3icit./1 6/./1 ///./././+@ 6/../0@ 6/.6-20 //+/5+-+ 6/+1.e Irritation 2 Ra00it $ermal SensitiCation 2 G!inea Pig @A2$a.@ 6+6//2/.02.ata Supporting Guideline *e5uire3ents 1or the *eregistration o1 Glyphosate RE1'IREMENT >92.02.@ 6/.562/ ///./+@ 6/.

1@ 6+2.29A ?.. 2 Ra00it 92Generation Re"rod!ction 2 Rat Gene M!tation 5Ames Test6 Str!ct!ral *romosomal A0erration Ot*er Genoto3ic Effects General Meta0olism 'SE PATTERN #CD$H #CD$H #CD$H #BCD$%H #BCD$%H #CDH #BCD$%H #BCD$%H #BCD$%H #CD$%H ITATION5S6 //+2.1/+ 6.251 6/-2-+/+@ 6/-2-+/.@ //+0.1/0 //+/5+.+. ///62020 ///5+2-6@ //+/1.+1/+ ///-52.sis P*otodegradation 2 )ater P*otodegradation 2 Soil Aero0ic Soil Meta0olism Anaero0ic A-!atic Meta0olism Aero0ic A-!atic Meta0olism Leac*ingBAdsor"tionB $esor"tion #BCD$%H #BCD% #% #B$%H CD CD #BCD //+/5+.0-.0-.2. 6+25.1/.2.A ?.B ?.+/+ 6+001+/+ 6.250 ///62026@ //+0.05-. 2 Rat Oncogenicit..252@ //+0.28 H.5-/+@ 6+2605/+@ ///.2< ?<29A ?<29B ?<2< ?=28 *ronic #eeding To3icit. 8792< 87. ../@ //+0.29B ?.28B ?.0-.5-/+@ //+100-6 6+-. 2 Non2 Rodent Oncogenicit.25+@ //+0.@ 6+-. 2 Mo!se $e+elo"mental To3icit..251 ///-52+. 2 Rat $e+elo"mental To3icit. EN%IRONMENTAL #ATE 87828 87829 8782.drol. 87928 8792. //+0/6/2@ //+1/126 ///6202.ata Supporting Guideline *e5uire3ents 1or the *eregistration o1 Glyphosate RE1'IREMENT ?. 6..

ata Supporting Guideline *e5uire3ents 1or the *eregistration o1 Glyphosate RE1'IREMENT 87<28 87<29 87<2.. 6./+@ 6+160. 87=28 87=2./+ 6+11..0-.050. 87=2< Terrestrial #ield $issi"ation A-!atic #ield $issi"ation #orest #ield $issi"ation onfined Rotational ro" ro"s Acc!m!lation 2 Irrigated Bioacc!m!lation in #is* HEMISTRY RE#EREN ES ARE 'SE PATTERN #BH CD % #C CD #BCD% 6.5/+ 6.0-.-21//+ 6.1/1@ 6/16+0/1 6+.1/6@ 6+160./.50/+ ITATION5S6 RESI$'E ONTAINE$ IN THE BO$Y O# THE RE$ 'N$ER SE TION IIID B .

#ppendix C Citations Considered to &e 'art of the Data Base S!pporting the Reregistration of %lyphosate .

A and its predecessor agencies in support of past regulatory decisions. IDENTIFICATION OF ENTRIES. CONTENTS OF BIBLIOGRAPHY. 1elections from other sources including published literature in those instances where they have been considered are included. 5- . In the case of unpublished materials submitted to the Agency the Agency has sought to identify documents at a level parallel to the published article from within the typically larger volumes in which they were submitted. Bibliographic conventions used reflect the standard of the American 0ational 1tandards Institute &A01I( expanded to provide for certain special needs. . In the case of published materials this corresponds closely to an article. ). "his number is unique to the citation and should be uses whenever a specific reference is required. UNITS OF ENTRY. "his bibliography contains citations of all studies considered relevant by E. "he Agency has also attempted to unite basic documents and commentaries upon them treating them as a single study.A in arriving at the positions and conclusions stated elsewhere in the Reregistration Eligibility Document. 2. FORM OF ENTRY. 6.rimary sources for studies in this bibliography have been the body of data submitted to E. It is not related to the six7digit !Accession 0umber! which has been used to identify volumes of submitted studies &see paragraph )&d(&)( below for further explanation(. "he entries in this bibliography are sorted numerically by =aster Record Identifier or !=RID 0umber!. "he unit of entry in this bibliography is called a !study!. "he resulting !studies! generally have a distinct title &or at least a single sub?ect( can stand alone for purposes of review and can be described with a conventional bibliographic citation. In addition to the =aster Record Identifier &=RID( each entry consists of a citation containing standard elements followed in the case of material submitted to E.G'I$E TO APPEN$I& %. In a few cases entries added to the bibliography late in the review may be preceded by a nine character temporary identifying number is also to be used whenever specific reference is needed.A by a description of the earliest @nown submission.

1ubmitter . Ahen b. Ahen no individual was identified the Agency has shown a identifiable laboratory or testing facility as the author. Ahen the date appears as &%BCC( the Agency was unable to determine or estimate the date of the document. "he third element is the submitter. +or studies submitted to the Agency in the past the trailing parentheses include &in addition to any self7explanatory text( the following elements describing the earliest @nown submission$ &%( 1ubmission Date . "he six7 digit accession number follows the symbol !'D<! which stands for !'ompany Data <ibrary!. Document Date. Author. Ahen the date is followed by a question mar@ the bibliographer has deduced the date from the evidence contained in the document. Administrative 0umber . "his accession number is in turn followed by an alphabetic 5- . Tra ! n" Parenthe#e#. authorship is de7faulted to the submitter this element is omitted. "he date of the study is ta@en directly from the document. "he next element immediately following the word !under! is the registration number experimental use permit number petition number or other administrative number associated with the earliest @nown submission. &2( &6( &)( 3olume Identification &Accession 0umbers( . Ahen no author or laboratory could be identified the Agency has shown the first submitter as the author. "he final element in the trailing parentheses identifies the E.a. Ahenever the author could confidently be identified the Agency has chosen to show a personal author. d.A accession number of the volume in which the original submission of the study appears. "he date of the earliest @nown submission appears immediately following the word !received!. c. T t!e. In some cases it has been necessary for the Agency bibliographers to create or enhance a document title. Any such editorial insertions are contained between square brac@ets.

5- .suffix which shows the relative position of the study within the volume.

4 I II. /reensboro 0. Rig gleman to Robert A. from :. &8npublished study including letter dated =ay 26 %B5. Riggleman Robert A. &%B5B( =etolachlor F /lyphosate F <inuro Dual . .D 'D<$265. du .ahrs received =ar %4 %B5B under %**7-. Inc.. 1ummary of studies 265.ahrs received =ar %4 %B5B under %**7-.I.D 'heung =. . from :. Inc.A.6D prepar ***%-54* ***%-54% ***%-542 ***%-546 ***%-54) 5- .araquat77 1oybeans$ 0o and =inimum "illage Applications$ Report 0o.I.2%7E( . &%B5B( "an@ =ixes of =etolachlor &.' 'D<$265.2%7'( 1earcy 3. . submit by 'iba7/eigy 'orp. du .$ 'D<$265. &%B5B( =etolachlor F /lyphosate F <inuronD Dual .E( plus <inuron or =etribu#in plus .D 'D<$265.ont de 0emours G 'o.2%7B through 265.2%7A( . and AD' <aboratories submitted by 'iba7/eigy 'orp.6D prepared in cooperation with E.ahrs received =ar %4 %B5B under %**7-. /reensboro 0. &%B5B( =etolachlor &Dual&R( .2%7E.ont de 0emours 'o.***%-5-B .'. from :.D 9erman D.ahrs received =ar %4 %B5B under %**7prepared in cooperation with Roc@y =ount Experiment 1tation A <aboratories and E.'.I.ont de 0emours G 'o.6D submitted by 'iba7/eigy 'orp. Inc.I II. &8npub7 lished study received =ar %4 %B5B under %**7-.ahrs R.E plus <inuron or =etribu#in plus /lyphosate771oybeansD "an@ = of =etolachlor &. )B-4 I II A.'.D.ahrs received =ar %4 %B5B under %**7-.I.A. &8np lished study including letter dated =ay 26 %B5. ). /reensboro 0. . AB 5B*2B.D. )546 I II. du .E F Roundup )E F <orox -*A$ A/7A 0o. &8npublished study including letter dated =ay 26 %B5. du . from Riggleman to Robert A. &8npublished study including letter dated =ay 26 %B5.6D prepared in cooperation with E. from Riggleman to Robert A.incaid <.B6 I II. and AD' <aboratories submitted by 'iba7/eigy 'orp /reensboro 0. and AD' <aboratories submitted by 'iba7/eigy 'orp /reensboro 0.2%7D( Rose A. &8npublish study including letter dated =ay 26 %B5./. &%B5B( =etolachlor F /lyphosate F <inuronD Dual Roundup )E F <orox -*A$ A/7A 0o.E(D /lyphosate &Round )E(D =etribu#in &1encor -*A($ A/7A 0o. )54.2%7B( 1chnappinger =.E F Roundup )E F <orox -*A$ A/7A 0o.ont de 0emours 'o. Riggleman to R ert A.D. &%B5B( =etolachlor F /lyphosate F <inuronD Dual .incaid <.'. Inc.E F Roundup )E F <orox -*A$ A/7A 0o. .D 'D<$265.6D prepared in cooperation with E. ).D Aorsham D.

in cooperation with AD' <aboratories and E.I. du ,ont de 0emou G 'o. Inc. submitted by 'iba7/eigy 'orp. /reensboro 0.'. 'D<$265.2%7+( ***%-541chnappinger =./. &%B5.( =etolachlor &Dual .E(D /lyphosate &Roundup )E(D =etribu#in &1encor -*A($ A/7A 0o. )..5 I II. &8npublished study including letter dated =ay 26 %B5. from :. Riggleman to Robert ;ahrs received =ar %4 %B5B under %**7prepared in cooperation with AD' <aboratories and E.I. du ,ont de 0emours 'o. Inc. submitted by 'iba7/eigy 'orp. /reensb 0.'.D 'D<$265.2%7/( 1earcy 1.D 9erman D. &%B5B( =etolachlor &Dual .E(D /lyphosat &Roundup )E(D =etribu#in &1encor -*A($ A/7A 0o. ).B- I II. &8npublished study including letter dated =ay 26 %B5. from Riggleman to Robert A. ;ahrs received =ar %4 %B5B under %**7 -.6D prepared in cooperation with AD' <aboratories and E.I. ,ont de 0emours 'o. Inc. submitted by 'iba7/eigy 'orp. /reensboro 0.'.D 'D<$265.2%79( Rose A.D Aorsham D. &%B5B( =etolachlor &Dual .E(D /lyphosate &Roundup )E(D =etribu#in &1encor -*A($ A/7A 0o. )B-. I II A. &8npublished study including letter dated =ay 26 %B5. from Riggleman to Robert A. ;ahrs received =ar %4 %B5B under %**7 -.6D prepared in cooperation with AD' <aboratories and E.I. ,ont de 0emours G 'o. Inc. submitted by 'iba7/eigy 'orp. /reensboro 0.'.D 'D<$265.2%7I( =onsanto 'ompany &%B5)( Residues of /lyphosate Atra#ine and 1ima#ine in or on +ield 'orn /rain 1weet 'orn and 'orn +orage and +odder following a "an@ =ix ,re7emergent =inimum "ill Application of Roundup Atra#ine and 1ima#ine. &8npublished study received Dec %B %B55 under -2)76*.D 'D<$262-%.7B( 9ouseworth <.D.D 1chnappinger 9./.D 1lagows@i :.<.D et al &%B5B( "an@ =ixes of =etolachlor &4E .E( plus 1ima#ine andHor Atra#ine plus ,araquat or /lyphosate77'orn$ 1ummary of Resid Data$ Report 0o. ABR75B%*-. &8npublished study received Dec %* %B5B under %**7-.6D prepared in cooperation with 'hevron 'he ical 'o. and others submitted by 'iba7/eigy 'orp. /reensboro 0.'.D 'D<$2)%4)57A( =onsanto 'ompany &%B5)( 1ummary of Residue Data. &8npublishe study received :an %4 %B5. under -2)72.-D 'D<$2624.*7B(

