Plants that heal wounds.

A review
RAJESH SINGH PAWAR1*, FEDELIC ASHISH TOPPO2 VNS Institute of Pharmacy Vidya Vihar, Neelbud, Bhopal Madhya Pradesh 462044 India
1 2 Vedica College of Pharmacy Near RGPV Campus, Bhopal Madhya Pradesh 462033 India

*corresponding author: mobile: +919826219429, fax: +917552696748, e-mail:
Summary Plants have traditionally been used as a source of medicine in India by indigenous people of different ethnic groups inhabiting various terrains for the control of various ailments afflicting human and their domestic animals. Recently, focus on plant research has increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems. More than 13,000 plants have been studied during last 5 years. Our review aims to compile data generated through the research activity using modern scientific approaches and innovative scientific tools in last few years. This article represent wound healing activity of various plants found and used traditionally. We have made an attempt to give an insight into different plants of potential wound healing properties which could be beneficial in therapeutic practice. Key words: wound healing, phytoconstituents, pharmacological actions

The development of traditional medicinal systems incorporating plants as means of therapy can be traced back to the Middle Paleolithic age some 60,000 years ago as found from fossil studies [1]. Recently, developed countries have
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exciting technologies that accelerate normal wound healing and counter the pathophysiologic processes that lead to chronic wound formation has come. Over the past 20 years. epithelialization and granulation tissue formation. which has been used as a biochemical marker for tissue collagen [9]. epithelization. granulation. collegenation and tissue remodeling [8]. The process of wound healing occurs in different phases such as coagulation.RS. From growth factors to bioengineered skin substitutes. 5]. The prostaglandins (PGE1 and PGE2) are released in the inflammation area and seem to be the final mediators of acute inflammation. Wound contraction occurs as a myofibroblasts contract. Healing of wound is a biological process that is initiated by trauma and often terminated by scar formation [7]. HEALING OF WOUNDS Wound is defined as a loss or breaking of cellular and anatomic or functional continuity of living tissues [6]. Platelets release growth factors and other cytokines [10]. These are responsible for overlaying debris. The mechanism of wound repair occurs by four basic processes such as inflammation. the major component which strengthens and supports extracellular tissue. FA. Pawar. Along with this knowledge the development of new. Inflammation starts immediately after the disruption of tissue integrity. contains substantial amounts of hydroxyproline. At the initial stages wound contraction begin slowly but became rapid on the day 3 or 4. the future of wound healing holds great promise. The active motile white cells migrate into the wound and start engulfing cellular debris. MECHANISM OF WOUND HEALING Wound healing is the physiological response to the tissue injury that results in the replacement of destroyed tissue by living tissue and thus restoration of tissue integrity. our knowledge of the wound healing process has increased dramatically. Collagen. The platelets became adherent with clotting factors and form haemostatic plug to stop bleeding from the vessels. wound contraction. They also can play a haemostatic role for white cells and fibroblasts. The epithelialization of the wound occurs mainly by proliferation and migration of . almost 65% of the world’s population has incorporated the value of plants as a methodology of medicinal agents into their primary modality of health care [3]. This estimate suggests that plant-derived drugs make up a significant segment of natural product– based pharmaceuticals. The myofibroblasts present in the margin of the wound appear to constitute the machinery for the wound contraction. Toppo 48 turned totraditional medicinal systems that involve the use of herbal drugs and remedies [2] and according to the World Health Organization (WHO). It is often noted that 25% of all drugs prescribed today come from plants [4.

