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PLAN OF WORK Plan of Work

 Review of Literature  Selection of drug and excipients  Selection & Procurement of API, polymers, other excipients and instruments  Drug-excipients compatibility study  Preformulation studies27: a) Bulk density (ρb): It includes inter and intra particle spaces which is determined by measuring cylinder. Granules passed through US standard sieve number 22 #. The weighed amount (W) of granules are transferred in 100 ml cylinder and volume is measured (Vb).

b) Tapped density: Granules passed through US standard sieve number 22 #. The weighed amount (W) of granules is transferred in 100 ml cylinder. This cylinder is tapped at 2 second interval on hard surface from height of 1 inch until constant volume (Vt) achieved.

c) Hausner’s Ratio: It is the ratio of tapped density to bulk density.

a) Carr’s index (%CI): it is percentage compressibility which gives indication of compressibility of powders.

Where, TD = tapped density, BD = bulk density

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Hardness of the tablet of each formulation was determined using Pfizer Hardness tester. dropping those tablets at a distance of 6 inches with each revolution. physical flaws and consistency and legibility of any identifying marking. the loss in the weight of tablet is the measure of friability and is expressed in percentage as Friability =[(Initial weight. Friability: Friabillator consist of a plastic-chamber that revolves at 25 rpm. 5. shape. 3. Organoleptic characteristics The general appearance of a tablet. At the end of test tablets were dusted and reweighed. surface texture.Final weight) / (Initial weight)] x 100 4. The tablets were rotated in the friabillator for at least 4 minutes. Disintegration Time: For determination of disintegration time. one tablet was placed in each tube of disintegration apparatus (Electrolab ED 2L. The weight variation test would be a satisfactory method to determining the drug content uniformity. Hardness : Hardness of tablet is defined as the force applied across the diameter of the tablet in the order to break the tablet. its visual identity and over all "elegance" is essential for consumer acceptance and tablet's size. Disintegration test was carried out using distilled water as disintegrating at 24 ± 2oC. twenty tablets were taken and their weight was determined individually and collectively on a digital weighing balance. Water absorption Ratio: Page 29 . presence or absence of an odour.PLAN OF WORK  Formulation fast dissolving Tablet  Evaluation of fast dissolving Tablet 1. The average weight of one tablet was determined from the collective weight. Weight variation: Indian Pharmacopoeia procedure for uniformity of weight was followed. taste. 6. India). 2. colour. The resistance of the tablet to abrasion or breakage under condition of storage transformation and handling before usage depends on its hardness.

A tablet was put on the paper & the time required for complete wetting was measured. Other media such as 0. 7. The wetted tablet was then weighed. wa is weight of tablet before water absorption & wb is weight of tablet after water absorption. Page 30 . was determined using following equation. R = 10 (wa/wb) Where. is a good place to start with scouting runs for a bioequivalent FDT. R.8) should be evaluated for FDT much in the same way as their ordinary tablet counterparts.1 M HCl and buffer (pH 4. In vitro Dissolution test: The development of dissolution methods for FDTs is comparable to the approach taken for conventional tablets and is practically identical. with a paddle speed of 50 rpm commonly used.PLAN OF WORK A piece of tissue paper folded twice was placed in a small Petridish containing 6 ml of water.5 and 6. Dissolution conditions for drugs listed in a pharmacopoeia monograph. It has been suggested that USP 2 paddle apparatus is the most suitable and common choice for orally disintegrating tablets. Water absorption ratio.