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=onsanto 'ompany &%B5B( Analytical Residue =ethod for 07,hosphonomethylglycine &/lyphosate( and Aminomethylphosphoni acid in 1ugarcane Bagasse Raw 1ugar and =olasses. &8npubli study received Dec 2. %B5B under -2)7662D 'D<$*BB%-57B( =onsanto 'ompany &%B54( /lyphosate Residues in ,eanuts followi ,reemergent "reatment with Roundup 9erbicide. &8npublished s received +eb 22 %B.* under -2)76*.D 'D<$*BB6*47A( =onsanto 'ompany &%BCC( Analytical Residue =ethod for 07&,hosphonomethyl( glycine Aminomethylphosphonic acid and 070itroso70&phosphonomethyl( glycine in ,eanuts. &8npublished study received +eb 22 %B.* under -2)76*.D 'D<$*BB6*47B( =onsanto 'ompany &%B56( 1ummary and 'onclusion$ Residue Data &8npublished study received Dec 6* %B5- under -2)76*.D 'D<$ 22)*427A( =onsanto 'ompany &%B5)( Analytical Residue =ethod for 07,hosphonomethyl glycine and Aminomethylphosphonic acid in 1o and Aater. =ethod B dated 0ov 2% %B5). &8npublished study received 1ep 2- %B5- under 4/%45BD 'D<$*B-6-47A( =onsanto 'ompany &%B5)( Analytical Residue =ethod for 07,hosphonomethyl glycine and Aminomethylphosphonic acid in +orage and /rain. =ethod B dated =ar % %B5). &8npublished s received 1ep 2- %B5- under 4/%45BD 'D<$*B-6-47B( ;ramer R.=.D Beasley R.;.D 1teinmet# :.R.D et al. &%B5-( Interim Report on ', 45-56 Residue and =etabolism. ,art 2.$ Determination of Residues of /lyphosate and Its =etabolite in +ish$ Agricultural Research Report 0o. 65.. &pp. %7%6 onlyD unpublished study received 1ep 2- %B5- under 4/%45BD submit by =onsanto 'o. Aashington D.'.D 'D<$*B-6-47I( =onsanto 'ompany &%B5-( Analytical Residue =ethod for 07,hosphonomethylglycine and Aminomethylphosphonic acid in +is "issue. =ethod dated 1ep 2 %B5-. &8npublished study receive 1ep 2- %B5- under 4/%45BD 'D<$*B-6-47;( +in@ R. &%B5-( +inal Report$ >ne /eneration Reproduction 1tudy77=allard Duc@$ ,ro?ect 0o. %6B7%*%. &8npublished study received 1ep 24 %B5- under 4/%45BD prepared by "ruslow +arms Inc. submitted by =onsanto 'o. Aashington D.'.D 'D<$*B4).

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=onsanto 'ompany &%B54( Residues of /lyphosate Alachlor and 'yana#ine in or on +ield 'orn +orage +odder and /rain following a "an@ =ix ,re7emergent =inimum "ill Application o Roundup <asso and Blades. &8npublished study received Apr % %B5B under -2)72.-D 'D<$26.%457B( =onsanto 'ompany &%B5B( Analytical Residue =ethod for 07,hosphonomethyl /lycine Aminomethylphosphonic acid and 070itrosoglyphosate in +ield 'orn +orage +odder and /rain. =ethod dated :an 22 %B5B. &8npublished study received Apr %. %B5B under -2)72.-D 'D<$26.%457'( 'owell :.E.D "aylor A.<.D 1tran# :.<.D et al. &%B5)( +ina Report on ', 45-46 Residue and =etabolism$ ,art 2%$ Determination of ', 45-56 and ', -*)6- Residues in /rapes$ Agricultural Research Report 0o. 665. Includes undated method entitled$ Roundup and metabolite residue analytical method. &8npublished study received >ct ) %B5) under -fl-4*D submit by =onsanto 'o. Aashington D.'.D 'D<$*B)24%7A( Rueppel =.<.D 1uba <.A.D =oran 1.:.D et al. &%B5)( +inal Report on ', 45-56 Residue and =etabolism$ ,art 2*$ "he =etabolism of ', 45-56 in /rape ,lants$ Agricultural Research Report 0o. 66-. &8npublished study received >ct ) %B5) unde -+%-4*D submitted by =onsanto 'o. Aashington D.'.D 'D<$*B)24%7B( Beasley R.;.D Daniels R.:.D <auer R.D et al. &%B5)( +inal Report on ', 45-56 Residue and =etabolism77,art %5$ Determination of 'rop Residues in 'orn Aheat 1oybeans 1mall /rains 1oil and Aater$ Agricultural Research Report 0o. 62&8npublished study received :an 6% %B55 under -2)76*.D submitted by =onsanto 'o. Aashington D.'.D 'D<$*B-5.57B( 'owell :.E.D "aylor A.<.D 1tran# :.<.D et al. &%B5)( Roundu and =etabolite Residue Analytical =ethod. &8npublished study ceived %B5) under -/%-4%D submitted by =onsanto 'o. Aashingto D.'.D 'D<$*B)24)7B( 1utherland =.<.D =arvel :.".D Banduhn =.'.D et al. &%B5-( 1ummary of =etabolism 1tudies of /lyphosate in 'itrus ,lants &8npublished study received :an 24 %B54 under -2)76*.D submitted by =onsanto 'o. Aashington D.'.D 'D<$*B)B-.7B( Beasley R.;.D ;ramer R.=.D 'arstarphen B.A.D et al. &%B5-(

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'D<$*B-*4-7A( ***6B655 'on@in R.'.447E( =onsanto 'ompany &%BCC( 1ummary and 'onclusions$ Roundup on Barley Buc@wheat >ats Rice Rye and 1orghums.%B5.447 =onsanto 'ompany &%B5-( /lyphosate Residues in Aheat /rain. =ethod dated =ar % %B5). &8npublished study received 1ep 2.447D( =onsanto 'ompany &%B5-( /lyphosate Residues in 1mall /rains.D 9annah <.9.under -+%-64D 'D<$*B).under -+%-64D 'D<$*B).5 ***)))22 ***)))26 ***)))24 5- . ***6B6.D 1tewart E.D.% ***)**.D Arras D..=. &8npublished study received :an 24 %B54 under 4/%56)D submitted by =onsanto 'o. &%B5-( Residue Data for Roundup on Rice and in +ish.ramer R.4 ***)**. &8npublished study received Aug %6 %B5.D 'D<$ *B-6--7A( =onsanto 'ompany &%B5-( 1torage 1tability of +ield Residue 1amples and /lyphosate7%)' "reated 'rops. Aashington D. an others submitted by =onsanto 'o.D 'D<$*B)B**7'( . &8npub7 lished study received Aug %6 %B5. &8npublished stu received on un@nown date under 1/%-26D 'D<$*B)*647'( =onsanto 'ompany &%B56( Roundup =etabolite in 3arious /rains. Aashington D.) ***)**. &8npublished study received Aug %6 %B5.under -+%-64D 'D<$*B).D et al. &8npublished study received on un@nown date under -/%-26D 'D<$*B)*647B( =onsanto 'ompany &%B5)( Analytical Residue =ethod for 07.D Beasley R.447A( =onsanto 'ompany &%B5-( /lyphosate Residues in 1oybeans.6 ***)**.***)**. Aashington D.1ummary of /lyphosate &Roundup( Residue 1tudies in 'itrus +rui and .und 4/%45BD prepared in cooperation with Aashington 1tate 8niv.. &8npublished study received 24 %B5. &%B5-( +ina Report on '.rocessed +ractions.under 49-%*4D submitted by =onsanto 'o.'.hosphonomethyl glycine and Aminomethylphosphonic acid in +orage and /rain.under -+%-64D 'D<$ *B).R. 652.447B( =onsanto 'ompany &%B5-( /lyphosate Residues in 'orn.under -+%-64D 'D<$ *B). &8npublished study received Aug %6 %B5. 45-56 Residue and =etabolism$ Agricultural Resear Report 0o.A. &8n lished study received Aug %6 %B5.

*( "erato 1tudy in Rabbits$ IRD' 0o.D submitted by =onsanto 'o. =ethod dated =ay % %B54. &8npublished study receiv 1ep %4 %B. &%B55( lytical Residue =ethod for 07.D "as@er E..R. )*%7*-4.D Blair A.D 'D<$2)2-%47B( =onsanto 'ompany &%B56( Residue Data.D Blair =. 6)) &8npublished study received :un 6 %B54 under -2)76*..* under -2)76*.2 ***-%B. &8npublished study received :un 6 %B54 under -2)76*.*( /lyphosat Residues in 'otton following "opical "reatment with Roundup ***)4646 ***).xx Aashington D. %B55.E.D 'D<$*BB42-7B( Interregional Research .hosphonomethylglycine and Aminomethylphosphonic acid in /re 'offee Beans. &'ompilationD unpublis study received on un@nown date under -2)7EI72%D 'D<$2266567E( =onsanto 'ompany &%B5-( Residue Results. submitted by =onsanto 'o. &%B.".D 'D<$*B4%557I( Beasley R.D =arvel :. &%B.D et al.=.* under -2)76*. &%B5-( +inal Report '.R. )*%7*-). &8npublished study ceived :un 6 %B54 under -2)76*.:.45-56 Residue and =etabolismD . &8npublished study received 0o %B %B.D 'D<$2)2-%47A( Rodwell D.D submitt by =onsanto 'o.'.hosphonomethyl glycine and Amino methylphosphonic acid in +orage <egumes and /rasses$ Report =1<7**4%.D 'D<$*B4%557D( =onsanto 'ompany &%B54( Analytical Residue =ethod for 07.D "as@er E.2. =ethod dated :un 2.D 'D<$*B4%557+( =ali@ :. &8npublished st including IRD' no.'. Aashington D.6 ***-6**- ***-B*-* ***4*%*6 5- .* ***-%B.D prepared by International Resear and Development 'orp. 45-56 in 'offee .&8npublished study received on un@nown date under -/%-26 *B)%--7+( ***)4642 'D<$ Rodwell D.:.E.D et al. Aashington D.D 'owell :. &%B.'.D 1teinmet# :.D 'urtis ". submitted by =onsanto 'o.D et al.* under -2)76* prepared by International Research and Development 'orp.*( "eratology 1tudy in Rats$ IRD' 0o. Aashington D.D <ottman =.( 1ummary of /lyphosate Residues in /uava.D "aylor A.=.art 2)$ "he =etabolism of '.D et al. BBB7*2%D received =ay 26 %B.) ***-%B. &8npublished study receive =ay 26 %B.ro?ect 0umber ) &%B5.'.lants$ Agricultural Research Report 0o.1.* under lE2))6D 'D<$*BB56B7A( Bas#is 1.<.

45-5676$ .6.apaya$ .hosphonomethyl(7glycine Aminomethylphosphonic Acid and 070itroso70&phosphonomethyl(7glycine in +orages /rains 1oi and Aater. &8npublished study re ceived on un@nown date under -2)7EI72)D 'D<$*B-6)-7:( =onsanto 'ompany &%BCC( Analytical Residue =ethod for 07. &8npublished study receiv =ar %% %B54 under -2)76*. Aashington D.A.* entitled$ Analytical residue method for 07 &. &8npublished study received 0ov 2* %B. &8npublished study received =ay % %B55 under -2)76*.* under -2)6*.<.57D( +ra#ier 9.'.apaya. =1<7%2. J75*7B*.hosphonomethyl(7glycine$ 070itrosoglyphosate$ Report 0o.'.9erbicide$ Report 0o. -*4). &8npublished study received :an 6* %B5 ***465%6 ***465%) ***4-5-% ***4-5-2 ***4-5-6 ***45*6B 5- .ro?ect 0o.D 'D<$*BB52*7A( ***4%--***4%--B =onsanto 'ompany &%B5)( Residue Results.57'( =onsanto 'ompany &%B44C( Analytical Residue =ethod for 07&.D. Interim rept.D 'D<$*BB5-%7B( =onsanto 'ompany &%B44C( Analytical Residue =ethod for 07&.D Rueppel =. &8npublished study received =ay %2 %B55 u -2)6*. Includes method dated Aug %2 %B.* under -2)7EI7-)D submitte =onsanto 'o.D 'D<$*B-%)%7E( =onsanto 'ompany &%B5B( 1ummary of /lyphosate Residues in .D submitted by =onsanto 'o.ro?ect 0o.hosphonomethyl(glycine Aminomethylphosphonic acid and 070 troso707&.D 'D<$22B5. 8ndated method %.hosphonomethyl glycine &/lyphosate( and Aminomethylphosph acid in 1ugarcane 1ugarcane <eaves Bagasse 1ugar and =olasses Irrigation Aater and 1oil.hosphonomethyl(glycine in forages and grains.D 'D<$ 22B5.D 'D<$22B5.57E( Birch =.* under -2)76 'D<$ *BB5-%7A( =onsanto 'ompany &%B5B( Analytical Residue =ethod for 07. +inal rept. &%B54( 'rop =etabolism 1tudies of 0&. &8npublished study received 0ov 2* %B.hosphonomethylglycine and Aminomethylphosphonic acid in .hosphonomethyl(7glycine Aminomethylphosphonic Acid and 0itroso70&phosphonomethyl(7glycine in +orages /rains and Aate 8ndated method 2. Aashington D. &%B5*( "oxicological Investigation of '. &8npub lished study received 0ov %2 %B. &8npublished study received =ay %2 %B55 under -2)76*.

