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Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec...

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This month we bring you an opportunity to read the booklet by Jonathan V. Wright, M.D. 'D-Mannose & Bladder Infection'. The full text of this book is below for you to read at no cost.

Note that UTI is the American term for what the UK public more commonly call cystitis.

D-Mannose & Bladder Infection
The Natural Alternative to Antibiotics
Jonathan V. Wright, M.D. And Lane Lenard, Ph.D. Published by Dragon Art 36646 32nd Avenue Southeast Auburn, Washington 98001 Fax #253-874-2677 (c)2001 Jonathan V. Wright, M.D. All Rights Reserved ISBN No. 0-9713600-0-6

D-Mannose: The Natural Alternative to Antibiotics for Urinary Tract Infections
In this booklet, we describe a completely natural approach to treating UTI that involves the use of the simple sugar D-mannose, a close cousin of D-glucose. When taken by mouth, relatively large quantities of D-mannose can cure more than 90% of all UTIs within one to two days. Even more remarkably, D-mannose accomplishes this feat without killing a single bacterium! Yes, you read that correctly. D-mannose cures UTIs, but it doesn’t kill

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coli. If you or someone you love has a UTI or is prone to recurrent UTIs. By actual count. and bladder” with no apparent reason for all the infection.” and that she would likely need a kidney transplant during the next few years.d-mannoseworks. pleasant to use. except when she was sleeping. we urge you to read this booklet and then try D-mannose. http://www. a spoonful of sugar is the medicine. And as a bonus. How D-mannose accomplishes this substantial feat will be explained later. Suffice it to say that. children actually enjoy taking it. Extensive tests showed “normal kidneys. Because it tastes so good (it is a sugar. inexpensive. Yes.. D-mannose has no known drawbacks. and many natural or “alternative” treatments as well. after all!). women (even pregnant women) who are susceptible to recurrent UTIs can safely take D-mannose as a preventative measure to head off future attacks. Amy’s mother also brought with her a very detailed set of notebooks in which she’d recorded descriptions of her daughter’s numerous hospitalisations and extensive tests for nearly continuous urinary tract infections (UTIs). it actually tastes good. D-mannose is also ideally suited for children with UTI. no resistance. Fortunately. Moreover. Mom also had records of Amy’s many urine bacterial cultures. Where a “spoonful of sugar” helped the medicine go down in Mary Poppins’ day. Nevertheless.. because it gets rid of UTI-causing bacteria without committing “bacteriacide. no yeast infections. 2 of 17 11/16/2012 1:13 PM .Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. ureters. all of which showed the same bacteria: E. D-mannose has no adverse side effects of any kind. coli. with D-mannose for UTIs. because her kidneys were beginning to fail from the chronic infection. Odds are you’ll soon find that UTIs – and antibiotics – are a thing of the past. these doctors had told Amy’s mother and father that they were “running out of effective antibiotics. At first glance D-mannose may sound too good to be true: a “medicine” that’s highly effective. nearly 15 years of clinical experience have shown that it is just about as effective at curing UTIs as antibiotic drugs.* the microorganism that causes most UTIs. and had been on antibiotics for most of her short life. Because it is so effective and so benign.” people who use it suffer none of the unwanted side effects of antibiotics: no GI side effects. Although D-mannose is virtually unknown to practitioners of conventional medicine. Amy had been seen by 72 different physicians. perfectly safe. I advised her mother to give Amy ½ to 1 teaspoon (approximately ½ to 1 gram) of D-mannose powder stirred into a glass of water every two to three hours. The Story of Amy Amy was not yet five years old when her mother brought her to the Tahoma Clinic in the late 1980s. it is true! Unlike virtually any conventional medication. In fact. and available without a doctor’s prescription. At the end of our consultation.com/ bacteria. many research reports have demonstrated its mode of action and effectiveness against E.

ureters. While these drugs are usually – but not always – effective. Under these conditions. They also kill millions of other “friendly” bacteria that belong in the body where they serve numerous important functions. 1-4 Some UTIs are merely painful (sometimes very painful) and annoying. The reason is that friendly bacteria that normally inhabit the vagina keep the yeast (usually Candida 3 of 17 11/16/2012 1:13 PM .. of course. relapsing only when her family forgot to take the D-mannose with them on vacation.com/ A note about terminology: In this booklet. women who have suffered one UTI are very likely to experience a recurrence from time to time. “not-so-friendly” yeasts. Amy’s infection vanished.. nausea and occasionally. where infection can lead to serious damage and even kidney failure. vomiting. Because they kill off “friendly ” bacteria living in the gastrointestinal (GI) tract. as Amy’s case illustrates. all these infections have a similar origin and are typically treated the same way. or kidneys. antibiotics can cause unwanted side effects. Over the next ten years or so. She remained infection free for over two years. When she resumed taking it. Although they usually make quick work of the UTI-causing bugs. they don’t just stop there. If enough friendly bacteria are killed. which refers to the most common form of UTI. many women who take antibiotics (to treat UTI or any other infection) soon come to expect that they will develop a vaginal yeast infection requiring them to take yet another drug – this time an antifungal – to kill the yeast. Still. has kept her kidneys. Some people seem to be more susceptible than others.d-mannoseworks. the infection immediately cleared. UTIs are responsible for 10 million doctor visits. Each year. we use the general term “UTI” (urinary tract infection) to refer to any infection of the bladder. Amy has had no further UTIs and.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. Although Amy’s case is extreme. UTI remains a common and distressing disease that affects up to 50% of all women and girls (and a much smaller number of men and boys) over the course of a lifetime. bacteria may ascent to the kidneys. or not treated promptly and properly – can be quite dangerous. Despite being a bit dubious that a simple sugar prescribed by a “natural medicine” doctor (remember. they also have some important drawbacks: Antibiotics are equal-opportunity microbe killers. curing most infections in a few days. and bacteria – all of which can produce unwanted toxins – are encouraged to take their places. The majority of us are more familiar with the term bladder infection . moulds. Since friendly bacteria normally produce significant amounts of several vitamins – folic acid and vitamin K are the best known examples – antibiotic use can contribute to long-term hidden vitamin deficiency. In addition. recurrent. constipation. other UTIs – especially if they’re chronic. However. Within 48 hours. Conventional medical treatment of UTIs involves the use of antibiotics. http://www. this was the 1980s) would do anything. such as diarrhoea. she tried it.

