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Biology 1A03 -

October 2006 Dr. J. R. Jacobs

Part A = /30 marks to be posted on WebCT

Name: ID# Lab Section:

This test has 9 pages and 37 questions. You are responsible for ensuring that your copy of the test is complete. Bring any discrepancies to the attention of your invigilator. PLEASE WRITE YOUR NAME, STUDENT # AND LAB SECTION IN PEN ON PAGE 1 AND ON PAGES 8 and 9 OF THIS TEST PAPER.

Answer Questions 1-30 (Part A) on the optical scan sheets in dark HB pencil. Note: THE FIRST QUESTION REQUIRES YOU TO INDICATE WHICH VERSION OF THE TEST YOU ARE WRITING. Carefully read the following instructions for the optical scan sheets. The scanner, which reads the sheets, senses the shaded areas by their non-reflection of light. A heavy mark must be made, completely filling the circular bubble, with an HB pencil. Marks made with a pen or felt-tip marker will NOT be sensed. Erasers must be thorough or the scanner may still sense a mark. Do NOT use correction fluid or correction tape on the sheets. Do NOT put any unnecessary marks or writing on the sheet. 1. Print your Name, Student Number, Course Name, and the Date in the space provided at the top of Side 1 (Red side) of the form for Questions 1-30. The sheet MUST be signed in the space marked SIGNATURE. 2. Mark your Student Number in the space provided AND fill in the corresponding bubbles underneath. 3. Mark only ONE choice from the alternatives (A, B, C, D, E) provided for each question. The question number is to the left of the bubbles. Make sure that the number of the question on the scan sheet is the same as the question number on the test paper. It is your responsibility to ensure that you have filled out your scanner sheet properly.

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Biology 1A03 -

October 2006

Multiple Choice (worth 30 marks) Please answer Questions 1 to 31 on the OMR Scan Sheet in HB pencil, NOT pen. Select the option which best answers the question. There is no penalty for guessing. Each question is worth 1 mark. 1. Which Version of the Test are you writing? (Refer to the top left corner of the Front Page.) A. A B. B C. C D. D E. E

2. H3N2 virus, first documented in 1900, re-emerged as the 1968 Hong Kong Flu. Given the predominant method of viral mixing and evolution, the re-emergence of the virus was due to A) Survival in a non-virulent form in human or pig populations, and then mutating to become virulent again B) Exhumation of cadavers (to dig up human remains) from the earlier epidemic, re-releasing virus into the environment C) Survival and mixing in populations of wild fowl, until re-infecting mammals like pigs or humans D) Loss of immunity because a new generation of humans was exposed. 3. Which of the following is true: A) !-glucose and "-glucose are optical isomers and convert spontaneously in solution B) !-glucose and "-glucose are geometric isomers and convert spontaneously in solution C) !-glucose and "-glucose are optical isomers and conversion requires an isomerase D) !-glucose and "-glucose are geometric isomers and conversion requires an isomerase

Figure 1

4. Refer to Figure 1. This part of a glycogen molecule contains: A) 7 -!-1,4 glycosidic linkages and 1 !-1,6 glycosidic linkage B) 7 -!-1,4 glycosidic linkages and 1 "-1,6 glycosidic linkage C) 7 -!-4,1 glycosidic linkages and 1 "-6,1 glycosidic linkage D) 7 -!-4,1 glycosidic linkages and 1 !-6,1 glycosidic linkage

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Biology 1A03 -

October 2006

5. If you were selecting a polysaccharide for synthetic synovial (knee joint) fluid replacement, would you: A) prefer an unbranched polysaccharide because of its tensile strength B) prefer an unbranched polysaccharide because it had better molecular memory, and could restore its shape C) prefer a branched polysaccharide because it was more stable D) prefer a branched polysaccharide because it would hold water better

Figure 2 6. According to Figure 2 shown above, at which bond would water need to be added to achieve hydrolysis of the dipeptide shown, back to its component amino acids? A) A B) B C) C D) D E) E

Figure 3 7. Which of these peptide sequences, shown in Figure 3 above, in a protein is more likely to bind DNA? A) a poly HIS peptide B) a poly ASP peptide C) a poly ASN peptide D) a poly LEU peptide 8. With reference to Figure 3, which of these peptides is more likely to be folded inside a protein? A) a poly HIS peptide B) a poly ASP peptide C) a poly ASN peptide D) a poly LEU peptide
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Biology 1A03 9. A nucleosome is: A) the fundamental packing unit of chromosomal DNA B) a protein that binds DNA C) a ribonucleoprotein complex D) DNA coiled around histone proteins E) A and D

