You are on page 1of 8

Chemistry / 97

Chemistry
The Department of Chemistry, in conjunction with modified oligonucleotide synthesis, design of
other departments of the university, offers a broad mechanistically inspired enzyme inhibitors
education and the opportunity to do research in radiosensitizing agents, and sensors.
chemistry and related fields. The great diversity Tamara Hendrickson, Assistant Professor:
of the field of chemistry, ranging between physics bioorganic chemistry and enzymology—chemical,
and biology, is reflected in the research interests of biochemical, and mechanistic studies of complex
the faculty. Undergraduate chemistry majors usu- enzyme systems, including C-terminal protein
ally go on to graduate study in chemistry, chemical glycosylation, microbial protein biosynthesis, and
engineering, biology, oceanography, geochemistry, tRNA-protein molecular recognition.
biophysics, environmental sciences, or medicine, Kenneth D. Karlin, Ira Remsen Professor: inorganic
while others enter the chemical industry. The Ph.D. and bioinorganic chemistry—synthetically
in chemistry leads to professional careers in col- derived structural, spectroscopic and functional
leges and universities, research institutes, industry, models for copper and iron proteins, copper-
and government laboratories. dioxygen reversible binding and metal-mediated
substrate oxidation, O2-reduction with copper
The Faculty cluster compounds, porphyrin-iron and copper
Kit H. Bowen, E. Emmet Reid Professor: experimental chemistry relevant to heme-copper oxidases,
chemical physics—photoelectron spectroscopy of metal-catalyzed ester and amide hydrolysis, metal
negative ions, structure and dynamics of gas phase, complex protein and DNA interactions.
weakly bound molecular clusters. Walter S. Koski, Bernard N. Baker Professor:
Paul J. Dagdigian, Arthur D. Chambers Professor: physical chemistry—nuclear and hot atom
experimental chemical physics—dynamics of chemical phenomena, nuclear and electron
gas-phase chemical reactions, collisional energy resonance spectroscopy, ion molecule reactions,
transfer, molecular electronic spectroscopy, laser- scattering of low energy ions.
induced fluorescence and ionization. Thomas Lectka, Professor: organic chemistry—the
John P. Doering, Research Professor: experimental design and synthesis of theoretically interesting
chemical physics and geophysics—electronic and nonnatural products with applications in
ionic collision phenomena including electron bioorganic and physical organic chemistry,
energy loss spectroscopy, electron ionization materials science and supramolecular chemistry,
coincidence spectroscopy, planetary atmospheres. novel approaches to asymmetric catalysis,
David E. Draper, Vernon Kriebel Professor: physical theoretical organic chemistry.
biochemistry—RNA folding, RNA-ligand inter- Gerald Meyer, Professor: inorganic chemistry—
actions, NMR of protein and RNA, translational photochemistry and electrochemistry of metal
control of gene expression. complexes and inorganic solids, light-induced
D. Howard Fairbrother, Associate Professor: electron and energy transfer, materials science,
physical chemistry—the structure of chemically artificial photosynthesis.
protective surfaces, chemistry of adhesives, Douglas Poland, Professor: theoretical chemistry—
environmental surface chemistry. statistical mechanics, kinetics of cooperative
David Goldberg, Associate Professor: inorganic biological and physical-chemical phenomena,
and bioinorganic chemistry—structure/function use of moments to calculate energy and ligand-
relationships in heme proteins, artificial binding distributions.
enzyme design, biomimetic molybdenum and Gary H. Posner, Jean and Norman Scowe Professor:
tungsten coordination compounds, redox active organic, medicinal, and organometallic
ligands, synthesis of tetrapyrrolic macrocycles chemistry—new synthetic methods, asymmetric
(phthalocyanine and porphyrin-based systems) synthesis of natural products having
for small-molecule activation and materials pharmacological (e.g., anti-tumor, contraceptive,
applications. antimalarial) activity, chemical carcinogenesis,
Marc M. Greenberg, Professor: organic and and cancer chemotherapy and chemoprotection.
bioorganic chemistry—application of chemical, Justine P. Roth, Assistant Professor: inorganic
biochemical, and biological techniques to chemistry and enzymology—rational design
studies on DNA damage and repair, independent of redox catalysts, selective bond activation/
generation and study of reactive intermediates, oxidation by enzymes and transition metal
development and application of methods for complexes, synthetic systems for light to chemical
energy transduction.
98 / Chemistry