and a single urethra. coli over 90% of the time) that affects the inside lining tissue of the urinary system (or tract). This system includes two kidneys. Lastly. the urinary system is hostile territory for bacteria.. 5 Despite all these built-in safeguards.” Infections that reach the kidneys are known as “nephritis” or “pyelonephritis. Just as it's hard to breathe through swollen and inflamed nasal passages. simple urination expelled 99. the infection is called “ . tubes that carry urine from the kidneys to the muscular bladder. overwhelmingly women. Most UTIs begin when bacteria originating in the bowels travel to and grow in the urethra. swollen and inflamed urinary ducts can partially obstruct normal flow.5). the final common path from the bladder to the outside world. http://www. viruses or any other microorganisms. they would typically be flushed out with the normal flow of urine.” When bacteria travel upstream to the bladder. which stores it. making themselves “immune” to the effects of antibiotics. making it painful and difficult to pass urine.d-mannoseworks. Bugs that do make their way into a healthy urinary tract are likely to find an inhospitable acidic environment (pH <5. So effective are these natural antibacterial defenses that in a study in which bacteria were instilled into the bladders of guinea pigs. the yeast organisms are free to grow unchecked. The likelihood that resistant bacteria will develop is enhanced by the misuse and overuse of antibiotics. Ordinarily. still develop UTIs. irritated and swollen. Infections limited to the urethra are known as “urethritis. The tissues become inflamed. The development of antibiotic-resistant bacteria is a major problem in medicine today that has many experts fearing the inevitable arrival of a “superbug” that is resistant to all known antibiotic drugs. What is UTI? A UTI is a bacterial infection (caused by the bacteria E. the use of antibiotics promotes the development of bacterial species that are able to resist these drugs. Once these friendly bacteria are taken out of the picture by the antibiotic.) Even if micro organisms manage to overcome these considerable obstacles. They are also subject to attack by the body’s immune defenses. The urinary tract reacts to a bacterial infection in much the same way that the upper respiratory system reacts to a cold virus..9% of the bugs.com/ albicans ) population under control. Those bacteria that have become immune then pass this ability on to their offspring or other bacteria. every year a few people are rushed to the hospital because of allergic reactions to these drugs.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. which form urine from liquid waste in the blood: two narrow ureters . (Adult men have the added protection of a specific bacterial growth inhibitor squirted directly into the urinary system by their prostate gland. Bacteria are very clever in their ability to mutate genes. Although most of us can tolerate antibiotics without immediate side effects.” cystitis 4 of 17 11/16/2012 1:13 PM . each year millions of people.

when E. Even small differences in the location of these openings can make a big difference. all of these non-E. of course. Poor hygiene. In time. Because the urethra is in front of the anus. they manage to gain entry to the urinary tract via the urethra. increasing the chances that a urethral infection will quickly become a bladder infection. In one study of women who tended to get UTIs over and over again. Mycoplasma. behave themselves without bothering us. multiply and spread. however. vagina. making it too far a distance for most E. If. which could then easily gain access to the urethra. Mycoplasma and N. mothers teach their small daughters to “always wipe from front to back” to avoid introducing bacteria from the anus into the urethra. such as Proteus or Staphylococcus (“Staph”). coli that cause most UTIs are among the most common “friendly” bacteria in the GI tract. Thus. and anus are all in close proximity. Chlamydia. then they attach to the internal lining of the bladder. Who Gets UTI? Anatomy is UTI destiny. Although up to 90% of UTIs are caused by E. people with certain anatomic anomalies. anything that inhibits the flow of urine can increase the risk of UTI.. 6 In males. In men. enlargement of the prostate gland can impede the flow of urine. coli infections combined amount to no more than 10% of all UTIs. where they aid digestion. the flow of urine from kidneys to bladder to the urethra washes out most bacteria. This means that the distance bacteria have to travel to reach the female bladder is much shorter. The female urethra is also far shorter than the male’s.. In uncircumcised males. Unlike E. However. stroke. coli. because it makes it relatively easy for bacteria from the bowel to gain a “foothold” in the vagina or the urethra or both. Bladder weakness due to diabetes. the urethral opening was just 0. these bugs tend to be transmitted via sexual contact and rarely cause the more serious bladder and kidney infections. Women are far more likely to develop UTI than men. stones. a few UTIs are caused by other bacteria. residual urine can serve as a growth medium for bacteria. coli. if not cleansed properly. this stagnant. in tailor-made for UTI. Neisseria gonorrhoeae. and others. or other neurologic disorder can sometimes lead to the “pooling” of urine in the bladder after urination.d-mannoseworks.com/ The E. The reason lies in a difference in anatomy between the two sexes. the foreskin. can serve as an excellent breeding ground for bacteria. the urethra exits the body via the penis. produce a few vitamins. UTI is also quite 5 of 17 11/16/2012 1:13 PM . or cystitis. and in general. tumours or strictures (narrowings) are more likely to have recurrent UTIs.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. gonorrhoeae infections do not respond to D-mannose treatment and will probably require antibiotic treatment. coli to travel. Failure to remove bacteria from the region surrounding the urethra is an important cause of UTI. coli and other bugs exit the lower GI tract. in which the urethral opening. Blocking the flow of urine. Normal female anatomy. Normally. the remaining 10% are caused by bacteria known as Chlamydia. Still. In addition.2 cm closer to the anus than women who never got UTI. as well as blood clots. http://www.

