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Medical College of Georgia Health System

Department of Pharmacy
Anti-neoplastic Compounded Sterile Products (CSPs) Stability Compendium
Chemical STABILITY (not sterility) reported*

VIAL BEYOND USE DATE
INFUSION SOLN
BEYOND USE DATE

DRUG VIAL SIZE DILUENT CONC Refrigerate Room Temp Refrigerate
Room
Temp
BAG/SYR FLUID TYPE
FINAL PRODUCT
STABILITY/COMMENTS
Aldesleukin
(Interleukin 2)
22 million units 1.2 ml SWFI 18 mil unit/ml 48 hrs 48 hrs
Syringe:
5 days
Bag: 24 hrs
24 hrs
Syringe / IV
bag
Per protocol
(50 ml D5W)
Protect from light; Swirl do not
shake
Alemtuzumab

30 mg In solution 10 mg/ml 24 hrs 8 hrs 8 hrs 8 hrs IV bag
100 ml NS
(D5W)
Protect from light; Swirl do not
shake
Amifostine 500 mg 9.7 ml NS 50 mg/ml 24 hrs 5 hrs 24 hrs 5 hrs IV bag NS
Recommended concentration = 5-40
mg/ml
Asparaginase 10,000 units 1 ml SWFI
10,000
units/ml
8 hrs 8 hrs 8 hrs 8 hrs Syringe
IM only; Use filter if particles
present.
Asparaginase PEG 3750 units In solution 750 units/ml 24 hrs 24 hrs 24 hrs 24 hrs Syringe IM only; Swirl do not shake
Azacitidine 100 mg 4 ml SWFI 25 mg/ml 8 hrs 1 hr 8 hrs 1 hr Syringe
Bevacizumab
3
100, 400 mg In solution 25 mg/ml 8 hrs 8 hrs 8 hrs 8 hrs IV bag 100 ml NS
Bleomycin 15, 30 units
15: 5 ml NS
30: 10 ml NS
3 units/ml 28 days 10 days 28 days 10 days Syringe NS
Bortezomib
3
3.5 mg 3.5 ml NS 1 mg/ml 8 hrs 8 hrs 8 hrs 8 hrs Syringe Protect from light
Busulfan 60 mg In solution 6 mg/ml 24 hrs 8 hrs 12 hrs 8 hrs IV bag
NS: volume of
concentrated
busulfan times
10
Use filter provided; ALWAYS add
drug to fluid not fluid to drug
Carboplatin
50, 150, 450
mg Powder (P)
or
Solution (S)
50: 5 ml SWFI
150: 15 ml SWFI
450: 45 ml SWFI
In solution
10 mg/ml
P: 5 days
S: 14 days
24 hrs
Syringe:
5 days
Bag: 8 hrs
S: 24 hrs
B: 8 hrs
Syringe
(CCC)
500 ml NS
(D5W)
(Inpatient)
Protect vials from light
Carmustine 100 mg
3 ml EtOH +
27 ml SWFI
3.3 mg/ml 24 hrs 8 hrs 24 hrs 8 hrs IV bag 250 ml D5W Protect from light; glass bottle
Cetuximab
3
100 mg In solution 2 mg/ml 12 hrs 8 hrs 12 hrs 8 hrs IV bag Undiluted
Do not shake or dilute; attach filter
set to final product; Prime tubing
with NS
Cisplatin 50, 100 mg In solution 1 mg/ml ---- 28 days ----
a
28 days
a
IV bag
500 ml NS
(W/ mannitol)
a
Once mixed with mannitol, beyond
use date is 48 hrs at RT, and 96 hrs
refrigerated
Cladribine 10 mg In solution 1 mg/ml 7 days 7 days 24 hrs 24 hrs IV bag 500 ml NS
Clofarabine
(Clolar)
2,3 20 mg In solution 1 mg/ml ---- 24 hrs 24 hrs 24 hrs IV bag
D5W or NS
100-500 ml
Use with 0.22 micron filter
Cyclophosphamide 1, 2 gm
1 gm: 50 ml SWFI
2 gm: 100 ml SWFI
20 mg/ml 6 days 24 hrs 6 days 24 hrs
Syringe
(CCC)
250 - 500 ml
NS (D5W)
(inpatient)
NS or D5W for lupus patients
Cytarabine 100 mg IT 5 ml PFNS 20 mg/ml 8 hrs 8 hrs 8 hrs 8 hrs Syringe QS as ordered INTRATHECAL
Cytarabine-
lipsosmal
(Depocyt)
3
50 mg In solution 10 mg/ml Discard any unused portion 4 hrs 4 hrs Syringe
***Intrathecal only***
**Do not filter**
Cytarabine
500 mg
1, 2 gm
500: 5 ml BWFI
1 gm: 10 ml BWFI
2 gm: 20 ml BWFI
100 mg/ml 7 days 48 hrs 7 days 48 hrs
Syringe or
IV bag
250 ml NS
Syringe for Subcutaneous
administration
Dacarbazine 200 mg 19.7 ml SWFI 10 mg/ml 72 hrs 8 hrs 72 hrs 8 hrs IV bag
250 - 500 ml
NS (D5W)
Protect from light
Dactinomycin 0.5 mg 1.1 ml SWFI 0.5 mg/ml 24 hrs 24 hrs 24 hrs 24 hrs Syringe
Daunorubicin 20 mg In solution 5 mg/ml 48 hrs 24 hrs 48 hrs 24 hrs Syringe
June 2006
VIAL BEYOND USE DATE
INFUSION SOLN
BEYOND USE DATE