1 2012 . ex DC. Figure 1 Figure 2 sitosterol Figure 2 βFigure 1 Stigmasterol Stigmasterol β. Apart from the above. alkaloids. Various herbal products have been used in the management and treatment of wounds for years. PHYTOCONSTITUENTS Various plants of wound healing property and also contain flavonoids as active constituents have been found.) R.sitosterol (fig. Alternanthera sessilis (L. The leaves are used in eye diseases. The process of wound healing is promoted by several natural products [14]. The hematoma within the wound may be replaced by granulation tissue which consists of new capillaries and fibroblasts.Br. in cuts and wounds. promoting contraction of the wound and increasing the formation of capillary vessels and fibroblasts [12. MEDICINAL PLANTS Plants or chemical entities derived from plants used in the treatment and management of wounds need to be identified and formulated. a number of herbal products are being investigated at present.Plants that heal wounds. in skin diseases [17]. antidote to snake bite and scorpion sting. stigmasterol (fig. flavonoids [15] and biomolecules [16]. 58 No. Tannins promote the wound healing through several cellular mechanisms. (Amaranthaceae) The plant consists of chemical constituents like α. 1). 13]. plant also contains β. plant products composed of active principles like triterpenes. A review 49 the marginal basal cells lying close to the wound margin. The fibroblasts are responsible for the production of the mucopolysaccharide ground substance. For this case. The lymphatics develop new nerve fibers and also acts in the formation of scar tissue in which collagen turn over increases [11]. chelating of the free radicals and reactive species of oxygen. lupeal isolated from roots.sitosterol Vol.and β-spinasterols. 2) etc.

RS. 6-epoxy-β-ionol-3-O-β-apiofuranosyl (1→6)-β-glucopyranoside). tannins. 3) (R-configuration) and alkannin (S-configuration) found in those families are enantiomers and their derivatives are potent pharmaceutical Figure 2 β. The presence of alkaloid hygroline in the leaves was also reported [20]. Pawar. A new megastigmane diglycoside (3-hydroxy-5. Figure 3 Figure 4 Berberine Shikonin Figure 4 3 Shikonin Figure Berberine F Berberis lyceum Royle (Berberidaceae) The root of Berberis lyceum contains flavonoids. Shikonin (fig. Their astringent and antimicrobial properties also contribute to wound contraction and increase the rate of epithelialization [19]. inflammation of throat and stomatitis. Figure 8 Epifriedelinol Figure 7 Curcumin F Centella asiatica (L. asiatica contains 3 principal ingredients – Asiaticoside (fig. 4). alkaloids including berberine (fig. oral ulcers. Toppo 50 Arnebia densiflora (Nordm. flavonoids and glyceroglycolipids were isolated from the leaves. and madecassic acid – all known to be clinically effective in .sitosterol substances a wide spectrum of biological properties. cuts and wounds.) Urban (Mackinlayaceae) The titrated extract of C. asiatic acid.) Ledeb. saponins and triterpenoids. (Boraginaceae)  The roots of some genera of the Boraginaceae family are rich in naphthoquinones. condensed tannins. 6). [18]. Triterpenoids and saponins are thought to promote the wound healing process due to their antioxidant and antimicrobial activities. namely wound healing Figure 1with Stigmasterol etc. 5) were reported to possess free radical scavenging activity. two megastigmanes. FA. new proanthocyanidins (fig. Figure 5 Proanthocyanidins Figure 6 Asiaticoside Carallia brachiata Merrill (Rhizophoracea) The bark is mentioned to be useful in the treatment of itching. From the bark.