http://www. coli (and yeast) colonisation. Although blockages can promote infection in both sexes. In other words. The incidence of UTI increases after women reach menopause. 9 Antibiotics! Yes. which lowers the pH of the vagina.. coli to stick to the epithelial cells that line the vagina. like E. it is possible to “inoculate” the urethra during masturbation and same-sex sexual activity). coli.. such as low pH. urethra. urine may be naturally fatal to many bacteria. Any condition that impairs normal immune function can 6 of 17 11/16/2012 1:13 PM . “Honeymoon cystitis” results when bacteria move from the vagina and the perianal area to the urethra during intercourse. The relatively acidic normal environment helps keep the population of yeasts and unfriendly bacteria.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. you have a good chance of having it too. Some contraceptive methods also increase the chances of UTI. they also allow yeasts and other bacteria to thrive in the vagina. that actively discourage bacterial growth. it’s true that antibiotics are widely used to treat UTI. The same thing is true for condoms with spermicide. known as Lactobacilli that inhibit the vagina. Taking the joy out of sex. It also kills the friendly bacteria. and bladder. are much more likely to develop a UTI the next day. With Lactobacilli out of the way. coli. kills a lot more than just sperm. allowing pathogenic organisms to grow unchecked. if your mother had recurrent UTI. which can easily become contaminated. The lack of youthful levels of oestrogen leads to a loss of Lactobacilli with a subsequent rise in vaginal pH leading to E. coli can more easily reach the urethra and bladder and begin the infection cycle all over again. the pH rises (less acid). Other women seem to lack certain antigens that normally inhibit bacterial adhesion (“stickiness”). the best way to get UTI is to have sexual intercourse. but one possibility is that some UTI-prone women have a protein that makes it easier for E. In some fortunate instances. 7 Not only do spermicides promote the growth of E. or just the spermicide itself. Getting older. How can that be? Like spermicide. Research has shown that women who use a diaphragm with a spermicidal jelly or foam. Still other women have elements in their urine. many antibiotics kill vaginal Lactobacilli. 12 Immune impairment. In the genes. coli (and yeast) infection. the absence of Lactobacilli leaves the vagina vulnerable to E. they are the primary cause of UTI in males. 8 It seems that nonoxynol-9.d-mannoseworks. urinary and faecal incontinence can also pave the way to UTI. Once the antibiotic treatment ceases. One of Lactobacilli’s main functions is to produce lactic acid. Some people have a genetic predisposition to UTI. For many women. The reasons are not entirely clear.com/ common in people who are severely debilitated and require a urinary catheter (a tube inserted into the urethra to drain the bladder). under control. (In a similar manner. Nonoxynol-9 may also promote infection by making it easier for E. the most commonly used spermicide. coli to “stick” to their urinary tract tissue. but it’s also true that antibiotics given for UTI or any other infection can actually increase the risk of UTI. 10 Once in the vagina. 11 In very old (and very young) people. making them more resistant to infections. E.

including E. milky or reddish urine When these symptoms are combined with a fever.g. Other symptoms of kidney infections are nausea. have no appetite. Longer treatment is especially indicated in cases where symptoms have lasted more than a week. However. coli in the GI tract and Lactobacilli in the vagina.d-mannoseworks. or when the individual has diabetes (or other diseases in which the immune system may be impaired). The antibiotic drugs most often prescribed for UTI include: Trimethoprim (Trimpex) 7 of 17 11/16/2012 1:13 PM . people with diseases. In children.com/ make the urinary tract a more hospitable place for bacteria. despite a strong urge to urinate A painful. http://www. the symptoms of UTI are not always obvious. such as diabetes or AIDS or people taking immunosuppressive drugs (e. have no low-grade fever with nausea and vomiting.. it is far more common to have at least some symptoms. When women are subject to recurrent UTI. If children are sick for more than a day with a high temperature but have no “cold” symptoms. should be extra careful. many doctors prescribe daily low dose antibiotics for as long as two or three years! One problem with such long-term treatment is that it is guaranteed to seriously disrupt the body’s normal ecological balance by eradicating friendly bacteria. doctors often recommend taking antibiotics for 10 to 14 days just to make sure no relatively resistant bacteria survive. Parents should be on the lookout for UTI if their kids are irritable. who may not be able to describe how they feel. one or both kidneys may be infected. Even though the infection may appear to be gone in a couple of days. burning feeling in the area of the bladder or urethra during urination or even when not urinating An uncomfortable pressure above the pubic bone (in women) or a fullness in the rectum (in men) Cloudy. The most common symptoms of UTI include: A frequent urge to urinate Trickling of urine. This is especially true in very young children. which typically cure most infections within one or two days. What Are the Symptoms of UTI? Some people with UTI have no symptoms and are completely unaware of their infection. corticosteroids).. Thus. when the infection is recurrent. Conventional Antibiotic Treatment Conventional medical treatment of UTI involves the use of antibiotic drugs. and/or if their urine smells “funny”. they may have UTI..Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. vomiting and back or side pain below the ribs.