DRUG VIAL SIZE DILUENT CONC Refrigerate Room Temp Refrigerate
Room
BAG/SYR FLUID TYPE
FINAL PRODUCT
Temp STABILITY/COMMENTS
June 2006
Dexrazoxane 500 mg 50 ml MFR diluent 10 mg/ml 6 hrs 6 hrs 6 hrs 6 hrs Syringe Dilute in buretrol
Docetaxel 20, 80 mg MFR diluent 10 mg/ml 28 days 28 days 4 hrs 4 hrs IV bag
250 ml NS
(D5W)
Non-PVC (Excel) bag and tubing set
Doxorubicin
Powder (P): 10,
20, 50, 150 mg
Solution (S): 5,
10, 25, 100 mg
5, 10, 25, 75 ml NS
In solution
2 mg/ml
P: 15 days
S: 28 days
P: 7 days
S: 28 days
28 days 28 days Syringe NS (D5W) Protect from light
Doxorubicin
liposomal
20 mg
50 mg
In solution 2 mg/ml 24 hrs 24 hrs 24 hrs 24 hrs IV bag 250 ml D5W
Protect from light; Do not use with in
line filter; Dilute with D5W only
Epirubicin
50 mg
200 mg
In solution 2 mg/ml 28 days 14 days 14 days 14 days Syringe Extravasation warning
Etoposide 100 mg In solution 20 mg/ml 28 days 28 days
0.2 mg/ml: 96 hrs
0.4 mg/ml: 24 hrs
IV bag
NS (D5W);
volume
depends on
dose
Desired final concentration 0.4
mg/ml (stability issues)
Floxuridine 500 mg 5 ml SWFI 100 mg/ml 14 days 7 days 7 days 7 days Syringe Per protocol
For Hepatic Artery Infusion; qs to 20
ml w/ dexamethasone, heparin, NS
per protocol. The arbitrary
application of an extended
expiration date to floxurideine
solution used in ambulatory pump
systems is questionable.
1