(Zingiberaceae) Figure 7 Curcumin The part used are rhizomes containing curcumin (fig. turmeric oil or turmerol and 1. Vol. It also contains epifriedelinol (fig. lupeol and stigmasterol [25]. 7-bis. 8]. isodeoxyelephantopin and scabertopin. Curcuma longa also Figure 5 Proanthocyanidins Figure contains protein. 22]. A review Figure 2 β. Phytochemically the plant has been reported to contain sesquiterpene lactones deoxyelephantopin. abnormal scar formation and keloids. asiatica. Turmeric has been 8 used for treating the wounds in the rats [24]. Figure 4 Berberine is the 3 main active constituent and exhibits significant wound-healing activity in Figure 4 Berberine Shikonin Figure 3 Shikonin Figure and normal delayed-healing models [23]. C etc. 1 2012 .hepta-diene-3.) all of which have an important role in 6 Asiati Figure 7 Curcumin Figure Epifriedelinol 5and Proanthocyanidins Figure 6 Asiaticoside wouldFigure healing regeneration. B.Figure 2 β. vitamins (A. (Asteraceae) The whole plant is macerated and applied on the wound surface to promote wound healing. 6. This extractFigure significantly shortens the wound-healing time.sitosterol Figure 1 Stigm 51 the treatment of systemic scleroderma. fats. acting more specifically on 2 β. Asiaticoside. Figure 8 Epifriedelinol Figure 7 Curcumin Figure7 7 Curcumin Figure Curcumin Figure 8 Epifriedelinol Figure 8 Epifrie Figure 8 Epifriedelinol Elephantopus scaber L. Figure 3 Shikonin Figure 3 Shikonin Figure 5 Proanthocyanidins Figure 5 Figure 4 Berber Figure 4 Berberine Figure 5 Proanthocyanidins Proanthocyanidins Figure Figure 6 6 Asiaticoside Figure 6 Asiaticoside Asiaticoside Curcuma longa L. isolated from C.sitosterol Figure 1 Stigmasterol the immediate process of healing [21. 7) (diferuloyl methane).sitosterol Figure 1 Stigmasterol Plants that heal wounds. 5-dione. 58 No.

12) and jasminol [28]. (Oleaceae) The alcohol free defatted extract of J. auriculatum leaves has been reported to contain lupeol (fig. FA. and damaged and/or inflamed tissue as well as to rejuvenate the skin. The phytochemical analysis of the flower extract both by qualitative and Figure 9 Embelin Figure 10 Vilangin Figure Embelin Figure 10 constituents Vilangin thin 9 layer chromatography showed the absence of active such as polyphenols. (Myrsinaceae) Leaf pastes of this species are used to cure cut wounds and leprosy. Juice of leaves of J. auriculatum has been shown to be beneficial in wound healing.RS. 9) (3-undecyl 2. Figure 7 Curcumin Figure 8 Epifriedelino Figure 8 Curcumin Figure 9 Embelin Figure 10 Vilangin Hibiscus rosa sinensis L. its chemical constituent is 2. Fruits Figure 7 Epifriedelinol contain a quinone derivative embelin (fig. alkaloids. and carboxylic acids [27]. 11). 6-benzoquinone [26]. 10). an alkaloid christembine and a volatile oil vilangin(fig.5-dihydroxy. triterpenoids (fig. tannins.4-benzoquinone). flavonoids. wound healing. (Malvaceae) It is used as an herb in Ayurvedic or alternative medicine in India to treat colds. saponins.5-dihydroxy-4-undecyl-3. locally Figure 13 Quinolizine Figure 13 Quinolizine Figure 14 AlphaFigure 14 Alphapyridone pyridone . Pawar. Figure 11 Triterpenoids Figure 11 Triterpenoids Figure 11 Triterpenoids Figure 12 Lupeol Figure Figure 12 Lupeol 12 Lupeol Jasminum auriculatum Vahl.Figure Toppo 5 Proanthocyanidins Figure 5 Proanthocyanidins Figure 6 Asiaticoside Figure 6 Asiaticoside 52 Embelia ribes Burm. 1. When applied in the form of jelly.