E. 15-17 How taking D-mannose can treat or prevent UTI. and happily sail off into the porcelain sunset. pharmaceutically based medicine typically confronts the problem by throwing the most potent poisons it can find at the bugs. any E. coli couldn’t turn around without bumping into D-mannose “just floating around” in the urine. Another. this approach does have some very serious drawbacks. Noroxin. inviting the fimbria of E. The E.. Furadantin. Here they act as “receptors”. conventional. Trimox. In addition to its natural occurrence in the cells lining the epithelial tract. Cipro. apples. more natural way to eliminate E. While there’s nothing essentially wrong with killing disease-causing bacteria. Velcro-like grip. Septra. 14 If not for this attachment to the cells’s mannose. as we have noted earlier. 14 It turns out that molecules of mannose (produced inside urinary tract lining cells) naturally dot the surfaces of these cells. coli attach to cells lining the bladder and urinary tract using filmy hair-like projections called fimbria on their cell walls. coli that had successfully ventured up the urethral river would be unable to stick to the slippery surface and would be washed right back out on the next tide of urination. bacteria usually have to find a way to adhere (stick) to the body tissue they’re infecting.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. 13 At the tip of each fimbrium is a glycoprotein (a combination carbohydrate and protein) called a lectin that is programmed to bind to the first molecule of the sugar mannose that it encounters. the sugar D-mannose is also found in relatively large quantities in fruit such as peaches. In UTI.. and allowing them to bind to the tissue in a right. coli left clinging to mannose molecules on cells then become easy prey for white blood cells and other agents of the immune system. “bacteria-cide” is not the only possibly avenue of attack.com/ Trimethoprim/sulfamethoxazole (Bactrim. If they’re going to cause trouble. Trovan) Ampicillin (Many brands) Treating UTI Naturally with D-Mannose When faced with a potentially pathogenic germ like E.d-mannoseworks. technically termed “urinary tract antispetics”) Fluoroquinolones (Floxin. Those few E. Unable to resist the tasty bait they suddenly find themselves swimming in. they would latch on to the nearest mannose molecules. http://www. coli. coli infections from the urinary tract is to beat them at their own game.* What happens when we take D-mannose to treat a UTI? Now imagine what would happen to E. Cotrim) Amoxicillin (Amoxil. Happily. 8 of 17 11/16/2012 1:13 PM . Wymox) Nitrofurantoin (Macrodantin. coli to attach. coli in the urinary tract if those sweet little mannose molecules they crave were present not just on the surface of the epithelial cells but surrounding them in the urine as well.

only the D. like cranberries and blueberries. D-mannose is not readily converted to glycogen (and stored) in the liver. http://www. Those that do are said to be “mannose-specific.(levo-) (literally. It also unsticks most of the E.(dextro-) and an L.forms of a molecule to have very different activity profiles.and L. coli it might encounter.* a white crystal sugar similar to glucose. glucose is absorbed more than eight times faster. The D-mannose-sweetened urine flows from the kidneys through the ureters to the bladder and on to the urethra.. It is not uncommon for the D.) Moreover.. Extracted in the form of D-mannose.) When someone with UTI consumes a dose of D-mannose. 18.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. Adults: 1 teaspoonsful dissolved In water or juice every 2 or 3 hours.19 As the D-mannose-laden blood passes through the kidneys.form is useful for dislodging E. the sugar is absorbed in the upper GI tract. a considerable proportion of the sugar is extracted and added to the urine. coli already “Velcro-ed” to the inner surface of the bladder and urinary tract.com/ oranges and certain berries.14 + Many molecules have D.) D-Mannose: Guidelines for Use Ongoing infections Children: ½ to 1 teaspoonful Dissolved in a glass of water or juice every 2 or 3 house. coli find the mannose molecule such a treat. coli. (Mannose can also be synthesized from other simple sugars. Adjust amounts downward if Possible Preventing “honeymoon cystitis” 1 teaspoonful one hour prior to immediately afterwards. so they can’s stick to cells any more. it can be easily dissolved in a liquid and swallowed. but instead passes directly into the bloodstream largely unchanged. Preventing infections Start with quantities noted above. ultimately flushing them all down the drain. 9 of 17 11/16/2012 1:13 PM . but at a much slower rate than most other sugars. (For example. In the case of mannose. literally sugar-coating any free-floating E.” and they are the ones that can potentially cause UTI.d-mannoseworks. (* Not all varieties of E. unlike other sugars. right and left) forms.

