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Chemical information about 5-Aza-2’-deoxycytidine
5-Aza-2’-deoxycytidine (5-AzadCyD, 5-Aza-CdR, decitabine) is a specific inhibitor of DNA methylation. It functions in a similar manner to aza-citidine, although decitabine can only be incorporated into DNA strands while azacitidine can be incorporated into both DNA and RNA chains. 5-AzadCyD is a prodrug that requires activation via phosphorylation by deoxycytidine kinase. The nucleotide analog is incorporated into DNA, where it produces an irreversible inactivation of DNA methyltransferase. 5-AzadCyD was demonstrated to be a potent antineoplastic agent against leukemia and tumors in animal models. Name:5-Aza-2'-deoxycytidine EINECS:219-089-4 Molecular Formula:C8H12N4O4 CAS Registry Number:2353-33-5 Synonyms:s-Triazin-2(1H)-one,4-amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-(7CI,8CI); 2-Desoxy-5-azacytidine; 2'-Deoxy-5-azacytidine; 5-Azadeoxycytidine; DAC; Dacogen; 1,3,5-Triazin-2(1H)-one,4-amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-; b-Decitabine; InChI:InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2, (H2,9,11,15)/t4-,5+,6+/m0/s1 Appearance:white crystalline powder Molecular Weight:228.20528 Density:1.9 g/cm3 Boiling Point:485.8 °C at 760 mmHg Melting Point:200℃ (dec.) Flash Point:247.6 °C Storage Temperature:?20°C Refractive index:1.779 Solubility:acetic acid/water (1:1): 50 mg/mL Biological Activity:Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation. Stability:Stable. May be light or air sensitive. Incompatible with strong oxidizing agents. Usage:Decitabine (CAS NO.2353-33-5) is used as a drug. Chemical Properties: white crystalline powder

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Usage: Used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines. General Description: Fine white crystalline powder. Used as a drug. Air & Water Reactions: Probably light and air sensitive. Water soluble. Decomposes in aqueous solution at a rate that depends on pH: at pH 7 the drug is more stable than at pH 9, but is less stable than at pH 6. At pH 7 and 99°F, approximately 7% conversion occurs in 1 hour . Reactivity Profile: 5-Aza-2'-deoxycytidine is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Fire Hazard: Flash point data for 5-Aza-2'-deoxycytidine 5-Aza-2'-deoxycytidine is probably combustible. are not available.

Biological Activity :Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.