Insulin

Insulin
Apidra (insulin glulisine [rDNA origin] injection) Apidra SoloSTAR (prefilled) Apidra Cartridge Humalog Vial (insulin lispro) Humalog Cartridge Humalog Pen (prefilled) NovoLog Vial (insulin aspart) NovoLog PenFill NovoLog FlexPen (prefilled) Humulin R (Regular) Vial a Novolin R Vial® (Regular human insulin) ReliOn/Novolin R Vial ® Humulin N (NPH) Vial
Humalog

Manufacturer
sanofi-aventis sanofi-aventis sanofi-aventis

Onset (approximately)
15–30 minutes 15–30 minutes 15–30 minutes

Peak (approximately)
0.5–2.5 hours 0.5–2.5 hours 0.5–2.5 hours 0.5–2.5 hours 0.5–2.5 hours 0.5–2.5 hours 1–3 hours 1–3 hours 1–3 hours 2–4 hours 80–120 minutes 80–120 minutes 2–8 hours 2–8 hours 4–12 hours 4–12 hours 4–12 hours

Duration (approximately)
5 hours or less 5 hours or less 5 hours or less 5 hours or less 5 hours or less 5 hours or less 3–5 hours 3–5 hours 3–5 hours 5–8 hours 8 hours 8 hours 14–24 hours 14–24 hours 24 hours 24 hours 24 hours

RAPID ACTING

Apidra

Eli Lilly & Company 15–30 minutes Eli Lilly & Company 15–30 minutes Eli Lilly & Company 15–30 minutes Novo Nordisk Novo Nordisk Novo Nordisk 10–20 minutes 10–20 minutes 10–20 minutes

NovoLog

SHORT ACTING

Eli Lilly & Company 30–60 minutes Novo Nordisk Novo Nordisk 30 minutes 30 minutes

Eli Lilly & Company 1–2 hours
Humulin N Pen

INTERMEDIATE ACTING

Humulin N (NPH) Pen (prefilled) Novolin N PenFill® (NPH human insulin isophane) Novolin N Vial® (NPH human insulin isophane) ReliOn/Novolin N Vial®

Eli Lilly & Company 1–2 hours Novo Nordisk Novo Nordisk Novo Nordisk 1.5 hours 1.5 hours 1.5 hours

All insulins listed are U-100 strength. All insulins should be refrigerated at 36°–46° F. a: Also available in U-500 by prescription only. b: Lantus and Levemir release at a relatively constant rate over a 24-hour period. c: Pens in use (open) should not be stored in the refrigerator.
www.DiabetesHealth.com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH

* For type 1 diabetes . Future insulin changes should be directed by your healthcare professional based on blood sugar testing. If this low blood sugar (severe hypoglycemia) happens. NovoPen Junior N/A N/A AMYLIN MIMETIC Amylin is co-secreted in the beta cells of the pancreas along with insulin. (800) 545-5979 Novo Nordisk (800) 727-6500 sanofi-aventis (800) 633-1610 www. especially if you have type 1 diabetes.start SYMLIN at 15 mcg injected subcutaneously. use heavy machinery. Mild nausea is more likely during the first weeks after starting Symlin and usually does not last long. just before major meals (meal must have at least 250 calories or 30 grams of carbohydrate). SYMLIN® (pramlintide acetate) injection SymlinPenTM (pramlintide acetate) pen-injector Amylin Pharmaceuticals. When you use Symlin and insulin.Need to Roll Room Temperature Briskly 10+ Storage Range (59°–86° F) Times? Up to 28 days Up to 28 days Up to 28 days Up to 28 days Up to 28 days Up to 28 days c Up to 28 days Up to 28 days Up to 28 days Up to 28 days N/A Up to 42 days Up to 28 days Up to 14 days c 14 days Up to 42 days Up to 42 days No No No No No No No No No No No No Yes Yes Yes Yes Yes Cartridge Sizes N/A N/A 3 mL N/A 3 mL N/A N/A 3 mL 3 mL N/A N/A N/A N/A N/A 3 mL N/A N/A Pens That Fit the Cartridges N/A N/A OptiClik® N/A Autopen N/A N/A NovoPen 3. Talk to your healthcare professional for advice on how to manage nausea.com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH . Inc. drive a car. NovoPen Junior N/A N/A N/A N/A N/A N/A NovoPen3.start SYMLIN at 60 mcg injected subcutaneously. * For type 2 diabetes . just before major meals (meal must have at least 250 calories or 30 grams of carbohydrate). It’s a first-in-class injectable medication used with mealtime insulin to control blood sugar in adults with type 1 or type 2 diabetes. your healthcare professional should tell you to reduce the dose of insulin you take before meals by 50 percent.DiabetesHealth. it is seen within three hours after a Symlin injection. your blood sugar may drop too low. or do other risky activities where you could hurt yourself or others. Customer Support: Eli Lilly & Co. Nausea is the most common side effect of Symlin. and take your Symlin exactly as prescribed. It is critical to the safe and effective use of Symlin that you understand your healthcare professional’s instructions. When you first start Symlin. follow them carefully. The amount of SYMLIN used depends on whether the patient has type 1 or type 2 diabetes. Type 2: 120 mcg Type 1: 60 mcg with major meals Insulin-induced low blood sugar (severe hypoglycemia): Low blood sugar is a serious side effect of insulin therapy. Severe low blood sugar makes it hard to think clearly.