coli -based urinary tract infection for almost two years. In one laboratory study. coli-infected mice led to a 90% reduction in bacterial attachment to the urinary tract. administering a mannose-like substance (methyl a-D-mannopyranoside) to E.com/ What is the proof that D-mannose really works? First. I advised her parents to take her off the antibiotics and begin giving her D-mannose (½to 1 teaspoon (approximately ½ to 1 gram)) stirred into some water or juice every three to four hours. literally tens of thousands of women working with natural medicine doctors have successfully applied this science to their won UTIs. The result? No further infections. There’s no argument at all about this among researchers who’ve studied it. coli . As part of Anne Marie’s overall treatment plan. though.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. described at the beginning of this booklet. 1 teaspoon of D-mannose every two to three hours clears 10 of 17 11/16/2012 1:13 PM . coli. Not surprisingly. placebo-controlled study to prove this. Nearly constant antibiotic treatment had been ineffective in clearing her infection. Second. the “molecular mechanism” of the action of D-mannose on E. In over 90% of such cases. While it would certainly be nice to have the results of a double-blind. http://www. for example. We have found that women prone to very frequent recurrent UTIs not necessarily related to sexual intercourse can also often benefit from taking D-mannose preventively at the same dose. we have been recommending D-mannose to people with UTI since the mid-1980s with great success. who was avoiding sex because she would get a bladder infection “every time” she and her husband had intercourse.. When Anne Marie’s parents took her back to her urologist for what had previously been monthly or bimonthly visits. a prerequisite if urinary levels are to rise. those rats also given D-mannose were found to have significantly lower levels of bacteria in their urine.” Caroline was a married woman. To save expense. it’s hard to doubt the value of D-mannose when we see case after case like that of Amy. rats’ urinary tracts were inoculated with E. At the Tahoma Clinic. comes from the experience of people who have used it. who had a very serious genetic disease called galactosemia: Among her other problems. Anne Marie had been suffering from an E. they were told to check back again in another two years! D-mannose can also be very effective in cases of “honeymoon cystitis . coli is scientifically proven. this was causing some discord in her marriage. Since a culture of her urine showed the presence of E. combined with common sense and over 15 years of clinical experience. Her UTI vanished within two weeks and never returned. makes a compelling case for the therapeutic value of D-mannose. By far the most frequent use of D-mannose has been by thousands of women who have suffered single (nonrecurrent) episodes of bladder infection. Considerable circumstantial evidence. Within one day. she started taking D-mannose. 1 teaspoon one prior to intercourse and again shortly afterwards. or of four-year-old Anne Marie. some women have been able to “taper down” their dosage and dose frequency. 21 Perhaps the best available evidence. Research in humans shows that ingesting D-mannose significantly elevates blood mannose levels. 20 In another study.d-mannoseworks..

the amount of D-mannose (even with proanthocyanidin) in a glass of cranberry juice is far less than the therapeutic dose we recommend in this booklet. Resisting the urge to urinate too often or for too long can damage the delicate tissue that lines the urinary tract and permit bacteria to thrive.com/ the infection in one to three days. so invading bacteria are likely to be washed out. if possible. We often hear from other medical practitioners who give it to their patients. not baths. who wanted to avoid antibiotics. Plus. None of them requires taking any drugs: Drink a lot of water or other fluids.” It’s always best to urinate when we feel the need. coli to “stick around. most cranberry juice products are loaded with added sugars. Drink cranberry juice. but we’d be open to “scientific criticism” if we didn’t.. Fluids keep the urine flowing. It turns out that cranberry juice works. the kind of sugars that are known to suppress the activity of the white blood cells that destroy unfriendly bacteria (see below). we apologise for repeating what every woman learned from her mother. Even some of the ones that were of chronic nature have improved to the point that a single weekly dose of D-mannose is keeping them problem-free. To this day.” 22. In uncircumcised infants. Don’t “hold it in. in part.. 1 For both: Cleanse the genital and anal areas before sexual intercourse. discourage bacterial growth. Take vitamin C supplements. http://www. if possible. by itself. UTI-prone women. Bath water contains millions of 11 of 17 11/16/2012 1:13 PM . I have tried everything imaginable for kidney and bladder problems with mixed results or at least not reproducible results. drinking unsweetened cranberry juice may help prevent future infections. For just a few of us: take showers. foreskin infections are up to 20 times more common compared with circumcised infants. we have not had a single patient that did not improve with D-mannose. (As guys. Use the ascorbic acid form of vitamin C. Although drinking large volumes of cranberry juice would probably not. Hygiene: For women: “front to Back” wiping.d-mannoseworks. The following is typical: “During my 38 years of practice. For many years. because it contains some D-mannose. 48 to 64 ounces daily.23.) Men who’ve been lucky enough to escape circumcision should keep their foreskin area clean. It is not just Tahoma Clinic patients who are achieving these remarkable results with D-mannose.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. while others involve diet. people can do many things to avoid getting bladder infections and other UTIs. be sufficient to cure an established infection. However. have tried drinking cranberry juice. which can help acidify the urine and thus. Some are hygienic.” Preventing UTI In addition to taking D-mannose. as well as a substance called proanthocyanidin that works in a slightly different way to make it difficult for E.