Harris J. Silverstone, Professor: theoretical Lecturers


chemistry—development of mathematical David Klein, Senior Lecturer.
techniques for applying quantum mechanics Louise Pasternack, Senior Lecturer.
to chemical problems, high-order perturbation Tina Trapane, Senior Lecturer.
theory, semiclassical methods, divergent
expansions, photoionization, LoSurdo-Stark Facilities
effect, magnetic resonance spectral simulation,
The Department of Chemistry is well-equipped with
hyperasymptotics.
the instrumentation to perform modern chemical
Joel R. Tolman, Assistant Professor: biophysical
research. Major routine instrumentation is housed
chemistry—protein-protein interactions, protein
in the Instruments Facility in Remsen Hall and is
dynamics and structure, NMR methodology.
maintained by staff within the department. In addi-
John P. Toscano, Professor (Chair): organic
tion, there is a large variety of custom-built equip-
chemistry—photochemistry and photobiology,
ment in individual research laboratories. Nuclear
time-resolved IR spectroscopy, structure/
magnetic resonance instrumentation includes 300,
reactivity relationships for reactive intermediates,
400, and 500 MHz spectrometers. The lower-field
the design of phototriggered nitric oxide-
instruments are used for more routine synthetic
releasing drugs for applications in medicine.
chemistry applications, while the high-field instru-
John D. Tovar, Assistant Professor: organic chemistry-
ment is primarily dedicated to multidimensional
organic electronics, conjugated and conducting
analysis of proteins and nucleic acids. In addition,
polymers, electrochemistry, nanostructured
the undergraduate instructional laboratories house
materials, polymer chemistry bioinspired self
a Varian Mercury 200 MHz spectrometer, which is
assembly and supramolecular chemistry.
also available for research use. The department also
Craig A. Townsend, Alsoph H. Corwin Professor:
has a wide range of mass spectrometric instrumen-
organic and bioorganic chemistry—biosynthesis
tation, including a laser desorption time-of-flight
and chemistry of natural products, stereo-
(MALDI-TOF) mass spectrometer, a gas chromato-
chemical and mechanistic studies of enzyme
graph (GC) mass spectrometer, and an electrospray
action, small molecule/DNA interactions,
ionization mass spectrometer (ESI-MS) fitted with
application of spectroscopic techniques to the
a liquid chromatography and having capability of
solution of biological problems.
multiple mass spectral analyses, as well as a high-
David R. Yarkony, D. Mead Johnson Professor:
resolution GC-mass spectrometer. The department
theoretical chemistry—electronic structure
also maintains an electron paramagnetic spectrom-
theory, multi-configuration self-consistent-field
eter (X band and low temperature).
methods, excited state chemistry, electronic
Many of the faculty research laboratories have
energy transfer in chemical reactions, spin-
purchased or constructed highly specialized
forbidden processes and electronically
instrumentation tailored to their specific research
nonadiabatic processes.
objectives. These include the following: several
Adjunct, Emeritus, and Joint Appointments molecular beam apparatus, negative ion photo-
electron spectrometers, ultra-high vacuum sur-
Alsoph Corwin, Professor Emeritus.
face analysis chambers with Auger electron and
Dwaine O. Cowan, Professor Emeritus.
X-ray photoelectron spectrometers, atomic-force
David Gracias, Assistant Professor (Chemical and
microscope, time-resolved infrared spectrometer,
Biomolecular Engineering).
numerous laser systems (Nd: YAG, excimer, dye,
John W. Gryder, Professor Emeritus.
optical parametric oscillator, argon ion), phase
Blake Hill, Assistant Professor (Biology).
fluorimeter, fluorescence microscope, and nano-
Howard E. Katz, Professor (Materials Science and
phase material generators.
Engineering).
In addition to computers and workstations
Albert S. Mildvan, Professor (Biological Chemistry,
dispersed throughout all the individual research
School of Medicine).
groups, a dedicated computer lab is housed in
Brown L. Murr, Professor Emeritus.
Remsen Hall, with access available to students.
Alex Nickon, Vernon Krieble Professor Emeritus.
Lawrence M. Principe, Professor (joint appoint-
ment in History of Science and Technology).
Undergraduate Programs
Dean W. Robinson, Professor Emeritus. Programs for undergraduate majors can be tailored
Michael (Seungju) Yu, Assistant Professor (Materials to individual interests so that a major in chemistry
Science and Engineering). is excellent preparation not only for further work
in chemistry, but also for any field that rests on a
Chemistry / 99

