Code No: RR412306

Set No.1

IV B.Tech. I Semester Supplementary Examinations, February -2007 MOLECULAR PATHOGENESIS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks

1. (a) Write short notes on freund’s complete and incomplete adjuvants? (b) Write advantages and disadvantages of in vitro and in vivo experimental models? [16] 2. Write in short about the following: (a) Nosocomial (b) Endemic (c) Epidemic (d) Pandemic. 3. Write the defense mechanisms of the following: (a) Skin (b) Eye (c) Mouth. [16] [16]

4. What is Vaccine? Write the properties of Vaccines and routes of Vaccination? [16] 5. Write short answers for the following: (a) Superantigen (b) Monoclonal Antibody (c) Affinity and Avidity (d) Toxoid (e) Immuno Survillence (f) Clonal selection theory (g) Epitope and paratope (h) Immunotoxins. 6. (a) Write the difference between diarrhoea and dysentry? (b) What is an opportunistic infection? Write briefly about any one fungal infection? [16] 7. (a) What is ulcer and how is it caused? 1 of 1 [16]

Code No: RR412306

Set No.1

(b) What bacteria causes ulcer? Write briefly about pathogenesis and treatment. [16] 8. What are Immunoglobulins? Write in short about the structure, types and functions of Immunoglobulins in immune system. [16]

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Code No: RR412306

Set No.2

IV B.Tech. I Semester Supplementary Examinations, February -2007 MOLECULAR PATHOGENESIS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks

1. What are Immunoglobulins? Write in short about the structure, types and functions of immunoglobulins in immune system? [16] 2. What is rheumatic fever? Write briefly about the pathogen, symptoms, pathogenesis and treatment. [16] 3. Write short answers for the following: (a) Immunotoxins (b) Toxoid (c) Monoclonal Antibody (d) Affinity and Avidity (e) Immuno Survillence (f) Clonal selection theory (g) Epitope and paratope (h) Superantigen. [16]

4. (a) Why is Hardy weinberg law not applicable for microbial population genetics? (b) Why does infectious dose vary among different hosts? [16]

5. What are the mechanisms adopted by microorganisms to evade the immune response? [16] 6. Define Vaccines. How does Vaccination enhance immune system? [16]

7. What is botulism? Write briefly about the pathogen, symptoms, pathogenesis and treatment. [16] 8. Write briefly about the pathogen, symptoms, pathogenesis, treatment and vaccines for the following diseases. (a) Leprosy (b) Tuberculosis [TB]. [16]

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Code No: RR412306

Set No.3

IV B.Tech. I Semester Supplementary Examinations, February -2007 MOLECULAR PATHOGENESIS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks

1. (a) What are haptens, adjuvant and carrier molecules? (b) Why is it not possible to develop vaccines against most of the parasites pathogens? [16] 2. What is genetic diversity? Write the methods to detect genetic diversity in microbial pathogens? [16] 3. Write short answers for the following: (a) Monoclonal Antibody (b) Affinity and Avidity (c) Immunotoxins (d) Toxoid (e) Immuno Survillence (f) Super antigen (g) Clonal selection theory (h) Epitope and paratope. 4. (a) What is the difference between innate and adaptive immunity? (b) Write in short about the cells involved and their role in innate and adaptive immunity? [16] 5. Write short notes on the following: (a) Vaccines (b) Immunomodulators. [16] [16]

6. Define inflammation. Write the steps or stages and the different components involved and their role in inflammation. [16] 7. What is colonisation? Write in detail about the diphtheria disease? [16]

8. Write about two human diseases caused by mycobacterial pathogens and briefly explain their pathogenesis. [16]

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Code No: RR412306

Set No.4

IV B.Tech. I Semester Supplementary Examinations, February -2007 MOLECULAR PATHOGENESIS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks

1. Write short answers for the following: (a) Epitope and paratope (b) Superantigen (c) Immunotoxins (d) Toxoid (e) Immuno Survillence (f) Clonal selection theory (g) Monoclonal Antibody (h) Affinity and Avidity. 2. What is pathogenesis? Define cryptic disease with an example. 3. Define Virulence. Write the factors which contribute to Virulence. [16] [16] [16]

4. Write in short about different cells of immune system and their mode of action. [16] 5. What is immune modulation? Write few immunomodulators and mechanism of action. [16] 6. Define toxin and write the mode of action of the following toxins: (a) Cholera toxin (b) Diphtheria toxin (c) Tetanus toxin. [16]

7. What is rheumatic fever? Write briefly about the pathogen, symptoms, pathogenesis and treatment. [16] 8. What is hypersensistivity? Briefly write about all the four types of hypersensitivity? [16]

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