'. B07.D prepared by E/ G / Bionomics submitted by =onsanto 'o.B5 ***54)B% ***54)B2 5- . &8npublished study received 0ov %B56 under -2)76*.A.% under -2)76*. Aashington D.'.9.% under -2)76*.'. Includes method dated :ul % %B and undated methods entitled$ 2 )7D in wheat forage straw a grainD Dicamba in wheat forage straw and grainD Residues of alachlor in wheat grain forage and strawD Atra#ine in wheat forage straw and grainD 'yana#ine in wheat forage straw and grainD =etribu#in and metabolites in wheat forage straw and grain.D prepared by Jounger <aboratories Inc.*7)746)D =onsanto 1tudy 0o. III &%B. &8npublished study including letter dated +eb 2% %B.9.*7)746-D =onsanto 1tudy 0o. Aashington D.D 1urprenant D.A.'.*7*5).D 1leight B.*7*5-.* under -2)76*.D 1urprenant D. ***5*. &8npublished study including published data receive Dec 2B %B. III &%B56( Research Report 1ubmitted to =onsa 'ompany$ Exposure of +ish to %)'7Roundup$ Accumulation Distribution and Elimination of %)'7Residues.D 'D<$%2*4) +in@ R. &8npublished study received 0ov B %B56 under -2)76*.*( Acu "oxicity of Roundup to Bluegill &<epomis macrochirus($ Repor KBA7.'. Aashington D.* from R. III &%B.*( Residues of /lyphosate and >ther 9erbicides in Aheat following 'hemical +allow Applications o Roundup "an@ =ix 'ombinations. >leson to Robert +oster received Apr 2 %B.D 1urprenant D. 2)%7%*4.9.ro?ect 0o.D prepared by E/ G / Bionomics submitted by =onsanto 'o. III &%B. Aashington D. &8npublished stu received Apr ) %B.*7)7464D =onsanto 1tudy 0o.A. Aashington D.D 'D<$**.*( Acu "oxicity of Roundup to the Aater +lea &Daphnia magna($ Repor KBA7. by =onsanto 'o. submitted by =onsanto 'o.D prepared by E/ G / Bionomics submitted by =onsanto 'o.D 'D<$ 2))5)B7+( 1leight B.'. &%B56( +inal Report$ Eight7day Dietary <'-*77Bobwhite Euail$ .% under -2)76*.'.D 1leight B.)4*7'( ***45)2- submitt =onsanto 'ompany &%B.D 'D<$2)6BB*7AD 2t6BB%( <eBlanc /.D 1leight B.*( A "oxicity of Roundup to Rainbow "rout &1almo gairdneri($ Report KBA7.D prepared by Environmental 1ciences 'orp.D 'D<$2))5)B7B( <eBlanc /.'.B- ***5*.B6 ***5*.*7*5B.9. B07.under -2)76*.D 'D<$ 2))5)B7D( <eBlanc /. &8npublished study received Apr 2 %B.D prepared by Bionomic Inc. B07.

'.% under -2)76*.=. &8npublishe study received :ul % %B.D.*- Aashington D.**2B6.D. &8npublished study received :ul % %B.D 'D<$*5**.R.D 'D<$*5*%5*7:( Branch D.D 'D<$%2*4)*7D( Bas#is 1..D +ol@ R.=..D submitted by =onsa 'o... &8npublished study received :ul % %B. &%B.. Aashington D.*7AA to Rabbits$ E9< .*7AA to Rabbits$ E9< .*( /lyphosate Residues in ..D submitted by =onsant 'o.D 1tout <. Aashington D.'.D.D submitt by =onsanto 'o..'. Aashington D.**2B2.*7A to Rabbits$ E9< .D +ol@ R.. &%B.% under -2)76*.%( .D 'D<$*5D%5*7I( Branch D. &%B.D submi by =onsanto 'o.*7A to Rabbits$ E9< .67A( Branch D. Includes method dated :ul % %B5B.D.%( .**2B*.*7A to Rabbits$ E9< ..D 1erdy +.%( Acute Dermal "oxicity of =>0 2%6B 0+7.%( . Aashington D.D.D 1tout <.ostemergent 1pot "reatment with Roundup 9erbicide$ Report 0o.%( Acute >ral "oxici of =>0 2%6B 0+7.D 1tout <.**2B-.D +ol@ R.'.%( ... &%B.D 1tout <.=.=.D.D 'D<$*5*%5*7<( Branch D.1.rimary 1@in Irri tation of =>0 2%6B 0+7.=.D +ol@ R.D +ol@ R.% under -2)76*.**2B%. &8npublished study received :ul % %B.D 1tout <.rimary 1@in Ir tation of =>0 2%6B 0+7.% under -2)76*. &%B. ***5522B ***5526* ***5526% ***55262 ***55266 ***5526) 5- .D submitted by =onsant 'o.%( Acute Dermal "oxicity of =on 2%6B 0+7..D 'D<$*5*%5*7=( Branch D.% under -2)76*.rimary Eye Irr tion of =>0 2%6B 0+7. Aashington D.'.D +ol@ R.D 1tout <.D Dubelman 1.asture /rasses <egumes and Alfalfa following . &%B.D +ol@ R. &8npublished st received =ay %% %B..'.'. =1<7%%)*.*7AA to Rabbits$ E9< .D submitted by =onsanto 'o. &%B.( Branch D.=..D 1tout <. &%B. Aashington D.=.D +ol@ R.% under -2)76*. ***54.D 1tout <.D 'D<$*5*%5*7.submitted by =onsanto 'o.D submitted by =onsa 'o.% under -2)76*.'.**2B4. Aashington D.**2B5. &8npublished study received :ul % %B.rimary Eye Irrit tion of =>0 2%6B 0+7.D. &%B.D 'D<$*5*%5*7/( Branch D.. &8npublishe study received :ul % %B.D 'D<$*5*%5*79( Branch D.%( Acute >ral "oxi ***55225 ***5522.*7AA to Rats$ E9< .% under -2)76*. &8npubli study received :ul % %B.D submitted by =onsanto 'o Aashington D..'.D.=.

%B5B under -2)76*.'.2667B( "hompson '. &%B5.*7646( to Rainbow "rout &1almo gairdne ri($ 1tatic Acute Bioassay Report K246%4.4..D =oriya =.D 1tout <.D.45-56 &/lyphosate(. &8npublished study received :ul % %B.( +inal Report 1almonella =utagenicity Assay of /lyphosate$ "est 0o.R.D 'D<$26.. +inal rept. & 8npublished study received :ul % %B. 'D<$26.% under -2)76*.. unpublished study received :ul % %B.D 1tout <.**2-B.4%B ***5.D /riffen :.D 'D<$*5*%5*7R( =onsanto 'ompany &%B5-( Residue Results.*A &AB7. Aashington D. &%B5..D prepared by Analytical B ***55264 ***55265 ***5526.%( .( =icrobial =utagenic "esting on '.D 'D<$*5*%5*70( ***5526Branch D.D 'D<$*5*%5*7E( Dubelman 1.'.=.D submitted by =onsanto 'o.D Boudreau .%( /lyphosate Residues in Aater following Application of Roundup 9erbicide to +lowing Bo ies of Aater$ =1<7%).D +lowers <.=.D. &'ompilationD unpublished study including published data received =ar %% %B54 under -2)76*.D 'D<$*B-%)%7A( 1hirasu J.of =on *%6B to Rats$ E9< .D 'D<$*5*%5*7*( Branch D. &%B.rimary 1@in Ir tation of =>0 *%6B to Rabbits$ E9< .% under -2)76*... &8npublished study received :ul % %B.'. Aashington D. Aashington D. &%B..% under -2)76*.=.D +ol@ R.2667A( .*. Aashington D.D submitted by =onsanto 'o Aashington D.42* ***5. <+75.D sub7 mitted by =onsanto 'o. &8npublished study received :ul % %B.D submitted by =onsanto 'o.D 'D<$*5*%5*7.'. Includes method dated 1e %B.D.D..% under -2)76*.4-- 5- .D +ol@ R.D +ol@ R.%B5B under -2)76*.D >hta ".**2-.'. &8npublished st received :ul % %B. &%B.D 1tout <.'. &%B.%( .D 9annah <.D 1teinmet# :.**24*. Aashington D.% under -2)76*.( Branch D.9.D submitted by =onsanto 'o.ier <.:.**2-5.7%4 &8npublished study received Apr 2. ***556*% ***5.*( Acute "oxic of =>0 2%6B 0+7.=. &%B. Aash7 ington D.%( Acute Dermal "oxicity of =>0 *%6B to Rabbits$ E9< .rimary Eye Irr tion of =>0 *%6B to Rabbits$ E9< .'.D prepared in cooperation with Analytical Biochemistry <abs submitted by =onsanto 'o.D prepared by Institute of Environment "oxicology :apan submitted by =onsanto 'o. &8npublished study received A 2.% under -2)76*.

%( Acute "oxicity of =>0 *%6B &<ot <8R" %2*%%( &AB7.*A &AB7.% under -2)76*.44* ***5.*764-( to Daphnia magna$ 1tatic Acute Bioassa Report K246%5.442 5- .. &%B. submitted by =onsanto 'o.% under -2)76*.D prepared by Analytical Bio 'hemistry <aboratories Inc.D /riffen :.*( Acute "oxicity of =>0 2%6B70+7.% under -2)76*.( to Bluegill 1unfish &<epomis macrochirus($ 1tatic Acute Bioassay Report K246%.*7AA &AB7. &8npublished study rece :ul % %B.=.D /riffen :. &%B.' 'D<$*5*%5%79( /riffen :.D prepared by Analyt Bio 'hemistry <aboratories Inc.D +orbis A.*764B( to Daphnia magna$ 1tatic Acute Bioassay Report K2462*.% under -2)76*.=.=. submitted by =onsanto 'o. &8npublished study received :ul % %B. &8npublished study receiv :ul % %B. Aashington D.'.%( Acute "oxicity of =>0 *%6 &<ot <8R" %2*%%( &AB7. Aashington D.D +orbis A.% under -2)76*.4-..4-4 "hompson '.*7AA &AB7.*7645( to Rainbow "rout &1almo gai neri($ 1tatic Acute Bioassay Report K246%B. &%B.4-5 ***5.D 'D<$*5*%5%7+( Boudreau . &%B.D /riffen :. Aashington D.D &%B.'.*764.D prepared by Analytical Bio 'hemis <aboratories Inc.4-B ***5. submitted by =onsanto 'o.'.D prepared by Analytical B 'hemistry <aboratories Inc. &%B.*( Acute "oxicity of =>0 2%6B 0+. Aashington D.D 'D<$*5*%5%7E( "hompson '.*( "he Acute "oxicity of =>0 2% 0+7.'.D /riffen :. submitted by =onsanto 'o.=. &8npublished study received :ul % %B.*A &AB7.=.*764)( to Bluegill 1unfish &<epomis macrochirus($ 1tatic Acute Bioassay Report K246%-.*( Acute "oxicity of =>0 2%6B70+. submitted by =onsanto 'o.D "hompson '. &8npublished study received :ul % %B. submitted by =onsanto 'o.% under -2)76*.44% ***5.%7*56( to Bluegill 1unfish &<epomis macr ***5.*7AA &AB7. &%B. Aashington D 'D<$*5*%5%7'( +orbis A. Aashington D.D prepared by Analytical Bio 'hemistry <aboratories Inc.D.D.*( Acute "oxicit of =>0 2%6B 0+7.D.'.%7*52( to Rainbow "rout &1almo gairdne 1tatic Acute Bioassay Report K252*2.D 'D<$*5*%5 "hompson '. Aashington D..D Boudreau . submitted by =onsanto 'o.D 'D<$*5*%5 "hompson '. &8npublishe study received :ul % %B. ***5.D 'D<$*5*%5%7B( ***5.D prepared by Analytical Bio 'hemistr <aboratories Inc.'hemistry <aboratories Inc.