chemical foundation. It is a good choice for a pre- • Freshman/Spring Term


medical student interested in medical research. 030.102 Introductory Chemistry II
Calculus
Requirements for the B.A. Degree Language
(See also General Requirements for
Departmental Majors, page 46.) • Sophomore/Fall Term
030.205 Introductory Organic Chemistry I
Core Courses: 030.225 Organic Chemistry Lab
030.101-102 Introductory Chemistry I, II 171.101 or 171.103 General Physics
030.105 Introductory Chemistry Lab 173.111 General Physics Lab
030.205-206 Intro Organic Chemistry I, II
030.225 Organic Chemistry Lab • Sophomore/Spring Term
030.228 Intermediate Organic Chemistry Lab 030.206 Introductory Organic Chemistry II
030.356 Advanced Inorganic Lab 030.228 Intermediate Organic Chemistry Lab
030.301-302 Physical Chemistry I, II 171.102 or 171.104 General Physics
030.305-306 Physical Chemistry 173.112 General Physics Lab
Instrumentation Lab I, II • Junior/Fall Term
030.301 Physical Chemistry I
Outside Courses:
030.305 Physical Chemistry Lab I
Outside courses required for both of the sample
Electives
programs are
171.101-102 General Physics or 171.103-104 • Junior/Spring Term
173.111-112 General Physics Lab 030.302 Physical Chemistry II
Differential and integral calculus, preferably 030.306 Physical Chemistry Lab II
110.108-109 Calculus I, II Electives
Advanced Elective Courses: • Senior/Fall Term
Six credits of advanced chemistry beyond 030.356 Advanced Inorganic Lab
030.305-306. Electives
Nine additional credits composed of advanced • Senior/Spring Term
chemistry, science electives at the 300-level or Electives
higher approved by a Department of Chemistry
adviser, and/or mathematics beyond Calculus II. Sample Program B
None of the advanced course requirements may A premedical student majoring in chemistry might
be fulfilled with research. Although a student may take the following sequence of courses:
take more than 12 credits of independent research,
• Freshman/Fall Term
only 12 may count toward the 120 required credits.
030.101 Introductory Chemistry I
Lecture and laboratory courses should be taken
030.105 Introductory Chemistry Lab
in sequence. In particular, 030.228 Intermediate
Calculus
Organic Chemistry Lab must be taken before
Language
030.356 Advanced Inorganic Lab.
To allow maximum flexibility in choosing elec- • Freshman/Spring Term
tives, students should complete both physics and 030.102 Introductory Chemistry II
organic chemistry by the end of the sophomore Calculus
year. 030.449 Chemistry of Inorganic Compounds Language
is required for an American Chemical Society
accredited degree. • Sophomore/Fall Term
030.205 Introductory Organic Chemistry I
Sample Program A 030.225 Organic Chemistry Lab
A typical program might include the following 171.101 or 171.103 General Physics
sequence of courses: 173.111 General Physics Lab

• Freshman/Fall Term • Sophomore/Spring Term


030.101 Introductory Chemistry I 030.206 Introductory Organic Chemistry II
030.105 Introductory Chemistry Lab 030.228 Intermediate Organic Chemistry Lab
Calculus 171.102 or 171.104 General Physics
Language 173.112 General Physics Lab
100 / Chemistry

