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Letter re: Steffen - Message
From: Sharon L. Anderson
To: Schwartz MD, Gary
Sent: Sun 4/7/2013 1:33:35 AM GMT
Please take LegalNotice via www.ag.state.mn.us Sun7Apr.2013
re Uof M Merger with Fairview/Sandford.
FURTHER: Affiant Sharon Scarrella Anderson aka Peterson only saw Rene Pelteir Age 79 1 ti
stated Cataract in L Eye Bifocals Ordered FREE
Mar.8th Saw Dr. Tom Rice St.Paul Eye now CEO Grand Ave, was Scheduled for Surgery, did not have Transport
2nd Opinion Mar27 Diane Tanube Lufkin Clinic, Pressured Laser which wrecked L Eye, Ringing Ears, Com plaint filed
Apr.www.bmp.state.mn.us
Then Martha Wright apparantly your Superio
r at the Uof M techinally a State Employee, Recycled the Eye Drops Cambigan without a Rece
Feb. 2013 Dr. Tani, stated Ìnoperable, re: Tubbs and You,
AT ALL TÌMES MATERÌAL NO PREOPT WAS TAKEN, SPECÌFÌCALLY BY DR. TANUBE,
AFFÌANTS GOOD FAÌTH ÌS TO CHARGE DR. TANUBE WÌTH NEGLÌENCE, TO FORCE BLÌNDNESS ON SHARON
ANDERSON.
FURTHER: Affiants call to St.Paul Eye mandate's that Dr. Tom Rice oversee this Matter,
Further Affiant Sayet not at this time except clarification of your Letter to Steffen is somewhat Vague,Misleading
Puts the www.stpauleye.com at Risk Either Dr. Tom Rice was in Error or Tanube must be Criminally Charge for her
without PreOpt of Affiants Physical Health. Affiant also sugested to Wright that the Cost of GTravaton, Allergic that Ma
on a Test Basis, Affiant also has Mecury Fillings on the L upper Teeth for 50 years,
Now Deaf in R. Ear, Blind in L Eye. /s/ Sharon Anderson Sharon4Anderson@aol.com www.sharon4anderson.org
www.sharon4mnag.blogspot.com
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Medicare BiIIings - Message
From: Sharon L. Anderson
To: Schwartz MD, Gary
Sent: Thu 4/11/2013 5:57:01 PM GMT
Please Submit online Medicare Billings, so Ì can refer to Ramsey County for Payments.
Thanking you in Advance
Further Ìt may be apparant that Google Lufkin ie: Diane Tanube facebook and other is connected
Soon Ì will pdf the Complaint filed against Tanube. Furher Affiant has Mecury Fillings Cha
Cells apparantly destroyed Mar 28th,2012
Medical Billings are Relevant www.sharon4anderson.org www.facebook.com/sharon4anderson
Sharon4Anderson@aol.com tel 651-776-5835 PS Dr. Tani signed off 4 Metro Mobility, "but for" does not accept Debit Master
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RE: Medicare BiIIings - Message
From: Kim Stigman
To: Sharon Anderson
Received: Thu 4/11/2013 7:14:08 PM GMT
Attachments:
04112013160803967
Hi Sharon,
Please find a copy of your statement. Lisa is also mailing you a copy.
Thank you
Kim
--- Original message ---
From: Sharon L. Anderson
To: Schwartz MD, Gary
Subject: Medicare Billings
Sent: 4/11/2013 5:57:01 PM GMT
Please Submit online Medicare Billings, so Ì can refer to Ramsey County for Payments.
Thanking you in Advance
Further Ìt may be apparant that Google Lufkin ie: Diane Tanube facebook and other is connected to Associated Eye Care,
Soon Ì will pdf the Complaint filed against Tanube. Furher Affiant has Mecury Fillings Challenge Tanube's Laser Treatment as Brains
Cells apparantly destroyed Mar 28th,2012
Medical Billings are Relevant www.sharon4anderson.org www.facebook.com/sharon4anderson
Sharon4Anderson@aol.com tel 651-776-5835 PS Dr. Tani signed off 4 Metro Mobility, "but for"
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Pseudoexfoliation syndrome
Classification and external resources
ICD-10 H40.1
(http://apps.who.int/classiIications/icd10/browse/2010/en#/H40.1)
OMIM 177650 (http://omim.org/entry/177650)
eMedicine article/1206366 (http://emedicine.medscape.com/article/1206366-
overview)
Contents
Ŷ 1 History
Ŷ 2 Symptoms
Ŷ 3 Diagnosis
Ŷ 4 Causes
Ŷ 5 Prevalence
Ŷ 6 Treatment
Ŷ 7 Research
Ŷ 8 Alternative names
Ŷ 9 ReIerences
Pseudoexfoliation syndrome
From Wikipedia, the Iree encyclopedia
Pseudoexfoliation syndrome,
(other names: Exfoliation
glaucoma, Pseudoexfoliation
glaucoma, Pseudoexfoliation
of the lens, Exfoliation
svndrome) sometimes
abbreviated as PEX,
|1|
is an
agingrelated systemic disease
maniIesting itselI primarily in
the eyes which is characterized
by the accumulation oI
microscopic granular amyloid-like protein Iibers.
|2|
Its cause is
unknown, although there is speculation that there may be a genetic
basis. It is more prevalent in women than men, and in persons past the
age oI seventy. Its prevalence in diIIerent human populations varies; Ior
example, it is prevalent in Scandinavia.
|2|
The buildup oI protein
clumps can block normal drainage oI the eye Iluid called the aqueous
humor and can cause, in turn, a buildup oI pressure leading to glaucoma
and loss oI vision.
|3|
As worldwide populations become older because
oI shiIts in demography, PEX may become a matter oI greater concern.
|4|
History
PseudoexIoliation syndrome (PEX) was Iirst described by an
ophthalmologist Irom Finland named John Lindberg in 1917.
|5||4|
He built his own slit lamp to study the condition and reported
"grey Ilakes on the lens capsule", as well as glaucoma in 50° oI
the eyes, and an "increasing prevalence oI the condition with
age."
|6|
Several decades later, an ocular pathologist named
Georgiana Dvorak-Theobald suggested the term
pseudoexIoliation to distinguish it Irom a similar ailment which
sometimes aIIected glassblowers called true exfoliation
syndrome. The latter ailment is caused by heat or "inIrared-
related changes in the anterior lens capsule" and is characterized
by "lamellar delamination oI the lens capsule."
|4|
Sometimes the
two terms "pseudoexIoliation" and "true exIoliation" are used
interchangeably
|6|
but the more precise usage is to treat each case
separately.