&8npublished study received :un %5 %B. Aashington D.'.%45) 5- .D prepared by Analytical Bio 'hemistry <aborato7 ries Inc.% under -2)76*.% under -2)76*.%( A "hree7/eneration Reproduction 1tudy with /lyphosate in Rats$ . Aashington 'D<$*5*%5%7=( ***5.44) ***5.446 +orbis A.lantations with Roundup 9erbicide$ =1<7%-...D prepared by Analytical B 'hemistry <aboratories Inc.*( /lyphosate Residues in Brewed and Instant "ea following ..26 =onsanto 'ompany &%B5. &%B. &%B.D Boudreau .%7*5)( to Daphnia magna$ 1tatic Acute Bi assay Report K252*6.*7242( to Rainbow "rout &1almo gairdneri($ 1tatic Acute Bioassay Report K24*2*.D 'D< *5*%5%7:( "hompson '.D /riffen :.% under -2)7 6*.ro?ect 0o.D 'D<$*5*%5%7I( ***5.D 'D<$2)--457A( =onsanto 'ompany &%B. submitted by =onsanto 'o..( "hompson '.=. D ***5. &%B.D 'D<$2)--457B( 1chroeder R. &8npublishe study received :ul % %B. Aashington D.D Boudreau .444 %B. 5572*4 ***5.*( Acute "oxicity of =>07*%6B7 I755 &AB7. & 8npublished study received :ul % %B.*( Acute "oxicity of =>07*%6B7I755 &AB7. &%B. under -2)76*. submitted by =onsanto 'o.'.D.chirus($ 1tatic Acute Bioassay Report K252*%.D prepared by Analytical B 'hemistry <aboratories Inc.*7246( to Bluegill 1unfish &<epomis macrochirus($ 1tatic Acute Bioassay Report K24*%B.*724)( to Daphnia magna$ 1tatic Acute Bioassay Report K24*2%.ostemergent Directed "reatment in "ea .% under -2)76*. &8npublished s received :un %5 %B.D 'D<$ *5*%5%7. submitted by =onsanto 'o.=.%( Acute "oxicity of =>0 *%6B &<ot <8R" %2*%%( &AB7. submitted by =onsanto 'o.2) ***..44- ***5. Aashington D. &%B.D 'D<$*5*%5%7<( +orbis A. &8npublished study received :ul % under -2)76*.2.D.% under -2)76*.'.D prepared by Analytical Bio 'hemistry <aboratories Inc. & 8npublished study received :ul % %B. submitted by =onsanto 'o..D /riffen :. &8npublished stu received :ul % %B.'.D 9ogan /.( /lyphosate Residues in "ea <eaves following .E.. Aashington D.*( Acute "oxicity of =>07*%6B7I755 &AB7.D prepared by Analyt Bio 'hemistry <aboratories Inc.ostemergent Directed "reatment with Roundup 9erbicide$ =1<7*B*.

552*42.% under -2)76*.D prepar by BioHdynamics Inc. su mitted by =onsanto 'o.D prepar by BioHdynamics Inc. &8npublished study received :an 2* %B.art B$ "he /ross Distribution o ***B)B5% ***B.D submitted b =onsanto 'o.547A( :ohnson D.D 0air .2 under -2)76*.roducts 'o. 45-56 Residue and =etabolism$ .2 under -2)76*.'.5B <an@as /.D =iller :. 1t. &8npublished study received Apr %2 %B. &%B. IR7.D 1uba <. **%*..hosphonomethyl( /lycine$ Report 0o =1<72*-4. 1t..'.%( A <ifetime +eeding 1tudy of /lyphosate &Roundup "echnical( in Rats$ . 2B5.D 'D<$2)522. <ouis =>D 'D<$*B6. &%B.R.'.)B7'( 'olvin <. 45-56 in 1oybeans 'otton Aheat and 'orn$ Agricultural Research Report 0o...2( 2%7d Dermal "oxicity 1tudy in Rabbits$ )*%7%4. &%B56( +inal Report on '..D submitte by =onsanto 'o.D 9ogan /.art .D =onsanto 0o. &%B. &8npublished stu received 0ov %2 %B56 under )/%)))D submitted by =onsanto 'ommercial .&8npublished study received 1ep 22 %B.'. Aashington D'D 'D<$2)55B67A( Rueppel =.roducts 'o.2( <etter sent to R.D =ali@ :.. &8npub7 lished study received :ul 5 %B. Aashington D.*BB 5- . 25)B5 received =ar 2 %B.D 'onoyer =. 45-56 Residue and =etabolism$ . &8npublished study including final bioconcentrati report no.D Riley :.2 under -2)76*.%( A Reinvestigation of the 1tatic Exposure of 'hannel 'atfish to %)'7<abeled /lyphosate 07&. 45-56 Residue and =etabolism$ .R.art %*$ "he =etabolism '.2$ Roundup herbicide$ Addendum to pathology report for a three7 generation reproduction study in rats with glyphosate.%7 %B-.D =arvel :.'.D prepared by International Research and Development 'orp. &%B56( +inal Report on '.2 under -2)76*.D 2)44%BD 2)442*D 2)442%( /rabia@ =. &%B56( +inal Report on '.D 'D<$2)4.urdum xx.7A( 1treet R.D 'D<$2)-B*B7A( ***B6.D et al.E.D =iller :. "aylor dated :ul 4 %B.D 'D<$2)44%57AD 2)44%.)B7B( 'olvin <.D et al. <ouis =>D 'D<$*B6. 6*). Aashington D. &%B. &'. submitted by =onsanto 'o. Aashington D.. Aashington D.=.D .*B. &8npublished study received 0ov %2 %B56 under )/%)))D submitted by =onsanto 'ommercial .ro?ect 0o.D =arvel :. submitted by =onsanto 'o.)4* **%*-BB- **%*.9.'.$ "he /ross =etabolism of .*B5 **%*. 45-567%)'( in the <aboratory Rat following a 1ingle Dose$ Agricultural Research Report 0o.

1t.art %2$ "he Isolation a Identification of the =etabolites of '.D =oran 1. &%B56( Acute "oxicity of Roundup to Bluegill &<epomis macrochirus(. &%B56( +inal Report on '.)B +in@ R..D =iller :. &8npublished study received :ul %2 %B5) under -+%-64D prepared by Bionomics I submitted by =onsanto 'o.ro?ect 0o. 6*4. 45-56 Residue and =etabolism$ .%*5 **%*.%%2 **%*. &8npublished study received 0ov %2 %B56 under )/%))) submitted by =onsanto 'ommercial .D 'owell :.D et al.D Rueppel =. &8npublished study received 0ov %2 %B56 under )/%)))D mitted by =onsanto 'ommercial .%%- 5- .roducts 'o. &%B56( +inal Report$ Eight7day Dietary <'-*77=allard Duc@s$ "echnical '. 1t.%%* **%*.. &%B56( Acute "oxicity of Roundup &"echnical( to /rass 1hrimp &.art %%$ "he =etabolism of .alaemonetas vulgaris( and +iddler 'rab &8ca pagilator(..D et al. submitted by =onsanto 'o. '. submitted by =onsanto 'o Aashington D'D 'D<$*B)%5%7=( =orrill <. &8npublished study received :ul %2 under -+-64D prepared by Bionomics Inc. &8npublished study7received :ul %2 %B5) under -+%-64D **%*. Aashington D'D 'D<$*B)%5%7<( Bentley R. submitted by =onsant 'o.%** 'olvin <.)B7D( **%*.roducts 'o. 45-567%)' in the Rabbit$ Agricultural Research Report 0 2B.. &%B5)( +inal Repor '. <ouis => 'D<$*B6.%*% **%*. -*)6-7%)' in the <aboratory Rat$ Agricultural Research Re 0o. <ouis =>D 'D<$ *B6. Aashington D'D 'D<$*B)%5%7I( Bentley R.roducts 'o.45-56$ .art %. 45-56 Residue and =etabolism$ . 45-56 Residue and =etabolism$ . 2)%7%*5. '. Aashington D'D 'D<$ *B)%5%70( <auer R. &%B56( Acute "oxicity of Roundup &"echnical( to Atlantic >yster &'rassostrea virginica(.D 1tran# :.$ Determination of Re idues in =eat =il@ and Eggs$ Agricultural Research Report 0 624. &8npublished study received :ul %2 %B5) under -+%-64D prepared by Enviro mental 1ciences 'orp. &8 published study received 0ov %2 %B56 under )/%)))D submitted =onsanto 'ommercial . &8npublished study received :ul %2 %B5) under -+%-64D prepared by Bionomics Inc.. 6*6.D 'olvin <. 1t. <ouis =>D 'D< *B6. 45-567%)' Excreted by the <aboratory Rat$ Agricultural Research Report 0o.)B7E( =oran 1. &%B56( +inal Repor '.D et al.%%% **%*.

D <ottman '.D 'D<$*B5*B)7B( 'owell :.%)B **%*. <ouis =>D 'D<$*B)%. 45-56 Residue and =etabolism$ . &%B54( /lyphosate Residues in Avocados following .D submitted by =onsanto 'o.2%7A( =onsanto 'o. &'ompilationD unpublished study received 1ep 5 %B54 under -2)76*. Aashington D'D 'D<$*B446%7A( =onsanto 'o. &%B54( Residue 8pta@e and =etabolism 1tudies$ **%*.D prepared in cooperation with 8niv.D et al. &'ompilationD unpublished stud received +eb %) %B5.ome +ruit >rchards.%)5 **%*. +i rept. 6*B. ))*. &%B5-( /lyphosate Residue and =etabolism 1tudie 1ugarcane and 1oils.%-% 5- . under -2)7EI7))D 'D<$*B4.%%4 1t.D 'D<$*B-24B7'( 'owell :. &'ompilationD unpublished study received :ul % %B54 under 4/%. **%*. &8npublished study received :an %% %B55 under -2)76*.%)* **%*.D 'able =. &%B55( 1tudy$ Residue and =etabolism Analyses o Roundup on 1pecific +oodstuffs.l 1ciences submitted by =onsanto 'o. &%B55( Residue and =etabolism$ Roundup on +orag /rasses <egumes and .D =iller :. &8npublished study received :ul %2 %B5) under -+%-64D submitted by =onsanto 'o. Aashington D'D 'D<$*B-5*67A( =onsanto 'o.*7'( =onsanto 'o.%B55 under -2)76*.%62 **%*. 1t.D et al. of 'alifornia77Riverside Dept. &'ompilationD unpublished study received :an %% %B55 under -2)76*.%)) **%*.art %6$ "he Dynamics of Accumulation and Depletion of >rally Ingested 07.D .asture 'rops. under -2)76*.%66 **%*. +inal rept.*7A( 'olvin <.ramer R. of . &8npublished study receive =ay B %B5. &%B54( Determinatio of Roundup 9erbicide Residues in Raisins$ Report 0o.24D 'D<$*B-B527B( =onsanto 'o. ))5. &%B54( Residue 1tudies and =ethods of Analysis 8se of /lyphosate in .submitted by =onsanto 'o. &%B56( +inal Report on '.D :ordan <.%2B **%*. &8npublished study received 0ov %.D =arvel :. <ouis =>D 'D<$*B)%.asture 'rops$ /lyphosate.ost7directed "reatments with Roundup 9erbicide$ Report 0o.hosphonomethylglycine7%)'$ Agricultural Research Report 0o. &%B54( Residue 1tudies in /reen and Dry Alfalfa =etabolism 1tudies in .D 'D<$*B-5*)7A( =onsanto 'o.

)7A( **%*. under -2)76*.4 5- . &%B54( Residue 1tudies and =ethods of Analysis fo **%*. under -2)766*D 'D<$ *B5)*27'( E/ G / Bionomics &%B5-( 'hronic "oxicity of /lyphosate to the +athead =innow &.%54 **%*. &%B5-( Efficacy of Roundup on 'orn and >ther /r &'ompilationD unpublished study received Dec 6 %B5. &'ompilationD unpublished study received :un 2* %B5B under -2)76*.D 'D<$*B554*7AD *B554%D *B5542( =onsanto 'o.%B55 under -2)76*.%5) **%*. &8npublish study received Dec 25 %B5. &%B5-( Residues$ /lyphosa on 1oybeans G 'otton. under -2)76*. submitted by =onsanto 'o.re7emergent 8se of /lyphosate in 'otton.%4. Aashi ngton D'D 'D<$*B55-B7'( =onsanto 'o. **%*.roducts 'o.D +orbis A. &'ompilationD unpublished study received >ct 2. &'ompilationD unpublished study received Aug 6* %B5.%5% **%*.Roundup.6627A( =onsanto 'o.-%%7A( =onsanto 'o. &8npublished study re ceived Dec 25 %B5.-B7A( =onsanto 'o. &'ompilationD unpublished study received :un 2% %B55 under 5+%B5%D 'D<$*B4%B%7A( =onsanto 'o.72*%( to Daphnia magna.under -+%-64D 'D<$*B5. Aashington D'D 'D<$*B55-B7B( =cAllister A.D 'D<$*B46B.%5- **%*. &%B5-( Residue 1tudies and =ethods of Analysis .%-6 %B55 =onsanto Agricultural . &'ompilationD un7 published study received =ay 2* %B54 under 4+%5B.%-B **%*.%52 **%*.%56 **%*. &'ompilationD unpublished study receive Dec 25 %B5.( Acute "oxicity of "echnica /lyphosate &AB75.D prepared by Analytical Bi 'hemistry <aboratories Inc.7A( =onsanto 'o.D submitted by =onsan 'o.imephales promelas Rafinesque(. &%B55( Residue and =etabolism 1tudies$ Roundup. &'ompilationD unpublished study received Dec 22 under -2)7EI7)6D 'D<$*B44. &%B55( Residue 1tudies and =ethods of Analysis the 8se of /lyphosate as a 1ugarcane Ripener. &%B5B( Residue 1tudies77BananasD >lives$ Roundup.( Residue 1tudies for 8se of Roundup 9erbi in Aquatic 1ituations.D 'D<$*B.D 'D<$ *B. &%B5. &%B5. under -2)76*.%.

