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By: Sabrina Formosa

CIPA
(Congenital Insensitivity to Pain with Anhidrosis) Congenital
Insensitivity to

Pain with
Anhidrosis

CIPA
Congenital insensitivity to pain with anhidrosis is a condition that most people are born with, it means you cant feel pain and temperature.

Causes of CIPA
• This condition is inherited in a recessive pattern, which means both copies of the gene in each cell have mutations. They typically do not show signs and symptoms of the condition.

Risks?
• Not feeling pain or temperature. • You can’t take care of yourself • Injuries are very common • Eye injuries, fever and burns, infections

Symptoms
• Cant feel pain • Cant feel heat

Diagnosed
• People with congenital insensitivity to pain with anhidrosis (CIPA) should receive a physical exam and provide a family history. During the patient interview, a clinician should focus on the patient's receptiveness to pain and history of injuries.

Treatments
• Treatments for CIPA do not always work, there are some cases where naloxone may be used as a treatment. • Naloxone is a chemical that acts within the nervous system of the body by blocking the nervous system from causing the inactions that occur within the group of cells that receives the message to initiate the sensation of pain, heat, or cold. • Most treatments are hard to narrow down for this condition because each CIPA patient may have other conditions including the absence of sweat glands, nerve fibers, ulcers, and other conditions.

Prognosis
• The prognosis is poor. • It is unpredictable. • Usually patients don’t live to be an adult.

How to prevent it
• CIPA is not preventable it is proved that it is hereditary

When was it first discovered?
• First described by Dearborn in 1932. Since the discovery of congenital insensitivity to pain with anhidrosis, not more than 60 cases have be reported.

Similar Diseases to CIPA
• Hereditary insensitivity to pain with anhidrosis • Hereditary sensory and autonomic neuropathy, type 4 • Hereditary sensory and autonomic neuropathy type IV • HSAN4 • HSAN type IV

Facts about Congenital Insensitivity to pain with Anhidrosis
• The signs of CIPA appear early, usually at birth. • With medical attention, affected individuals can live into adulthood. • An inability to feel pain and temperature often leads to repeated severe injuries. • Unintentional self-injury is common in people with CIPA, by biting the tongue, lips, or fingers.

Facts continued…
• People with CIPA heal slowly from skin and bone injuries. • Repeated trauma can lead to chronic bone infections (osteomyelitis) or a condition called Charcot joints, where the bones and tissue surrounding joints are destroyed.

More Facts
• Most CIPA patients die by the age of three simply from overheating • People with CIPA suffer from untreated ulcerations of the lips, mouth and tongue, dental infections, minor breaks in the bones and other conditions that can lead to infection, that would cause intense pain in any other person • It is more common in homogeneous populations • Anhidrosis is the inability to sweat

Websites
• • • • • • http://ghr.nlm.nih.gov/condition/congenital-insensitivity-to-pain-withanhidrosis http://ghr.nlm.nih.gov/condition/congenital-insensitivity-to-pain-withanhidrosis#inheritance http://www.sharecare.com/health/genetic-disorders/how-cipa-diagnosed http://www.medhelp.org/posts/Neurology/Genetics-of-CongenitalInsensitivity-to-Pain-with-Anhidrosis-CIPA/show/293378 http://ghr.nlm.nih.gov/condition/congenital-insensitivity-to-pain-withanhidrosis http://house.wikia.com/wiki/CIPA