Symptoms
Page 1 of 9 Pseudoexfoliation syndrome - Wikipedia, the free encyclopedia
4/15/2013 http://en.wikipedia.org/wiki/Pseudoexfoliation_syndrome
Dr. Lindberg in 1917 built his own
slit lamp to study pseudoexIoliation
syndrome. A slit lamp in an
ophthalmology clinic in recent times.
Patients may have no speciIic symptoms.
|4|
In some cases,
patients may complain oI lessened visual acuity or changes in
their perceived visual Iield, and such changes may be secondary
to or diIIerent Irom symptoms normally associated with cataracts
or glaucoma.
|4|
PEX is characterized by tiny microscopic white
|5|
or grey
|6|
granular Ilakes
|4|
which are clumps oI proteins within the eye
which look somewhat like dandruII when seen through a
microscope and which are released by cells.
|7|
The abnormal
|8|
Ilakes, sometimes compared to amyloid-like material,
|4||2|
are
visible during an examination oI the lens oI an eye by an
ophthalmologist or optometrist, which is the usual diagnosis.
|7|
The white IluIIy material is seen in many tissues both ocular and
extraocular:
|8|
in the anterior chamber structures,
|4||5|
trabecular
meshwork, central disc, zonular Iibres, anterior hyaloid
membrane, pupillary and anterior iris, trabecula, and
occasionally the cornea.
|9||10|
The Ilakes are widespread.
|8|
One
report suggested that the granular Ilakes were Irom abnormalities
oI the basement membrane in epithelial cells, and that they were
distributed widely throughout the body and not just within structures oI the eye.
|4|
There is some
research suggesting that the material may be produced in the iris pigment epithelium, ciliary epithelium,
or the peripheral anterior lens epithelium.
|4|
A similar report suggests that the proteins come Irom the
lens, iris, and other parts oI the eye.
|3|
A report in 2010 Iound indications oI an abnormal ocular surIace
in PEX patients, discovered by an eye staining method known as rose bengal.
|11|
PEX can become problematic when
the Ilakes become enmeshed in a
"spongy area" known as the
trabecular meshwork and block its
normal Iunctioning,
|2|
and may
interact with degenerative changes in
the Schlemm's canal and the
juxtacanalicular area.
|4|
The
blockage leads to greater-than-
normal elevated intraocular pressure
|2|
which, in turn, can damage the
optic nerve.
|7|
The eye produces a
clear Iluid called the aqueous humor
which subsequently drains such that
there is a constant level oI saIe
pressure within the eye, but
glaucoma can result iI this normal
outIlow oI Iluid is blocked.
|7|
Glaucoma is an umbrella term
indicating ailments which damage
Page 2 of 9 Pseudoexfoliation syndrome - Wikipedia, the free encyclopedia
4/15/2013 http://en.wikipedia.org/wiki/Pseudoexfoliation_syndrome
Diagram oI the eye. a ÷ optic nerve; b ÷ optic disc; c ÷ sclera; d ÷
choroid; e ÷ retina; I ÷ zonular Iibres; g ÷ posterior chamber; h ÷ iris;
i ÷ pupil; j ÷ cornea; k ÷ anterior chamber (Iilled with aqueous
humour); l ÷ ciliary muscle; m ÷ lens; n ÷ suspensory ligament; o ÷
vitreous humour; p ÷ Iovea
the neural cable Irom the eye to the
brain called the optic nerve, and
which can lead to a loss oI vision.
|7|
In most cases oI glaucoma, typically
called primarv open-angle
glaucoma, the outIlow does not
happen normally but doctors can not
see what is causing the blockage;
with PEX, however, the Ilakes are
believed to be a cause oI the
blockage.
|7|
PEX Ilakes by
themselves do not directly cause
glaucoma, but can cause glaucoma
indirectly by blocking the outIlow oI
aqueous humor, which leads to
higher intraocular pressure, and this
can cause glaucoma.
|4|
PEX has been
known to cause a weakening oI
structures within the eye which help
hold the eye's lens in place, called
lens zonules.
|2|
Diagnosis
PEX is usually diagnosed by an eye
doctor who examines the eye using a microscope. The method is termed slit lamp examination and it is
done with an "85° sensitivity rate and a 100° speciIicity rate."
|4|
Since the symptom oI increased
pressure within the eye is generally painless until the condition becomes rather advanced, it is possible
Ior people aIIlicted with glaucoma to be in danger yet not be aware oI it.
|7|
As a result, it is
recommended that persons have regular eye examinations to have their levels oI intraocular pressure
measured, so that treatments can be prescribed beIore there is any serious damage to the optic nerve and
subsequent loss oI vision.
|7|
Causes
The cause or etiology oI pseudoexIoliation glaucoma is generally unknown.
|7||4||2|
PEX is generally believed to be a systemic disorder,
|4||6||2|
possibly oI the basement membrane oI the
eye.
|2|
Researchers have noticed deposits oI PEX material in various parts oI the body, including in the
skin, heart, lungs, liver, kidneys, and elsewhere.