as well as the media. in the early 1960s. 2001. http://www. The World According to the FDA In an ideal world. the scientific and clinical evidence discussed here should be sufficient at least to pique the interest of medical practitioners. take a cleansing shower first. Director. Pearson v. that without “FDA approval. coli from the anus could float over to the vagina or urethra.” a remedy is “unproven. Crout. The FDA has never officially denied the statement made by Dr Richard J. they do not offer the astronomical profits that patentable drugs do.g. If you’ve had frequent UTIs. The FDA admitted that it has no objective standard for such proof.com/ bacteria that get washed off our bodies. In the absence of a financial incentive to do the same kinds of trials on D-mannose. known as Prescription Drug User Fees. 1 Sadly. It is quite possible that E. Sugar and Food Allergies In natural medicine.) 1 By law passed in 1992. Congress gave the Food and Drug Administration (FDA) the exclusive legal power to decide which remedies were “proven” or which were not. Lacking such a standard. As discovered by Federal judges in recent court cases (e. Unfortunately. Avoid using feminine hygiene sprays and scented douches.. leads to scandalous conflicts of interest that have recently been decried in an editorial the British medical journal. FDA’s (then) Bureau of Drugs: “I never have and never will approve a new drug to an individual. the FDA has been able to “disapprove” nearly all remedies that are not sponsored by a major pharmaceutical company. there are very few pieces of published evidence one can point to to “prove” definitively (according to the FDA’s undefined standards) that it is as effective and safe as we say it is. this practice. 2 Because natural substances like D-mannose cannot be patented. pharmaceutical companies are permitted to pay the FDA hundreds of millions of dollars to help expedite new drug “approvals. because refined sugar interferes with the ability of white blood cells to engulf and destroy microorganisms.” even when real-world proof is abundant. double-blind placebo-controlled laboratory and clinical trails that are paid for by the pharmaceutical (patent medicine) industry. making infection easier and may also 12 of 17 11/16/2012 1:13 PM . expensive. but only to a large pharmaceutical firm with unlimited finances.d-mannoseworks. The use of patented. except when they have been ordered to do so by a court. which could lead to infection. Shalala). it’s axiomatic that refined sugar and hidden food allergies are “behind” most recurrent infections.” (Quoted in the Spotlight for January 18. but can’t resist a long.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. 2 UTI.357:1544-1545. These products may irritate the urethra. 1982. 24 Food allergies appear to irritate and inflame "target-organ” tissues.” Not surprisingly. The Lancet. FDA-approved antibiotic drugs for treating UTI is supported by large. hot soak in the tub.. the FDA has convinced nearly all practicing physicians.

the women in the oestriol group had had more than 50% fewer UTIs than the women in the placebo group (31% vs. or recurrent skin rashes). coli (and yeasts). As long ago as 1976.) 27. 25. happily spewing lactic acid into their surroundings. Estrace (the “oestrogen patch”) and other patented products. All were asked to follow elimination diets. Of the 50 children.. including UTI. hives.” Only eight of the fifty children showed no improvement. placebo controlled study published in the New England Journal of Medicine. take “anti-allergic” medication. When oestrogen is plentiful. In a randomised. please read Natural Hormone Replacement for Women Over 45 by Jonathan V. please avoid – at all costs – conventional pharmaceutical HRT (“hormone” replacement therapy) that employs such unnatural or synthetic hormone-like drugs as Premarin. 67% respectively. While they may reduce the chances of getting a UTI. making the area more hospitable to E. and to receive specific allergy desensitisation. This naturally created. which allows the pH to rise (become less acidic). oestradiol and especially oestriol in the proportions in which they occur naturally in healthy young women.com/ interfere with the function of the immune system. Replacing missing oestrogen can help restore this natural defense. After eight months. they can be very dangerous and may cause many unpleasant side effects. including oestrone. However. asthma.26 Doctors working with the “natural” approach to health care find that eliminating sugar and food allergies is frequently sufficient to significantly reduce the incidence of any recurrent infection. If a woman decides to use hormone replacement. “friendly” bacteria known as Lactobacilli thrive in the vagina.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. the Lactobacillus population begins to dwindle. eczema.” while nine had a “rapid and spectacular cure. in both children and adults.g. coli and other bacteria.D. double-blind.d-mannoseworks. All the children had an allergic “background.28 In addition to preventing UTI.. M.” including hay fever. normally low pH (relatively high acidity) of the vagina discourages the growth of E. Wright.. and 14 were “noticeably improved. though. The use of natural human estrogens by menopausal women is a vitally important subject that is beyond the scope of this booklet. nasal obstruction or other breathing difficulty (e. identical-to-human oestrogens.” 19 had cures after six to nine months. To learn more. http://www. 42 (84%) “definitely benefited. there are many other good reasons for menopausal women to replace their oestrogens and progesterone as their ovarian function wanes. As oestrogen levels fall during and after menopause. 13 of 17 11/16/2012 1:13 PM . 93 postmenopausal women with a history of recurrent UTI applied a cream containing the natural oestrogen oestriol or a placebo to their vaginas. persistent coughing. Provera. results were reported from a study of 50 children (aged 4 to 18 years) who had chronic recurrent UTI despite urologic examinations that were otherwise completely normal. it’s essential for her to opt for the use of natural. UTI and Menopause Women generally find that their chances of developing a UTI increase as they reach their menopausal years.

