Code No: RR412305

Set No. 1

IV B.Tech I Semester Supplementary Examinations, February 2007 MOLECULAR BIOLOGY OF CANCER (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. Write short notes on any 2 of the following:(a) TGF(b) Family of E2 F (c) MPF (d) Cyclins. 2. (a) What is autocrine induction? (b) Write the mechanism of autocrine induction of growth factors leading to malignant transformation in the cell. [8+8] 3. P 53 is designated as the guardian of the genome. Support the concept. [16] [8+8]

4. Which chemical carcinogens are involved in the induction of skin cancers? Name the source of these carcinogens. [16] 5. (a) Name the different units that measure radiation energy. (b) Describe the rate of release of energy and its biological effects. 6. Comment on the following for their role in carcinogenesis: (a) Fruits & vegetables (b) Hormones (c) Vitamins. [6+6+4] [8+8]

7. Name the different forms of radiographic examinations in diagnosis of tumors of different types. [16] 8. (a) Name the plant alkaloids used as antineoplastic drugs. What is their main mechanism of action? (b) Taking 2 examples from this group, describe their specific action, the type of cancers treated and side effects produced by them. [8+8] ⋆⋆⋆⋆⋆

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Code No: RR412305

Set No. 2

IV B.Tech I Semester Supplementary Examinations, February 2007 MOLECULAR BIOLOGY OF CANCER (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. (a) Name the 2 main families of proteins that control cell cycle. (b) Also the specific complexes formed by these families of proteins in animal cells that control the cell cycle at G1 and G2 check points. [8+8] 2. (a) Discuss the possible mechanisms by which proto oncogenes give rise to oncogenes. [6] (b) Give a specific example of at least 2 proto oncogenes that have become oncogenes and their protein products. [4] (c) Cellular activity that is affected by these oncogenes. [6]

3. Name the 2 different types of retinoblastomas. Discuss the genetic basis for each. [16] 4. Describe Ames Test in detail. Which chemicals are subjected to this test? 5. (a) Name the different units that measure radiation energy. (b) Describe the rate of release of energy and its biological effects. [8+8] [16]

6. The American Cancer Society has listed some very common warning signals as cautions. List these signals. Why is it important to check for these signals? Discuss. [16] 7. Write short notes on the usefulness of the following in cancer diagnosis: (a) Angiography (b) Isotope Scan (c) Ultrasonography. (d) Mammogram. 8. Name the major classes of drugs that are used in chemotherapy of cancer patients with at least one example in each and describe the mechanism of their action. [16] ⋆⋆⋆⋆⋆ [4x4]

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Code No: RR412305

Set No. 3

IV B.Tech I Semester Supplementary Examinations, February 2007 MOLECULAR BIOLOGY OF CANCER (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. Describe the phases of cell cycle and the events that occur in each. Name the important phases that check cell cycle progression. [16] 2. Name one proto oncogene that functions in signal transduction pathway controlling cellular proliferation and its oncogenic protein leading to malignant transformation. [16] 3. What type of mutation causes proto oncogenes to convert them to oncogenes? Give one specific example. [16] 4. Discuss the role of different environmental substances as causative agents of cancers providing some specific examples. [16] 5. Write short notes on any 2 of the following:(a) UV radiation and carcinogenesis (b) Ionizing radiation and carcinogenesis (c) Defects in DNA repair enzymes and carcinogenesis. [8+8]

6. The American Cancer Society has listed some very common warning signals as cautions. List these signals. Why is it important to check for these signals? Discuss. [16] 7. Compare the 2 techniques- ‘Biopsy’ and ‘Papsmear’ with reference to technical ease, results obtained, tissues to be screened and risk factors. Are they mutually exclusion techniques? [16] 8. What biological effects are produced with radiation therapy and how are they related to cancer treatment? [16] ⋆⋆⋆⋆⋆

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Code No: RR412305

Set No. 4

IV B.Tech I Semester Supplementary Examinations, February 2007 MOLECULAR BIOLOGY OF CANCER (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE Questions All Questions carry equal marks ⋆⋆⋆⋆⋆ 1. (a) Name the different members of the family of cyclins and cyclin dependent kinases (b) With the help of a diagram, demonstrate how these members control cell cycle regulation. [8+8] 2. (a) Define transformation of cells. (b) Describe the changes produced when cells in normal tissue culture are transformed by tumor viruses. [8+8] 3. Describe the function of the normal Rb gene in controlling cell cycle progression. [16] 4. (a) Based on the mode of action on DNA, into how many, groups are chemicals classified? Name them. (b) Describe in detail the mechanism of action of one of the groups in inducing mutations. [8+8] 5. (a) Name the different units that measure radiation energy. (b) Describe the rate of release of energy and its biological effects. [8+8]

6. The American Cancer Society has listed some very common warning signals as cautions. List these signals. Why is it important to check for these signals? Discuss. [16] 7. Describe the basis on which radio labeled monoclonal antibodies Scintigraphic imaging is used. Which antigens are detected by this test? [16] 8. Name the major conventional therapies for cancer. Summarize the role of each in cancer treatment. [16] ⋆⋆⋆⋆⋆

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