|6|
Nevertheless, what is puzzling is that PEX tends to
happen in only one eye Iirst, which scientists call unilateralitv,
|2|
and in some cases, gradually aIIlicts
the other eye, which is termed bilateralitv.
|9||4|
According to this reasoning, iI PEX were a systemic
disorder, then both eyes should be aIIected at the same time, but they are not.
|9|
There are contrasting
reports about the extent and speed with which PEX moves Irom one eye to both eyes. According to one
report, PEX develops in the second eye in 40° oI cases.
|4|
A contrasting report was that PEX can be
Page 3 of 9 Pseudoexfoliation syndrome - Wikipedia, the free encyclopedia
4/15/2013 http://en.wikipedia.org/wiki/Pseudoexfoliation_syndrome
Iound in both eyes in almost all situations iI an electron microscope is used to examine the second eye,
or iI a biopsy oI the conjunctiva was done, but that the extent oI PEX is the second eye was much less
than the Iirst one.
|4|
A diIIerent report suggested that two thirds oI PEX patients had Ilakes in only one
eye.
|12||9|
In one long term study, patients with PEX in only one eye were studied, and it was Iound that
over time, 13° progressed to having both eyes aIIlicted by PEX.
|9|
Scientists believe that elevated levels
oI plasma homocysteine are a risk Iactor Ior cardiovascular disease,
|4|
and two studies have Iound higher
levels oI plasma homocysteine in PEX patients,
|13|
or elevated homocysteine concentrations in tear
Iluids produced by the eye.
|14|
There is speculation that PEX may be caused by oxidative damage and the presence oI free radicals,
although the exact nature oI how this might happen is still under study.
|4|
Studies oI PEX patients have
Iound a decrease in the concentrations oI ascorbic acid,
|15|
increase in concentrations oI
malondialdehyde,
|16|
and an increase in concentrations oI 8-iso-prostaglandinF2a.
|17|
There is speculation that genetics may play a role in PEX.
|4||6|
A predisposition to develop PEX later in
liIe may be an inherited characteristic, according to one account.
|4|
One report suggested the genetic
component was "strong".
|1|
One study perIormed in Iceland and Sweden has associated PEX with
polymorphisms in gene LOXL1.
|5|
A report suggested that a speciIic gene named LOXL1 which was a
member oI the Iamily oI enzymes which play a role in the linking oI collagen and elastin inside cells.
LOXL1 was responsible Ior "all the heritability" oI PEX, according to one source.
|6|
Two distinct
mutations in which a single nucleotide was changed, or called a single nucleotide polvmorphism or SNP,
was discovered in Scandinavian populations and conIirmed in other populations, and may be involved
with the onset oI PEX.
|6|
The gene is called LOXL1 ... Because pseudoexIoliation syndrome is associated with
abnormalities oI the extracellular matrix and the basement membrane, this gene could
reasonably play a role in the pathophysiology oI the condition.
Dr. Allingham
|6|
Researchers are investigating whether Iactors such as exposure to ultraviolet light, living in northern
latitudes, or altitude inIluence the onset oI PEX.
|4|
One report suggested that climate was not a Iactor
related to PEX.
|4|
Another report suggested a possible link to sunlight as well as a possible autoimmune
response, or possibly a virus.
|1|
Prevalence
Scientists are studying diIIerent populations and relationships to try to learn more about the disease.
They have Iound associations with diIIerent groups but it is not yet clear what the underlying Iactors are
and how they aIIect diIIerent peoples around the world.
Ŷ Glaucoma patients. While PEX and glaucoma are believed to be related, there are cases oI
persons with PEX without glaucoma, and persons with glaucoma without PEX.
|4|
Generally, a
person with PEX is considered as having a risk oI developing glaucoma, and vice versa. One
study suggested that the PEX was present in 12° oI glaucoma patients.
|4||18|
Another Iound that
PEX was present in 6° oI an "open-angle glaucoma" group.
|19|
PseudoexIoliation syndrome is
Page 4 of 9 Pseudoexfoliation syndrome - Wikipedia, the free encyclopedia
4/15/2013 http://en.wikipedia.org/wiki/Pseudoexfoliation_syndrome
PEX is more prevalent in regions such as Scandinavia but it
is not clearly understood why this is the case. In picture: a
scene Irom western Norway.
considered to be the most common oI identiIiable causes oI glaucoma.
|5|
II PEX is diagnosed
without glaucoma, there is a high risk oI a patient subsequently developing glaucoma.
|3|
Ŷ Country and region. Prevalence oI
PEX varies by geography. In Europe,
diIIering levels oI PEX were Iound;
5° in England, 6° in Norway, 4° in
Germany, 1° in Greece, and 6° in
France.
|4|
One contrary report
suggested that levels oI PEX were
higher among Greek people.
|20|
One
study oI a county in Minnesota Iound
that the prevalence oI PEX was 25.9
cases per 100,000 people.
|21|
It is
reportedly high in northern European
countries such as Norway, Sweden and Finland,
|2|
as well as among the Sami people oI northern
Europe, and high among Arabic populations,
|22||23|
but relatively rare among AIrican Americans
and Eskimos. In southern AIrica, prevalence was Iound to be 19° oI patients in a glaucoma clinic
attending to persons oI the Bantu tribes.
|24|
Ŷ Race. It varies considerably according to race.
|4|
Ŷ Gender. It aIIects women more than men. One report was that women were three times more
likely than men to develop PEX.
|4||25|
Ŷ Age. Older persons are more likely to develop PEX.
|4||2|
And persons younger than 50 are highly
unlikely to have PEX. A study in Norway Iound that the prevalence oI PEX oI persons aged 50
59 was 0.4° while it was 7.9° Ior persons aged 8089 years.
|26|
II a person is going to develop
PEX, the average age in which this will happen is between 69 to 75 years, according to the
Norwegian study.
|4|
A second corroborating report suggested that it happens primarily to people
70 and older.
|2|
While older people are more likely to develop PEX, it is not seen as a "normal"
part oI aging.
|4|
Ŷ Other diseases. Sometimes PEX is associated with the development oI medical problems other
than merely glaucoma. There are conIlicting reports about whether PEX is associated with
problems oI the heart or brain; one study suggested no correlations
|27|
while other studies Iound
statistical links with Alzheimer's disease, senile dementia, cerebral atrophy, chronic cerebral
ischemia, stroke, transient ischemic attacks, heart disease, and hearing loss.
|4|
Treatment
While PEX itselI is untreatable as oI 2011, it is possible Ior
doctors to minimize the damage to vision and to the optic nerves
by the same medical techniques used to prevent glaucoma.
