Tropical Gastroenterology 2011;32(3):161–163

Editorial

Percutaneous drainage of liver hydatid cysts: Is evidence enough to accept it as first modality of choice?
Showkat Ali Zargar

Human hydatid disease or cystic echinococcosis, caused by the larval form of cestode Department of Gastroenterology, Sher-i-Kashmir Institute of Medical Echinococcus granulosus, still continues to be a common health problem in most sheep Sciences (SKIMS), rearing regions of the Asia, Europe, the Mediterranean, South America, Australia and New Srinagar, Kashmir, India Zealand. The liver is the most frequently parasitized organ in humans with about 60% infestation
Correspondence: rate and with 75% of cysts being located in the right lobe.1,2 Dr. Showkat Ali Zargar Until three decades ago, surgery was the only treatment option available for liver hydatid Email: showkatzargar6@gmail.com

cysts (LHCs). However, surgery is not possible if the cyst is located centrally in the liver or in contiguity with vascular structures. Surgery, the oldest and still most common treatment employed for LHCs carries a definite risk of morbidity and mortality. Also, the recurrence of more than 10% is a bigger concern associated with surgery. The figures of morbidity, mortality and recurrence further increase in patients with multiple cysts, disseminated disease or recurrent disease. Also, patients with cardiac, respiratory, renal or neurologic co-morbidities who carry high risk for general anesthesia are not good candidates for surgery.3-5 Therefore, an effective and safe alternative treatment modality will be highly desirable. During the last three decades, two alternative forms of therapy for LHCs have evolved; systemic chemotherapy and percutaneous drainage (PD). Mebendazole was the initial chemotherapeutic agent but has limited use due to its poor efficacy. Mebendazole has been largely replaced with albendazole which is well absorbed unlike the former compound. Although the success rate of the systemic chemotherapy varies with the type of cyst, clinical experience indicates that about one-third of the patients are cured with such treatment. Chemotherapy achieves a cyst disappearance rate of 30%, partial response in another 30% and no response in 40%. It is effective in small cysts (<4 cm diameter), cysts with thin walls and in younger patients. It is indicated in patients who are high risks for surgery, in patients with multiple peritoneal cysts, disseminated systemic disease, to prevent secondary echinococcosis after spillage during surgery, and in combination with PD. Imidazoles cause hepatic and hematologic toxicities and are potentially embryotoxic and teratogenic.6-9 The third option for treatment of hydatid cysts in the liver and some other locations is the PAIR procedure wherein “P” stands for percutaneous puncture of the cyst under sonographic guidance; “A” stands for aspiration of substantial amount of the cyst contents; “I” stands for injection of proctoscolicidal agent (e.g. hypertonic saline, 95% ethanol, albendazole or betadine), and “R” for reaspiration. Recent experiences on PAIRs in thousands of patients from different parts of the world have documented excellent results in terms of efficacy, safety and cost-effectiveness.10-12The long-term results are equally satisfactory.13-18Other advantages include requirement for minimal infrastructure and can be performed in remote resource poor regions where echinococcosis is endemic.