• Junior/Fall Term Graduate Programs


020.305 Biochemistry Each student’s background and interests deter-
020.315 Biochemistry Lab mine the course of study. The normal program
030.356 Advanced Inorganic Lab leads to the Ph.D. degree. A student is not usually
Electives accepted for a terminal M.A. degree.
• Junior/Spring Term Requirements for the M.A. and Ph.D. Degrees
020.306 Cell Biology Normally, the minimum course requirement for
020.316 Cell Biology Lab both the M.A. and the Ph.D. degrees is eight one-
Electives semester graduate courses in chemistry and related
• Senior/Fall Term sciences. Exceptionally well-prepared students may
030.301 Physical Chemistry I ask for a reduction of these requirements.
030.305 Physical Chemistry Lab I Requirements for the Ph.D. degree include a
Electives research dissertation worthy of publication, and
a knowledge of chemistry and related material as
• Senior/Spring Term demonstrated in an oral examination. Each stu-
030.302 Physical Chemistry II dent must teach for at least one year.
030.306 Physical Chemistry Lab II Requirements for the M.A. degree, in addition to
Electives completion of formal course work, include a satis-
factory performance on an oral examination.
Honors in Chemistry
Each year, the Chemistry faculty will award honors Financial Aid and Admissions
in Chemistry to graduating seniors with a major About 80 fellowships, research appointments, and
in chemistry who have achieved an outstanding teaching assistantships are available for graduate
academic record in science and chemistry, or who students. There are no fixed admission require-
have completed a distinguished research project ments. Undergraduate majors in chemistry, biol-
carried out under the supervision of a faculty mem- ogy, earth sciences, mathematics, or physics may
ber in the Department of Chemistry. To carry out an apply as well as well-qualified individuals who will
honors research project, formal application to the have received a B.A. degree.
department advising coordinator (currently Profes- For further information about graduate study in
sor Poland) must be made by the beginning of the chemistry, contact Secretary, Committee for Gradu-
senior year, submitting a transcript and a letter of ate Admission, Department of Chemistry, or visit
sponsorship by the faculty member under whom a the Web site www.jhu.edu/~chem/.
research project will be carried out. A written thesis
based on one year of research must be submitted
to the faculty adviser.

Undergraduate Courses
030.101 (N) Introductory Chemistry I for molecules including an introduction to hybrid orbit-
An introduction to the fundamental principles of chemis- als. Prerequisite: 030.101.
try. The main topics to be covered are atomic and molec- Staff 3 credits spring
ular structure at the level of dot structures and VSEPR
geometries, the periodic table, stoichiometry and the 030.105-106 (N) Introductory Chemistry Laboratory
balancing of chemical equations, the gas laws, the law of Laboratory in the fundamental methods of chemistry
mass action and chemical equilibrium, acids and bases, with related calculations. Corequisites: 030.101-102. Pre-
and elementary chemical thermodynamics. Corequisite: requisite: 030.105 is prerequisite for 030.106.
030.105. Pasternack 1 credit fall and spring
Staff 3 credits fall
030.205 (N) Introductory Organic Chemistry I
030.102 (N) Introductory Chemistry II The fundamental chemistry of the compounds of carbon.
A continuation of 030.101 with an emphasis on chemical Methods of structure determination and synthesis. The
kinetics and chemical bonding. Topics will include the mechanisms of typical organic reactions and the relations
energy levels and wavefunctions for the particle-in-a-box between physical and chemical properties and structures.
and the hydrogen atom and approximate wavefunctions Prerequisites: 030.101-102, 030.105.
Staff 4 credits fall
Chemistry / 101

