Code No: RR412301

Set No. 1

IV B.Tech I Semester Supplementary Examinations, February 2007 GENOMICS AND PROTEOMICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. Explain in detail how life has originated. [16]

2. Explain how chromatin structure plays important role in Eukaryotic gene regulation. [16] 3. Explain where are genomic variations are found. 4. How could you compare genomes clustal W Alignment tool? 5. Discuss in detail how cDNA is prepared. 6. What do you mean by biochipnology. Discuss? 7. Write short notes: (a) Human Metabolome (b) Functional Genomics. 8. What is the role of ELSI in research programs? ⋆⋆⋆⋆⋆ [8+8] [16] [16] [16] [16] [16]

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Code No: RR412301

Set No. 2

IV B.Tech I Semester Supplementary Examinations, February 2007 GENOMICS AND PROTEOMICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. Discuss in detail about biodiversity. 2. Discuss in detail about Lactose operon. 3. Discuss in detail about repetitive DNA. 4. How could you evaluategene prediction Engines? 5. Write short notes: (a) Protein sequence data (b) Sequence database search. 6. Write short notes: (a) Biochips (b) Micro arrays. 7. How SNP plays an important role in identifying disease gene? 8. How could you explain drug design using known receptor structures? ⋆⋆⋆⋆⋆ [8+8] [16] [16] [8+8] [16] [16] [16] [16]

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Code No: RR412301

Set No. 3

IV B.Tech I Semester Supplementary Examinations, February 2007 GENOMICS AND PROTEOMICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. Write short notes (a) 5’ caping in mRNA (b) 3’ Poly A Tailing in mRNA 2. wirte short notes (a) Histone proteins (b) Chromatin 3. Expalin in detail about mobile DNA and its classification. 4. Write short notes: (a) Comparative genomics (b) Functional genomics. 5. How could you find genes by searching the proteins sequence database? 6. What do you mean by biochipnology. Discuss? 7. Explain how SNPs are usefull to find disease genes. 8. How could you explain drug design using known receptor structures? ⋆⋆⋆⋆⋆ [8+8] [16] [16] [16] [16] [8+8] [16] [8+8]

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Code No: RR412301

Set No. 4

IV B.Tech I Semester Supplementary Examinations, February 2007 GENOMICS AND PROTEOMICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. Write short notes: (a) DNA lagging strand synthesis (b) Enzymes involved in DNA replication. 2. Discuss in detail about Lactose operon. 3. Explain kinetics of DNA renaturation. 4. How could you compare genomes clustal W Alignment tool? 5. Discuss in detail about homology modeling and drug design. 6. Explain how disease genes can be identified by proteomics. 7. How EST library plays an important role in identifying disease gene? 8. Explain the metabolism of drug. ⋆⋆⋆⋆⋆ [8+8] [16] [16] [16] [16] [16] [16] [16]

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