4 hours Novo Nordisk 10–20 minutes 2.5–5 hours Humulin 70/30 Pen (prefilled) Humulin 70/30 Pen Eli Lilly & Company 30–60 minutes 2–4 hours Novolin 70/30 Vial® (70% NPH/30% Regular) Novo Nordisk 30 minutes 2–12 hours ReliOn/Novolin 70/30 Vial All insulins listed are U-100 strength.5 hours None Novo Nordisk 50–120 minutes Relatively flat Levemir Novo Nordisk 50–120 minutes Relatively flat INTERMEDIATE/RAPID ACTING Eli Lilly & Company 15–30 minutes 0.5 hours Novo Nordisk 10–20 minutes 2. b: Lantus and Levemir release at a relatively constant rate over a 24-hour period.5–2.5–2.5 hours Peak (approximately) None b sanofi-aventis sanofi-aventis Lantus Lantus 1.5 hours None b LONG ACTING Lantus SoloSTAR® (prefilled) Levemir Vial (insulin detemir [rDNA origin] injection) Levemir FlexPen (insulin detemir [rDNA origin] injection) Humalog Mix 75/25 Vial sanofi-aventis 1.5 hours INTERMEDIATE/SHORT ACTING Humulin 70/30 Vial (70% NPH/30% Regular) Eli Lilly & Company 30–60 minutes 0.com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH .5–2.Insulin Insulin Lantus Vial (insulin glargine [rDNA origin] injection) Lantus Cartridge Manufacturer Onset (approximately) 1. All insulins should be refrigerated at 36°–46° F.5 hours Humalog Mix 75/25 Pen (prefilled) NovoLog Mix 70/30 Vial® (70% insulin aspart protamine suspension/30% aspart) NovoLog Mix 70/30 FlexPen® NovoLog Mix 70/30 FlexPen Eli Lilly & Company 15–30 minutes 0.4 hours Humulin 50/50 Vial (50% NPH/50% Regular) Eli Lilly & Company 30–60 minutes 0. a: Also available in U-500 by prescription only. Novo Nordisk 30 minutes 2-12 hours www. c: Pens in use (open) should not be stored in the refrigerator.DiabetesHealth.

com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH .DiabetesHealth.Duration (approximately) 24 hours Room Temperature Storage Range (59°–86° F) Up to 28 days Need to Roll Briskly 10+ Times? No Cartridge Sizes N/A Pens That Fit the Cartridges N/A 24 hours Up to 28 days No 3 mL OptiClik 24 hours Up to 28 days No N/A N/A Up to 24 hours Up to 42 days No N/A N/A Up to 24 hours Up to 42 days No 3 mL N/A Up to 24 hours Up to 28 days c Yes N/A N/A Up to 24 hours Up to 10 days Yes N/A N/A Up to 24 hours Up to 28 days Yes N/A N/A Up to 24 hours Up to 14 days Yes 3 mL N/A Up to 24 hours Up to 28 days Yes N/A N/A Up to 24 hours Up to 28 days Yes N/A N/A Up to 24 hours Up to 10 days Yes N/A N/A 24 hours Up to 42 days Yes N/A N/A 24 hours Up to 42 days Yes N/A N/A Customer Support: Eli Lilly & Co. (800) 545-5979 Novo Nordisk (800) 727-6500 sanofi-aventis (800) 633-1610 www.