inexpensive. it is likely that the causative organism if not E. By using this remarkably safe. very little. There are anecdotal reports that some people with diabetes experience a transient increase in blood sugar levels. Antibiotics for Bladder Infections 14 of 17 11/16/2012 1:13 PM . D-Mannose vs.) Still. and a visit to the doctor for a conventional antibiotic drug is therefore necessary. Instead.com/ and John Morgenthaler. women can usually treat their own UTIs without the need for expensive doctor visits. this allows them to identify the infecting bacteria and select an appropriate conventional antibiotic as quickly as possible.. it makes it impossible for E. prescription drugs. coli or any “friendly” bacteria. D-mannose should be continued for two to three days after the last symptom is gone. Ninety percent of the time. Try D-Mannose First! We strongly urge people with UTI to try D-mannose before resorting to antibiotic drugs. A WORD OF CAUTION If a UTI treated with D-mannose does not show significant improvement within 24 hours (about 10% of cases). Although D-mannose can eliminate UTIs as quickly as conventional antibiotic drugs. 1997. coli and D-mannose doesn’t work. coli bacteria to stick to the lining of the urinary tract. Is D-mannose Safe for People With Diabetes? People with diabetes usually need to limit their intake of sugar.. How does this affect their use of D-mannose? Fortunately. http://www.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. there’s no harm in doing this. CA. Summary D-mannose is a simple sugar that can be used to treat or prevent the 90% or more of UTIs that are caused by the bacteria E. Petaluma. it is far safer because it does not kill E. natural treatment. which allows the normal flow or urine to wash the bugs down the drain.coli. Smart Publications. and insurance company reimbursements. (Even though symptoms are improved within 24 hours. coli and will respond to D-mannose treatment with significant symptom reduction within 24 hours.” Unlike with conventional antibiotics. lasting only for the length of time mannose is used. effective. UTI is caused by E.d-mannoseworks. but the effect is not great and never permanent. In the one chance in ten that the infection is not caused by E. coli. just to “make sure. if possible just before starting D-mannose. many physicians think it’s a good idea to collect a urine specimen for bacterial culture.

Norden CW. Quart Rev Nat Med. Am J Clin Nutr. 1980. A prospective study of risk factors for symptomatic urinary tract infection in young women. Reeser JL. I. Ofek I. Horesh AJ. J Biol Chem. 10. Murray S. Sharon N. 1938.60:127-133. 1982. Sharon N. Deuel H. Mannose metabolism. Biochem Mol Med.125:79-85. 2000. Int J Antimicrob Agents. Ofek I. The role of bacterial adherence. Clin Infect Dis. Roberts PL. Effect of D-mannose and D-glucose on Escherichia coli bacteriuria in rats. Plotkin B.335:468-474. 1968. Freeze HH.329:753-756. 15. Nuutinen M. N Engl J Med. 17. Mirelman D. Role of host defenses. 20. Urinary tract infections in females.17:269-271.47:2689-2700. Crouch E. Kjaergaard S. Hilliard J. 4. 1971.29:417-424. Ann Allergy.24:488-498. II. Hooton TM.33:61-67. Sundqvist K.322:1-5. 21. Ikaheimo R. 24. Goldman R. Herman RH. 1999. N Engl J Med. Am J Clin Nutr. 1997. Antibacterial mechanisms of the urinary bladder. Alton G. Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women. Sobel JD. Goldhar J. Uhari M.36:16-22. Adv Exp Med Biol. 1998.. Skovby F. A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. J Urol. For specific advice concerning any individual episode of any illness. Heiskanen T. Pathogenesis of urinary tract infection.18:1-10.22:247-254.26:1180-1184. 1993. Etchison JR. 9.265:64-69. Urol Res. Kontiokari T. Smith HS. et al. Role of sugars in human neutrophilic phagocytosis. quiz 11-12. Johnson C. J Infect Dis. Mannose-binding activity of Escherichia coli: a determinant of attachment and ingestion of the bacteria by macrophages. Stamm WE. Hughes JP. Am J Public Health. Sanchez A. Stapleton AE. et al.d-mannoseworks. 1976. Invest Urol. 11. Lau HS. This book is general information.. Antecedent antimicrobial use increases the risk of uncomplicated cystitis in young women. Stamm WE. 16. 7. Hooton TM. 31.com/ Antibiotic Drugs Eliminates UTI within 1-2 days Kills “friendly” bacteria Can safely sto treatment in a few days Can ca!se "I ! set Can romote yeast infections Can ca!se aller#ic reactions $ell-s!ited for re#nant women $ell-s!ited for infants and Yo!n# children $ell-s!ited for lon#-term% &re'entati'e !se (e)!ires a doctor*s rescri tion Yes Yes No Yes Yes Yes No No No Yes D-mannose Yes No Yes No No No Yes Yes Yes No References 1. 6. Roberts PL. 3. Clark AM. Lower urinary tract antibacterial defense mechanisms. contact your 15 of 17 11/16/2012 1:13 PM . Koskela M.17:93-97. 23. Eshdat Y. Ann Allergy. Schaeffer A. Stamm WE. 28. Allergy and recurrent urinary tract infections in childhood.164:1216-1219.29:1600-1601. Clin Infect Dis. Raz R. The comparative metabolism of d-mannose and d-glucose. Nonoxynol-9: differential antibacterial activity and enhancement of bacterial adherence to vaginal epithelial cells. Escherichia coli bacteriuria and contraceptive method. 1976.22:91-99. 1979.11:97-102.11:531-549. Hallman L. Hooton TM.Dec. 12. 1996. Jama. Allergy and recurrent urinary tract infections in childhood. Pokka T. Foxman B. Oral ingestion of mannose elevates blood mannose levels: a first step toward a potential therapy for carbohydrate-deficient glycoprotein syndrome type I.36:174-179. Hooton TM. Studies on ketosis: XV. Kass EH. et al. Keisari Y. not individualised to any person or circumstance. 1983. Perineal anatomy and urine-voiding characteristics of young women with and without recurrent urinary tract infections. Stamey TA.117:472-476. Fennell CL. VII. I. 2. 2000. Infect Immun. Urinary tract infection risk factors and gender. 13. Hillier S. 1998:269-270. Studies of introital colonisation in women with recurrent urinary infections. 19.25:63-68. 1973. Ofek I.. et al. Clin Infect Dis. Infect Immun. The importance of mannose specific adhesins (lectins) infections caused by Escherichia coli. 1991. Hooton TM. Michaels E. Hughes JP. Recurring urinary tract infection: incidence and risk factors. 1991. Siitonen A. BMJ. 26.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. Chmiel J. 25. Green GM. 1978. The role of C-type lectins in the innate immunity against pulmonary pathogens. 2001. Infect Dis Clin North Am. 5. Fowler JE. Kunin CM. Bar-Shavit Z. Clin Infect Dis. Antiadherence factor for cranberry discovered. 1997. 1990. Horesh AJ. Raz R. Jr. 1994. Brown D. Postmenopausal women with recurrent UTI. Recurrence of urinary tract infection in a primary care setting: analysis of a 1-year follow-up of 179 women. Scholes D. J Clin Invest. Harrington RD. 27. Hooton TM. Mannose binding and epithelial cell adherence of Escherichia coli. 1997. 1977.80:331-333. 18. Beachey EH. J Gend Specif Med. 1996. et al.3:27-34. Ofek I. Scand J Infect Dis Suppl. 8. http://www. 2001.479:27-36. 14. 22. Mulholland SG.