October 2006

10. In the liquid crystal or gel state, A) the acyl chains of phospholipids are highly ordered, and act effectively as a permeability barrier B) the acyl chains of phospholipids are mobile enough to interact with each other C) neighbour-neighbour exchange is restricted D) acyl chains can fold to establish a semi-permeable barrier 11. The isoprene ring domain of cholesterol: A) participates in hydrogen bonding B) participates in hydrophobic interactions C) associates with the outer domains of membrane lipid acyl tails D) A and C E) B and C 12. The M2 ion channel on the influenza virus undergoes a conformational change when the pH drops. A) This triggers virus endocytosis into the endosome B) This is required for the virus to maintain homeostasis C) This triggers a conformational change in neuraminidase required for membrane fusion D) This is required to inactivate the scaffolding function of M1 E) A and C above 13. Facilitated diffusion requires A) an open protein channel through the membrane B) a carrier or exchanger in the membrane C) a pump linked to ATP hydrolysis D) None of the above 14. In an isotonic solution A) The concentration of each ion is the same across the membrane B) The concentration of solutes is the same across the membrane C) The concentration of water is the same across the membrane D) B and C above E) All of the above 15. Compared to C16O2H28, a less saturated fatty acid A) will have a lower melting temperature B) will have a higher melting temperature C) will have more kinks in the acyl chain D) A and C above E) B and C above

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Biology 1A03 -

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16. The significant difference between receptor mediated endocytosis for nutrition (cholesterol) and signaling (EGF) is that A) the receptor is degraded in nutrition and not in signaling. B) the endosome pH does not drop for signaling, but does for nutrition. C) the receptor is degraded in signaling and not in nutrition. D) the endosome pH does not drop for nutrition, but does for signaling. 17. An immunologist is trying to create a drug which prevents newly replicated influenza viruss from budding off the host cells. Which of the following proteins should she NOT target? A) neuraminidase B) M1 C) M2 D) B or C E) She cant target any of these proteins 18. van der Waals interactions require A) oxygen B) charged ions C) hydrogen bonding D) a lack of molecular polarity 19. A transmembrane protein normally found in the endoplasmic reticulum (ER) contains a large network extensively branched carbohydrates. How did it get there? A) All the carbohydrates were added to the protein in the ER. B) Carbohydrates were added in the cytoplasm, and the protein translocated to the ER. C) Carbohydrates were added in the Golgi apparatus, and then targeted for return to the ER. D) It is impossible for ER proteins to have covalently attached carbohydrates. 20. Uncoating of the endocytotic vesicle occurs A) before fusion with the early endosome B) after fusion with the early endosome C) during vesicle recycling to the cell surface D) at the cell surface. 21. To travel to the cell surface, vRNPs must employ cytoskeletal motors. vRNPs require A) (-) directed actin based motors B) (+) directed actin based motors C) (-) directed microtubule based motors D) (+) directed microtubule based motors

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Biology 1A03 -

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Figure 4 22. Figure 4 above at left is a drawing of a resting nematocyst, an epidermal cell type in jellyfish that explodes to project a barb, and poison, to any animal that attacks or eats it. The picture at right is a nematocyst after exploding. Given what you know about cell polarity, which letter likely labels the basal surface of the cell?
A) A B) B C) C

D) The basal surface is not indicated. E) This cell has no basal surface. 23. The polarity of cytoskeletal filaments is established by A) the orientation of monomers in the polymer B) the kinetics of monomer exchange at each end of the filament C) proteins similar to MAPs that bind to the polymers D) A and B above E) All of the above 24. Which of the following membrane compartments is not involved in lysosome targeting? A) plasma membrane coated pits B) autophagosomes C) pinocytotic vesicles D) peroxisomes E) C and D above 25. Intermediate filaments link the cytoskeleton to specialised cell junctions called desmosomes. This network is essential for: A) cell-cell communication. B) stabilizing the plasma membrane. C) distribution of stress between cells. D) localizing intracellular organelles. E) all of the above 26. In order to kill his lawn grubs, your neighbour has coated his grass with a toxin that blocks (-) directed axon transport. What effect might you see? A) Accumulation of organelles at the synapse. B) Accumulation of organelles in the cell body C) Misdirection of newly synthesized proteins D) All organelle movement stops

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Biology 1A03 -

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27. Microtubule (MT) stablising drugs, like Taxol are useful in cancer chemotherapy because mitosis is blocked. Mitosis cannot occur because: A) MTs cannot depolymerise to allow separation of the chromosomes in anaphase B) MTs cannot depolymerise between interphase and prophase to allow the mitotic spindle to form C) MTs cannot polymerise in prophase to establish the mitotic spindle D) MTs cannot polymerise in interphase to establish the cytoskeleton 28. A mutated virus encodes an Hemagluttinin (HA) gene lacking a signal sequence. As a result, viruses are not released, and look like this (Figure 5):

Figure 5 This is because: A) B) C) D) E) HA was not successfully targeted to the endoplasmic reticulum HA was targeted to the basal rather than apical cell surface HA is required to bend the membrane, and allow the virus to pinch off A and C above B and C above

29. Morris the mitochondrion is near the microtubule organizing centre (MTOC), and is required at the apical surface of the cell. How can he tell which microtubule to travel along to get to the apical surface? A) Apically oriented MTs will have different microtubule associated proteins (MAPs) than basally oriented ones. B) Only apically oriented MTs are able to activate MT motor proteins. C) Basally oriented MTs are not anchored in the MTOC. D) Only apically oritented MTs will have their (+) end directed to the cell surface. 30. The structural feature that allows DNA to replicate itself is the A) sugar-phosphate backbone B) complementary pairing of the bases C) phosphodiester bonding of the helices D) twisting of the molecule to form an !-helix E) three-part structure of the nucleotides

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