14) type alkaloids which are the potent inhibitors of acetylcholineesterase and triterpenoids. 30]. as well as the number of wounds that attain healing are a part of the objective that is efficacy. The evidence of efficacy is derived from randomized. wounds and Figure 11the Triterpenoids burns [31]. lycoposerramine-A. 1 2012 . Lycoposerramine F-O. MECHANISM OF ACTION OF WOUND HEALING PLANTS Plants with mechanism of action are given in table 1. Lycopodium serratum (Lycopodiaceae) The plant is reported to contain alkaloids like serrtezomines A-C. Vol. 13) or pyridine and alpha-pyridone (fig. the juice is found to promote wound healing [29. improved or faster healing.Plants that heal wounds. Figure 13 Quinolizine Figure 13 Figure 13 Quinolizine Quinolizine Figure 14 AlphaFigure 14 pyridone Alpha-pyridone Figure 14 Alphapyridone SAFETY AND EFFICACY OF PLANT MATERIAL No system of medicine is entirely safe. however. quinolizine (fig. The tribal groups of Western Ghats of Chikamagalur region Figure 12 Lupeol Figure 11 Triterpenoids use this plant for treating wounds. cuts. Some of the risks are inherent in the medication prescribed. The whole plant is ground in hot water and Figure 12 Lupeol thick paste is thus obtained and applied externally to sores. I argue that other clinical parameters such as patient satisfaction. improvement of well-being. a methodology that has not been used in Ayurvedic or other traditional systems of medicine. controlled trials. A review Figure 9 Embelin Figure 10 Vilangin 53 on linear uniform excised wound in rats. 58 No. the experience of the practitioner also plays an important role.

(Malvaceae) latex 38 latex by increasing vascular permeability and angiogenesis by enhancing wound contraction.synthesis of collagen and by increase in the rate of wound contraction due to its epithelial proliferative action 35 Calendula officinalis L.) R. expression of proliferation related factors. growth of bone. D. and transforming growth factor-β1. Pawar. (Asteraceae) Carapa guianensis L. Arg. to a higher extent. 32 gel by enhancing keratinocyte multiplication and migration. which enhance healing of wounds by arresting wound bleeding. (Asteraceae) leaf 25 Euphorbia nerifollia Linn. shortened epithelialization period. Br. (Euphorbiaceae) Hibiscus rosa sinensis L. (Apocyanaceae) leaves 34 roots 19 flowers by increasing wound contraction and tensile strength. (Asteraceae) Aloe vera (Liliacea) Part used roots Mechanism of action by antioxidant and antimicrobial activities Ref. Plant name Ageratum conyzoides Linn. by increasing rate of wound contraction. increased tensile strength 39 flowers 27 . formation of granulation tissue. ex DC (Amaranthaceae) leaves 17 Arnebia densiflora (Nordm. and epidermis formation. (Boraginaceae) roots 18 Aspilia africana C. cartilage and other connective tissues an increase in the synthesis of collagen.) Ledeb. fibronectin. (Meliaceae) flowers 36 leaves 37 Elephantopus scaber Linn. augmented hydroxyproline content by stimulating the proliferation and. Adams (Compositae) Berberis lyceum Royle (Berberidaceae) Catharanthus roseus L. the migration of fibroblasts.RS. Plants with mechanism of action No. by increasing collagen content and degree of collagen cross-linkage within the wound they may also promote cell division . (Euphorbiaceae) Hevea brasiliensis Müll. FA. inhibiting the growth of microbial wound contaminants by astringent and antimicrobial properties 33 Alternanthera sessilis (Linn. Toppo 54 Ta b l e 1 . skin breaking strength and hydroxyproline content by increasing cellular proliferation.