030.206 (N) Introductory Organic Chemistry II characterization of transition metal and organometallic
A continuation of 030.205. Prerequisite: 030.205. compounds. Methods used include vacuum and inert atmo-
Staff 4 credits spring sphere techniques. Instrumental approaches and modern
spectroscopic techniques are applied to the characteriza-
030.225 (N) Organic Chemistry Laboratory tion of compounds generated. Prerequisite: 030.225.
Techniques for the organic chemistry laboratory includ- Roth 3 credits fall
ing methods of purification, isolation, synthesis, and
analysis. Prerequisites: 030.101-102, 030.105. Corequisite: 030.425 (N) Advanced Mechanistic Organic Chemistry I
030.205 or 030.104. Chemistry majors should take this The course covers the application of techniques in physi-
course in the fall semester. cal chemistry to the study of organic reaction mecha-
Klein 3 credits fall and spring nisms. Topics include chemical bonding and structure,
stereochemistry, conformational effects, molecular orbital
030.228 Intermediate Organic Chemistry Laboratory theory, methods to determine reaction mechanisms, reac-
Laboratory skills acquired in the introductory organic tive intermediates, and photochemistry. Prerequisites:
chemistry laboratory will be further developed for the 030.205-206.
synthesis, isolation, purification, and identification of Staff 3 credits fall
organic compounds. Spectroscopic techniques and their
applications will be emphasized. Prerequisite: 030.225. 030.426 (N) Advanced Mechanistic Organic Chemistry II
Greenberg 3 credits spring This course covers advanced organic reactions and their
mechanisms. Emphasis is given both to methods of pos-
030.301 (N) Physical Chemistry I tulating mechanisms for rationalizing reaction results and
The laws of thermodynamics, their statistical foundation, to the use of mechanistic thinking for designing reac-
and application to chemical phenomena. Prerequisites: tions and reagents. This course is intended to be taken in
general physics, general chemistry, and calculus (two sequence with 030.425. Prerequisites: 030.205-206.
semesters recommended). Staff 3 credits spring
Staff 3 credits fall
030.441 (N) Spectroscopic Methods of Organic
030.302 (N) Physical Chemistry II Structure Determination
An introduction to quantum mechanics and its applica- The course provides fundamental theoretical background
tion to simple problems for which classical mechanics for and emphasizes practical application of ultraviolet/
fails. Topics include the harmonic oscillator, the hydro- visible and infrared spectroscopy, proton and carbon-13
gen atom, very approximate treatments of atoms and nuclear magnetic resonance and mass spectrometry to
molecules, and the theoretical basis for spectroscopy. the structure proof of organic compounds.
Prerequisite: 030.301. Recommended: 110.302 Differen- Hendrickson 3 credits fall
tial Equations.
Silverstone 3 credits spring 030.442 (N) Organometallic Chemistry
An introduction to organometallic chemistry beginning
030.305-306 (N) Physical Chemistry Instrumentation with structure, bonding and reactivity and continuing
Laboratory I, II into applications to fine chemical synthesis and catalysis.
This course is designed to illustrate the principles of phys- Chemistry 030.449 or the equivalent is required as a co-
ical chemistry and to introduce the student to techniques or prerequisite.
and instruments used in modern chemical research. Roth 3 credits spring
Chemistry majors are expected to take this sequence
of courses, rather than 030.307. Pre- or corequisites: 030.445 (N,Q) Applied Mathematics
030.301-302. Numerical methods useful in physical sciences will be
Fairbrother, Tolman 3 credits fall and spring developed. Topics include linear algebra, differential equa-
tions, quadrature and function approximation. Knowledge
030.307 (N) Physical Chemistry Instrumentation of a programming language is required.
Laboratory III Yarkony 3 credits not offered yearly
This is a one-semester course which selects experiments
which are most relevant to chemical engineering. Prereq- 030.449 (N) Chemistry of Inorganic Compounds
uisites: 030.301-302 or equivalent. The physical and chemical properties of inorganic, coor-
Trapane 3 credits fall dination and organometallic compounds are discussed in
terms of molecular orbital, ligand field, and crystal field
030.345 (N) Chemical Applications of Group Theory theories. Emphasis is placed on the structure and reac-
The theory of the representations of finite and continu- tivity of these inorganic compounds. Other topics to be
ous groups will be applied to problems in chemistry. discussed include magnetic properties, electronic spectra,
Yarkony 3 credits spring magnetic resonance spectra, and reaction kinetics. Coreq-
uisites: 030.301-302.
030.356 (N) Advanced Inorganic Laboratory Staff 3 credits fall
Laboratory designed to illustrate the principles and prac-
tice of inorganic chemistry through the synthesis and
102 / Chemistry