Ŷ Eyedrops. This is usually the Iirst treatment method.
Eyedrops can help reduce intraocular pressure within the
Page 5 of 9 Pseudoexfoliation syndrome - Wikipedia, the free encyclopedia
4/15/2013 http://en.wikipedia.org/wiki/Pseudoexfoliation_syndrome
Conventional surgery to treat
glaucoma makes a new opening in the
meshwork. This new opening helps
Iluid to leave the eye and lowers
intraocular pressure.
In a surgical procedure called
trabectome, the trabecular meshwork
is removed to help glaucoma patients.
eye.
|7|
The medications within the eyedrops can include
beta blockers (such as levobunolol or timolol) which slow
the production oI the aqueous humor.
|7|
And other
medications can increase its outIlow, such as prostaglandin
analogues (e.g. latanoprost).
|7|
And these medicines can be
used in various combinations.
|7|
In most cases oI
glaucoma, eyedrops alone will suIIice to solve the
problem.
Ŷ Laser surgery. A Iurther treatment is a type oI laser
therapy known as trabeculoplasty in which a high-energy
laser beam is pointed at the trabecular meshwork to cause
it to "remodel and open" and improve the outIlows oI the
aqueous humor. These can be done as an outpatient
procedure and take less than twenty minutes. One report
suggests this procedure is usually eIIective.
|2|
Ŷ Eye surgery. Surgery is the treatment method oI last resort
iI the other methods have not worked. It is usually
eIIective at preventing glaucoma.
|2|
Eye surgery on PEX
patients can be subject to medical complications iI the
Iibers which hold the lens have become weakened because
oI a buildup Irom the Ilakes; iI the lens-holding Iibers have
weakened, then the lens may become loose, and
complications Irom eye surgery may result.
|7|
In such
cases, it is recommended that surgeons act quickly to
repair the phacodonesis beIore the lenses have dropped.
|28|
A surgeon cuts an opening in the white portion oI the eye
known as the sclera, and removes a tiny area oI the
trabecular meshwork which enables the aqueous humor to discharge.
|7|
This lowers the internal
pressure within the eye and lessens the chance oI Iuture damage to the optic nerve.
|7|
Cases with
pseudophacodonesis and dislocated IOL have been increasing in number, according to one report.
|28|
In cataract surgery, complications resulting Irom PEX include capsular rupture and vitreous
loss.
|2|
Ŷ Drug therapy. There are speculations that iI genetics plays a role in PEX, and iI the speciIic
genes involved can be identiIied, that possibly drugs can be developed to counteract these
mutations or their eIIects.
|6|
But such drugs have not been developed as oI 2011.
Patients should continue to have regular eye examinations so that physicians can monitor pressure levels
and check whether medicines are working.
Research
Scientists and doctors are actively exploring how PEX happens, its causes, and how it might be
prevented or mitigated. Research activity to explore what causes glaucoma has been characterized as
"intense".
|7|
There has been research into the genetic basis oI PEX. One researcher speculated about a
Page 6 of 9 Pseudoexfoliation syndrome - Wikipedia, the free encyclopedia
4/15/2013 http://en.wikipedia.org/wiki/Pseudoexfoliation_syndrome
possible "two-hit hypothesis" in which a single mutation in the LOXL1 gene puts people at risk Ior
PEX, but that a second still-to-be-Iound mutation has some eIIect on the proteins, possibly aIIecting
bonds between chemicals, such that the proteins are more likely to clump together and disrupt the
outIlow oI aqueous humor.
|6|
Alternative names
Ŷ ExIoliation glaucoma; XFG
Ŷ PseudoexIoliation glaucoma
Ŷ PseudoexIoliation oI the lens
Ŷ ExIoliation syndrome; XFS
References
1. `
D E F
"Glaucoma In-Depth Report" (http://health.nytimes.com/health/guides/disease/glaucoma/print.html).
The New York Times. 2011-07-09. Retrieved 2011-07-09. "PseudoexIoliation (PEX) syndrome ... The
substance is composed oI proteins produced by the lens, iris, and other parts oI the eye. People can have this
condition and not develop glaucoma, but they are at high risk."
2. `
D E F G H I J K L M N O P Q R S
Yichieh Shiuey, MD (March 26, 1997). "Glaucoma Quiz
1" (http://www.djo.harvard.edu/print.php?url÷/physicians/kr/466&print÷1). Digital Journal of
Ophthalmologv. Retrieved 2011-08-21. "... In Scandinavia, this condition represents greater than 50° oI all
cases oI open angle glaucoma."
3. `
D E F
"Glaucoma" (http://health.nytimes.com/health/guides/disease/glaucoma/causes.html). The New York
Times. 2011-08-19. Retrieved 2011-08-19. "... PseudoexIoliation (PEX) syndrome (also known as exIoliation
syndrome) is the most common identiIiable condition associated with glaucoma. The substance is composed
oI proteins produced by the lens, iris, and other parts oI the eye."