by accelerating healing of cutaneous wounds which is related to TGF-β1/ Smad signaling pathway and improves reorganization of the regenerating tissue. (Orchidaceae) leaves 50 PLANTS THAT HEAL WOUND Plants which have been used in management and treatment of wounds over the years are given in table 2. Promoting contraction of the wound and increasing the formation of capillary vessels and fibroblasts by increasing the migration of epithelial cells Ref. (Rubiaceae) bark leaves 43 44 Pterocarpus santalinus Linn. (Cluciaceae = Guttiferae) Leucas hirta (Roth) Spreng. Br. Vol. 1 2012 . 58 No. Breaking strength and hydroxyprolline in granulation tissue by stimulating mitochondrial activity and proliferation of dermal fibroblasts. Increase in collagen deposition.. chelating of the free radicals and reactive species of oxygen. Plant name Hippophae rhamnoides L. (Fabaceae) Radix paeoniae (Paeonaceae) Radix Rehmanniae (RR) (Scrophulariaceae) stem root herb 45 46 47 Rheum officinale Baill (Polygonaceae) roots 48 Terminalia bellirica Roxb. by astringent and antimicrobial property. 40 Hypericum perforatum L. which seems to be responsible for wound contraction and increased rate of epithelialization by stimulating a growth factor or factors signal cascade system by decreasing the surface area of the wound and increasing the tensile strength by better developed scars and epithelialization as well as good formation of capillaries with enhanced VEGF expression. (Elaeagnaceae) Part used seed oil Mechanism of action possesses antioxidant properties as evidenced by significant increase in reduced glutathione (GSH) level and reduced production of reactive oxygen species (ROS) in wound granulation tissue may be a result of the fibroblast migration and stimulation of collagen synthesis by increasing rate of wound contraction.) Poirett (Mimosaceae) Morinda citrifolia Linn.Plants that heal wounds. reduction in the epithelization. by cellular mechanism. A review 55 No. (Labiateae) aerial parts leaves 41 42 Mimosa tenuiflora (Willd. (Combretaceae) fruits 49 Vanda roxburghii R.

Plants that heal wound No. incision and dead space excision. incision and dead space excision. (Arecaceae) Argemone mexicana Linn. alcoholic and water extracts alcoholic bark extract latex aqueous and ethanolic extract petroleum. (Asclepiadaceae) Canthium parviflorum Lam. Pawar.Br. incision and dead space wounds incision and excision incised and gap wounds in bovine calves excision. incision and dead space excision.) R. (Rutaceae) Allamanda cathartica Linn. (Rubiaceae) Carallia brachiata Merrill (Rhizophoracea) Cassia fistula Linn. (Boraginaceae) Azadirachta indica (Meliaceae) Berberis lyceum Royle (Berberidaceae) Bryophyllum pinnatum (Lam. ex Guill & Pern  (Combretaceae) Aristolochia bracteolate Lam. Plant name Acalypha indica Linn. incision and dead space excision excision and incision excision excision and incision excision 55 ethanol extract betel nut extract ethanolic extract the extract of the roots in olive oil pure neem oil and neem ointment aqueous and methanolic extract of root leaf. (Aristolochiaceae) Areca catechu L.) Kuntze (Papilionaceae) Calotropis gigantea L. (Apocyanaceae) Alternanthera sessilis (Linn.ex DC (Amaranthaceae) Alternanthera brasiliana Kuntz (Amaranthacea) Anogeissus latifolia (Roxb. ethyl acetate and methanol extract of bark alcoholic leaf extract 56 57 58 18 59 19 60 61 62 63 20 64 . (Leguminosae) Extract used whole plant ethanolic extract methanolic extract of plant aqueous extract chloroform extract of leaves methanolic extract of leaves Model studied excision and incision excision and incision excision and incision incision and excision excision and incision Ref.) Ledeb. 51 52 53 17 54 ethanolic extract of bark excision and incision excision. (Papaveraceae) Arnebia densiflora (Nordm.RS. (Euphorbiaceae) Aegle marmelos Corr. Toppo 56 Ta b l e 2 . FA.) (Crassulaceae) Butea monosperma (Lam. ex DC ) Wall.