030.451 (N) Spectroscopy 030.507-508 Independent Research in Biochemistry I


The spectroscopy and structure of molecules starting from Research under the direction of members of the bio-
rotational, vibrational, and electronic spectra of diatomic chemistry faculty.
molecules and extending to polyatomic molecules as time Staff 1-3 credits
permits. Prerequisites: 030.301-302 or equivalent.
Dagdigian 3 credits not offered yearly 030.509-510 Independent Research in Biochemistry II
Research under the direction of members of the bio-
030.452 (N) Materials and Surface Characterization chemistry faculty. Prerequisites: 030.507-508 and permis-
The chemistry associated with surfaces and interfaces as sion of instructor.
well as a molecular level understanding of their essential Staff 1-3 credits
roles in many technologically. The first half of this course
addresses various analytical techniques used to study sur- 030.521-522 Independent Research in Inorganic
faces including X-ray, photoelectron spectroscopy and scan- Chemistry II
ning tunneling microscopy. The second half of this course Research under the direction of the inorganic chemis-
uses a number of case studies to illustrate the application of try faculty. Prerequisites: 030.503-504 and permission of
surface analytical techniques in contemporary research. instructor.
Fairbrother 3 credits spring Staff 1-3 credits

030.453 (N) Intermediate Quantum Chemistry 030.523-524 Independent Research in Physical


The principles of quantum mechanics are developed and Chemistry II
applied to chemical problems. Prerequisites: 030.301-302 Research under the direction of the physical chemistry
or equivalent. faculty. Prerequisites: 030.501-502 and permission of
Silverstone 3 credits fall instructor.
Staff 1-3 credits
030.466 (N) Physical and Analytical Methods
This course surveys a number of commonly used spec- 030.525-526 Independent Research in Organic
troscopic and analytical techniques with the objective of Chemistry II
showing how each method works and what kinds of infor- Research under the direction of the organic chemistry
mation can be obtained. The course reviews basic theory faculty. Prerequisites: 030.505-506 and permission of
and instrumentation underlying each method along with instructor.
a review of data reduction and error analysis. Illustrative Staff 1-3 credits
examples are presented from a range of disciplines. Pre-
requisite: 030.302 or equivalent. Cross-Listed
Meyer 3 credits not offered yearly
250.326 Biological Macromolecules: Structure and
030.480 (N) Mathematical Models in Chemistry Function
This course explores the wide range of behavior in non- Woodson, Garcia-Moreno 3 credits spring
linear chemical reaction schemes in open systems. The
main mathematical tools used are nonlinear differential 570.306 Chemistry of Environmental Issues
equations and matrix algebra. Among the topics covered Roberts 3 credits
are linear stability analysis, oscillating reactions, limit
cycles, chemical waves, pattern formation, chaotic behav-
ior, and enzyme cycles. Prerequisite: 030.301.
Poland 3 credits not offered yearly Graduate Courses
Advanced graduate courses are open to qualified under-
030.501-502 Independent Research in Physical
Chemistry I
graduate students. Not all 600-level courses are offered
Research under the direction of members of the physical every year.
chemistry faculty.
030.601 Statistical Mechanics
Staff 1-3 credits
An introduction to the statistical mechanics of coopera-
030.503-504 Independent Research in Inorganic tive phenomena using lattice gases and polymers as the
Chemistry I main models. Topics to be covered will include phase
Research under the direction of members of the inor- transitions and critical phenomena, scaling laws, and the
ganic chemistry faculty. use of statistical mechanics to describe time dependent
Staff 1-3 credits phenomena. Prerequisite: 030.301.
Poland 3 hours spring
030.505-506 Independent Research in Organic
Chemistry I 030.603 Organic Photochemistry
Research under the direction of members of the organic The fundamental principles and methods of investigating
chemistry faculty. photochemical reactions are developed and applied to
Staff 1-3 credits physical organic, synthetic organic, and biological systems.
Topics covered include the study of reactive intermediates,
Chemistry / 103

