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Transforming Drug Development

It’s not just for researchers – you can participate!

Health 2.0 New Orleans November 21, 2013 Thomas Krohn, RPh, MBA Eli Lilly and Company

Drug Development - today

Innovation
Precompetitive
patent

Process
Competitive

Business Model Performance

Productivity Down, Costs Up

Future revenues under pressure

Unsustainable Business Model
Source: FDA.gov

Moore’s vs. Eroom’s Law

The Far Side by Gary Larson

Incremental Improvement

Disruptive Innovation

to S1'

Performance

to S2 S1
Disruptive Change

Time

Simpler, Faster, Cheaper?

Disruption in motion

Generation and Access to Data

Patient Digital Monitoring

Patient Communities

Patients as microexperts – not subjects

Patient-Driven Research

The Disruption

Power to the Patient

Clinical Research as part of Healthcare
Public Perception •! 94% of people recognize the importance of participating in clinical research in order to assist in the advancement of medical science. Yet 75% of the general public state they have little to no knowledge about the clinical research enterprise and the participation process. (www.centerwatch.com) •! Less than five percent of cancer patients participate in clinical trials. If ten percent participated, studies could be completed in one year, instead of the three-five years that studies currently require. (National Cancer Institute) •! It's not uncommon for your cancer doctor or treatment team to discuss the option of a clinical trial as the best treatment choice for your cancer type. (www.mayoclinic.com)

Standard of Care

Clinical Trial Info & Innovation

ClinicalTrials.Gov and Patients

2

98,000,000
Pageviews/Month1

47,000,000
Patient driven pageviews/Month

What if….?

Sources: 1) clinicaltrials.gov site 2) D. Zarin 2007 Overview

Patient-Centric Study Representation & Voice

1
Study Representation
PatientCentric Design Design Challenge
Ct.Gov Informed Consent Document Open

Study Design
Patients Patient Voice
Platform

2

•! Clear eligibility •! Risk/Benefit •! My doctor’s role •! Study treatment •! Time to results •! Logistics
ctdesign.challengepost.com November 14

Patient-Centric Information

Open

Patients
Platform

labs.lillycoi.com

Clinical Open Innovation

Open
Open Web REST API

Daily Updates

Patients
Platform

api.lillycoi.com

Enabling patient matching to studies
Study Sponsors

Patient & Communities
Patient Study “Target Profiles”

Open
Open Web REST API

Daily Updates

Match Process

Consent to Match

Patients
Platform

Personal Electronic Medical Records

api.lillycoi.com

Patient Engagement App Challenge

http://patientengagement.challengepost.com

Join the transformation

•! •! •! •! •!

Learn the business model Understand patient needs Identify options for value creation Explore open data and patient engagement Participate in challenges

Most people are afraid of making mistakes. Leaders are afraid of missing opportunities.

References
•! •! •! •! •! Website: www.lillycoi.com API: api.lillycoi.com App Lab: labs.lillycoi.com Whitepaper: link Twitter: @Lilly_COI, @takmad

Thanks!