4. `
D E F G H I J K L M N O P Q R S T U V W X Y Z [ \ ] DD DE DF DG DH DI DJ
Mauricio E Pons, MD; ChieI Editor: Hampton Roy Sr,
MD; contributing authors: Babak Eliassi-Rad, MD; BradIord Shingleton, MD; Simon K Law, MD, PharmD
(Aug 4, 2011). "PseudoexIoliation Glaucoma" (http://emedicine.medscape.com/article/1206366-overview).
Medscape. Retrieved 2011-08-15.
5. `
D E F G H
Damji, Karim F. (October 2007). "Progress in understanding pseudoexIoliation syndrome and
pseudoexIoliation-associated glaucoma" (http://pubservices.nrc-cnrc.ca/rp-ps/absres.jsp?jcode÷cjo&Itl÷i07-
158&lang÷eng). Canadian Journal of Ophthalmologv 42 (5): 657658. doi:10.3129/I07-158
(http://dx.doi.org/10.3129°2FI07-158). PMID 17891191 (//www.ncbi.nlm.nih.gov/pubmed/17891191).
Retrieved 2009-04-19.
6. `
D E F G H I J K L M N
Tony Realini, M.D. "A new gene Ior
pseudoexIoliation" (http://www.eyeworld.org/article.php?sid÷4670). EveWorld. Retrieved 2011-08-05. "A
new gene deIect has been Iound that accounts Ior essentially all the heritability oI pseudoexIoliation
syndrome."
7. `
D E F G H I J K L M N O P Q R S T
Arthur J. Sit, MD, ophthalmology, Mayo Clinic, Rochester, Minn. (April 23,
2006). "Many types oI glaucoma, one kind oI damage to optic
nerve" (http://articles.chicagotribune.com/2006-04-23/Ieatures/0604230427¸1¸aqueous-humor-glaucoma-
optic-nerve). Chicago Tribune. Retrieved 2011-08-15. "Glaucoma ... Because elevated intraocular pressure
(IOP) is the most important risk Iactor Ior glaucoma, most treatments are directed at lowering this pressure."
8. `
D E F
N Demir, T Ulus, O E Yucel, E T Kumral, E Singar and H I Tanboga (June 24, 2011). Assessment of
mvocardial ischaemia using tissue Doppler imaging in pseudoexfoliation svndrome
(http://www.nature.com/eye/journal/vaop/ncurrent/Iull/eye2011145a.html). doi:10.1038/eye.2011.145
(http://dx.doi.org/10.1038°2Feye.2011.145). Retrieved 2011-08-15.
Page 7 of 9 Pseudoexfoliation syndrome - Wikipedia, the free encyclopedia
4/15/2013 http://en.wikipedia.org/wiki/Pseudoexfoliation_syndrome
9. `
D E F G H
M Citirik, G Acaroglu, C Batman, L Yildiran and O Zilelioglu. A possible link between the
pseudoexfoliation svndrome and coronarv arterv disease
(http://www.nature.com/eye/journal/v21/n1/Iull/6702177a.html) 21 (1). doi:10.1038/sj.eye.6702177
(http://dx.doi.org/10.1038°2Fsj.eye.6702177). Retrieved 2011-08-15.
10. ^ Mizuno K, Murois S (1979). "Cycloscopy oI pseudoexIoliation". Am J Ophthalmol 87 (4): 513.
PMID 443315 (//www.ncbi.nlm.nih.gov/pubmed/443315).
11. ^ "Data Irom E. Viso and colleagues advance knowledge in exIoliation syndrome epidemiology." Biotech
Week. NewsRX. 2010. 12 Sep. 2012, Highbeam Research article (http://www.highbeam.com/doc/1G1-
224605737.html) Quote÷An abnormal ocular surIace detected by rose bengal staining is highly prevalent
among subjects with pseudoexIoliation.
12. ^ Henry JC, Kruptin T, Schmitt M, LauIIer J, Miller E, Ewing MQ et al. (1987). "Long-term Iollow-up oI
pseudoexIoliation and the development oI elevated intraocular pressure". Ophthalmologv 94 (5): 545552.
PMID 3601370 (//www.ncbi.nlm.nih.gov/pubmed/3601370).
13. ^ Vessani RM, Ritch R, Liebmann JM, JoIe M (2003). "Plasma homocysteine is elevated in patients with
exIoliation syndrome". Am J Ophthalmol 136 (1): 416. PMID 12834668
(//www.ncbi.nlm.nih.gov/pubmed/12834668).
14. ^ Roedl JB, Bleich S, Reulbach U, Rejdak R, Kornhuber J, Kruse FE et al. (2007). "Homocysteine in tear
Iluid oI patients with pseudoexIoliation glaucoma". J Glaucoma 16 (2): 2349.
doi:10.1097/IJG.0b013e31802d6942 (http://dx.doi.org/10.1097°2FIJG.0b013e31802d6942).
PMID 17473737 (//www.ncbi.nlm.nih.gov/pubmed/17473737).
15. ^ Koliakos GG, Konstas AG, Schlotzer-Schrehardt U, BuIidis T, Georgiadis N, Ringvold A (December
2002). "Ascorbic acid concentration is reduced in the aqueous humor oI patients with exIoliation syndrome".
Am J Ophthalmol 134 (6): 87983. PMID 12470757 (//www.ncbi.nlm.nih.gov/pubmed/12470757).
16. ^ Yimaz A, Adiguzel U, Tamer L, Yildirim O, Oz O, Vatansever H (February 2005). "Serum
oxidant/antioxidant balance in exIoliation syndrome". Clin Experiment Ophthalmol 33 (1): 636.
doi:10.1111/j.1442-9071.2005.00944.x (http://dx.doi.org/10.1111°2Fj.1442-9071.2005.00944.x).
PMID 15670081 (//www.ncbi.nlm.nih.gov/pubmed/15670081).