incision and dead space excision excision and incision excision. (Elaeagnaceae) Extract used aqueous and ethanolic extract of leafs alcoholic extract ethanolic extract ethanol extract of bark oil ethanol and aqueous extracts of whole plant extract of tuber alcoholic leaf extract ethanolic extract of aerial parts ethanolic leaf extract aqueous ethanol ethanol extract of the leaves ethanolic extract of leaf aqueous extract of latex methanol extract alcoholic extract of leaf whole plant ethanolic extract crude leaf paste ethanol extract of flower aqueous extract of leaf Model studied excision burn wound incision. (Euphorbiaceae) Flaveria trinerva (Asteraceae) Gmelina arborea Roxb. incision and dead space excision. (Asteraceae) Embelia ribes Burm (Myrsinaceae) Eucalyptus globulus (Myrtaceae) Euphorbia nerifollia Linn. (Malvaceae) Hippophae rhamnoides L. incision and dead space excision and incision excision excision. incision and dead space excision. 22 67 68 69 70 71 72 73 25 26 74 38 75 76 51 77 27 78 Vol. (Amaranthaceae) Centella asiatica L.G. 65 66 21. (Cecropiaceae) Celosia argentea Linn. incision and dead space burn incision excision. incision and dead space burn rat wound excision and incision excision. excision.) Rumph.Plants that heal wounds. (Umbelliferae) Cinnamomum zeylanicum Blume (Lauracea) Cocos nucifera Linn. (Verbenaceae) Heliotropium indicum (Boraginaceae) Hemigraphis colorata (Blume) H. Plant name Cecropia peltata L. ex  Nees (Solanaccae) Dendrophthoe falcata (L. incision and dead space excision. and dead space excision. incision and dead space models excision Ref. (Arecaceae) Coronopus didynamous (Brassicaceae) Cyperus rotundus Linn. A review 57 No.f) Ettingsh (Loranthaceae) Desmodium triquetrum (Leguminosae) Elephantopus scaber Linn. Hallier (Acanthaceae) Hibiscus rosa sinensis L. 1 2012 . (Cyperaceae) Datura alba  (Bernh. 58 No.

(Euphorbiaceae) Extract used seed oil methanolic extracts of leaf methanol extract of leaf methanolic extract of leaf ethanolic extract of leaf alcoholic extract of aerial parts alcoholic extract of flowers leaf juice and hydroalcoholic extract aqueous extracts difference extracts of leaf aqueous and methanolic leaf extracts methanol extract 70% ethanolic extract ethyl acetate extract of dried leaf methanol extract of rhizomes ethanolic extract of leaves alcohol and petroleum ether extracts of whole plant ethanolic extract of flowers plant extract Model studied burn wounds incision and excision excision and incision excision and incision excision.)  (Lamiaceae) Indigofera enneaphylla Linn. (Rubiaceae) Lantana camara Linn. incision and dead space excision. incision and dead space excision. incision and dead space excision and incision dead space excision excision and incision excision and incision excision.RS. (Hypericaceae) Hypericum patulatum Thumb (Hypericaceae) Hyptis suaveolens (L. (Labiateae) Leucas lavandulaefolia Rees. (Labiatae) Lycopodium serratum (Lycopodiaceae) Moringa oleifera Lam. (Moringaceae) Nelumbo nucifera (Nymphaceae) Ocimum sanctum Linn. Toppo 58 No. (Elaeagnaceae) Hypericum hookerianum (Hypericaceae) Hypericum mysorense Wight and Arn. incision and dead space excision.. (Labiaceae) Oxalis corniculata (Oxalidaceae) Pentas lanceolata (Rubiaceae) Phyllanthus emblica Linn. (Fabaceae) Ixora coccinea  Linn. 40 79 80 81 82 83 84 85 53 86 42 87 31 88. incision and dead space excision and incision excision excision. 89 90 91 92 93 94 . incision and dead space excision excision Ref. Plant name Hippophae rhamnoides L. Pawar. (Lauraceae) Lawsonia alba Lam. (Lythraceae) Leucas hirta (Roth) Spreng. (Verbenaceae) Laurus nobilis Linn. FA.

