Code No: RR411105

Set No. 1

IV B.Tech I Semester Supplementary Examinations, February 2007 PHYSIOLOGICAL SYSTEMS MODELLING (Bio-Medical Engineering) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. With neat sketches discuss the characteristics of models? 2. pertaining to endocrine systems, explain the following terms (a) Chemical reactions (b) Transport process 3. Write short notes on (a) Global models (b) Cellular and sub cellular (c) Organ Models [16] [8] [8] [16]

4. What are perturbation schemes? Explain this as an approach to modeling for a metabolic system? [16] 5. (a) Explain Biological receptor with examples? (b) Explain Adaptation by giving examples? 6. (a) Explain the need for model decomposition? (b) Discuss how decomposition helps in the case study of insulin model? 7. Explain the model of glucose utilization? [8] [8] [8] [8] [16]

8. (a) With the help of necessary data explain a descrete statistical approach to a metabolic system modeling? [8] (b) Write short notes on continous statistical signals? ⋆⋆⋆⋆⋆ [8]

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Code No: RR411105

Set No. 2

IV B.Tech I Semester Supplementary Examinations, February 2007 PHYSIOLOGICAL SYSTEMS MODELLING (Bio-Medical Engineering) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. Explain the characteristics of different models? [16]

2. (a) Regarding endocrine systems explain the transport process by fluid circulation? [8] (b) Explain the chemical reactions pertaining to endocrine systems. 3. Write short notes on (a) Purpose of compartmental models. (b) Global models 4. Write short notes on (a) Dynamic equilibrium (b) Small signal perturbation. 5. Explain the terms (a) Biological receptor (b) Adaptation [8] [8] [8] [8] [8] [8] [8]

6. Make a case study for glucose insulin model to estimate insulin sensitivity with proper statistical data? [16] 7. Explain the significance insulin sensitivity index in detail? 8. Write note on the following (a) Continous statistical signals (b) Discrete statistical signals ⋆⋆⋆⋆⋆ [8] [8] [16]

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Code No: RR411105

Set No. 3

IV B.Tech I Semester Supplementary Examinations, February 2007 PHYSIOLOGICAL SYSTEMS MODELLING (Bio-Medical Engineering) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. Describe the techniques of mathematical modeling used in physiological systems? [16] 2. (a) Explain the process of fluid circulation with regard to endocrine system? [8] (b) What is a controlled process with respect to endocrine system? Explain? [8] 3. Describe the terms (a) Levels of modeling in a metabolic system (b) Model reduction. 4. Discuss the mathematical representation of compartment system models? 5. Describe the terms (a) Adaptation (b) Rate sensitivity 6. Explain insulin sensitivity with a model. [8] [8] [16] [8] [8] [16]

7. Explain a model for glucose utilization. How it is related to gluxoseMinsulin model for insulin sensitivity? [16] 8. Write short notes on: (a) Statistical approach to modeling. (b) Averaging approach to modeling. ⋆⋆⋆⋆⋆ [8] [8]

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Code No: RR411105

Set No. 4

IV B.Tech I Semester Supplementary Examinations, February 2007 PHYSIOLOGICAL SYSTEMS MODELLING (Bio-Medical Engineering) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. (a) Explain the need for modeling? (b) Explain about different types of models? [8] [8]

2. Explain the process of diffusion between two compartments with a signal flow diagram. [16] 3. Describe the terms (a) Levels of modeling in a metabolic system (b) Model reduction. [8] [8]

4. Bring out the differences between compartmental and non compartmental models. [16] 5. Describe the terms (a) Adaptation (b) Rate sensitivity [8] [8]

6. (a) Compare the glucose insulin model with that model of glucose utilization. [8] (b) What is model decomposition. Explain. 7. Write short notes on: (a) Insulin sensitivity index (b) Model comparison [8] [8] [8]

8. Discuss the significane of a averaging computation in modelling with an example. [16] ⋆⋆⋆⋆⋆

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