photoinitiated organic transformations, singlet oxygen 030.617 Special Topics in Inorganic Chemistry
chemistry, and photomedicine. Prerequisite: 030.425. Topics from the recent primary literature in inorganic
Toscano 3 hours not offered yearly chemistry will be discussed, via instructor lectures and
presentations by the graduate-undergraduate students
030.610 Chemical Kinetics enrolled in the course. The topics covered may range
The molecular mechanism of elementary physical and from bioinorganic to organometallic to solid-state inor-
chemical rate processes will be studied. Topics such as ganic chemistry. Prerequisite: 030.449 or equivalent.
elastic scattering, collisional vibrational and rotational Karlin 3 hours spring
energy transfer, chemically reactive collisions, and the
theory of unimolecular decay will be covered. Pre- or co- 030.619 Chemical Biology I
requisite: one year of quantum mechanics. Parts I and II constitute the core course of the Chemistry-
Bowen 3 hours fall Biology Interface (CBI) Program. An introduction to the
structure, synthesis, reactivity, and function of biological
030.611 Electron Transfer Processes
macromolecules (proteins, nucleic acids, carbohydrates,
Electron transfer processes are distinguished by their
and lipids) will be provided using the principles of organic
ubiquity and essential roles in many physical, chemical,
and inorganic chemistry. Discussion will incorporate a
and biological processes. Rates of electron transfer in
broad survey of molecular recognition and mechanistic
cytochromes and semiconductors span over 20 orders
considerations, and introduce the tools of molecular and
of magnitude. Therefore, it is important to understand
cellular biology that are utilized in research at the inter-
the factors which underlie this large rate variation. This
face of chemistry with biology and medicine. Prerequisite:
course is concerned primarily with this issue. Electron
030.206 or equivalent.
transfer theories will be developed from historic point of
Townsend 3 hours fall
view. Basic concepts and terminology will be discussed as
well as the spectroscopic and electrochemical techniques 030.620 Chemical Biology II
useful for quantitating electron transfer processes. The Beginning at the surface of cells, chemical events of pro-
final third of this course will highlight recent electron tein-protein, protein-nucleic acid and carbohydrate recog-
transfer studies in biology, the solid state, and solution. nition will be discussed proceeding to mechanisms of cell
Prerequisite: 030.356 or permission of instructor. signaling and controls of metabolism in cells. The roles of
Meyer 3 hours spring metals in cellular homeostasis and oxidative stress, gene
activation, control of the cell cycle, protein modification
030.612 Nucleic Acids Chemistry
and engineering by rational and selection methods, and
A survey of the physical properties of DNA and RNA. Areas
biotechnological tools as combinatorial chemistry, the use
to be explored include conformations of secondary and
of arrays, biomaterials, proteomics and informatics will be
tertiary structures, polyelectrolyte properties, folding and
discussed. Prerequisite: Chemical Biology I or permission
unfolding reactions, and recognition by small molecules
from instructor.
and proteins. Prerequisite: 030.301 or its equivalent.
Townsend 3 hours spring
Draper 3 hours spring
030.621-622 Seminar on the Chemical Literature
030.613-614 Chemistry-Biology Interface Program
Seminars are presented by advanced graduate students
Forum
on topics from current chemical journals. Most first-year
Chemistry-Biology Interface (CBI) program students and
graduate students are expected to attend this course for
faculty will meet weekly in a forum that will host presen-
credit. Undergraduate students may take the course on a
tations from CBI faculty and students as well as invited
satisfactory/unsatisfactory basis.
guest speakers. These meetings will serve as a valuable
Staff 1 hour fall and spring
opportunity for students to develop presentation skills
and interact with CBI students and faculty. Enrollment 030.634 Topics in Bioorganic Chemistry
is required for first and second year CBI students, and is Each year, topics in modern bioorganic chemistry will be
recommended for advanced year graduate students. treated in depth, drawing from the current literature as
Greenberg 1 hour fall and spring a primary resource. Topics will include natural products
030.615 Topics in Biological Inorganic Chemistry chemistry, biosynthetic reaction mechanisms, and drug
This course is concerned with the chemistry of metals in design. Methods of synthesis, combinatorial synthesis, and
biological systems. Major emphasis is placed on metallo- genetics will be described throughout. Carbohydrates,
proteins in which a transition metal is known to occupy lipids, polyketides, polypeptides, terpenes, and alkaloids
the active site of the protein. Chemical approaches to are some of the molecule classes to be examined. Prereq-
modeling bioinorganic systems also are discussed. The uisites: Chemical Biology I or two semesters of organic
lectures illustrate how chemical, spectroscopic, and struc- chemistry and one of biochemistry.
tural methods have been used to understand the structure Hendrickson 3 hours spring
and function of metals in biology. Prerequisites: 030.301-
030.635 Methods in Nuclear Magnetic Resonance
302 or the equivalent; some background in biochemistry
This course will introduce the necessary theoretical back-
or inorganic chemistry is helpful but not required.
ground required for an appreciation of modern tech-
Goldberg 3 hours fall
niques in magnetic resonance. The concepts developed
104 / Chemistry

