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University of Vermont Department of Medical Laboratory and Radiation Sciences (www.uvm.edu/mlrs) MLRS 242, Principles of Immunology, Course Syllabus, Spring 2014 Course Description Lecture course dealing with cells, organs, development, interactions and the functioning (infectious process, immunodeficiency, immunity, hypersensitivity reactions, transplantation and tumor immunology) of the innate and the adaptive immune system Prerequisite: one semester of biochemistry. Lecture: T, Th 8:30 – 9:45am Place: Room 118, Rowell Building Professor: Eyal Amiel, Ph.D. Contact: email@example.com, Office: Rowell 302A, (802) 656-0522 Textbook (required): “Kuby Immunology” Owen, Punt, and Stranford, W H Freeman and Company, 7th Edition, 2013 (ISBN-10: 1-4292-1919-X / ISBN-13: 978-14292-1919-8) General Course Goals:
1. Understanding of the origins of immunology as a discrete medical science. 2. Appreciation of the distinct roles and functions of the innate and adaptive immune systems. 3. Knowledge of the origin, relationships and functions of the cells involved in immunity. 4. Knowledge of the structure and composition of antigens. 5. Knowledge of the structure and composition of antibodies, including their diversity. 6. Knowledge of the structure and function of T- and B- lymphocytes. 7. Understanding of the immunological basis for inflammation, hypersensitivity, immunizations, immunodeficiency, autoimmunity, transplant rejections, and the response to cancer. 8. Understanding of the clinical applications of immunological principles in the diagnosis and treatment of various disease states.
Blackboard This course utilizes Blackboard. Lectures outlines and other course material will be available online. Professional Course Designation MLRS 242 is a required course in the Medical Laboratory Science curriculum and as such is considered a “Professional Course”. As a professional course in the MLS and NMT curriculum, it is required for graduation and attendance is required. Students must obtain a grade of C or above. Please review the academic scholarship policy of the department with your advisor if you have any questions about your academic/professional status. Make-up/Missed Work Policy It is solely the student’s responsibility to make-up missed work, acquire handouts/assignments from missed lectures, and to turn in assignments by their due date. If
you are sick or have to miss a session, it is your responsibility to notify the course instructor. At least 24-hour notice prior to assignment deadline is required for the opportunity to makeup an assignment for full credit. Only excused medical absences will allow for making up exams. Other excuses for missed exams are not guaranteed consideration and will be handled on a case-by-case basis at the discretion of the instructor. Class Participation I expect you to actively participate in class. Participation is expected in terms of answering questions during lecture and group activities that will be assigned during most class sessions. Take-home quizzes will consist of study questions that I have provided for the lecture topics based on the textbook reading assignment. You will be expected to have completed these study questions prior to the lecture to be turned in at the beginning of class according to due dates outlined in the syllabus schedule. ! Grading The grading breakdown for the course is as follows: 4 Unit Exams (lowest score dropped) 20% each, 60% of Final Course Grade Take-home Quizzes 10% of Final Course Grade Journal Discussion and Reports 10% of Final Course Grade Cumulative Final Exam 15% of Final Course Grade Class Participation 5% of Final Course Grade The Unit Exams will include different types of questions (e.g., multiple choice, true/false, matching, and short answer). The Final Exam is cumulative and will cover major themes from the entire course. Weekly Take-home Quizzes will be due according to the Syllabus and Blackboard communications. Journal Discussion and Reports will be explained in more detail as the semester progresses. Grading Scale: The following numerical scale will be used to assign letter grades. 90-92 A80-82 B70-72 C60-62 D<60 F 93-96 A 83-86 B 73-76 C 63-66 D 97-100 A+ 87-89 B+ 77-79 C+ 67-69 D+