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retrospective. short follow-up. and percutaneous treatments in 355 patients over a period of 10 years and concluded that PAIR is an effective and safe option.4 days vs. The article in this issue of the journal27 describes a technique almost similar to those described by Schipper et al Tropical Gastroenterology 2011. in most reported studies PAIR technique was highly efficient and safe for uncomplicated unilocular cyst (Gharbi type 1 or WHO CE1) and unilocular cyst with ruptured laminated membranes (Gharbi type 2 or WHO CE3a). The aim in surgical treatment is to inactivate the parasite. lower rates of morbidity.32(3):161–163 and Haddad et al. fine needles and catheters and the right intercostal transhepatic route for puncture. it remains an open question as to whether PAIR can be used as the first line of therapy for LHCs. These long-held concerns have been challenged by many studies with PAIR.072 hepatic cysts undergoing PAIR plus albendazole therapy and compared the findings with 952 era-matched controls treated with surgery. Some authors reported high failure rate of upto 30% in PAIR of multivesicular cysts. but there is insufficient evidence to support or refute PAIR with or without benzimidazole coverage for treating patients with uncomplicated hepatic hydatid cyst and suggested need to undertake well-designed randomised clinical trials to address this issue. Likewise.8 They concluded that PAIR seems promising. etc).20. A non-operative therapy always carries potential economic and societal advantages. Saremi et al25described a percutaneous approach in which a special cutting instrument is used to fragment and evacuate daughter cysts and laminated membrane while the cavity is continuously irrigated with scolicidals. laparoscopic surgery. surgery and/or PAIR for LHCs and concluded that PD plus albendazole resulted in safe and efficient treatment for selected patients. Schipper et al 26described a percutaneous evacuation of cyst contents (PEVAC) using a large bore catheter after dilatation of the tract over two sessions. They found that PAIR plus chemotherapy is associated with significantly greater clinical and parasitological efficacy. The wide bore of the instrument permits effective percutaneous removal of all hydatid contents. A Cochrane data systemic review in 2006 assessed the benefits and harms of PAIR with or without benzimidazole coverage for patients with uncomplicated hepatic hydatid cyst in comparison with sham/no intervention. A number of modified percutaneous techniques have been developed to address some of the shortcomings of PAIR to effectively and safely treat multivesicular cysts. Kabaalioglu et al20 in 2006 concluded that PAIR is safe and effective for LHCs of types I and II and surgery should be reserved for type III and certain active type IV cysts.22 On the basis of current evidence PAIR procedure is a safe and efficient option for uncomplicated LHCs of types I and II by Gharbi classification or CE1 and CE3a (WHO-IWGE classification) but the evidence for type III (Gharbi) or CE2 and CE3b (WHO classification) multivesicular cysts with slight or significant non-drainable contents in favour of modified .28 These modified PAIR procedures are interesting and encouraging for the treatment of types CE2 and CE3b LHCs (type 3 Gharbi cysts) but suffer from flaws of including small number of patients and short follow-up.26.20-22On the basis of positive short-term and long-term results World Health Organization (WHO) recommended PAIR approach for management of uncomplicated LHCs in selected cases. mortality and disease recurrence.24For effective treatment of such LHCs each daughter cyst has to be punctured separately which is laborious and inconvenient for the patient. surgery or medical treatment. Smego et al21conducted a meta-analysis across 21studies comprising of 769 patients with 1.21Such results are interesting but suffer from the same flaws (small series. evacuate the cyst cavity.162 PD of LHCs has been contraindicated for risk of anaphylactic shock and spillage and seeding of scolices resulting in peritoneal implantation and dissemination.10-18 Randomized controlled19as well as uncontrolled studies have shown superiority of PAIR over surgery in terms of shorter hospital stay. 15 days). A recent paper from Turkey reported a single-center experience comparing surgery. complications and cost-effectiveness. but many authors experienced problems regarding efficacy and safety with PAIR in patients with multivesicular cysts with minimal (Gharbi type 3 or WHO type CE2) or predominant non-drainable contents (Gharbi type 3 or WHO type CE3b). Their described technique is similar to surgery. Anaphylaxis is a very rare complication of PAIR procedure. one comparing PAIR versus surgical treatment19 and the other comparing PAIR (with or without albendazole) versus albendazole alone. and shorter hospital stay (2.23 The authors identified only two randomised clinical trials.23Although. The aim of percutaneous treatment is the same except for removal of the germinal layer. rupture and spillage during PAIR procedure is rare because of use of improved imaging. remove the germinal membrane and obliterate the residual cyst cavity. In presence of availability of three treatment options. Aspiration of both fluid and solid contents including the membranes facilitates the anti-parasitic effect of scolicidals more effectively. Dziri et al29 attempted to address the role of chemotherapy.

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