This action might not be possible to undo. Are you sure you want to continue?
J Dent Shiraz Univ Med Scien 2012; 13(4): 169-175
Relationships of Stress and Coping Styles to Periodontal Disease: A Case-Control Study
Radafshar G.a, Zarrabi H.b, Jalayer S.c
Dept. of Periodontics, Oral and Maxillo-Facial Developmental Disease Research Center, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran b Dept. of Psychiatry, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran c Dentist, Private Practice, Rasht, Iran
KEY WORDS Coping Skills; Attachment Loss; Psychological adaptation; Emotional stress
Received April 2012; Received in revised form July 2012; Accepted Sept. 2012.
ABSTRACT Statement of Problem: The effects of individual variations in coping strategies have been debated in studies of the association between stress and chronic periodontitis, with conflicting results. Purpose: To investigate the associations between stress, coping styles and periodontal disease in a sample of Iranian population. Materials and Method: Forty patients with chronic periodontitis and forty control subjects with a healthy periodontium were enrolled in this study and matched for age and gender. Participants were patients undergoing periodontal treatment at the Department of Periodontics, Guilan University of Medical Sciences. A single examiner performed periodontal examination. Psychological assessments, including the Life Events Questionnaire and the Ways of Coping Questionnaire were done by a second examiner; both examiners were blind to the study. Bi-variate and multivariate logistic regression analyses were used to compare results for patients and control subjects. Results: Statistically significant differences in the problem-focused coping (p< 0.01), intensity of stress (p< 0.006), as well as escape-avoidance (p< 0.01), and accepting responsibility (p< 0.001) subscales were observed between the patient and control groups. Multivariate logistic regression identified a negative association between periodontitis and tooth-brushing frequency (OR= 3.3, 95% CI: 1.22- 8.69), as well as the accepting responsibility coping style (OR= 1.5, 95% CI: 1.14- 1.98), and a positive association with stress intensity (OR= 1.081, 95% CI: 1.023-1.143). Conclusion: The results suggest that psychological stress associated with various life events is a significant risk indicator for periodontal disease. Although statistically small, there was a clinically important link between coping strategies and periodontal disease.
v i h
Corresponding Author: Radafshar G., Dept. of Periodontics, Oral and Maxillo-Facial Developmental Disease Research Center, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran Tel: +98-0131-3263616, +98-0111318266 Fax: +98-0131-7757636 E-mail: email@example.com
Cite this article as: Radafshar G., Zarrabi H., Jalayer S. Relationships of Stress and Coping Styles to Periodontal Disease: A Case-Control Study Journal of Dentistry Shiraz University of Medical Sciences 2012; 13(4): 169-175.
Introduction Economic development and modernisation have introduced a variety of new stressors with disadvantageous consequences on the welfare and happiness of individuals in developed and developing countries. Clinical observations and epidemiologic studies have found that host defence and vulnerability to oral inflammatory infectious diseases are influenced by psychological fac169
tors and tension of behavioural and emotional challenges induced by life events, known as psychosocial stress [1-5]. There were more than 50,000 papers published over the past few decades discussing this issue in different aspects; from the impacts of stress on physical and mental health to its mechanism and consequences at cellular and genomic level. The potential relationship between stress and oral inflammatory infectious dis-
with more than 30% of the evaluated sites having clinical attachment level (CAL) ≥ 5 mm.6% of the US population . Over the past several years. et al. and bactericidal abilities of polymorphonuclear leukocytes (PMNs). The examiner was blinded to the study and trained for correct assessment. and salivary IgA secretion are considerably declined by continued elevation in cortisol concentrations. It consisted of 40 patients (23 women. serum. with CAL ≤ 3 mm and having no more than 7 sites with 4 mm CAL and/or PPD. HIV infection. pregnant women. some observational studies have showed that periodontal disease and its progression may be associated with psychosocial stress. placing the host in an immunosuppressive status. current smokers. and outcome of periodontitis is important . Coping Styles. anti-depressive.periodontal probe. treatment. Baseline characteristics and socioeconomic data were collected before periodontal evaluation. psychological stress was known as a predisposing factor in the aetiology of necrotising ulcerative gingivitis for more than four decades . such as the need for antibiotic prophylaxis. and the individual’s way of coping with stress [10-13] In contrast. S f D I Clinical Examination The periodontal clinical examination was carried out by an examiner using a manual probe (Williams. IgG production. financial stress. and periodontal departments of the Faculty of Dentistry. according to Armitage et al . 