Code No: RR410808

Set No. 1

IV B.Tech I Semester Supplementary Examinations, February 2007 TECHNOLOGY OF PHARMACEUTICALS AND FINE CHEMICALS (Chemical Engineering) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. Give reasons for the following. (a) Potassium Iodide is used in the Limit test for Arsenic. (b) Cotton wool impregnated with lead acetate is kept in the tube through which the gas passes before coming is contact with mercuric chloride paper in Arsenic Limit test. (c) Citric acid is used in the limit test for Iron (d) Hydrochloric acid is used in Sulphate limit test. (e) Alcohol is used in Sulphate limit test. (f) Nitric acid is used in Chloride limit test. (g) Dithizone is used in limit test for lead. (h) Mercuric chloride paper is used in Arsenic limit test. 2. Discuss past, present and future status of Paracetamol in pharmaceutical industry. [16] 3. Discuss the manufacture of fluorescence in brief. Enlist various parameters and process conditions and discuss in brief. [16] 4. Discuss the past, present and future status of calcium gluconate in pharmaceutical industry. [16] 5. With a flow sheet explain the manufacturing process of phthalic anhydride from naphthalene. [16] 6. Describe the manufacture of hard-gelatin capsules, including formulation and filling. [16] 7. By means of a sketch explain the design and operation of Portable Autoclaves. [16] 8. Describe with diagram, the process of sterilization by filtration. What the advantages and disadvantages of such method. [16] ⋆⋆⋆⋆⋆ [8x2=16]

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Code No: RR410808

Set No. 2

IV B.Tech I Semester Supplementary Examinations, February 2007 TECHNOLOGY OF PHARMACEUTICALS AND FINE CHEMICALS (Chemical Engineering) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. (a) Explain the principle, reaction involved and the technique of limit test for chloride [8] (b) What happens when i. ii. iii. iv. Ferrous salt reacts with thioglycolic acid in alkaline medium Barium chloride is treated with sulphates Arsenic compounds are treated with concentrated hydrochloric acid Dithizone is treated with lead compounds [8]

2. Compare the consumption and economical aspects of nicotinamide and riboflavin in pharmaceutical industry? [16] 3. Discuss the testing method for safe use of fluorescence. Enlist its important properties? [16] 4. Discuss the materials required and the manufacturing process for manufacture of 1 metric ton aspirin. [16] 5. Describe anyone method of manufacturing of phthalic anhydride. [16]

6. Explain the sugar coating process for tablets. Comment its merits and demerits. [16] 7. By means of a sketch explain the design and operation of Portable Autoclaves. [16] 8. By means of neat sketches, describe the different models of Ceramic Filters in common use. [16] ⋆⋆⋆⋆⋆

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Code No: RR410808

Set No. 3

IV B.Tech I Semester Supplementary Examinations, February 2007 TECHNOLOGY OF PHARMACEUTICALS AND FINE CHEMICALS (Chemical Engineering) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. (a) Explain the principle, reaction involved and the technique of Limit test for chloride [8] (b) Complete the following equations i. ii. iii. iv. HAsO3 AsH3 + Hgcl2 2+ SO4 + BaCl2 P b2+ + C6 H5 N = NCSNHNHC6 H5
Zn/HCL

[4x2=8] −− − − −→ −→ −→ −→

2. How do you test safety and purity aspects of riboflavin? Discuss various aspects of above? [16] 3. Discuss the testing method for safe use of procaine hydrochloride. Enlist its important uses? [16] 4. Describe various properties and uses of calcium gluconate and aspirin. [16]

5. Discuss the manufacture of phthalic anhydride in brief. Enlist important reactions and process conditions. [16] 6. Discuss the various methods involved in the manufacture of tablets. 7. Write short notes on the sterilization of the following: (a) rubber closures (b) glass vials (c) filling rooms (d) tissue transplants 8. Discuss the use of the following for sterilization of pharmaceuticals. Describe how they are applied? [8x2=16] (a) gamma rays (b) β-propiolactone ⋆⋆⋆⋆⋆ [16] [4x4=16]

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Code No: RR410808

Set No. 4

IV B.Tech I Semester Supplementary Examinations, February 2007 TECHNOLOGY OF PHARMACEUTICALS AND FINE CHEMICALS (Chemical Engineering) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. (a) Write the principle and reaction involved in the following limit tests. [4x2=8] i. Arsenic ii. Lead (b) Explain the impurities in pharmaceuticals arising out of raw materials used in the manufacturing [8] 2. Outline the synthesis of para-amino salicylic acid and isonicotinic acid hydrazide. Write their uses. [16] 3. Discuss the testing method for safe use of isonicatinic acid hydrazide. Enlist its important uses? [16] 4. Describe in detail methods for recovery of penicillin from crude fermentation liquor. Give an account of various grades of penicillin. [16] 5. Describe anyone method of manufacturing of phthalic anhydride. 6. (a) Factors influencing the process of extraction. (b) Hot extraction [16] [8] [8]

7. Explain the need to sterilize pharmaceutical preparations. Describe the common types Injections in common use with examples [16] 8. Discuss the comparative aspects of Depth and Screen Filters. ⋆⋆⋆⋆⋆ [16]

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