Fludarabine 50 mg 2 ml SWFI 25 mg/ml 16 days 16 days 16 days 48 hrs Syringe
Fluorouracil
500 mg
2.5 gm
In solution 50 mg/ml 28 days 28 days 28 days
S: 7 days
B: 24 hrs
Syringe
(CCC)
1000 ml NS
(inpatient)
Protect from light
Ganciclovir 500 mg 10 ml SW 50 mg/ml 28 days 12 hrs 14 days 12 hrs IV bag 100 ml NS
Gemcitabine 200, 1000 mg
200- 5 ml NS
1000- 25 ml NS
38 mg/ml ---- 28 days ---- 48 hrs IV bag 250 ml NS Do not refrigerate
Gemtuzumab
3
5 mg 5 ml SWFI 1 mg/ml
**< 2 hrs once reconstituted; < 16 hours once diluted; 2 hr
infusion; MAX < 20 Hrs**
2

IV bag 100 ml NS
Protect from light; hood light MUST
be turned off for preparation; attach
filter set to final product
Idarubicin 5, 10 mg In solution 1 mg/ml 28 days 24 hrs
S: 14 days
B: 48 hrs
24 hrs Syringe
Ifosfamide 1000 mg In solution 50 mg/ml 28 days 7 days 24 hrs 24 hrs IV bag
500-1000 ml
NS

Infliximab 100 mg 10 ml SWFI 10 mg/ml 3 hrs 3 hrs 3 hrs 3 hrs IV bag 250 ml NS
Attach filter set to final product;
Swirl, do not shake
Interferon Alfa-2b 10 million units In solution
10 mil
units/ml
28 days 7 days 14 days 7 days Syringe Subcutaneous only
Irinotecan
40 mg
100 mg
In solution 20 mg/ml 28 days 28 days 48 hrs 24 hrs IV bag 500 ml D5W
Protect from light; max
concentration: [2.8 mg/ml]
Leucovorin (Bedford
/ Gensia Sicor)
350 mg
B- 17.5 ml BWFI
GS- 17 ml BWFI
20 mg/ml 14 days 14 days 48 hrs 24 hrs Syringe Per protocol Protect from light
Mechlorethamine 10 mg 10 ml SWFI 1 mg/ml Use within 20 min of preparation Syringe Use within 20 min of preparation
Melphalan 50 mg
10 ml MFR diluent
(add quickly, then
shake vigorously)
5 mg/ml
Use within 60 minutes;
**90 minute MAX**
1

IV bag
NS:
Final desired
concentration
<0.45 mg/ml
Protect from light
Mesna 1000 mg In solution 100 mg/ml 28 days 7 days 7 days 24 hrs
Syringe / IV
bag
20 mg/ml NS
(D5W)

Methotrexate 20 mg 10 ml NS 2 mg/ml 24 hrs 24 hrs 8 hrs 8 hrs Syringe
INTRATHECAL; filter w/0.22
micron filter
Methotrexate
50 mg
100 mg
250 mg
1000 mg
In solution 25 mg/ml 28 days 7 days
7 days
(IT: 8 hrs)
7 days
(IT: 8 hrs)
Syringe / IV
bag
Per protocol
Protect from light; for IT doses,
filter with 0.22 micron filter and
QS w/NS to order volume
VIAL BEYOND USE DATE
INFUSION SOLN
BEYOND USE DATE