Plants that heal wounds. Br. chloroform. (Compositeae) Trigonella foenum-graecum Linn. acetone extracts methanol extract whole plant.) Lam. Plant name Plagiochasma appendiculatum Lehm. (Asteraceae) Extract used alcohol and ethanolic extract leaf saponin extract methanolic extract of peels crude aqueous extract of galls methanol extract of flower ethanolic extract of aerial parts ethanolic extract 50% ethanolic extract of bark and tannins ethanol extract of fruits alcoholic extract of leaf aqueous extract of fruit ethanol. aqueous extract of seed extract of whole plant aqueous and methanol leaf extracts crude aqueous extract of plant aqueous extract Model studied excision and incision excision. (Combreteaceae) Terminalia bellirica Roxb. f. (Rutaceae) Tragia involucrate L. (Araliaceae) Punica granatum L.) W&A. (Fabaceae) Vanda roxburghii R. incision and dead space excision excision. (Orchidaceae) Vernonia arborea HK (Asteraceae) Vanda roxburghii R. (Orchidaceae) Wedelia calendulacea (L. (Punicaceae) Quercus infectoria Oliver (Fagaceae) Rafflesia hasseltii (Rafflesiaeae) Sphaeranthus indicus Linn. 108 109 50 110 111 112 Vol. incision and dead space excision. 58 No. et Lind. incision and dead space excision excision. aqueous extract.) Less. 1 2012 . petroleum ether.) Pers. Br. incision and dead space excision and incision excision and incision wounds incision and in vitro incision and excision excision and incision excision dead space excision. (Leguminosae) Terminalia arjuna (Roxb. (Euphorbiaceae) Tridax procumbens Linn. (Asteraceae) Tephrosia purpurea (Linn. incision and dead space induced wounds excision excision. (Combretaceae) Thespesia populnea Soland ex Correa (Malvaceae) Toddalia asiatica (Linn. 95 96 97 98 99 100 101 102 49 103 104 105 106 107. A review 59 No. incision and dead space incision and excision Ref. (Aytoniaceae) Polyscias scutellaria (Burm. (Combretaceae) Terminalia chebula Retz.) Fosberg.

This is mainly achieved by the synthesis of the connective tissue matrix. Collagen is a major protein of the extracellular matrix and is the major component that ultimately contributes to wound strength. and experimental investigation of indigenous drugs and their biological activities. natural products isolated from plants will still remain an essential component in the search of new medicines. Utilization of plants for medicinal purposes in India has been documented long back in ancient literature because they are essential to human survival. In spite of the various challenges encountered in the medicinal plant-based drug discovery. Shanidar IV. Plants and their extracts have immense potential for the management and treatment of wounds. Science 1975. While it is possible that some time-tested herbal remedies are indeed effective. Popular use of Medicinal plants in the Maltese Islands. management and valuation of wild plants are central aspects of traditional knowledge in many human populations. 2. Pawar. description. REFERENCES 1. CONCLUSION Wound healing is a fundamental response to tissue injury that results in restoration of tissue integrity. it seems to be often the case that the patient knows more about this form of medicine than the physician. biochemistry. Therefore. pharmacology. plants gathering the diffusion and conservation of knowledge within the community are traditional practices that have contribution to the subsistence of many cultures. . A Neanderthal flower burial in northern Iraq. The consumption. Solecki R. Insula 1992.RS. 190 (4217):880-1. It is based on botany. From ancient times. there is a need for scientific validation. Proper utilization of these resources and tools in bioprospecting will certainly help in discovering novel lead molecules from plants by employing modern drug discovery techniques and the coordinated efforts of various disciplines. However. 1: 34-5. Thus. Toppo 60 DISCUSSION The search for “natural remedies” for a common disorder such as wounds has drawn attention to herbals. it is important to study and examine all options available with which wound management may be improved. herbals have been routinely used to treat wounds and in many cultures their use in traditional medicine has persisted to present times. and many other disciplines that contribute to the discovery of natural products of biological activity. chemistry. FA. Lanfranco G. This review is an approach towards the herbal plants having wound healing potentials involving the observation. standardization and safety evaluation of plants of the traditional medicine before these could be recommended for healing of the wounds.

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