2*) **%*.D &%B56( Report to . Aashington D'D 'D<$26)%-27A( 'owell :..D Beavers :. under -2)76*.D et al.( Residues in 'rops following 1pot "reatments with Roundup 9erbicide$ Repo 0o.( Acute "oxicity of "echnica /lyphosate to Bluegill 1unfish &<epomis macrochirus($ 1tatic Acute Bioassay Report..artition 'oefficients <eaching and Aquatic =etabolism of =>0 *-56 and =>0 *%*%$ Report 0o. 45-56 in the 'ow$ IB" 0o..( 1olubility 3olatility Adsorption and .. under -2)76*. &8npublished study received 0ov %6 %B5. +inal rept. and Aashington 'ollege submitted by =onsanto 'o.. &%B5.D prepar by Aildlife International <td. %6B7%)%. '.D 1treet R.ro?ect 0o.D .2*6 **%*.ramer R. &8npublished study received :un 2% %B5.D 'D<$22. +ina rept.26% 5- . &%B5.2*5 **%*. submitted by =onsanto 'o.ome +ruit >rchards.8se of /lyphosate in . submitted by =onsanto 'o. &%B5.D +orbis A. =1<7*2. &8npublished study received :ul %% %B5.$ =il@ and "issue Residue 1tudy with . &%B5B( A 1hort Residue =et for /lyphosate Active Ingredient in Roundup 9erbicide$ =1<*.B).( +inal Report$ >ne7generation Reproduction study77Bobwhite Euail$ /lyphosate "echnical$ .D 1erdy +. &'ompilationD unpub7 lished study received 1ep 5 %B54 under -2)76*.D submitted by =onsanto 'o.7A( /rapenthien 0. =1<7*2*5. Aashington D'D 'D<$26.D Beavers :.D prepared by Aildlife International <td.( +inal Report$ Acute >r <D-*77Bobwhite Euail$ "echnical /lyphosate$ . under -2)76*. 4627*6.7A( **%*.D <ottman '. &%B5.. %6B% &8npublished study received :ul %) %B5.6 &8npublished study received :ul 6* %B5B under -2)76*. Aashington D 'D<$26)6%B7B( +in@ R.BB-7 **%*. Aashington D'D 'D<$26)6B-7A( =cAllister A..2*- **%*. &%B5. &8npublished study received :ul %) %B5 under -2)76*.D prepared by Analytical Bio 'hemistry <aborato ries Inc.2. Aashington D'D 'D<$ 26)6B-7B( +in@ R.%B2 Brightwell B.D =ali@ :.D submitted by =onsanto 'o.ro?ect 0o. Aashington D'D 'D<$26)%*. submitted by =onsanto 'o. under -2)76*. &8npublished study received :un7%2 %B5. under -2)76*.D Brown R.D prepared by Industrial Bio7"est <aboratories Inc. submitted by =onsanto 'o. Aashington D'D 'D<$26-B2)7B( 'on@in R.2** **%*.D :en@ins D.

+inal rept.2 under -2)76*.2 under .2H% for =onsantoD 'D<$ 2)56). &8npublished study received Dec 25 %B. %6B7%)6. &%B.( +inal Report$ >ne7generation Reproduction 1tudy77=allard Duc@$ /lyphosate "echnical$ . &%B. submitted by =onsanto 'o..2 under -2)76 prepared by Analytical Bio7'hemistry <aboratories Inc.D prepar by Analytical Bio7'hemistry <aboratories Inc.ostemergent Directed "reatments with Roundu 9erbicide$ Report 0o. &%BCC( 'rop Residues and "olerances.5)5.2 under -2) submitted by =onsanto 'o..1 . &8npublished stud received Dec 25 %B. sub7 **%%%B)- **%%%B)B **%%%B-6 **%225%- **%2)54* **%2)542 **%2)546 5- . &'ompilationD unpublished study received Dec . &8npublished study received Dec 25 %B. &%B5. &%B5. submitted by =onsanto 'o.2( Dynamic B47hour Acute "oxicity of Roundup &AB7. Aashington D'D 'D<$2)B%-B7'( =cAllister A.ee =.2( Dynamic ).D 'ranor xx. under -2)76*.5)4.( /lyphosate Residues in 1tone +ruit following .ramer R.D Beavers :.7B( =onsanto 'o.5)2. Aashington D'D 'D<$26-B2)7A( 1teinmet# :. &8npublished study received Apr B %B. Aashington D'D 'D<$*B54647A( +in@ R. =1<7*)-).D prepared by Aildlife International <td. &8npublished study received Dec %5 %B.D 'owell :.27*6-( to /ammarus pseudolim7 naeus$ Dynamic Acute Bioassay Report K2. &8npublished study received 0ov 2* %B5.**%*B25% =onsanto 'o.2766( to Bluegill 1unfish &<epomis macrochirus($ Dynamic Acute Bioassay Report K2.D .D 1chofield =.ro? 0o.lant =etabolism 1tudies. &%B.D 'D<$*B-4667A( Danhaus R. &%B54( Residue and .D =c. under -2)7EI7)5D prepared in cooperati with Analytical Development 'orp.D Boudreau . Aashington D'D 'D<$*5%2B47A( +orbis A. &%B.2 under -2)76*. %B54 under -2)76*. submitted by =onsanto 'o. Aashington D'D 'D<$2)B%-B7A( +orbis A.2( /lyphosate Residues in Ahea /rain following Ropewic@ Aiper "reatment with Roundup 9erbicid =1<72-4B.D prepared by Analytical Bio7'hemistry <aboratories Inc. submitted by =onsanto 'o.D Boudreau .7ho Acute "oxicity of Roundup &AB7.2( 'hro "oxicity of /lyphosate &AB7.27*64( to Daphnia magna under +low through "est 'onditions$ 'hronic "oxicity +inal Report AB' K2.D 1chofield =.D et al. &8npublished study received 0ov %6 %B5.

5572*4%$ BD0755)2*. 8npublished study prepared by =onsanto Agricultural Research Dept. &%B54( =etabolism of '. submitted by santo 'o.6 **%624. under -2)76*.lasma and Bone =arrow <evels of /lyphosate following Intrap toneal Administration in the Rat$ 1tudy 0o. =<7.6( A 1tudy of t . &%B.6( "he 9epatocyt . .45-56 in Representative 3egetables and Rotation 'rops$ +inal Report 0o. /1*%5.ne#evich A. &%B. Aashington D'D 'D<$2-%**57AD 2-%**. &%B5. 8npublished study prepared by =onsanto Agricultural Research Dept.D prepared by 0aylor Dana Institute for Disease . &8npublished study received 0ov %. &8n7 published study received 0ov %.67%--.revention submitted by =onsanto 'o.6AD 1ponsor >rder 0o. /1*%5. Aashington D'D 'D<$2-%5657B( <i A.7**6 1uba <.%B. &8npublished study received 0ov %. **%6*)*4 Aashington D'D 'D<$2)B%4*7A( .D et al. &%B.67%.D "ong '.6 under -2)76*.- **%624.%B.D +ol@ R. &%B.D +ol@ R.6( In vivo Bone =arrow 'ytogenetics 1tudy of /lyphosate in 1prague7Dawley Rats$ 1tu 0o. 6) p.( Bioaccumulation and =etabolism of /lyphosate in 'hannel 'atfish &Ictalurus punctatus$ +inal Report 0o.6 under -2)76*.ro?ect 0o.D prepared by BioHdynamics Inc.D .6 under -2)76*.6%.R" /ene =utation As with /lyphosate$ E9< 1tudy 0o.mitted by =onsanto 'o.6.%B.D submitted by =ons 'o.6*%*B.%. &%B5)( Roundup 5- .D submitted by =onsanto 'o.% **%624.D Briggs <.D +ol@ R.6( A 'hronic +eeding 1tudy of /lyphosate &Roundup "echnical( in =ice$ .D . Aashington D'D 'D<$2-%5657/( **%624.6**. -5 p.%.D 9ogan /. Aashington D'D 'D<$2-%5657D( Ridley A. &8npublished study received Aug %5 %B.4 /1*%5. .D et al.rimary 'ultureHD0A Repair Assay on 'ompound ::07%*2* 8sing 9epatocytes in 'ulture$ 0DItln vitro +acility Experimental 0o. =1<7*6. &%B. )*4. &8npublish study received 0ov %. +inal rept.6( '9>H9/. +inal rept.D submitted by =onsanto 'o.D Dir@s R. *.7**) Brightwell B.D et al. Aashington D'D 'D<$2-%5657+( Ailliams /.ier <.D 'owell :.6 under -2)76*. A97.7*%) <auer R.D 2-%**BD 2-%*% 2-%*%%D 2-%*%2D 2-%*%6D 2-%*%)( <i A.ier <. Dietrich =.%B.

lants. 'ummings dated +eb B %B55$ . Arch.. 8npublished method. =onsanto 'o.+.D :ulin A. =onsanto 'o.7*%5 =onsanto 'o.. 6 p. /1*%5. .7A) Ar@ansas. and Ailliams :. Environm. Lager dated 1ept. K-+%-64.7*2. 2* p. 2 p. &%B5. "oxicol.and =etabolite Residue =ethod Development for Animal "issues a .+.A. 5 p. /1*%5./. /1*%5. 'ontam. &%B54( Information to 1upport Establishment of a +ood Additive "olerance for /lyphosate in . )% . /1*%5. 9oerger and . 5- .enaga &%B52( .7*2+olmar <.1.( Analytical Residue =ethod for 07nitrosoglyphosate in Aater$ =ethod 6.<' =ethod trial on tomatoes and cottonseed.7*%.7*22 Lee .&%B5-( <ethal Dietary "oxicities of Environmental . )2). &%B54( Analytical Residue =ethod for 07nitnoso707phosphonomethyl /lycine in Aater$ =ethod D. &%B5-( =emorandum to :..-( Recommended 'hemicals for Aeed and Brush 'ontrol =.*( <etter sent7to E. 0elson dated :an %B %B. /1*%5. Ar@ansas 'ooperative Extension 1ervice &%B.7*%B 1torherr R.esticide Residues on .$24B725.A. K4+%566 and 4+%5-.D. 3ol % of % 1ections A7:. 'ummings dated 0ov % %B5-$ . 6 p. 8npublished study prepared by =onsanto p. /1*%5. &%B55( =emorandum to :. =ethod tryout for glyphosate on soybeans..Report77Aildlife 0o. 9ill E.roducts$ Appendix '. %B%. 1pann :. K>+262B glyphosate in or on peanuts by an 9.alm >il$ 1pecial Report 0o. /1*%5.7*26 Lee .. %B %B. &%B. &%B. 1pecial 1cientific . /1*%5. =ethod tryout for glyphosate in beef liver. 8npublished =ethod...D 1anders 9. 9eath R.<' procedure. &%B5B( "oxicity of the herbicide glyphosate and several of its formulations to fish aquatic invertebrates.%$ =ethod trial on .*$ /lyphosate 9.. 8npublished study.ollutants to Bird 8.7*2* 1torherr R.%( <etter sent to =.1.

&%B.)4*7'( Bohn :. submitt by =onsanto 'o. J75*7B*. Environ. .( "he . 9ughes gibba$ :.5( "he "oxicity of /lyphosate "echnical to Anabaena flosaquae$ <ab .II$ %447%.ro?ect 0o. ***45*6B Birch =. and =artin :. &%B. &%B. "he biologic and economic assessment of 2 ) -7" 'ooperative Impact Assessment "echnical Bulletin 0umber %45%. 8npublished study prepared by =alcolm . ).5 0o. 26 p.J.D prepared by Jounger <aboratories Inc.esticide 'ontent of 1urface Aater Draining from Agricultural +ields 7 A Review :.%$B72.%.irnie Inc. Academic .art 3.ro?ect ID$ %*B27*27%%**76.irnie Inc.p.5( An Evaluation of the .ress 0.D 'D<$**.5( "he "oxicity of /lyphosate "echnical to 0avicula pelliculosa$ <ab . 3ol Aauchope &%B5.reemergence 9erbicidal Activity of '. 8npublished study prepared by =alcolm . 8npublished study prepared by =alcolm .9.ro?ect ID$ %*B27*27%%**7-.esticides to Birds in their Environment.ro?ect ID$ %*B27*27%%**72. . 8npublished study prepared by =alcolm . Aashington D. 9ughes :. &%B. 2) p.enaga &%B56( +actors to be considered in the Evaluation of .ress 0. &%B5*( "oxicological Investigation of '. &%B46( 'ereal 'rops Rice 1orghum and =illets page 46-.9.ro?ect ID$ %*B27*27%%**7%.'orrelation of Representative Data as a Basis for Estimation o their =agnitude in the Environment. 26 p. 2.5( "he "oxicity of /lyphosate "echnical to <emn <ab . <eonard 81DA A. 8npublished study )*%-B6*% )*264B*% )*264B*2 )*264B*6 )*264B*) )*264B*- 5- . Eual. &8npublished study received :an 6* %B under -2)76*.D. 45-5676$ . Environmental Euality Academic .75*%6B$ <ab .irnie Inc. 8npublished study prepared by =onsanto Agricultural 'o. 26 p.J.5( "he "oxicity of /lyphosate "echnical to 1elenastrum capricornutum$ <ab .irnie Inc. 9ughes :.ro?ect ID$ *-4665. 9ughes :..5( "he "oxicity of /lyphosate "echnical to 1@eletonema costatum$ <ab . 5.'. &%B. Environmental Euality .ro?ect ID$ %*B27*27%%**7). 9ughes :. &%B.