17 men) with at least 20 teeth. There are considerable differences in the susceptibility of individuals to periodontal disease. The participants were recruited from adults attending restorative. The CAL (distance from the cement-enamel junction to the base of the pocket) and PPD (distance from the free gingival margin to the base of the pocket) were www. Severe general periodontitis is a chronic inflammatory disease induced by bacteria with a multifactorial aetiology. comprised patients with generalised advanced periodontitis. patients who reported any systemic conditions that could have hindered periodontal examination. socioeconomic. the aim of this case-control study was to investigate the relationship between stress and coping styles and periodontal disease in a sample of Iranian subjects. To reach the final sample size.Hence. from March to August 2011. more research is needed to get a clearer understanding of this relationship. and radiographic evidence of bone loss. and ethnic groups. anti-inflammatory. Materials and Method Study Population A c r v i h o e Based on a pilot study. The role of environmental risk factors such as smoking and diabetes in the progression. or immunosuppressive drugs or calcium channel blockers. Iran. which leads to elevation of cortisol concentrations in gingival crevicular fluid (GCF). bleeding on probing (BOP) in at least 50% of the sites. To take part in the study. Exclusion criteria included periodontal treatment within the past 3 months. informed consents were signed by all participants. or cardio-vascular disease. eases is not a new concept. severity. it seems reasonable to investigate the effects of stress and coping among people from different cultural and social communities. Leukocytic. These findings emphasise the importance of diagnosis. Cultural morals and values affect the appraisal of stress by individuals in different ways. probing pocket depth (PPD) ≥ 6 mm in at least 5 teeth. all whom required periodontal treatment. It affects roughly 7–15% of adults worldwide and about 12. Chicago. However. those taking antibiotics. The case group. endodontics. Rasht. One of the likely mechanisms of such relationship is activation of the hypothalamic-pituitary-adrenal axis following stressful life events.ir 170 . IL.Relationships between Stress. USA). 19 men) had at least 20 teeth. Hu-Friedy. This study was approved by The Research and Ethics Committee of the Faculty of Dentistry. Guilan University of Medical Sciences (GUMS). chemotactic. and prevention of periodontal disease as a major public health problem. distress. and Periodontal Disease: A Case-Control Study Radafshar G. The control subjects (21 women. Therefore. other studies found no association between stress and periodontal disease [14-16] Therefore. and other body fluids. and patients wearing orthodontic appliances. There are differences in the processes of stress and coping among different cultures. 280 patients were scrutinized for their eligibility. hence more vulnerable to periodontal infection and breakdown .SID. and depression. 80 patients between 18–65 years of age were included in this case-control trial. patients having diabetes. the results of the 2009-2010 National Health and Nutrition Examination Survey (NHANES) suggest that the prevalence of periodontal disease among the adult US population were underestimated by up to 50% .
To collect psycho-diagnostic data on coping strategies.5) Patients (n = 40) 2 (5) 10 (25) 10 (25) 18 (45) 0.5 2.94 ± 0.018). Comparisons between groups were conducted using an Independent t-test for variables with a normal distribution and a Mann-Whitney test for those with a non-normal distribution.75 ± 0. a combination of two scales was used: the Social Readjustment Rating Scale  and the Scale of Life Events . A c r v i h o e There were statistically significant differences in tooth-brushing frequency and income. All periodontal parameters were statistically different between the patients and healthy controls (Table 2).5 1. income. J Dent Shiraz Univ Med Scien 2012. Chi-square and Fisher’s exact test were used to present and compare frequency distributions for gender.04# To assess the number and intensity of stressful events. and the impact of each event was also measured using a five-point Likert scale.5) p 0. and self-controlling . including four subtests: seeking social support.5) 19 (47.2 21 (52. planfulproblem solving. The combined list comprised 84 questions.1±8. escape-avoidance. et al. between the case and control subjects. Control subjects significantly liked to use problem-based coping strategies compared to patients with periodontal disease (p =0.5) 4 (10) 8 (20) 17 (42.27 0.5 23 (57. and positive reappraisal.5) 18 (45) 22 (55) 31 (77. They have suggested two major coping strategies.SID. Psychometric Instruments Table 1 Baseline and socioeconomic characteristics of the subjects in the patient and control groups Characteristics Age* (mean ± SD) Gender† Female Male Educational level High school diploma< >High school diploma Marital status† Married Single Tooth brushing frequency* (mean ± SD) Income†§ <200 200–300 300–400 >400 Patients (n= 40) (%) 37.606 0.1) were fitted in a multivariate regression model to determine the odds ratio (OR) and 95% confidence intervals (CI) for associated risk indicators of periodontitis. and emotionfocused coping. which were answered Yes or No. Variables associated with clinical outcomes in a bivariate analysis (p< 0.0001 3.6 15 ± 17 