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Central vertigo is vertigo due to a disease originating from the central nervous system (CNS).

In clinical practice, it often includes lesions of cranial nerve VIII as well. Individuals with vertigo experience hallucinations of motion of their surroundings. Central vertigo may be caused by hemorrhagic or ischemic insults to the cerebellum, the vestibular nuclei, and their connections within the brain stem. Other causes include CNS tumors, infection, trauma, and multiple sclerosis.[1, 2] Vertigo due to acoustic neuroma is also included in the broader category of central vertigo. An acoustic neuroma develops within the eighth cranial nerve, usually within the course of the internal auditory canal, yet it often expands into the posterior fossa with secondary effects on other cranial nerves and the brain stem.

Pathophysiology
The brainstem, cerebellum, and peripheral labyrinths are all supplied by the vertebrobasilar arterial system. Thus, the central and peripheral ischemic vertigo syndromes overlap.

Vertebrobasilar arterial system


The basilar artery is formed from the 2 vertebral arteries within the cranium at the level of the medulla. The artery has 3 branches on each side that supply the cerebellum. The posterior inferior cerebellar artery branches from the vertebral artery, while the anterior inferior cerebellar artery and the superior cerebellar artery branch from the basilar artery. All 3 of the cerebellar arteries may have branches that supply brainstem tissue. A labyrinthine artery on each side branches from the basilar artery and supplies the labyrinth and associated structures via the internal auditory canal. In approximately two thirds of people, the basilar artery ends by bifurcating into the posterior cerebral arteries, with small posterior communicating arteries connecting to the internal carotid system in the circle of Willis.

Arterial occlusion and ischemic infarction


Arterial occlusion and ischemic infarction can result from cardioembolism, embolism of plaque from a vertebral artery, or local arterial thrombosis. One or both vertebral arteries, the basilar artery, or any of the smaller branches may be occluded. Even complete occlusion of a large artery may not result in death because of anastomotic retrograde flow via the circle of Willis and posterior communicating arteries. Temporary vertebrobasilar ischemia may present as migraine syndrome ortransient ischemic attacks (TIAs). While less common than cerebellar infarction, spontaneous cerebellar hemorrhage is an important life-threatening cause of vertigo associated with hypertensive vascular disease and anticoagulation.[3]

Multiple sclerosis
Multiple sclerosis is a demyelinating disease of the CNS. The course generally waxes and wanes, with varying neurologic symptoms and signs. Isolated vertigo may be the initial symptom in approximately 5% of cases. This disease is discussed in detail in the relevant article (see Multiple Sclerosis).

Acoustic neuromas
Acoustic neuromas are Schwann cell tumors that usually originate on the vestibular division of the eighth cranial nerve in the proximal internal auditory canal.[4] Usually unilateral in development, bilateral acoustic neuromas do occur in young adults, although rarely, in association with neurofibromatosis type 2. If untreated, an acoustic neuroma may expand into the cerebellopontine angle and compress facial and other cranial nerves.[5] If it compresses the brainstem, ataxia, gait disturbances, spasticity, and weakness from long-tract effects may result. See the image below.

CT scan of a patient with a large acoustic neuroma on the right side of the brainstem. The scan was performed after injection of intravenous contrast, which is critical for identifying tumors with CT imaging.

Other causes
Isolated vertigo due to CNS infection, such as a microabscess, or temporal lobe seizures is rare and is not discussed in this article. Vertigo and dizziness are common complications of head and neck trauma. Traumatic central vertigo may be caused by petechial hemorrhages in the vestibular nuclei of the brainstem. These may result from shearing forces on the brainstem. [6]

Epidemiology
Frequency
United States Approximately 500,000 people have strokes each year. About 85% of these strokes are ischemic, and 1.5% of ischemic strokes affect primarily the cerebellum. Ratio of ischemic to hemorrhagic cerebellar strokes is 3-5:1.[7] Up to 10% of patients with an isolated cerebellar infarction present with only isolated vertigo and imbalance.[8] Incidence of multiple sclerosis ranges from 10-80/100,000 per year, depending on the latitude. About 3000 cases of acoustic neuroma are diagnosed each year in the US.

Mortality/Morbidity
Vascular injuries and infarcts in the posterior circulation can cause severe permanent debilitating disease. The excellent recovery typical of acute vertigo caused by peripheral disease should not necessarily be expected in central vertigo. In one series, cerebellar infarctions had mortality rates of 7% and 17% when associated with the superior cerebellar artery and posterior inferior cerebellar artery distributions, respectively.[9] Infarctions in the latter distribution are associated more commonly with a mass effect and compression of the brain stem and the fourth ventricle. In another series of patients with cerebellar infarction and mass effect, mortality rate was 17% despite aggressive neurosurgical and medical management.[10] In one series of 94 patients, 20 presented with a Glasgow Coma Scale (GCS; see the Glasgow Coma Scale calculator) score less than 8, indicating significantly impaired consciousness. Mortality rate in the remaining patients who presented with GCS score higher than 8 was 20%. Acoustic neuroma has a low rate of mortality once diagnosed. The tumor often may be removed with preservation of facial nerve function, but unilateral hearing loss is common.

Sex
Incidence of cerebrovascular disease is slightly higher in men than in women. In one series of patients with cerebellar infarction, the ratio of men to women was about 2:1. Multiple sclerosis is about twice as common in women as in men.

Age
Incidence of stroke increases with age. The mean age of patients with cerebellar infarction in one series was 65 years, with half of the cases occurring in those aged 60-80 years.[7] In one series, the mean age of patients with cerebellar hematoma was 70 years.[3]