Blas#ca@ D.6D =onsanto Reference 0o. =onsanto Reference 0o. Aashington D'D 'D<$ 2-2%)27B( =aibach 9. **%65%6B **%65%)* )%)**4*) A''10$ 2-2%)2 **%65%65 Auletta '.. submitted by =onsanto 'o. submitted by =onsanto 'o.D Daly I.igs$ MRoundup +ormulationN$ BioHdynamics .ro?ect 0umber$ ).%B.7%%).67**. of 'alifornia771an +ransisco 1chool of =edicine submitted by =onsanto 'o.2D =onsanto Reference 0o.prepared by =alcolm .ro?ect 0o.ro?ect 0o.6 **5.$ =onsanto Reference 0o.D prepared by 8niv. Aashington D'D 'D<$2-2%)27A( Auletta '. &%B.7%%).olado "echnical$ **%65%6. %5 p..( .%B. )26)7.) under -2)76*. &%B. BD7. Aashington D'D 'D<$2-2%)27'( +ran# ".6( A Dermal 1ensiti#ation 1tudy in /uinea .. 8A7. 2* p..6( Evaluation of the . &8npublished study received :an .%B.2( M"oxicity$ %)'7glyphosate in =on@eysN. BD7. &%B..rimary Dermal Irritation 1tudy in Rabbi for /lyphosate "echnical &Aetca@e($ <ab . Blas#ca@ D... A B ' D =RID$ =RID$ =RID$ =RID$ **%65%65 **%65%6.%76)4. &8npublished study received :an .D prepare by 8niv.D Blas#ca@ D.D prepare by BioHdynamics Inc. BD7.D Blas#ca@ D.ercutaneous Absorption o Roundup +ormulations in =an 8sing an in vitro "echnique$ =onsanto 1tudy 0o.6( A Dermal 1ensiti#ation 1tudy in /uinea . Aashington D'D 'D<$2-2%)27D( 9irsch R. +inal rept.7.) under -2)76*. )26-7.( Eye Irritation 1tudy in Rabbits for /lyphosate "echnical &Aetca@e($ <ab .ro?ect 0umber$ ). 22 p.D et al.) under -2)76*. &8npublished study received :an . &%B.irnie )%)**4*6 Inc. &8npublished study received :an . &%B.D et al. &%B. **%65%6B **%65%)* )*)*-)*% 5- .D Augustin D..%B.57.) under -2)76*.. BD7.D prepared by BioHdynamics Inc. of Aashington 1chool of =edicine submitted by =onsanto 'o.5( 0itrosamine Analyses of Roun 9erbicide rodeo 9erbicide =>0 *%6B and . &%B. 8npublished study prepared BioHdynamics Inc.D Daly I. 8npublished study prepare BioHdynamics Inc.igs$ M/lyphosateN$ BioHdynami .

5( B*7day 1tudy of /lyphosate Administered in +eed to 1pragueHDawley Rats$ .$ <ab . &%B..'.47 6-%HE9< .7A( Reyna =.D :ohnson '.D Edwards /.9. submitted by =onsanto 'o.. 8npublished study prepared by =onsanto 'ompany Environmental 9ealth. )%)**4*2 )%-564*% )*--B)*% ***B6.ro?ect 0o.ro?ect 0umber$ =1<74%BB$ %**4. )%)**4*% Blas#ca@ D. &%BB*( . 1tout <.D . . 8npublished study prepared BioHdynamics Inc.6*%%4... 9erre B. =<7. &%B.D 'on@in R.* under 6*. Aashington D.( Acute Dermal "oxicity 1tudy in Rabbits f /lyphosate "echnical &Aetca@e($ <ab .A.. BD7.7%%). 8npublished study prepare BioHdynamics Inc..D 'D<$2)44%57AD 2)44%.6-. Blas#ca@ D. 5572*42 &8npublished study received :an 2* %B. &8npublished study received :ul 2 %B.( Acute >ral "oxicity 1tudy in Rats for /lyphosate "echnical &Aetca@e( .R. . %5 p.. ID =<7.. 8npublished study prepared by =onsanto Agricultural 'o.ro?ect 0o.%7 %B-...D 0air .ro?ect 0umber$ ).orndorfer '.'. p. 6%5 p.<aboratory .D submitted by =onsanto 'o. 8npublished study prepar by =onsanto Agricultural 'ompany.D prepar by BioHdynamics Inc.%( A <ifetime +eeding 1tudy of /lyphosate &Roundup "echnical( in Rats$ .D et al.roduct 'hemistr Data to 1upport the Registration of the 42O 1olution of the Isopropylamine 1alt of /lyphosate &=>07*%6B($ 1torage 1tabi 1tudy$ <ab .D et al. 2%2 p. &%B.D 'D<$2)522. IR7. &%B. D. BD7..=onsanto Reference 0o. %.A.D Riley :. Aashington D. <an@as /. %2 p. &%B.67%65$ 1t 0o.D 'D<$2)25BB7A :ohnson D.ro?ect 0umber$ ).'. 245 p.-( "welve =onth 1tudy of /lyphosate Administered by /elatin 'apsule to Beagle Dogs$ .47.ro?.ro?ect ID R.D Barclay :.$ =onsanto Reference 0o. prepared by International Research and Development 'orp. 8npublished stu prepared by =onsanto Agricultural 'o.5B ***64.2( 2%7d Dermal "oxicity 1tudy in Rabbits$ )*%7%4.4%2.2 under -2)76*.2 under -2)76*. Aashington D.. 0o.)4* **%-665) 5- .*( A "hree7=onth +eeding 1tudy of /lyphosate in =ice$ 1pecial Repor K =1<7%%-). &8npublished study received Apr %2 %B.'.7%%)..D =onsanto 0o.*6 ***B.E.A. submitted by =onsanto 'o. &%B..D 9ogan /.. &%B.D 2)44%BD 2)442*D 2)442%( 1treet R.

&8npublished study received :an 2* %B.ne#evich A. &%B. submitte =onsanto 'o. Aashington D'D 'D<$2)55B67A( )%4)6.67%65$ 1tud 0o. 5572*42.D 'D<$2)44%57AD 2)44%. 8npublished study prepared by =onsanto Agricultural 'o.E.5B <an@as /.D 9ogan /.1treet R.idney 1ections$ Addendum to +inal Report Dated :uly 2% %B.E.ro?ect 0o. .ro?ect 0o.6*%%4.D submitted by =onsanto 'o. . Reyna =. &8npublished study received Aug %5 %B.*( "erato 1tudy in Rabbits$ IRD' 0o.***B6. 8npublished study prepared by =onsanto 'ompany Environmental 9ealth. )*%7*-).6$ .6( A 'hronic +eeding 1tudy of /lyphosate &Roundup "echnical( in =ice$ . 2%5. BBB7*2%D received =ay 26 %B. &8npublished st including IRD' no. &%B.* under -2)76* prepared by International Research and Development 'orp.=.D 'D<$2)2-%47A( Rodwell D.:.ro?ect 0o.2( <etter sent t "aylor dated :ul 4 %B. 5572*4%$ BD07557)2*.D Ruec@er +. %*%).*( "eratology 1tudy in Rats$ IRD' 0o. submitted by =onsanto 'o. &%B. &%B.D 2-%**BD 2-%*%*D 2-%*%%D 2-%*%2D 2-%*%6D 2-%*%)( =c'onnel R. &%B. Aashington D.'. =<7. Aashington D. Rodwell D. submitted by =onsanto 'o.D et al.R. &%B. +inal rept.D "as@er E.D prepared by International Resear and Development 'orp. Aashington D. -B p.. &8npublished study receiv =ay 26 %B.*% **%-665) **%6*)*4 **%-*-4) ***)4642 ***)4646 5- .p.D 'D<$2)2-%47B( **%*-BB.D Blair =.D 2)44%BD 2)442*D 2)442%( 1tout <.%( A <ifetime +eeding 1tudy of /lyphosate &Roundup "echnical( in Rats$ . 8npublished study prepared by BioHdynamics Inc.D 9ogan /.'.D "as@er E.D et al.6 under -2)76*. &%BB*( 'hronic 1tudy of /lyphosate Adminitered in +eed to Albino Rats$ <ab . )*%7*-4. 5572*4%A.D..D prep by BioHdynamics Inc. submitted by =onsanto 'o.athology Report on Additional . &8npublished study received :ul 5 %B under -2)76*.2$ Roundup herbicide$ Addendum to pathology report for a three7generation reproduction study in rats with glyphosate.D prepared by BioHdynamics Inc.ro?ect 0o.:.2 under -2)76*. 6%5 p. &%B. Aashington D'D 'D<$2-%**57AD 2-%**.* under -2)76*.-( "welve =onth 1tudy of /lyphosate Administer by /elatin 'apsule to Beagle Dogs$ .D Blair A.-( A 'hronic +eeding 1tudy of /lyphosate &Roundup "echnical in =ice($ .'.ro?ect 0umber$ =1<7 %*)B-$ R.

&%B5.- 5- . &%B...D submitt by =onsanto 'o. &8npublished study received 0ov %.D +ol@ R. 0o. =1<752*4$ R.D.D +ol@ R.D 'hott R.ro?ect 0o$ =1<7%*6. 8npublished study prepared by =onsanto 'o. &8npublished study received :ul 5 %B. 8npublished study prepared by =onsanto Agricultural 'o. &%B.2 under -2)76*. Aashington D.( =icrobial =utagenicit "esting on '.2667A( Ridley A. Aashington D'D 'D<$2-%5657D 1hirasu J.ro?ect 0o.5. &8npublished study received 0ov %. &%B.R" /ene =utation Assa with /lyphosate$ E9< 1tudy 0o.**%*-BB- 1treet R.2( <etter sent ot R.6 ***5.D submitted by =onsanto 'o.D.D submitted by =onsanto 'o.6( '9>H9/. %%. +inal rept.'. 9owe R.%B5B under -2)76*. Aashington D.2$ Roundup 9erbicide$ Addendum to pathology reprot for a three generation reproduction study in rates with glyphosate.'.55. Aashington D'D 'D<$2-%5657B( <i A.4%6B &=1<752%-($ R.67%--.D 'D<$26.D . Ridley A.4%B )*545%*% )*545%*2 **%624.%B.D et al.D =irly .5 p. -.:. =<7. &%BB*( "wo /eneration Reproduction +eeding 1tudy w /lysophate in 1prague7Dawley Rats$ <ab .6**.55.ier <.ier <. &%B5.D . .ro?ect 0o. 0o.%B5B under -2)76*..45-56 &/lyphosate(.6 under -2)76*.D >hta ".D prepared by Institute of Environmental "oxicology :apan submitted by =onsanto 'o.D 9annah <. 8npublished study prepared by =onsanto 'o.p.6( A 1tudy of )%42%-*% ***5.D =oriya =. .D +ol@ R.D. &%B.42* **%624. . &%B. . . &8npublished study receive April 2.( +inal Report on 1almonella =utagenicity Assay of /lyphosate$ "est 0o.D submitted by =onsanto 'o. Aashington D'D 'D<$2)55B67A( Reyna =.2667B( <i A.6( In vivo Bone =arrow 'ytogenetics 1tudy of /lyphosate in 1prague7Dawley Rats$ 1tu 0o.%B. Identification 'haracteri#ation and Euantitation of /lyphosate and Its =etabolites after Intravenous and >ral Administration$ <aboratory .D =c'lanahan R.% **%624. &%B.( =etabolism of /lyphosate in 1prague7Dawley Rats. "aylor dated :ul 4 %B.D 'D<$26.9.6 under -2 6*. Excretion and "issue Distribution of /lyphosate and Its =etablites following Intravenous and > Administration$ <aboratory . <+75. %-.art I.( "he =etabolism of /lyphosate in 1prague Dawley Rats77.D +lowers <.ier <.art II.7 &8npublished study received Apr 2. Dietrich =.6.