0. Table 2 Periodontal clinical parameters in the test and control groups (mean ± SD) Clinical parameters Probing pocket depth (mm)* Clinical attachment level (mm)* Bleeding on probing (%) † * Independent t-test † Mann-Whitney test S f D I 11 (27..338 0. Although cases used emotion-based coping strategies more than controls. marital status.58 * Independent t test † Chi-square Fisher’s exact test # Significant § Expressed as US$.029# Controls (n = 40) p 3.5) 9 (22.43 0. distancing. All psychological assessments were performed by an examiner who was blinded to the study protocol and was trained and supervised by an expert psychiatrist.653 0. Individuals responded to each item on a four-point Likert scale showing the frequency of each strategy which were used.53 43 ± 19.01 ± 0. also including four subtests: confronting. monthly Descriptive data are expressed as means and standard deviations (SDs).5) Controls (n= 40) (%) 35.5) 17 (42. Healthy control subjects brushed their teeth more frequently than case subjects. A subsequent assessment at the subtest level revealed that the patients differed significantly from the controls in using more escape-avoidance (p= 0.0001 0. and educational level of the two groups. this difference was not statistically significant.5 ± 0.72 ± 0. A combined questionnaire was adapted for the Iranian population and its reliability and validity was verified in a study .40 2. 13(4): 169-175 assessed at 6 sites for each tooth. BOP was recorded using the bleeding point index  at 6 points for each 12 anterior teeth and a bleeding percentage was calculated for each patient.Radafshar G.5) 11 (27.0001 Results The baseline characteristics of the participants are shown in Table 1. accepting responsibility.ir .1±7.01) and less accepting responsibility (p= 0. Statistical Analysis 1.5) 24 (60) 16 (40) 29 (72.001) coping styles (Table 3).16 ± 0. problem-focused coping. we used the Iranian version of the Ways of Coping questionnaire (WCQ) by Folkman and Lazarus . Although there were similarities between the case 171 www.
Table 4 Multivariate logistic regression analysis expressing the Odds ratio. and the severity of life events negatively (OR: 1.023-1. and a positive relationship between the number of stressful life events and their intensity among all participants (r= 0. respectively).87 ± 3.5 ± 2. accepting responsibility positively (OR: 1. After controlling for toothbrushing frequency and income.07 ± 2.473 1. p= 0.5 ± 6.04 33.72 ± 3. as defined by CAL.97 9.13.58 p 0.1 ± 7.11).66 10. 1999 .837 # Figure 1b).81 10. We demonstrated that the risk of having periodontal disease is influenced positively by stress intensity and moderated by the accepting responsibility coping style (OR= 1. and a weakly negative correlation between AL and problembased strategies (r= -0. tooth-brushing frequency remained in the model.3).77 ± 3. and 0.143 0.32 37. moderate and severe according to the amount of attachment loss.16. influenced the outcome variable (periodontitis).37 ± 2.02 ± 1.271 0. Coping Styles.081). A c r v i h o e Discussion This study investigated the association between perceived stress and coping styles and periodontal disease in a sample of Iranian patients seeking dental treatment. et al.57 ± 3. 0.ir 172 .69 1.47 ± 3. and P values Variable β Odds ratio 3.1 ± 5 9.081 1.5).SID.5).27. we classified the subjects according to Armitage. and Periodontal Disease: A Case-Control Study Radafshar G.08. who defined periodontal disease based on the presence of attachment loss and further categorised the severity of periodontitis as mild.1 8.5 95% CL 1.85 Controls (n = 40) (mean ± SD) 35.01 8.013# 0.75 ± 1.53 7. p= 0. Table 4 shows the results of multivariate logistic regression analysis. Table 3 Scores for the coping strategies and subtests in the patient and control groups Coping strategy/ subtest Emotion-based* Confronting† Distancing† Escape-avoidance† Self-controlling† Problem-based* Accepting responsibility* Planful problem solving* Seeking social support† Positive reappraisal* * Independent t-test † Mann-Whitney test # Significant Patients (n = 40) (mean ± SD) 36.3 ± 7. none of which reached a significance level of p< 0.05 (data not shown).77.17 9.9 ± 2.44 8.21 9. From the periodontal view.1 6.47 ± 2.2 8.006 a b Figure 1a Correlation between mean scores for emotion-based and problem-based coping styles b Correlation between mean scores for the number and intensity of stressful life events www.98 p 0.22-8.15 9. Pearson correlation showed weakly positive relationships between attachment loss (AL) and emotion-based coping strategies and the number and intensity of stressful events (r= 0.018 0.35 ± 3.3 1. Figure 1a). Wimmer et al.23 9.Relationships between Stress. used the same criteria and S f D I 1.118 0.98 7.6 ± 2. There was also a negative relationship between periodontitis and tooth-brushing frequency (OR= 3. 95% confidence intervals (95% CI).0001.05 ± 3.01. the intensity of the stress experienced was significantly higher in the periodontal patients (Table 1).409 sibility Stress intensity 0.92 ± 3. and BOP.06 8. PPD.439 0.018# 0.82 frequency Accepting respon-0.004 Tooth-brushing -1. On the other hand.001 0.14-1.528 0.078 and control subjects regarding the total number of life events.11 0. there was a significant negative correlation between the emotion-based and problem-based coping styles (r= -0.
