Generic Name : AMPICILLIN Brand Name ; UNASYN Dosage: 210 mg IV q 6 hours ANST Classification: Antibiotic Indication: Treatment of respiratory

infections.

Mechanism of Action

Binds to bacteria cell wall, resulting in cell death, spectrum is broader than that of penicillin. Addition of sulbactam increases resistance to betalactamase, enzymes produced by bacteria that may inactivate ampicillin.

Side Effects diarrhea; difficulty breathing or swallowing; itching; mild skin rash; severe skin rash; upset stomach; vomiting

Contraindication

Adverse Reaction

Nursing Consideration

Contraindicated in patients hypersensitive to drug or other penicillins.

Ampicillin shares the toxic poten-  tials of the penicillins, including the risk of hypersensitivity reactions, and the usual A history of a previous precautions of penicillin hypersensitivity therapy should be reaction to any of the observed. Prior to penicillins is a initiation of therapy contraindication. with ampicillin careful Ampicillin is also inquiry should be made contraindicated in concerning previous infections caused by penicillinasehyperproducing organisms. sensitivity reactions to penicillins, cephalosporins, or other drugs.

Observe patients for signs and symptoms of anaphylaxis (rash, pruritus, laryngeal edema, wheezing). Discontinue the drug and notify the physician immediately if these occur. Keep epinephrine, an antihistamine, and resuscitation equipment close by in the event of an anaphylactic reaction.

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