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Obesity: A new appetite-increasing mechanism discovered

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Obesity: A New Appetite-Increasing Mechanism Discovered
Oct. 29, 2013 — Despite their efforts, many morbidly obese people continue to consume too much food (hyperphagia) compared to their reserves and their needs. And yet, the hunger hormone, called ghrelin, is most frequently found at a normal or even lower level in these patients. The Inserm Unit 1073 team "Nutrition, inflammation and dysfunction of the gut-brain axis" (Inserm/University of Rouen) has just explained this mechanism causing this paradoxical hyperphagia. Certain antibodies have a greater affinity for ghrelin in obese patients, leading to extended appetite stimulation.
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These results are published in the journal Nature Communications , on 25 October 2013.

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Obesity affects more than 15% of adults in France, and its constitutive mechanisms are still not completely Tw eet 63 explained. Normally, fine control of weight and food intake is coordinated by 11 a specialised part of the brain (the Section of rat stomach showing ghrelin-producing hypothalamus). It adjusts food intake 6 cells (in red) and immune cells (in green). (Credit: © depending on reserves and needs. In this way, after a period of excessive food Inserm / S. Fetissov) intake and weight gain, a healthy subject will tend spontaneously Related Topics to reduce their food intake for a while to return to their previous 1/5


Obesity: A new appetite-increasing mechanism discovered

weight. In many of the morbidly obese, this mechanism is faulty: despite their efforts, they continue to consume too much food (hyperphagia), contributing to maintaining a higher weight or even increasing it further. Even so, their brain should take in the information about over-eating and reduce food intake to encourage weight loss. This observation is all the more surprising given that the hunger hormone ghrelin, produced by the stomach and acting on the hypothalamus, is most frequently found at a normal, or even a reduced level in obese patients. The study conducted by Sergueï Fetissov and the team from joint research unit 1073 "Nutrition, inflammation and dysfunction of the gut-brain axis" (Inserm/University of Rouen), directed by Pierre Déchelotte, collaborating with Prof Akio Inui's team at the University of Kagoshima (Japan), reveals the molecular mechanism of this paradoxical hyperphagia. The researchers have highlighted the presence of specific antibodies, or immunoglobulins, in the blood of obese patients, antibodies that recognise ghrelin and regulate appetite. By binding to ghrelin, the immunoglobulins protect the hunger hormone from being broken down rapidly in the bloodstream. The ghrelin can then act on the brain for longer and stimulate appetite. "The immunoglobulins have different properties in obese patients," explains Sergueï Fetissov, researcher in the Inserm unit in Rouen and main author of the study. "They are more strongly 'attracted' to ghrelin than in subjects of normal weight or in anorexic patients. It is this difference in 'affinity' that enables the immunoglobulins to transport more ghrelin to the brain and boost its stimulating action on food intake," he continues.

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Appetite Hormone Misfires in Obese People (Aug. 20, 2013) — Glucagon, a hormone involved in regulating appetite, loses its ability to help obese The research team has confirmed this mechanism by people feel full after a meal, but it continues to experiments in rodents. When ghrelin was administered in suppress hunger pangs in people with type 1 combination with immunoglobulins extracted from the blood of obese patients, or with immunoglobulins derived from genetically- diabetes, according ... > read more obese mice, they stimulated food intake more strongly. Ghrelin Increases Willingness to Pay for Food Conversely, when ghrelin only was given, or combined with (July 15, 2011) — New research suggests that immunoglobulins from non-obese people or mice, the rodents ghrelin, a naturally occurring gut hormone, were better able to regulate their appetite by restricting food increases our willingness to pay for food, while intake. simultaneously decreasing our willingness to pay for non-food ... > read more "Our discover open a new opportunity to design treatments acting on the basis of this mechanism to reduce hyperphagia Anti-Obesity Vaccine Reduces Food

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Obesity: A new appetite-increasing mechanism discovered

observed in cases of obesity," emphasises Pierre Déchelotte, Director of the joint Inserm/University of Rouen unit. This study extends other work by the research team, published in 2011, on the role of immunoglobulins interfering with different hormones acting on appetite, satiety or anxiety in cases of anorexia, bulimia or depression, and on the probable involvement of intestinal flora (microbiotic) in these interactions. "Our results could also be used to study the opposite phenomenon, loss of appetite, such as observed in cases of anorexia," concludes Pierre Déchelotte. Share this story on Facebook , Twitter, and Google:
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Consumption in Animals (June 6, 2011) — A new therapeutic vaccine to treat obesity by suppressing the appetite-stimulating hormone ghrelin decreases food intake and increases calorie burning in mice, a new study ... > read more Action Of Ghrelin Hormone Increases Appetite And Favors Accumulation Of Abdominal Fat (May 26, 2009) — The ghrelin hormone not only stimulates the brain giving rise to an increase in appetite, but also favous the accumulation of lipids in visceral fatty tissue, located in the abdominal zone and ... > read more Exercise Suppresses Appetite By Affecting Appetite Hormones (Dec. 19, 2008) — A vigorous 60-minute workout on a treadmill affects the release of two key appetite hormones, ghrelin and peptide YY, while 90 minutes of weight lifting affects the level of only ghrelin. The ... > read more

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Other social book mark ing and sharing tools: Share Share Share Share Share Share Share | Story Source: The above story is based on materials provided by INSERM (Institut national de la santé et de la recherche médicale). Note: Materials may be edited for content and length. For further information, please contact the source cited above. Journal Reference : 1. Kuniko Takagi, Romain Legrand, Akihiro Asakawa, Haruka Amitani, Marie François, Naouel Tennoune, Moïse Coëffier, Sophie Claeyssens, Jean-Claude do Rego, Pierre Déchelotte, Akio Inui, Sergueï O. Fetissov. Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans. Nature Communications , 2013; 4 DOI: 10.1038/ncomms3685 Need to cite this story in your essay, paper, or report? Use one of the following formats: APA INSERM (Institut national de la santé et de la recherche médicale) (2013, October 29). Obesity: A new appetite-increasing mechanism

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Obesity: A new appetite-increasing mechanism discovered


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