6( Acute "oxicity of MInert IngredientN to Daphnia magna$ 1tatic Acute Bioassay Report 0o 6*)%4.lasma and Bone =arrow <evels of /lyphosate following Intraperitoneal Administration in the Rat$ 1tudy 0o.6( Acute "oxicity of <iqua7Aet to Daphnia magna$ Report 0o.6( Acute "oxicity of <iqua Ae to Rainbow "rout &1almo gairdneri($ Report K6*)*B.D +orbis A. &%B.%B.D =cAllister A.67%2* prepared by Analytical Bio7'hemistry <aboratories Inc. &%B.inter D. 8npubli study prepared by Analytical Bio7'hemistry <aboratories Inc.inter D.6 under -2)76*..6( Acute "oxicity of <I75** to Daphnia magna$ Report 0o.%B. 8npublished =onsanto 1tudy 0o.6( Acute "oxicity of .D +orbis A. &%B. 6*)%6. AB7.D +orbis A. 8npublish study prepared by Analytical Bio7'hemistry <aboratories Inc )4 p. Aashington D'D 'D<$2-%5657+( 1tudy 0o.6D 0o =RID or Accession 0o. &%B.esticides 'ontaminated with 07nitroso 'ompounds )2.%76)4D Date$ . 6) p. -% p.H6*H. &%B. 8npublished study prepare Analytical Bio7'hemistry <aboratories Inc. &%B.D +orbis A. "hompson '. 8npublished study prepared Analytical Bio7'hemistry <aboratories Inc.6*%*B.p. 8npublished =onsanto 1tudy 0o.D +orbis A. Burgess D. 8npubli study prepared by Analytical Bio7'hemistry <aboratories Inc.6( Acute "oxicity of <I75** to Rainbow "rout &1almo gairdneri($ Report 0o.assag Rainbow "rout &1almo gairdneri($ Report 0o. )4 p. 5- . &%B.67%22 prepared by **%-2-BB **%-24*% **%-2545 **%-2-B5 **%-24** **%-24*2 **%-254. )4 Burgess D. &8npublished study received 0ov %. Burgess D.6( Acute "oxicity of . 6*)%6. 8npublished study prepare Analytical Bio7'hemistry <aboratories Inc. 6.6( Acute "oxicity of MInert IngredientN to Rainbow "rout &1almo gairdneri($ 1tatic Bioass Report 0o. 6*)%*. .D +orbis A. 6) p. Burgess D. . 6*)%2.$ 8A7.D =cAllister A. 6*)%2.D submitted by =onsanto 'o.-) &:une 2. &%B. 6*)%-.*(! **%-2-B4 proposed policy )- "hompson '. AB7. .assage to Daphnia magna$ Report 0o.( !.

ro?ect 0umb =1<7B25%$ . submitted by =onsanto 'o.D.ressure Determinations for /lyphosate and =>0752**H%-%**$ .4( .5( . &%BB6( "he "errestrial +ield Dissipation of /lyphosate$ +inal Report$ <ab . =. Aashington D'D 'D<$ 2)2-%47'( 9ammon :. B2). =1<754)2D R.*( Dominant <ethal 1tudy in =ice$ IRD' 0o. E.D Arenn :.D =c/overn . 8npublished study prepared by "he Agricultural /roup of the =onsanto 'o. &%B. D.harmacology and "oxicology Research <aboratory. 8npublished study prepared by =onsanto 'o %52 p.i@e R.an7Agricultural <abs Inc.ro?ect 0o.D Blair A.ro?ect ID =1<74-65 R. 8npublished study prepared by =onsanto Agricultural 'o. 64 p. and . 0o.roduct 'hemistry Data "o 1uppport the 'ontinued Registration of /lyphosphate &07phosphonomethylglycine($ Report 0o.D . p. .hotodegradation of 'arbon7%) /lyphosate inHon 1oil by 0atural 1unlight$ <ab .B( . <eiber =.D et al.ro?ect 0o..Analytical Bio7'hemistry <aboratories )%66-%*% Inc. 4 p. &8npublishe study received =ay 26 %B. >ppenhui#en =.( 3apor . 8npublished study prepared by =onsanto Agricultural 'ompany.5.ro?ect 0umber$ =1<7%24-%$ 467R7%$ A<7B%7%2%.. Ruec@er +. %2)) p.roduct 'hemistry Data to 1uppo the Registration of =>07. =1<7-*44 &Revised($ . .D prepared by International Research and Development 'orp.2 p."R<7%-6A. &8npublished study received :un 6 %B54 under -2)76*. &%B.D 'D<$*B4%557D( **%42B%2 ***)464) **%4%666 )%*B4%*% ***4%--6 ***-%B. &8npublished study received on un@nown date under -2)7EI72)D 'D<$*B-6)-7+( =onsanto 'ompany &%B5-( Residue Results. 8npublished adde prepared by =onsanto Agricultural 'o. =.* under -2)76*. -B =onsanto 'ompany &%B5)( Residue Results..%B. &%B. 8npublished study prepared by . &%B. Rodwell D. &%B. 1hepler .6 &+allow=aster($ 1torage 1tabilit 1tudy$ <aboratory .4( Addendum to >ne7year "oxicology 1tudy in Do with /lyphosate$ 1pecial Report =1<7-B25. 5446. )*%7*4). B )254-**% )*--B6*% Barclay :. 0o. &%B.* 5- .

)4 p.6( Acute "oxicity of . Agricultural a +ood 'hemistry 4&-($64*764-.D 9aller A.*( 1ummary$ /lyphosate.7%4-( to Rainbow "rout &1almo gairdneri(. submitted by =onsanto 'o.D 'D<$ *BB42)7A( . AB7.p. &8npublished study received Dec . under -2)76*.under )/%))BD submitted by .4. %.45-56 and =on2%6B to Aor@er 9oney Bees.***-6**2 =onsanto 'ompany &%B. &%B5-( "he Results of "ests on the Amount of Residue Remaining Including a Description of the Analytical =ethods 8sed$ Endothall. 6* 8npublished =onsanto 1tudy 0o. "oxicol.B 5- . .ansas 'ity =o.. %B. &8npublished study received +eb % %B5.).A. %B44 under 5+*4%2D submitted by 'hemagro 'orp. &8npublished study received on un@nown date under )/%)))D prepared by 9untingdon Research 'entre submitted by =onsant 'o. &%B5. 'ontam.-( "oxicity of ad?uvan to bluegill.E.* under -2)76*.rocedure for /lyphosate and Aminomethylphosphonic acid analysis of cranberries.D also an unpublished submission received Aug %. &Reports by various sourcesD unpublished study received 1ep %.D 'D<$*B*5B47A( +orbis A.7%)2.ennwalt 'orp. **%-2544 **%-2B*6 **%--)55 ***24).%*2 **%6466B ****-2B.%B5.assage t Bluegill 1unfish &<epomis macrochirus($ Report K6*)%%.D =cAllister A. Includes undated method entitled$ Analysis of /lyphosate in cranberriesD unda method entitled$ /lyphosate and metaboliteD and undated method entitled$ . &%B52( "he Acute 'ontact and >ral "oxicities of '. +raser A. "acoma AAD *B6.4%7A( "hompson '. &%B.D "hayer D.( Acute "oxicity of "echnica /lyphosate &AB75. &%B-.D prepa by Analytical Bio 'hemistry <aboratories Inc. 6)$%6. &Report no. Aashington D'D 'D<$*B544%7B( Arthur B.D :en@ins /.'. Aat@ins '. 8npublished study prepared by Analytical Bio7'hemistry <aboratories Inc.( Biological activity of sever > >7Dial@yl alpha7acyloxyethyl phosphonates.6( Acute "oxicity of Inert Ingredient to Bluegi 1unfish &<epomis macrochirus($ 1tatic Bioassay Report 0o.D =callister A. ).D 'D<$*B6. Bull. Aashington D.7R( **%*.D 'asida :.ec@emet >. Environ.67%2% prepared by Analytic Bio7'hemistry <aboratories Inc. &%B. 'ohle .D. &%B.

D. Inc.62*% )%--2. %* 0icholls R.)%52. &%BB*( 'onfined Rotational 'rop 1tudy of /lypho .p.*% )2652-*) )%-)62*% 5- . 'o.722.harmacology and "oxicology Research <aboratory Inc. 8npublished study prepared by =onsan Agricultural 'o.ro?ect 0umber$ E+7. %*. %* p.art I$ In7+ield . 64 p. 9onegger :. %% )%4. &%BB2( Addendum to =1<7B. 'astle 1. 8npublished study prepared by =onsanto Agricultural 'o..5 and B by 0atural 1unlight$ <ab .ro?ect 0umber$ 266A7%$ 266A$ %*2*.%%$ 'onfined Rotational 'rop 1tudy of /lyphosate. %*%).athryn 1. Aerobic =etabolism carbon %) /lyphosate in 1andy <oam and 1ilt <oam 1oils with Biometer +las@$ 1upplement to =RID )%5)2B*%$ 8npublished stud prepared by =onsanto Agricultural 'omp.B.p. 9onegger :.D Ruec@er +.. )2 p. &%BB*( Dissipation of /lyphosate and Aminomethylphosphonic Acid in +orestry 1ites$ <ab . 4 p.5*% 1tout <. . 8npublished study prepared by =onsanto Ag. &%BB2( Addendum to =1<7%*-54$ Aerobic Aquatic =etabolism of Pcarbon %)Q /lyphosate$ 1upplement to =RID )%5264*%$ 8npublished study prepared by =onsanto Agricultur 'omp.ortion$ <ab .art II$ Euantitation 'harateri#ation and Identification of /lyphosate and its =etabolites in Rotational 'rops$ 1upplement to =RID )%-)62*2 8npublished study prepared by =onsanto Agricultural 'omp. &%BB2( Aquatic Dissipation of /lyphosate and A=.D Ru#o <. 8npublished study prepared by . --.A in Aater and 1oil 1ediment +ollowing Application of /lyphosate Irrigated 'rop and +orestry 8ses$ Addendum to =1<7. &%BB2( Addendum to =1<7%*-55$ Anaerobic Aquatic =etabolism of carbon %) /lyphosate$ 1upplement to =RID )%526 8npublished study prepared by =onsanto Agricultural 'omp.hotodegradation of 'arbon %) /lyphosate in a Buffered Aqueo 1olution at p9 .ro?ect 0umber$ =1<7%*)B-$ R. &%BB*( 'hronic 1tudy of /lyphosate Administered in +eed to Albino Rats$ <ab .D . &%BB*( Degradation 1tudy$ . /oure A. 9onegger :. 9oner <.an7Agricultural <abs.ro?ect 0umber$ =1<7BB)*D BB6.662H1upplement to RD . &%BB2( Addendum to =1<7%*-5. %B 9onegger :.B%*% )2652-*% )2652-*2 )2652-*6 )26. 8npublished study prepared by .

D +eng .ro?ect 0o. &%B.. &%BB*( 'onfined Rotational 'rop 1tudy of /lyphosate .ro?ect ID =1<7B6*).ro?ect 0o. &%B.D +eng .p.D .%%.ro?ect 0o. =1<756-. +orbis A. %2% p.( 3olume -$ Irrigated 'rops 1tudy77Determination of /lyphosate Residues in 'rops Irrigati Aater 1ediment and 1oil following "reatment of Irrigation 1ource with Rodeo$ <aboratory .p. =1<75).$ 9<A 4%*67%%2$ =1<75)2*.p.( 3olume )$ /lyphosate Residues in Alfalfa 9ay and 1eed following 1cattered 1pot "reatment with Roundup 9erbicide$ <aboratory ./oure A. &%B.B( 8pta@e Depuration and ioconcentration of 'arbon %)7/lyphosate to Bluegill 1unfish &<epomis macrochirus( ..D <ogusch E.atanella :.2. )*-)%6*) =ueth =.art II$ Euantitation 'haracteri#ation and Identification of /lyphosate and Its =etabolites in Rotational 'rops$ <ab .( 3olume 6$ 3alidation of an Analytical =ethod for the Determination of /lyphosate Residues in Animal "issues$ <aboratory . 8npublished study prepared by Analytic Biochemistry <aboratories Inc. )%22. )*-)%6*6 . &%B..( 3olume 2$ =etabolism 1tudy of 1ynthetic R'arbon %6H'arbon %)S77<abeled /lyphosate and Aminomethylphosphonic Acid in <aying 9ens$ <aboratory .ro?ect 0o. )%-)62*2 =c=ullan .atanella :. 5- ..D 9onegger :..( 3olume %$ =etabolism 1tudy of 1ynthetic R'arbon %6H'arbon %)S77<abeled /lyphosate and Aminomethylphosphonic Acid in <actating /oats$ <aboratory .ro?ect 0o. 8npublished study prepared by =onsanto 'o.i?anows@i . 8npublished study prepared by =onsanto 'o. =1<75466. )2652-*..ro?ect 0umber$ =1<7B. 8npublished study prepared by =onsanto 'o. 8npubli study prepared by =onsanto Agricultural 'o.. 9<A 4%*67%%6$ =1<75)-. )2..unstman :. &%B. )*-)%6*2 Bodden R.6*% )*-)%6*% Bodden R. Determination of /lyphosate Residues in 'rops Irrigation Aa 1ediment and 1oil +ollowing "reatment of Irrigation 1ource wit Rodeo 9erbicide$ 1upplement to =RID )*-)%6*-$ 8npublished s prepared by =onsanto Agricultural 'omp. &%BB2( Addendum to =1<75466$ Irrigated 'rop 1tudy. 8npublished study prepared by =onsanto 'o. 4.D . . %24p... )*-)%6*. &%B. %2Bp. 8npublished study prepared by =onsanto Agricultural <abs.. 2*6 p. 22p.

