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The principal adverse reactions of Novalgin are due to hypersensitivity reaction s.

The most serious are blood dyscrasias (agranulocytosis, leucopenia, thrombocy topenia) and shock. Both reactions are rare, but life-threatening, and they may occur even after Novalgin has previously been taken on many occasions without co mplications. The manifestations of agranulocytosis include high fever, chills, sore throat, d ifficulty in swallowing, inflammatory lesions in the mouth, nose, throat, as wel l as in the genital or anal regions. Immediate discontinuation is decisive for r ecovery. For this reason, in the event of any unexpected deterioration in genera l condition, if fever fails to subside or begins anew, or if painful mucosal les ions appear, especially in the mouth, nose or throat, Novalgin must be stopped i mmediately and the doctor consulted. Thrombocytopenia causes an increased tendency to bleeding with or without minute haemorrhagic spots in the skin and mucous membranes. The other major form of hypersensitivity reactions is shock. The warning signs o f imminent shock are cold sweat, giddiness, stupor, nausea, change of skin colou r and shortness of breath. In addition, there may be swelling of the face, itchi ng, a feeling of constriction in the heart region, rapid pulse and a sensation o f coldness in the arms and legs. These symptoms may occur at once or up to 1 hr after administration. If one or more of these signs is recognized, medical aid m ust be sought immediately. Until the doctor arrives, ensure that the patient rem ains lying with legs raised and airways patent. In occasional instances, mainly in patients with a history of preexisting renal disease or in cases of overdose, there have been transient renal disorders with reduction or cessation of urine production (oliguria, anuria), accompanied by ex cretion of protein in the urine (proteinuria) and inflammation of the kidney tis sue (interstitial nephritis). Further unwanted effects which may be encountered include hypersensitivity react ions affecting the skin (eg, urticarial eruptions), the conjunctivae and the nas opharyngeal mucosa, in very rare cases progressing to severe, sometimes life-thr eatening bullous skin reactions usually with mucosal involvement (Stevens-Johnso n syndrome or Lyell s syndrome). In the event of such skin reactions, Novalgin sho uld be discontinued at once and a doctor consulted. Attacks of asthma in patients predisposed to that condition may also be observed . ------------------------------------------------------------Efek Samping: - Blood Dyscrasias (agranulocytosis, leucopenia, thrombocytopenia) - Shock Manifestasi agranulositosis termasuk demam tinggi, menggigil, sakit tenggoroka n, kesulitan menelan, lesi radang pada mulut, hidung, tenggorokan, juga pada gen ital dan anus. Trombositopenia menyebabkan meningkatnya tendensi perdarahan dengan atau tanpa hemorragik spots pada kulit dan membran mukosa. Shock, ditandai dengan keringat dingin, pusing, mualm perubahan warna kulit, n afas pendek. Dapat terjadi juga bengkak wajah, gatal , nadi menjadi cepat, tanga n dan kaki terasa dingin, a feeling of constriction in heart region. Gejala dapa t muncul langsung atau setelah satu jam pemberian obat.