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Beta-carotene, Vit.

A e derivati

Lutein improves visual function in some patients with retinal degeneration: a pilot study via the internet. Dagnelie G, Zorge IS, McDonald M. !ptometry "###$%&:&'%(&)'. PURPOSE: The purpose of this article is to e a!ine the effects of lutein supple!entation on visual acuit", central visual-field area, and su#$ective visual distur#ances in retinitis pi%!entosa &RP' and related retinal de%enerations, in an international stud" population recruited via an (nternet !ailin% list. )ET*O+S: Si teen participants &,- .ith RP, three .ith other retinal de%enerations' co!pleted a /0-.ee1 pro%ra! of lutein supple!entation &23 !%4da" for 5 .ee1s, /3 !%4da" thereafter'6 ,3 participants also too1 733-!% docosahe aenoic acid &+*A'4da", vita!in B co!ple , and di%estive en8"!es. Ten participants previousl" ta1in% vita!in A and4or #eta-carotene continued those supple!ents throu%hout the stud". Participants self-tested their visual acuit" on their co!puter screen and their central visual-field e tent on a .all chart, .ee1l" for ,2 .ee1s, #i.ee1l" thereafter. RESU9TS: )ean visual acuit" i!proved #" 3.: dB and !ean visual-field area #" 3.-7 dB. (!prove!ents started / to 2 .ee1s after supple!entation #e%an, and plateaued at 0 to ,2 .ee1s. Visual acuit" %ains .ere stron%l" correlated .ith e"e color: ,./ dB in seven #lue-e"ed participants, #ut 3.- dB in seven dar1-e"ed participants. Participants .ho received previous supple!ents sho.ed %reater #enefits in central visual-field area &3.77 dB' than those not receivin% previous supple!ents &no chan%e'. ;o si%nificant effects of a%e, se , disease sta%e, or stud" supple!ent .ere found. <O;<9US(O;S: Short-ter! vision i!prove!ents after lutein supple!entation=previousl" reported in a%e-related !acular de%eneration=also occur in RP, especiall" in #lue-e"ed individuals6 vita!in A !a" increase visual field #enefits. *elation of serum antio+idant vitamins to the ris, of colorectal adenoma. -reuer(.atschins,i -, /emes ., Marr 0, et al. Digestion "##&$)1:'1('2. The relation #et.een ris1 of colorectal adeno!a and seru! concentrations of vita!ins A, <, E and carotene .as e a!ined in a population-#ased case-control stud" of ,37 cases of colorectal adeno!a and a si!ilar nu!#er of hospital controls sho.in% no pol"ps at colonoscop" and a second control %roup of population controls. There .ere no si%nificant associations .ith seru! concentrations of vita!ins < and E and carotene. Seru! concentrations of vita!in A .ere si%nificantl" inversel" related to the ris1 of colorectal adeno!a .hen cases .ere co!pared .ith #oth control %roups. After ad$ust!ent for ener%" inta1e, s!o1in%, alcohol, estro%en therap", #od"-!ass-inde and social class the inverse association #et.een vita!in A and colorectal adeno!a .as even !ore !ar1ed. >or the hi%hest versus the lo.est ?uartile of seru! levels the ad$usted RR .as 3./- &3.3:-3.:-' in relation to hospital controls and 3.3@ &3.3/-3./7' in relation to population controls. These findin%s su%%est that the ris1 of developin% colorectal adeno!as is reduced in those .ith hi%h vita!in A levels.

3ffects of 4eta(carotene supplementation for si+ months on clinical and la4oratory parameters in patients with cystic fi4rosis. *enner S, *ath *, *ust 5, et al. hora+ "##&$6):'2(6".

BA<ABROU;+: Patients .ith c"stic fi#rosis &<>' have si%nificantl" decreased plas!a concentrations of nutrient antio idant vita!ins, especiall" of #eta-carotene, .hich is thou%ht to result fro! fat !ala#sorption and chronic pul!onar" infla!!ation. The ai! of this dou#le #lind, place#o controlled stud" .as to investi%ate the effect of oral #eta-carotene supple!entation for si !onths on clinical para!eters. )ET*O+S: T.ent" four patients .ith <> .ere rando!ised to receive #eta-carotene , !%41%4da" &!a i!u! 73 !%4da"' for three !onths &hi%h dose supple!entation' and ,3 !%4da" for a further three !onths &lo. dose supple!entation' or place#o. At !onthl" follo. up visits the plas!a #eta-carotene concentration, total antio idant capacit", !alondialdeh"de &)+A' as a !ar1er of lipid pero idation, and clinical para!eters &Sh.ach!annAulc8"c1i score, #od" !ass inde &B)(', hei%ht, and lun% function &>EV&,''' .ere assessed. The nu!#er of pul!onar" e acer#ations re?uirin% anti#iotic treat!ent &in da"s' three !onths #efore and durin% the stud" .ere evaluated. RESU9TS: The plas!a concentration of #eta-carotene increased si%nificantl" to the nor!al ran%e durin% the three !onths of hi%h dose supple!entation &#aseline 3.3@ &3.32' !u!ol4l to 3.70 &3.-@' !u!ol4l6 pC3.33,' #ut decreased to 3.-/ &3.,5' !u!ol4l in the period of lo. dose supple!entation. (nitiall" raised plas!a levels of )+A fell to nor!al levels and the total antio idant capacit" sho.ed a non-si%nificant trend to.ards i!prove!ent durin% hi%h dose supple!entation. Anti#iotic treat!ent decreased si%nificantl" in the supple!entation %roup fro! ,2.7 &,2.5' da"s4patient durin% the three !onths #efore the stud" to 5.@ &,3.-' da"s4patient durin% hi%h dose supple!entation &pD3.3-0@' and to ,3.7 &5.5' da"s4patient durin% lo. dose supple!entation, #ut increased in the place#o %roup. The Sh.ach!ann-Aulc8"c1i score, lun% function, and B)( did not sho. an" chan%es in either of the treat!ent %roups. ;o adverse events .ere o#served durin% the stud" period. <O;<9US(O;: Oral #eta-carotene supple!entation in a dose of , !%41%4da" onl" .as effective in nor!alisin% the plas!a concentration of #eta-carotene and resulted in a decrease in pul!onar" e acer#ations. These data su%%est that patients .ith <> !a" #enefit clinicall" fro! supple!entation .ith #eta-carotene and further studies are .arranted.