17. ^ Koliakos GG, Konstas AG, Schlötzer-Schrehardt U, Hollo G, Katsimbris IE, Georgiadis N. "8-
Isoprostaglandin F2a and ascorbic acid concentration in the aqueous humour oI patients with exIoliation
syndrome". Br J Ophthalmol 87 (3): 3536. doi:10.1136/bjo.87.3.353 (http://dx.doi.org/10.1136°
2Fbjo.87.3.353).
18. ^ Roth M, Epstein DL (1980). "ExIoliation syndrome". Am J Ophthalmol 89 (4): 47781. PMID 7369310
(//www.ncbi.nlm.nih.gov/pubmed/7369310).
19. ^ Cashwell LF Jr, Shields MB (1988). "ExIoliation syndrome in the southeastern United States. I. Prevalence
in open-angle glaucoma and non-glaucoma populations". Acta Ophthalmol Suppl 184: 99102.
PMID 2853929 (//www.ncbi.nlm.nih.gov/pubmed/2853929).
20. ^ "Greek population has higher prevalence oI
pseudoexIoliation" (http://www.bioportIolio.com/news/article/617540/Greek-Population-Has-Higher-
Prevalence-OI-PseudoexIoliation.html). BioPortfolio. April 15, 2011. Retrieved 2011-08-15.
"PseudoexIoliation was Iound to be more prevalent in Greece than in other white populations,"
21. ^ Karger RA, Jeng SM, Johnson DH, Hodge DO, Good MS (2003). "Estimated incidence oI
pseudoexIoliation syndrome and pseudoexIoliation glaucoma in Olmsted County, Minnesota". J Glaucoma
12 (3): 1937. PMID 12782834 (//www.ncbi.nlm.nih.gov/pubmed/12782834).
22. ^ Summanen P, Tönjum AM (1988). "ExIoliation syndrome among Saudis". Acta Ophthalmol Suppl 184:
10711. PMID 2853905 (//www.ncbi.nlm.nih.gov/pubmed/2853905).
23. ^ Bialasiewicz AA, Wali U, Shenoy R, Al-Saeidi R (2005). "Patients with secondary open-angle glaucoma
in pseudoexIoliation (PEX) syndrome among a population with high prevalence oI PEX. Clinical Iindings
and morphological and surgical characteristics". Ophthalmologe 102 (11): 10648. doi:10.1007/s00347-005-
1226-2 (http://dx.doi.org/10.1007°2Fs00347-005-1226-2). PMID 15871021
(//www.ncbi.nlm.nih.gov/pubmed/15871021).
24. ^ Bartholomew RS (1973). "Pseudocapsular exIoliation in the Bantu oI South AIrica. II. Occurrence and
prevalence" (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1214820). Br J Ophthalmol 57 (1): 415.
PMC 1214820 (//www.ncbi.nlm.nih.gov/pmc/articles/PMC1214820). PMID 4705496
(//www.ncbi.nlm.nih.gov/pubmed/4705496).
Page 8 of 9 Pseudoexfoliation syndrome - Wikipedia, the free encyclopedia
4/15/2013 http://en.wikipedia.org/wiki/Pseudoexfoliation_syndrome
25. ^ Kozart DM, YanoII M (1982). "Intraocular pressure status in 100 consecutive patients with exIoliation
syndrome". Ophthalmologv 89 (3): 2148. PMID 7088504 (//www.ncbi.nlm.nih.gov/pubmed/7088504).
26. ^ Aasved H (1971). "Mass screening Ior Iibrillopathia epitheliocapsularis, so-called senile exIoliation or
pseudoexIoliation oI the anterior lens capsule". Acta Ophthalmol (Copenh). 49 (2): 33443.
doi:10.1111/j.1755-3768.1971.tb00958.x (http://dx.doi.org/10.1111°2Fj.1755-3768.1971.tb00958.x).
PMID 5109796 (//www.ncbi.nlm.nih.gov/pubmed/5109796).
27. ^ Shrum KR, Hattenhauer MG, Hodge D (2000). "Cardiovascular and cerebrovascular mortality associated
with ocular pseudoexIoliation". Am J Ophthalmol 129 (1): 836. doi:10.1016/S0002-9394(99)00255-X
(http://dx.doi.org/10.1016°2FS0002-9394°2899°2900255-X). PMID 10653417
(//www.ncbi.nlm.nih.gov/pubmed/10653417).
28. `
D E
Rich Daly. "PseudoexIoliation syndrome`s surgical challenge" (http://www.eyeworld.org/article.php?
sid÷2442&strict÷&morphologic÷&query÷implant). EveWorld. Retrieved 2011-08-21. "... Dr. Crandall urges
surgeons to probe Ior such changes early because it is surgically much easier to repair the phacodonesis
beIore the lenses have dropped."
Retrieved Irom "http://en.wikipedia.org/w/index.php?
title÷PseudoexIoliation¸syndrome&oldid÷543421276"
Categories: Diseases oI the eye and adnexa
Ŷ This page was last modiIied on 11 March 2013 at 13:35.
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Page 9 of 9 Pseudoexfoliation syndrome - Wikipedia, the free encyclopedia
4/15/2013 http://en.wikipedia.org/wiki/Pseudoexfoliation_syndrome
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Glaucoma shares a number of features with
degenerative brain diseases such as Alzheimer's,
Parkinson's, and Lou Gehrig's disease. Ìn all of these
diseases, age and family history are significant risk
factors, and specific areas of the brain are damaged
over time. Ìn glaucoma, the only difference is that the "specific area of the brain¨ affected is the eye
and optic nerve!
Ìndeed the eye's retina and optic nerve are a part of the brain: during early development, a small part
of the brain pouches out and becomes the retina and optic nerve. Ìnside the eye, a group of neurons
called retinal ganglion cells collect all of the visual information and pass it down their extensions,
called axons, through the optic nerve and back to the rest of the brain. The ganglion cell, which
collects all the vision information from the other retinal cells, is the one type of cell that is initially
damaged by glaucoma.