Course Evaluation A mandatory, anonymous, on-line course evaluation must be completed by each student at the end of the course before grades are submitted. Reference to UVM’s Learning Cooperative’s offerings Religious Holidays: All students at UVM have the right to practice the religion of their
choice. If you wish to observe any religious holiday(s) during the semester, you should submit a written request to me by the end of the Add/Drop period. You can make up any class work missed as a result of a religious holiday observance. Name Used in Class: The official UVM roster uses a student’s legal name (preferred). If you wish to be addressed by a different name you should let us know. Conduct in Classroom: Students are expected to treat others with respect in the classroom. Those who engage in behavior that disrupts a classroom may be subject to disciplinary action under the Code of Student Rights & Responsibilities. http://www.uvm.edu/~uvmppg/ppg/student/studentcode.pdf Disruptive classroom conduct means engaging in behavior that substantially or repeatedly interrupts either the instructor’s ability to teach or student learning. Academic Integrity: The concepts of academic integrity apply to this course. This means that all work turned in under your name, including case studies and exams must be the product of your own work or else appropriately referenced. Copying the work of others without permission or without identifying it as someone else's work is plagiarism and is a violation of academic honesty. Unless specifically noted, all work should be your own. Code of Academic Integrity: All academic work must conform to the UVM Code of Academic Integrity. http://www.uvm.edu/~uvmppg/ppg/student/acadintegrity.pdf. Violations may be in any of the following categories: plagiarism, fabrication, collusion or cheating. Any student, member of the University staff, or faculty may report any perceived violation of this Code to the Center for Student Ethics and Standards. Charges will be heard by the Academic Integrity Council. Sanctions may range from a letter of warning to dismissal from the University. Reasonable accommodation for learning disabilities: In keeping with University of
Vermont policy, any student with a documented disability interested in utilizing accommodations should contact ACCESS, the office of Disability Services on campus. ACCESS works with students to create reasonable and appropriate accommodations via an accommodation letter to their professors as early as possible each semester. Contact ACCESS: A170 Living/Learning Center; 802-656-7753; firstname.lastname@example.org; or www.uvm.edu/access.
MLRS 242 Tentative Schedule: Principles of Immunology, Spring 2014
Class 1 DATE TOPIC CHAPTER Unit I: Basic Principles of Immunology; Barrier and Innate Immunity Syllabus; Course Expectations; Introduction 1, 2, Quiz Due 2 5, Quiz Due 4 8, Quiz Due Report Due 1,2, 4, 5, and 8 3 7, Quiz Due 9 11, Quiz Due 13 (pgs. 427-48) 3, 7, 9, 11, 13 Report Due 10 12, Quiz Due 13 (pgs. 41526); 6, 14 15, Quiz Due Report Due 6, 10, 12, 13, 14, and 15 16
Overview of the Immune System 2 Cells and Organs of the Immune System Innate Immunity Cytokines and Chemokines 3 Antigen Presentation and Review Journal Discussion (Papers on Blackboard) 4 Exam#1 Unit II: Adaptive Immune Response (T Lymphocytes) B and T Cell Receptors 5 Lymphocyte Receptor Genes T Cell Development 6 T Activation, Differentiation and Memory Effector Responses: Cell-mediated Immunity 7 Exam#2 Journal Discussion (Papers on Blackboard) 8 B Cell Development B Activation, Differentiation and Memory Unit III: Adaptive Immune Response (B Lymphocytes) 9 Effector Responses: Ab-mediated Immunity; The Complement System The Immune Response in Space and Time 10 Allergy, Hypersensitivity, Chronic Inflammation; Immunoelectrophoresis Journal Discussion (Papers on Blackboard) 11 Exam#3 Tolerance Autoimmunity, Transplantation Unit IV: Applied Immunology 12 Infectious Disease and Vaccines Immunodeficiency Disorders 13 Cancer and the Immune System Experimental Systems and Methods 14 Exam#4 Journal Discussion (Papers on Blackboard) Cumulative Final Exam – Take Home
17, Quiz Due 18 19, Quiz Due 20, Quiz Due 16, 17, 18, 19 and 20 Report Due