DRUG VIAL SIZE DILUENT CONC Refrigerate Room Temp Refrigerate
Room
BAG/SYR FLUID TYPE
FINAL PRODUCT
Temp STABILITY/COMMENTS
Methotrexate 1 gm (Powder) 19.4 ml D5W 50 mg/ml ---- 48 hrs
S: 28 days
B: 7 days
7 days IV bag
500 ml D5W; or
per protocol
Protect from light; use 1 gm vials
for high dose ONLY
Mitomycin
b
b
IV formulation only
see compounding
book for
ophthalmic/ENT
formulation
20 mg 40 ml SWFI 0.5 mg/ml 14 days 7 days 24 hrs 24 hrs Syringe Protect from light
Mitoxantrone 20 mg In solution 2 mg/ml 14 days 7 days 14 days 48 hrs Syringe Further dilute prior to admin
Oxaliplatin 50, 100 mg
50- 10 ml SWFI
100- 20 ml SWFI
In solution
5 mg/ml 24 hrs 6 hrs 24 hrs 6 hrs IV bag
250-500 ml
D5W
D5W only; Will precipitate w/ NS
Paclitaxel
30, 100, 300
mg
In solution 6 mg/ml 28 days 28 days 24 hours 24 hrs IV bag
NS per infusion
rate
1 hr: 250 ml
3 hr: 500 ml
24 hr: 1 liter
Final concentration 0.3 to 1.2 mg/ml;
Must use non-PVC tubing set and
bag (Excel bag)
Pacitaxel, protein-
bound (Abraxane)
2,3 100 mg 20 ml NS 5 mg/ml 8 hrs 8 hrs 8 hrs 8 hrs IV bag
N/A; SEE
COMMENT
Inject the appropriate amount of
reconstituted ABRAXANE into an
empty, sterile, polyvinyl chloride
(PVC) or non-PVC type IV bag. The
use of an in-line filter is not
recommended. Protect from light.
2

Pamidronate 30 mg
10 ml SWFI
In solution
3 mg/ml 24 hrs 24 hrs 24 hrs 24 hrs IV bag 500 ml NS
Pemetrexed 500 mg 20 ml NS 25 mg/ml 24 hrs 24 hrs 24 hrs 24 hrs IV bag 100 ml NS Do not shake, swirl
Pentostatin 10 mg 5 ml SWFI 2 mg/ml 72 hrs 72 hrs 8 hrs 8 hrs IV bag
50 ml NS
(D5W)
Shake well


Rasburicase
(Elitek)
2,3 1.5 mg 1 ml MFR diluent 1.5 mg/ml 24 hrs 24 hrs 24 hrs 24 hrs IV bag
NS, Total
volume 50 ml
Do not shake, swirl
Rituximab 100, 500 mg In solution 10 mg/ml 24 hrs 24 hrs 48 hrs 24 hrs IV bag
NS; SEE
COMMENT
Desired concentration = 1 mg/ml
total volume
Streptozocin 1 gm 9.5 ml NS 100 mg/ml 96 hrs 48 hrs 96 hrs 48 hrs IV bag 50 ml NS
Thiotepa 15 mg 1.5 ml SWFI 10.4 mg/ml 28 days 7 days 48 hrs 24 hrs Syringe Filter prior to administration
Topotecan 4 mg 4 ml SWFI 1 mg/ml ---- 28 days 7 days 24 hrs
Syringe / IV
Bag
NS; SEE
COMMENT
Protect IV bag from light
Final concentration < 500 mcg/ml
Trastuzumab 440 mg 20 ml BWFI 21 mg/ml 28 days 24 hrs 24 hrs 24 hrs IV bag 250 ml NS
Vinblastine 10 mg In solution 1 mg/ml 28 days 24 hrs 7 days 24 hrs Syringe IV push Fatal if given IT
Vincristine 1, 2 mg In solution 1 mg/ml 28 days 7 days 7 days 24 hrs Syringe IV push Fatal if given IT
Vinorelbine 10, 50 mg In solution 10 mg/ml 28 days 24 hrs 24 hrs 24 hrs Syringe QS to 30 ml NS Fatal if given IT
Zolendronic Acid 4 mg In solution 0.8 mg/ml 24 hrs 24 hrs 24 hrs 24 hrs IV bag
100 ml NS
(D5W)

*Trissels Handbook of Injectable Drugs 13
th
Ed., Lexi Comp
2
, Manufacturer product insert
3

Notes*:
1. BWFI-Bacteriostatic water for injection
2. SWFI-Sterile water for injection
3. NS-single-use, preservative free, 0.9% saline
* If additional information is needed, please consult chemotherapy reference books


June 2006