The optic nerve continues to be a major focus for researching the underlying causes of glaucoma.
Whether due to mechanical trauma, decreased blood flow, or other causes, optic nerve axon injury
causes changes in retinal ganglion cells, eventually causing cell death. Researchers have observed
that specific areas of injured optic nerve axons and retinal ganglion cell loss match the peripheral
vision damage from glaucoma.
Because the retinal ganglion cell axon stretches from the
retina through the optic nerve to the brain, its surrounding
cells also become damaged by glaucoma. Within the retina,
other cells, such as amacrine cells, degenerate and rewire
their connections after retinal ganglion cells are lost.
There are also changes in the brain within the lateral
geniculate nucleus (the main brain target of optic nerve
axons), and even the visual cortex, which is the part of the
brain that helps us interpret visual information.
Page 1 of 2 Glaucoma and the Brain [ Glaucoma Research Foundation
6/22/2013 http://www.glaucoma.org/glaucoma/glaucoma-and-the-brain.php
251 Post Street, Suite 600
San Francisco, CA94108
(415) 986-3162
(800) 826-6693
Thus, in addition to treatments directed at lowering eye pressure, still the mainstay of glaucoma
therapy, there may be opportunities to develop treatments directed at the retina and the brain. Some
promising treatments that promote nerve health, called neurotrophic factors, could help at multiple
places in the visual pathway.
For example, neurotrophic factors such as ciliary neurotrophic factor (CNTF) may keep retinal
ganglion cells from dying, a process called neuroprotection; they may increase axon regrowth down
the optic nerve, called regeneration; and they may improve the support between the dying retinal
ganglion cells and their surrounding cells in the retina and brain, called neuroenhancement.
The understanding that one key to glaucoma is in the connections within the retina and to the brain
has led to exciting advances in research that may well lead to new potential treatments.
--
Article by Jeffrey L. Goldberg, MD, PhD, Associate Professor of Ophthalmology at
the Bascom Palmer Eye Ìnstitute.
Last reviewed on January 15, 2013
Glaucoma Research Foundation
www.glaucoma.org
This articIe appeared in the September 2010 issue of GIeams.
Page 2 of 2 Glaucoma and the Brain [ Glaucoma Research Foundation
6/22/2013 http://www.glaucoma.org/glaucoma/glaucoma-and-the-brain.php
Subj: UofM_Wright_Rice_Tanaube_Tani_Schwartz
Date: 3/14/2013 4:25:20 P.M. Central Daylight Time
From: Sharon4Anderson@aol.com
To: sharon4anderson@aol.com
CC: elisak10@umphysicans.umn.edu
Page 1 of 4
Thursday, March 14, 2013 AOL: Sharon4Anderson
Thurs 14Mar2013
Request4Records in their Entirety of Sharon Anderson's Eye's
How to Contact Dr. Tani
Tani Eye Associates and CIinics
17 Exchange St W Suite 200
Saint PauI, MN 55102
(651) 227-8275 (Office) Fax 651-298-0160
Map & Directions ·
Affiant_CIient re: Your Recommendations GIacoma SpeciaIist
Dr. PauI M. Tani, MD has admitting priviIeges at United HospitaI
Records are Extensive Affiant gives Permission to Dr. Tani to request
aII Records in this Matter from the Various Persons.
TRANSPORTATION IS MAJOR ISSUE
THEREFORE: Affiant Sharon Anderson aka Peterson_ScarreIIa caIIed
Associated Eye Care re: CarI Tubbs http://www.associatedeyecare.com/
280 Smith Ave N Suite 840
LocaI: 651-275-3000 Fax 651-275-3032 Contact Lisa Appt. Made with Gary S. Schwartz MD at the St.
PauI Office Wed. 3Apr2013 DISCLAIMER: Tubbs does not go to St.PauI Office.
ToII Free: 800-846-1877
LASIK: 888-466-2020
OpticaI: 651-275-3000
Saint PauI, MN 55102
Map & Directions :
Carl B. Tubbs, M.D.
SpeciaIties:
Comprehensive Ophthalmology Glaucoma Surgery
Cat
aract Surgery
Gary S. Schwartz, M.D.
SpeciaIties:
Comprehensive Ophthalmology Refractive Surgery
Cataract Surgery
Thomas J. Rice, MD (651)738-6500 or (800) 727-2279
Board-Certified OphthaImoIogist
'I enjoy the large range of ages of my patients and the positive impact
on quality of life for my patients. I also enjoy the rapidly expanding
technologies and positive patient interactions. I am open and
compassionate, and I take time to relieve patients' fears and
apprehensions. I believe eyecare should be fun for patients. I believe
they should receive high-quality care and a sense of being taken care
of. Seeing my patients become more at ease and no longer strictly
focusing on their medical problems but more on the normal things in
their lives is most gratifying for me."
In his spare time, Dr. Rice enjoys spending time with his famiIy,
hunting, outdoor sports, goIf, hockey and gourmet cooking (wiId game).