For example. CAL. followed by decreased immune competence of the host [2. This may be party caused by their different personalities. 10. and in contrast to the studies by Solis et al. It is important to keep in mind the limits of the implements to measure conceptual issues such as stress or coping skills. as participants may under or over-report their perceived stress for various reasons.. This study benefited from using a combination of two different adapted scales to integrate the most possible features of stress processes and to decrease the time needed to complete two separate questionnaires. In view of that. a wellaccepted biological test has not yet been established. while Crouched et al. the existing data are conflicting on this point. consciously or unconsciously. among which the respondent’s level of education is of great importance. It is essential to ensure a clear difference in exposure (measured by the amount of attachment loss) between case and control or healthy and periodontal disease groups. The impacts of stress and psychological disorders on individual health status probably lead to behavioural changes that reduce oral hygiene and increase health threatening behaviours. it is reported that neuroticism predisposes people to experience negative emotions and distress regardless of the level of stress. It was postulated that besides the stress. including PPD. Nevertheless. although there was no difference in the number of life events between the case and control groups. A recent systematic review of case-control. although several studies have explored associations among saliva cortisol levels. which may have been associated with theirp- A c r v i h o e sychological status. Several factors affect this accuracy.Radafshar G. and the number of missing teeth.SID. Using a validated questionnaire for the analysed sample is of considerable importance. Similarly. and immune systems. to limitations in periodontal disease classifications and the type of diseases being investigated. Vettore et al. inactive or inadequate adaptive capacity and the way of coping with stressful situations trigger up the regulation of neurotransmitters and corticosteroids. 27-28]. at least in part. BOP. stress.. collecting self-reported. [14-15] who did not find any association between anxiety. 24]. Other studies have also investigated the association between life event stressors and periodontal disease. According to Lazarus et al. individuals respond to stress. since several criteria have been applied to characterise periodontitis. Wimmer et al. On the other hand. are among the investigators who did not find a significant relationship between periodontal and psychometric variables [11. 13]. Individuals with different combinations of personality traits experience and manage stress in different ways. and BOP that we found between our case and control groups. However. our study groups had a statistically significant difference in daily tooth-brushing frequency (p< 0. and Monterio da Silva et al. cross-sectional. there is currently no generally accepted method for measuring stress. control or overcome the stressful situation successfully . indicated that alveolar bone loss and clinical AL are the best and most sensible measures of periodontal destruction . as well as their accuracy in measuring subjective data. J Dent Shiraz Univ Med Scien 2012. and Castro et al. CAL. In addition.04). included subjects with one site having AL ≥ 5 mm in the case group. depression. and also assessing different psychosocial variables and using a wide range of questionnaires.ir . and periodontal disease [7. 13(4): 169-175 further categorised the patients into two groups (mild and moderate/ severe periodontitis) in their analysis . personal information is a complex process. independent to other variables. the periodontal patients experienced significantly higher stress (expressed on the Likert scale as higher stress scores). reported a negative effect of stressful life events on the course of chronic periodontitis in a case-control study matched for age and gender . such as the statistically significant differences in mean PPD. This lack of consensus may be due. used the categorised form of AL. 8]. In our study. reducing the burden on the participants. proposed their own criteria defining health or periodontitis [1. a variable that had similar distributions between the case and control subjects in our study. documented an association between life event stressors and periodontitis severity . and prospective studies which investi- S f D I 173 www. This finding is consistent with other investigations presenting a positive correlation between stress and periodontitis [4. whereas extraversion is a predisposing trait for perceiving more positive effects . 31]. et al. by modulating the convoluted interactions of nervous. Green et al. and psychiatric or psychosocial factors. 24. alveolar bone loss. Teng et al. using certain types of coping skills to cut. Pistorius et al. endocrine. Nunn et al.