will be extended into the context of current applications, 030.678 Advanced Organic Synthesis II
with an emphasis on the practical aspects of solution-state An advanced discussion of organic stereochemistry and
NMR studies of macromolecules. Prerequisite: 030.302. its application to problems in asymmetric reactions and
Tolman 3 hours fall catalysis will be presented. Emphasis will be placed on the
latest reports in the literature, especially with respect to
030.637 Computational Organic Chemistry the development of new catalytic, asymmetric processes.
Topics to be covered include practical molecular orbital Prerequisite: 030.677.
theory, molecular dynamics, and mechanics calculations Lectka 3 hours spring
for organic chemists. Emphasis will be on the interac-
tive use of programs on SGI workstations. Prerequisite: 030.679 Advanced Asymmetric Synthesis
030.425. The asymmetric synthesis of organic molecules using stoi-
Lectka 3 hours not offered yearly chimetric and catalytic methodology will be addressed,
from the historical development of chiral auxiliaries to
030.638 Spectroscopy of Diatomic Molecules cutting-edge asymmetric catalysts. Prerequisite: 030.677.
A detailed study of diatomic molecules will be undertaken Lectka 3 hours not offered yearly
by rotational, vibrational, and electronic spectroscopy.
The Born-Oppenheimer approximation, Hunds coupling 030.682 Organic Chemistry of Nucleic Acids
cases, angular momentum coupling techniques. Wigner- Nucleic acids (DNA/RNA) are essential molecules for all
Eckart theorem, selection rules, intensity factors, external living beings. Studies on their structure, synthesis, chemical
fields, and other related topics will be discussed. properties, and noncovalent interactions with other mol-
Dagdigian 3 hours not offered yearly ecules are critical for understanding their role in biological
processes. More recently, these molecules have been used
030.639 Catalysis in Chemistry as therapeutic and diagnostic agents. This course focuses
Chemical catalysis is directly and indirectly responsible for on the structure, reactivity, and molecular recognition of
adding $500 billion a year of value to the U.S. economy. these molecules. The topic will be approached from the
In this course, the principles of chemical catalysis will be perspective of organic chemistry, but biochemical and bio-
discussed, accentuating kinetics and mechanistic experi- logical concepts will be included (and explained).
ments. Topics to be covered include catalysis in biological Greenberg 3 hours not offered yearly
and organic systems, as well as inorganic and organometal-
lic homogeneous and heterogeneous catalysis. The course 030.683-684 Inorganic Nights
will finish with a presentation on asymmetric catalysis. Contemporary research topics in inorganic and bioin-
Practical aspects of industrial catalytic reactions will also organic chemistry will be discussed, including modern
be considered. experimental methods, data analysis, and interpretation.
Lectka 3 hours fall An emphasis is placed on current research progress in
electron-transfer and biomimetic chemistry.
030.666-667 Organic Synthesis Research Seminar Goldberg, Karlin, Meyer, Roth 1 hour
Summaries and evaluations of research results and litera-
ture readings. 030.700-701 Research Seminar in Bioorganic
Posner 2 hours Chemistry
Weekly meetings alternate between presentations of
030.676 Green Chemistry: An Inorganic Perspective recent research progress and discussion of topics from
The course will provide background into green chemis- the current literature.
try and the minimization of hazardous materials associ- Townsend 2 hours
ated with chemical practices. Emphasis will be placed on
recent literature on green inorganic chemistry.
Karlin 3 hours spring

030.677 Advanced Organic Synthesis I


The reactions and principles involved in the synthesis of
simple and complex organic compounds. Discussion of
famous natural product syntheses and practice in develop-
ing rational designs for organic syntheses. Problems in the
design of syntheses and in the use of chemical literature.
Posner 3 hours fall