Board-Certified :: American Board of OphthaImoIogy, LASIK-Certified,
VISX®-Certified
Residency :: OphthaImoIogy, University of Minnesota HospitaI and
CIinics, MinneapoIis, MN
Internship :: Hennepin County MedicaI Center, MinneapoIis, MN
MedicaI Degree :: University of Minnesota MedicaI SchooI, MinneapoIis, MN
Graduate schooI :: MicrobioIogy, University of North Dakota, Grand Forks, ND
BacheIor of Arts :: St. Mary's CoIIege, Winona, MN
Member :: American MedicaI Association, American Society of Cataract and Refractive Surgery,
Minnesota Academy of OphthaImoIogy, Minnesota MedicaI Association, Ramsey MedicaI Society
Licensed :: Minnesota, Wisconsin CHRONOLOGY:
On or about 12May2012 hDan A. Nichols, MD
Board-Certified Ophthalmologist
"I've had a long-time interest in perception and neuroscience going back to
college. That combined with the powerful therapeutic potential of ophthalmic
surgery is what interested me in this field. The eye is the most fascinating
organ in the body. I'm still excited and amazed as I view the eye under the
microscope. I also enjoy the broad range of people I meet each day in the
office; everyone eventually needs eyecare. I am analytical and
problem/solution-oriented. I hope to give my patients a clear understanding of
their problem and how best to proceed. I have a strong academic background
in science and research, and I believe I can help each patient understand the
best solution to his or her problem based on current knowledge."
Board-Certified:: American Board of Ophthalmology
Fellowship:: Glaucoma, Wills Eye Hospital, Philadelphia, PA
Residency:: Ophthalmology, University of Arizona, Tucson, AZ
Ìnternship:: Ìnternal Medicine, Abbott-Northwestern Hospital Department of
Medicine, Minneapolis, MN
Medical Degree:: University of Minnesota Medical School, Minneapolis, MN
Bachelor of Arts:: Child Psychology, University of Minnesota, Minneapolis, MN
Member:: Association for Research in Vision and Ophthalmology, Spaeth Glaucoma Fellow Society, Ramsey
Medical Society, American Society of Cataract & Refractive Surgery
Adjunct Clinical Professor:: University of Minnesota, Department of Ophthalmology
Licensed:: Minnesota, Wisconsin
Author & Lecturer http://www.stpauIeye.com/
Diane S Tanabe | Lufkin Eye CIinic PA | St. PauI, MN | AIIina HeaIth
wellness.allinahealth.org/providers/3261Cached
Diane S Tanabe, MD has sepecial interests in glaucoma, eye implants, eye lid problems, cataract surgery,
blepharoplasty, blepharospasm, cornea, infectious ...
Then Diane S. Tanabe who does not do Cataract , GoogIe Search
Page 2 of 4
Thursday, March 14, 2013 AOL: Sharon4Anderson
pubIish's otherwise.
Surgery Did Lazer Diane Tanabe
Lufkin Eye Clinic, P.A.
S t. Paul
292-8200
From: elisak10@umphysicians.umn.edu
To: Sharon4Anderson@aol.com
Sent: 5/8/2012 5:29:33 P.M. Central Daylight Time
Subj: University of Minnesota Concerns
Hello Sharon
Ì attempted to leave you a voicemail today on your home phone, but regrettably Ì may have been cut
off.
Ì wanted to introduce myself to you as the Patient Relations Manager for UMPhysicians. Ì understand
from speaking to Cathy and Jody in our Opthamology clinic that you have expressed some concerns
to them. Ì wanted to let you know that the best outlet for those concerns is through my department. Ì
would like to request that you write a letter outlining your concerns to me and send it via email or letter
to the address listed at the bottom of this email. Once receiving your letter, Ì will look into the concerns
and provide you a response.
Please know that the best way to schedule and cancel appointments for the Opthamology clinic is
through their scheduling line. The emails to the Opthamology staff are not the appropriate avenue to
schedule, change or express your concerns in the future.
Thank you and Ì look forward to hearing from you.
Esther
Esther Lisak, MBA
Manager of Patient ReIations
University of Minnesota Physicians
Mayo MaiI Code 88
Office: Mayo B-374
420 DeIaware St. SE
MinneapoIis, MN 55455
eIisak10@umphysicians.umn.edu
(612)626-5268 direct
(612) 626-9323 fax
(612)899-9371 pager
**CONFÌDENTÌALÌTY NOTÌCE**
DO NOT READ THÌS EMAÌL ÌF YOU ARE NOT THE ÌNTENDED RECÌPÌENT.
The information in this email may contain confidential and/or
privileged material. Ìf you are not the intended recipient, your
review, forwarding, copying, distribution, or any other use or
disclosure of any information in this email is prohibited. Ìf you
received this email in error, please destroy and delete this message
from any computer and contact us immediately by return email.
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Thursday, March 14, 2013 AOL: Sharon4Anderson
Sharon4Anderson@aoI.com AttorneyProSe_Private AG, ECF 65913 Pacer:sa1299 TeI:
651-776-5835 HEALTH CARE Candidate
MN Attorney GeneraI www.sharon4mnag.bIogspot.com 2014 2012Senate64
www.sharonsenate64.bIogspot.com
http://sharon4anderson.wordpress.com/2012/04/14/judiciaI-corruption-
_sharonscarreIIaanderson_IawIess-america/http://www.pacificIegaI.org/document.doc?
id=608&utm_source=Sentry+-+3%2F21%2F12+HeaIthcare&utm_campaign=3-21-
12+HeaIthcare+SENTRY&utm_medium=emaiIhttp://sbIog.s3.amazonaws.com/wp-
content/upIoads/2012/01/10-1032-bsac-Massachusetts.pdfhttp://sharon-mn-
ecf.bIogspot.com/2007/03/foia-06cv-permission-
to.htmIhttp://mpIs.startribune.com/news/metro/eIections/profiIes/26222.htmIhttp://www.angeIfire.com/pIanet/andersonadvocates/P
http://forums.e-democracy.org/groups/stpaul-issues/files/f/900-2007-02-27T034409Z/WritProA06-
1150_30Jun06.pdfhttp://sharon4anderson.wordpress.com/2009/09/23/google-lawmen-cases-mn-
62cv09-1163/
POA
http://www.angeIfire.com/mn3/andersonadvocates/2006water/PDFcorr/SADPA4172006.pdfhttp://wethepeopIeusa.ning.com/profiIe/SharonScarre
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