)2 p. 8npublished study prepared by IR7) 0ortheast Analytical <ab.reharvest Applications with Roundup 9erbicide$ =1<7 4B%B. **%4)52B Danhaus R.A in 1wine "issues Dairy 'ow "issues and =il@ <aying 9en "issues and Eggs$ <aboratory . &%B. %%* p. )*-*24*% .. 5%46.unstman :. 8npublished study prepared by =onsanto Agricultural 'o. )*5. 8npublished study prepared by =onsanto 'ompany. %B6 p.*% Baron :. &%B. &%BB%( 1torage 1tability of /lyphosate Residues in 'rop 'ommodities$ <ab ..ro?ect ID.62*4 62*5.( /lyphosate77=agnitude of Residue on >nions$ IR7) . ***4%--6 =onsanto 'ompany &%B5)( Residue Results.. =1<75. 8npublished study prepared by =onsanto 'o. B5 p. =1<7)24. %*6 p.) p. . 8npublished study prepared by IR7) 0ortheast Analytical <aboratory. 8npublished compilation prepared by =onsanto 'o. )*5.)6$ %*-%. &%B.asture /rasses Alfalfa and >ther <egumes for /lyphosate and Amino7 methylphosphonic Acid$ =1<7)-**.. .. 8npublished study prepared by =onsanto 'o.A( 7 A Round7 robin 1tudy$ Report 0o.ro?ect ID.5( /lyphosate Residues in =ilo /rain and +odder +ollowing .ro?ect 62*).otatoes and .6-2*% Baron :. and others. )*.6%*% Baron :. **%-45B6 . 6*% p.ro?ect 62*.=ueth =. )%B)*5*% =ueth =.ro?ect 0o.rocessed +ractions of . &%B.55. )*-62**) =anning =. 2*) p.ro?ect ID =1<75-%-. 8n7 published study prepared by =onsanto 'o.*2. . %)% p.otatoes After "reatment with Roundup 9erbicide$ .$ :obH. &%B.( 1torage 1tability 1tudy of /lyphosate and A=..**%-B)%B . &8npublished study re7 ceived on un@nown date under -2)7EI72)D 'D<$*B-6)-7+( )*-*24*.( 1torage 1tability of /lyphosate in 'rops and Aa7 ter 7 1tatus Report$ **446**.( /lyphosate Residues in .R762%*.-6*2 =ueth =. &%B. &%B.2 p. &%B. )*.( /lyphosate77=agnitude of Residue on "urnip$ IR7) .unstman :.-( 3alidation of a 0ew Residue =ethod for Analysis of /lyphosate and Aminomethylphosphonic Acid &A=.6( /lyphosate Residues in 1oybeans and 1oybean 5- .ro?ect 0umber$ =1<7%*. 8npublished study prepared by IR7) 0ortheast Analytical <ab.4( Reanalysis of Aater 'otton 1oybeans . &%B.( /lyphosate 7 =agnitude of Residue on Broccoli$ . &%B.untsman :.

rocedure for /lyphosate and Aminomethylphosphonic acid analysis of cranberries.rocessi 'ommodities +ollowing Directed 1pray "reatment with Roundup 9erbicide$ .ro?ect ID. &%B. %%5 p. 8npublished study prepared by =on7 santo Agricultural 'o. )*-*24*) . 8npublished study prepared by =onsanto Agricultural 'o. -*)6.5( /lyphosate Residues in 'orn /rain +ractions +ollowing .reharvest "opical "reatments with Roundup 9erbicide$ Report 0o. 45-56 and '.5( /lyphosate Residues in =ilo /rain and +odder +ollowing .5( /lyphosate Residues in 'orn /rain and +odder +ollowing .. )*%-B)*% Beasley R.D 'D<$ *BB42)7A( )*5..untsman :.unstman :.p.%*% .ro?ect 0umber$ =1<7B5B5. 1. 8npublished study prepared by =onsanto Agricultural 'o. &%B.5( /lyphosate Residues in =ilo /rain +ractions +ollowing . 8npublished study prepared by =onsanto 'o. )*-*24*% . %2 p. 8npublished study prepared by =onsanto 'o.* under -2)76*.-6*6 Adams 1. %%* p. 8npublished study prepared by =onsanto 'o. 8npublished study prepared by =onsanto 'o.unda 8. )%)5.reharvest Application of Roundup 9erbicide to 'orn$ <ab . =1<762-B$ . )*-*24*2 . &%B.*25. &Reports by various sourcesD unpublished study received 1ep %.rotein Research 'enter.reharvest Applications to 'orn with Roundup 9erbi7 cide$ =1<74B%5.ro?ec 0o. in cooperation with "exas AG= 8niv.reharvest Applications with Roundup 9erbicide$ =1<7 446.+ractions following Recirculating 1prayer and .Residues in 'itrus .reharvest Applications to =ilo with Roundup 9erbi7 cide$ =1<75*)6. &%B. Includes undated method entitled$ Analysis of /lyphosate in cranberriesD undate method entitled$ /lyphosate and metaboliteD and undated method entitled$ . &%B. %B.unstman :. &%B.reharvest Applications with Roundup 9erbicide$ =1<7 4B%B. 5- .unstman :. ***-6**2 =onsanto 'ompany &%B. 5%46. p. %2% p.. 8npublished study prepared by =onsanto 'o. )*-*24*6 . %54 p. %B.5( Determination of '.( /lyphosate Residues in /rapes and /rape . . +ood .rocess +ractions$ Additional Information in Respons to the /uidance Document for /lyphosate Registration and 1peci7 fically the .reviously 1ubmitted /lyphosate Residue 'hemistry 1tudy for 'itrus +ruits. =1<7.*( 1ummary$ R/lyphosateS. &%BB*( /lyphosphate Residues in or on 'orn /rits and +lour +ollowing .

( /lyphosate77=agnitude of Residue on =ango$ . 8n7 published study prepared by =G" 'hemicals Inc.B( /lyphosate Residues in Aheat /rain and 1traw after . &8npublished study received :un 6 %B54 under -2)76*. 8npublished study prepared by IR7) 0ortheas Analytical <aboratory.( /lyphosate77=agnitude of Residue on Asparagus$ <aboratory . B. 8npublished study prepared by 0J 1tate Agricultural Experiment 1tation. )%). p.( 3olume )$ /lyphosate Residues in Alfalfa 9ay and 1eed following 1cattered 1pot "reatment with Roundup 9erbicide <aboratory .R 62%2. &%B. %%* p. 8npublished study prepared by =onsanto 'o. 56 p.ro?ect ID$ IR7) .% =onsanto 'ompany &%B56( =aster 1ummary "able of . =1<75). %-.unstman :.= Residues of /lyphosate &'.p.D.A in >lives and >live >il +ollowing 8se of 1ting 1E771panish +ield "rials %BB*7%BB2$ <ab .=onsanto 'o.ro?ect ID$ .5( /lyphosate Residues in =ilo /rain and +odder +ollowing .reharvest Applications with Roundup 9erbicide$ =1<7 4B%B.%6.45-56( and /lyphosate =etabolite &'.ost7emergent Application.-*)6-( in /reen 'offee Bean 1tudies 8sing a 1ingle Directed .R762%6.D 'D<$*B4%557E( )*-.6.. 0o. %.)*% 9ontis A. 8npublished study prepared by =onsanto Agricultural 'o.4( "riphenyltin 9ydroxide77Responses to Euestions in the E. )*4)2)*% Baron :.2H% for =onsantoD 'D<$ 2)56).6.. &%B. 8npublished study prepared by =onsanto Agricultural 'o. )26B.1 .2 under . &%B.)6*% Allin :. ***-%B. &%BCC( 'rop Residues and "olerances.)( T/lyphosate Residues in Aheat /rain 1traw an =illingH+ractionation . %2% p. 8npublished study prepared by =onsanto 'o.4 &:acoby to 1heldon(.roducts following Ropewic@ Aiper "reat7 ment with Roundup 9erbicideU. &%B. &%B.p.. &8npublished study received Apr B %B. **%-*. 6.2. &%B. 8npublished compilation. &%BB2( Residues of /lyphosateHA=.ro?ect 0o.A <etter 1eptember 2) %B. )*%)B)*% 1heldon A. 5- . )*-)%6*) =ueth =. p **%*B25% =onsanto 'o.ro?ect 0umber$ %%%-$ =<<76*2B5. &%B.*)*% Baron :.7B( )*-*24*% . )64 p.reharvest "reatment with Roundup 9erbicide$ R. 4B p..

=1<75466. %B2 p.roducts +ollowing . **%-)6%% Armstrong ". %%4 p.( 3olume -$ Irrigated 'rops 1tudy77Determination of /lyphosate Residues in 'rops Irrigation Aater 1ediment a 1oil following "reatment of Irrigation 1ource with Rodeo$ <abo7 ratory . 2*6 p. 'omp. &%B. 8npublished study prepared by =onsanto 'ompany. =1<766B2D :obH.art II.roducts 'o.eanuts and . and 'raven <abor7 atories Inc.-( 1tatic 'rayfish &.* p. 2B6 p. &%B. in cooperation with Analytical Bio7'hemistry <abs.olyesterHAcryli . &%B. )*-62**% =anning =. )*-)%6*. 5%46.)( /lyphosate Residues in .ostemergent .7Day +eeding 1tudy$ <aboratory .D Ailson /. )*-62**2 =anning =.7Day +eeding 1tudy$ <aboratory . &%B. &%B.art I a .ro?ect ID =1<7452B.**%))6)% 1teinmet# :. &%B.A in Dairy 'ow "issues and =il@ +ollowing a 2.ro?ect 0o.-( 1tatic =arine =ollus@ &Rangia cuneata Bioconcentration 1tudy with Aater7applied T'arbon7%)U7/lypho7 sate and !0on7aged! 1andy <oam 1oil 1ubstrate . 62)p.unstman :.ro?ect 0o.D Ailson /. **%--%2* Armstrong ". 8npublished study prepared by =o santo Agricultural 'o.. 5- . %)5 p.D Ailson /.eanut +ractionation .rocambarus simulans +axon( Bioconcentration 1tudy with Aater7applied T'arbon %)U7 /lyophosate and !0on7aged! 1andy <oam 1oil 1ubstrate . %.5( Residue Determination of /lyphosat and A=. 8npublished compilation prepared by =onsanto 'o.A in 1wine "issues +ollowing a 2.5( Residue Determination of /lyphosat and A=. &%B.ro?ect ID =1<74454. 8npublished study prepared by =onsanto 'ompany.7Day +eeding 1tudy$ <aboratory . comp. in cooperation with AB' <aboratories Inc.. 8npublished study prepared by =onsanto 'o. 8npublished compilation prepared by =onsanto Agricultural . )*-62**6 =anning =.ro?ect ID =1<74425.ipewic@ "reatments with Roundup 9erbicide$ Report 0o.A in <aying 9en "issues and Eggs +ollowing a 2.art II$ 1pecial Report =1<7-%-B.art I and . 8npublished study prepared by =onsanto 'ompany.5( Residue Determination of /lyphosat and A=.

esticide +act 1heet &0o.R 0otice B%72 &Included in this RED( . 2. E. %.57%*62%) . 9ealth and Environmental Effects 1cience 'hapters Detailed <abel 8sage Information 1ystem &<8I1( Report /lyphosate RED +act 1heet &included in this RED( .4 Registration 1tandard($ 0"I1 1toc@ 0o. "hese accompanying documents are part of the Administrative Record for glyphosate and are included in the E. %. 2. Its purpose is to provide a path to more detailed information if it is required.esticide .#ppendix D 9ist of #vaila&le Related Doc!ments "he following is a list of available documents related to glyphosate.rograms . 6. . ).B. ..esticide .7+7B67*%%( for /lyphosate Registration 1tandard for .ort Royal Road 1pringfield 3A 22%4%. -..ublic Doc@et.roducts 'ontaining /lyphosate as the Active Ingredient &"he %B.AVs >ffice of .ertains to the <abel Ingredient 1tatement 'omplete Appendix A which details the use patterns sub?ect to reregistration +ederal publications on glyphosate are available and may be purchased from the 0ational "echnical Information 1ervice &0"I1( -2.A756.