” Terri Crosby-Hornbaker.D. except when we forgot to take the D-mannose on vacation with us once. hormones exactly identical to those present in a young woman’s body. rather than “hormones” concentrated from horse urine (Premarin®) or originated in a factory (Provera®). and teachers of a more natural approach to health care. As Linus Pauling said: “the right molecule in the right place at the right time. CH. and that’s over 90% of them. Wright. She’s had no further infections. Nutrition & Healing is written by Jonathan V. We had no problem giving it to her. In the past few years.. Author of The Yeast Syndrome “I had heard about D-Mannose at your seminar. she loved the taste. Nutrition & Healing has informed its readers about the first double-blind. as well as reminding us of decades-old but still very useful natural treatments.com/ physician.” Jeri Reddick “My wife recently had a urinary tract infection. (via e-mail) The effectiveness of D-mannose against bladder and other urinary tract infections was first described in the June 1999 issue of Nutrition & Healing An innovative and informative monthly newsletter. Discuss the information in this book with your pharmacist or physician to learn whether it is useful and relevant to your family. written by two of the world’s most experienced and respected clinicians. Nutrition & Healing reports the latest in effective vitamin..S. M. “D-mannose is exactly the right treatment for bladder infections caused by E. our daughter had one bladder infection after another until we started her on D-mannose. placebo-controlled experiment to demonstrate the successful reversal of early cancer of the cervix (“carcinoma-in-situ”) with an extract from common vegetables.” T. M.D.d-mannoseworks. CN “When she was younger. and also read about it in your Nutrition & Healing newsletter…I decided to try it personally as I had been having bladder infections nearly every time I had intercourse with my husband. I took ½ teaspoonful before and sometimes ½ teaspoonful after and had no more bladder infections! I have also recommended it to several patients at the clinic where I work and they have had excellent results as well. coli.” John Parks Trowbridge.. Medical Director of 16 of 17 11/16/2012 1:13 PM . scholars. It has extensively reported the unpublicised yet nation wide use (since 1983) of bio-identical hormone replacement therapy for women at and after the menopause. mineral and herbal therapies.” A perfect example of orthomolecular medicine.M.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. http://www. I had just read your article on D-mannose and quickly ordered some…it took only a couple of days on the D-mannose and she felt better.

Principles and Practice of Phytotherapy.d-mannoseworks. http://www.D.com/ Tahoma Clinic. Queensland..) Natural Hormone Replacement for Women Over 45 (with John Morgenthaler) The Natural Pharmacy (with six co-authors) Dr Wright’s Guide to Healing with Nutrition Dr Wright’s Book of Nutritional Therapy Internet shopping websites ©2012 Dimestream Privacy & cookie policy Terms & Conditions 17 of 17 11/16/2012 1:13 PM .. Kerry Bone is a master of herbal therapy and scholarship. FNIMH. Washington.D. Books by Dr Wright include: Why Stomach Acid is Good For You (with Lane Lenard. Gaby. Dr Wright is a graduate of Harvard University and the University of Michigan Medical School.) Maximise Your Vitality and Potency for Men Over 40 (with Lane Lenard Ph. Australia. FNHAA.Cystitis Treatment UK Urinary Tract Infection | d-mannose Bladder Infec. M.D. and author (along with Simon Mills) of the #1 textbook in herbal medicine. USA and Kerry Bone. Ph.) The Patient’s Book of Natural Healing (with Alan R. he’s also been author of monthly columns in Prevention magazine (1976-1986) and Let’s Live magazine (1986-1996). MCPP. of Warwick. Kent. In medical practice since 1970.