Wilton JM.  Wimmer G. Dye BA. Dunford RG. cortisol. Quintaniha RS. Polansky R.  Vettore MV. distress and inadequate coping behaviors to periodontal disease. gated the relationship between stress. the convenience rather than random method of sampling and cross-sectional data collection brings into question whether the sample was truly representative of the population from which it was obtained and to what extent the information can be generalised to the entire population. 15: 276-282.  Eke PI. and Periodontal Disease: A Case-Control Study Radafshar G. Evidence for the existence of high-risk groups and individuals and approaches to their detection.  Peruzzo DC. This finding is consistent with that of Wimmer et al. J Periodontol 2009. Pertl C Coping with stress: its influence on periodontal disease. Stress. Accuracy of NHANES periodontal examination protocols. Nogueira Filho GR. Tedesco LA. Gjermo P. Detection of high-risk groups and individuals for periodontal diseases. whereas the control group used plan-full problem solving and distancing most and least. depression. Salivary stress markers. et al. and other psychological variables and periodontal disease.  Breivik T. Gillett IR. References  Croucher R. indicated that only 5 of 14 studies used adapted questionnaires as a methodological approach . Furthermore. McCormick CM. Engel D. Anand SC. the results of our research provide a significant source of data at the exploratory level. and periodontal disease. 104: 327-334. The relationship of stress and anxiety with chronic periodontitis. Thrane PS. In the present study. Iran. Kaur J. Marcenes WS. A c r v i h o e  Rai B. J Periodontol 2011. J Clin Periodontol 1997. Murison R. Lamarca GA. Relationship of stress.e. Janda M. etiology and treatment. depression. the use of escape-avoidance (resigned coping) by periodontal subjects and active coping strategies by control subjects . Griffiths GS. Emotional stress effects on immunity. and periodontitis: a pilot study. Curtis MA. Second. Wilson DT. There are several notable limitations to our study. 78: 1491-1504. Hughes F. Ho AW. Benatti BB.  Rosania AE. Nevertheless. 80: 260-266. periodontal patients used escape-avoidance and accepting responsibility as the most and least frequent coping strategies. Borgnakke WS. Grossi SG. Casati MZ. while periodontitis is a chronic phenomenon. Monteiro Da Silva AM. This is due to the fact that the stress responses of the patients may be a reflection of recent symptoms. A review of diagnosis. J Clin Periodontol S f D I  Johnson BD. Sterne JA.  Johnson NW. Torres MC. J Periodontol 2007.ir 174 . Sheiham A. the case and control groups differed on the problem-focused coping subscales in such a way that the control subjects relied mainly on active coping in response to stress in contrast to the periodontal patients. This www. Rosania DA. there is a need for studies that address the role that stress and psychological imbalance play in the expression of at-risk behavioural habits. Wieselmann-Penkner K. 89: 1208-1213. based on multiple objective variables such as biomarkers of stress and repeated measurements of variables over a longitudinal approach and with larger sample sizes. The relationship between life-events and periodontitis. School of Dentistry for their kind cooperation in performing this study. J Periodontol 2002. in partial fulfilment of receiving a Doctorate Degree in General Dentistry. respectively. 70: 711-723. Leão AT. A systematic review of stress and psychological factors as possible risk factors for periodontal disease.SID. Jacobs R. gingivitis and periodontitis. J Periodontol 1986. 82: 287-292. Moreover. should be conducted. Maiden MF. stress. J Dent Res 2010.  Genco RJ. 73: 1343-1351. J Periodontol 1999. Wei L. Eur J Oral Sci 1996. First. Sallum EA. J Clin Periodontol 1988. Thornton-Evans GO. 57: 141-150. Coping Styles. the cross-sectional design of the study does not provide information on the temporal nature of stress exposure and the true effect that stress may have over the course of periodontal disease.Relationships between Stress. i. Ambrosano GM. gingivitis. Future studies with a particular focus on the effects of stress and coping on the initiation and progression of periodontal breakdown. A case-control study. 24: 39-43. Acute necrotizing ulcerative Acknowledgements We wish to thank the staff of the Guilan University of Medical Sciences (GUMS). with respect to differences in the ways of coping between the case and controls. Low KG. et al. investigation was based on a thesis submitted by the third author to the Faculty of Dentistry of GUMS. Jakse N.
