Code No: RR412303

Set No. 1

IV B.Tech I Semester Supplementary Examinations, February 2007 BIO PHARMACEUTICAL TECHNOLOGY (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. What are antimalarial drugs? Give structure and uses of the following (a) Quinine (b) Trimethoprim (c) Chloroquine (d) Amodiaquine. 2. (a) How are ionic / ionizable drugs absorbed (b) Buffered aspirin tablets are more suitable than sodium salt form of aspirin why? [8+8] 3. In contrast to zero order process, the half-life of a first-order process is considered to be an important Pharmacokinetic parameter, why? Explain with suitable reasons? [16] 4. What are the different types of reactions involved in the case of bulk drug manufacturing. [16] 5. Write about different stages involved in sugar coating. 6. What is GMP and how does it assure the quality of drug product? 7. Write the synthesis properties and uses of ascorbic acid. 8. Describe about the therapeutic importance of hormones, give examples? ⋆⋆⋆⋆⋆ [16] [16] [16] [16] [4+3+3+3+3]

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Code No: RR412303

Set No. 2

IV B.Tech I Semester Supplementary Examinations, February 2007 BIO PHARMACEUTICAL TECHNOLOGY (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. How many types of licenses can be issued for the manufacture of drugs? Describe the general procedure for obtaining a license stating the conductions to be satisfied. [16] 2. Describe various theories that explain drug dissolution. [16]

3. (a) Define Pharmacokinetics. Name and define the three pharmacokinetic parameters that describe a typical plasma level - time curve. (b) What are the various pharamcodynamic parameters? 4. (a) Describe the Laboratory filtration equipment and their usage? (b) What is cake filtration ? Describe the cake filtration process in the bulk drug manufacturing industry. [8+8] 5. Write about different stages involved in sugar coating. 6. What is GMP and how does it assure the quality of drug product? [16] [16] [8+8]

7. Indicate the importance of vitamins B1 , B2 , D and E, what are the sources of these vitamins. [16] 8. Differentiate between non-steroidal and steroidal contraceptives? Write about nonsteroidal (or) synthetic Estrogens. [16] ⋆⋆⋆⋆⋆

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Code No: RR412303

Set No. 3

IV B.Tech I Semester Supplementary Examinations, February 2007 BIO PHARMACEUTICAL TECHNOLOGY (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. (a) Describe the patents and designs act? Describe in brief the procedure for obtaining a patent? (b) What is meant by “piracy of registered design” and reciprocal arrangements under the designs act? Define the term “patent” and “invention”. [8+8] 2. (a) How are ionic / ionizable drugs absorbed (b) Buffered aspirin tablets are more suitable than sodium salt form of aspirin why? [8+8] 3. (a) Why are first-order processes said to follow linear kinetics? (b) Quote the examples of zero-order rate processes. [8+8]

4. (a) How the P H is controlled in the manufacture of bulk drugs? Explain with examples. (b) How the temperature is controlled in the case of bulk drug manufacturing. explain with examples. [8+8] 5. Write about different stages involved in sugar coating. [16]

6. Write about the control and assurance of manufacturing practices involved for drug. [16] 7. Write the synthesis properties and uses of ascorbic acid. [16]

8. Write the classification of antibiotics and describe about the production of penicillin and their therapeutic importance? [16] ⋆⋆⋆⋆⋆

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Code No: RR412303

Set No. 4

IV B.Tech I Semester Supplementary Examinations, February 2007 BIO PHARMACEUTICAL TECHNOLOGY (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. (a) Describe the standers of weight and measures act? (b) Briefly discuss the provisions of the insecticides Act regarding the import, manufacture, transport, distribution, and use of insecticides? [8+8] 2. What are the various mechanisms for drug-drug interactions in the GIT (Gastro Interstinal Track)? Describe in detail. [16] 3. (a) Define Pharmacokinetics. Name and define the three pharmacokinetic parameters that describe a typical plasma level - time curve. (b) What are the various pharamcodynamic parameters? [8+8]

4. What are the parameters used in the manufacture of bulk drugs? How the parameters are controlled. [16] 5. (a) Write about different methods of film coating. (b) What are the objectives of the tablet coating and list out different stages of sugar coating. [8+8] 6. What is GMP and how does it assure the quality of drug product? 7. (a) What are laxatives? How they differs from analgesics? (b) What are vitamins? How they differ from Hyperosmotic laxatives? 8. (a) How Laxatives differ from hormones. Explain with examples. (b) How non-steroidal contraceptives differ from Antibiotics. Explain with examples. [8+8] ⋆⋆⋆⋆⋆ [8+8] [16]

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