Broverman DM.  Lazarus RS. Chang YY. Huryn J. Personality and psychological stress. Asberg M. et al. The impact of ethnicity. J Pers Soc Psychol 1985. A clinical system for scoring a patient's oral hygiene performance. p. The Social Readjustment Rating Scale.  Nunn ME. et al. Dental plaque. Prusoff BA. Koch GG. Beck JD. Winter R. Association between psychosocial factors and periodontitis: a case-control study. J Clin Periodontol 2004. 33: 109-114. 13(4): 169-175 2003. J Periodontol 2006. J Periodontol 2004. Kopczyk RA. Weintraub JA. 11: 213-218. Periodontol 2000 2003.  Klages U. Comparison of stress. Söder B. 23: 789-794. Lee CH. Baker RW.  Folkman S. Marques AH. Lotufo-Neto F. and psychosocial stress factors. coping styles and marital status between breast cancer and normal women (dissertation). Psychosocial factors and adult onset rapidly progressive periodontitis. 67: 1060-1069. Offenbacher S. Willershausen B. 2007. Lloyd HM.  Paykel ES. 77: 1403-1409. Association of periodontal disease to anxiety and depression symptoms. Approximal plaque and gingival sulcus bleeding in routine dental care patients: relations to life stress. 48: 150-170. 32: 575-582. Tsai CC. Adaptational style and dispositional structure: coping in the context of the five-factor model. 64:735-74. Relationship between stress factors and periodontal disease. Boekste-  Monteiro da Silva AM. Kaplan BH. Ann Periodontol 1999. Weber AG. Oakley DA. gender.  Armitage GC.  Castro GD. J Am Dent Assoc 1973. Hollender LG. Wehrbein H. Alchieri JC. Newman HN. 30: 394-402.  Johannsen A. Periodontal disease as a function of life events stress. and elevated levels of interleukin-6 and cortisol in gingival crevicular fluid from women with stress-related depression and exhaust-ion. 74: 1169-1175. and marital status on periodontal and systemic health of older subjects in the Trials to Enhance Elders' Teeth and Oral Health (TEETH). 7: 393-398. gingival inflammation. Scaling of life events.  Watson D. somatization and depression.Radafshar G. Pannuti CM. 86: 849-852. 42: 2006-2018. S f D I  Pistorius A. (Rasht). J Appl Soc Psychol 2012. Understanding the etiology of periodontitis: an overview of periodontal risk factors. 25: 340-347. Ghazinour M. Persson RE. If it changes it must be a  Lenox JA. Arch Gen Psychiatry 1971. J Clin Periodontol 2006. Nohl FS.  Solis AC. Development of a classification system for periodontal diseases and conditions. 12: 32-36.. Rahe RH.Guilan University of Medical Sciences A c r v i h o e process: study of emotion and coping during three stages of a college examination. Haas AN. Yang YH. Mayer J. Rylander G. Krahwinkel T. Brunheiro EC. Marks B. 104. Tryon WW. 4: 1-6. Eur J Med Res 2002. J Psychosom Res 1967. Lifestyle and psychosocial factors associated with chronic periodontitis in Taiwanese adults. 75: 817-823.  Holmes TH. J Clin Periodontol 1996. 31: 633638.ir . Exploratory case-control analysis of psychosocial factors and adult periodontitis.  Padyab M. Lotufo RF. J Periodontol 1996. J Dent Shiraz Univ Med Scien 2012. J Pers 1996.  Delsooz LS. gen C.  Green LW. Lazarus RS. Oppermann RV. Richter J. Factor Structure of the Farsi version of the Ways of Coping Questionnaire.  Moss ME. Uhlenhuth EH.  Persson GR. J Pers 1957. Kiyak HA.  Teng HC. Hung HC. 175 www. 25: 559577. et al. Hubbard B. J Periodontol 2003. J Human Stress 1986. J Clin Periodontol 2005.SID. 32: 11-23.
This action might not be possible to undo. Are you sure you want to continue?
We've moved you to where you read on your other device.
Get the full title to continue listening from where you left off, or restart the preview.