Principle of protection of Alcohol, Carbonyl & Carboxyl group

VIRENDRA SINGH; MSc. (FINAL) 9/2/2013

In many preparations of delicate organic compounds, some specific parts of their molecules cannot survive the required reagents or chemical environments. Then, these parts, or groups, must be protected.

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ABSTRACT INTRODUCTION PRINCIPLE OF PROTECTING GROUP LIST OF P.G FOR ALL F.G. PROTECTION OF ALCOHOLS ETHER PROTECTING GROUP FOR ALC. ESTER PROTECTING GROUPS FOR ALC. ACETAL PROTECTING GROUP OF ALC. PROTECTION OF CARBOXYLIC ACIDS PROTECTION OF AMINES AMIDE PROTECTIVE GROUP OF AMINES CARBAMATE PROTECTIVE GROUP FOR AMINES SYNTHETIC TOOLBOX:OVERVIEW OF ORGANIC TRANSFORMATIONS NUCLEOPHILE AND ELECTROPHILE OXIDATION AND REDUCTION BIBLOGRAPHY

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A protecting group or protective group is introduced into a molecule by chemical modification of a functional group in order to obtain chemoselectivity in a subsequent chemical reaction. It plays an important role in multistep organic synthesis. In many preparations of delicate organic compounds, some specific parts of their molecules cannot survive the required reagents or chemical environments. Then, these parts, or groups, must be protected. For example, lithium aluminium hydride is a highly reactive but useful reagent capable of reducing esters to alcohols. It will always react with carbonyl groups, and this cannot be discouraged by any means. When a reduction of an ester is required in the presence of a carbonyl, the attack of the hydride on the carbonyl has to be prevented. For example, the carbonyl is converted into an acetal, which does not react with hydrides. The acetal is then called a protecting group for the carbonyl. After the step involving the hydride is complete, the acetal is removed (by reacting it with an aqueous acid), giving back the original carbonyl. This step is called deprotection. Protecting groups are more commonly used in small-scale laboratory work and initial development than in industrial production processes because their use adds additional steps and material costs to the process. However, the availability of a cheap chiral building block can overcome these additional costs (e.g. shikimic acid for oseltamivir).

ABSTRACT

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Introduction

f a target molecule contains more than one functional group, then its

synthesis Becomes increasingly challenging. The synthesis of a complex natural product is difficult not only because there are many transformations that must be accomplished, but also because care must be taken to ensure that the functional groups do not interfere with each other. Those functional groups not involved in a given reaction sequence must be stable to the various reagents and reaction conditions being employed. One way to achieve this stability is by using a protective group to temporarily mask (or hide) the functional groups reactivity. The strategy involves installing a protective group, conducting a reaction elsewhere in the molecule, and then removing the protective group (called deprotection). Protective groups are usually denoted using abbreviations, which can make a natural product synthetic scheme seem like alphabet soup to the beginning student! However, as you spend more time with the literature, you will quickly become familiar with the more widely used protective groups,and you will likely be able to recognize certain transformations as a protection or deprotection step, even if you do not know a particular abbreviation.

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imilar functional groups may be differentiated by selective protection,

such as protecting a more reactive aldehyde in the presence of a ketone or aless hindered primary alcohol in the presence of a tertiary alcohol. Protective groups can be used to hide the acidic proton of an alcohol or the electrophilic carbonyl of a ketone. Protection of the functional groups found in amino acids (carboxylic acids, amines, and thiols) finds significant applications in the synthesis of peptides and proteins. While hundreds of protective groups have been developed for use in organic synthesis,* only a brief sampling is provided here. A wide variety of protective groups is available since each has its own advantages and disadvantages; factors such as the reactions conditions needed to install and remove the protective group, as well as the stability of the protective group to various reaction conditions are taken into consideration when planning a given synthesis.

Principle of protecting group;

he idea behind the principle of protecting group is it allows us to

overcome simple problems of Chemoselectivity. It is easy to make alcohols from keto ester by reduding more reactive carbonyl group. Making alcohols by reducing the less reactive carbonyl group is not easy but can be accomplished by using the greater reactivity of the ketone to introduce a protecting group which deoes not react with 4 the chosen reducing agent . The ovious protecting group is the Acetal.

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An above given synthesis of (3), the acetals is easily made and and easily hydrolysed, both in good yeild, resists reagents such as bases, nucleophiles,and reducing agents which would attack the unprotected ketone and resists 4 when it attacks the ester.
A protecting group must be;

Easy to put in and remove. Resistant to reagents which would attack the unprotected Functional group. Resistant to as wide a variety of other reagent as possible.

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GROUP ALDEHYDE(RCHO)

List of available protecting group for all Functional group;

PROTECTING GROUP ACETAL (RCH(OR)2 TO ADD ROH, + TO REMOVE + ;2 + ;2 2 2 , / + , Base, /2 ,2 ,cat. Or , + , , , 2 , . ; , 3 ACETAL (Ketal) Nucleophiles, bases, reducing agents

P.G RESISTS P.G REACTS WITH Nucleophiles,bases,reducing Electrophile Oxidising agents agents

KETONE

Electrophiles, oxidising agents

ACID

-ESTER 2 ,2 , 2 2 ,Anion,2 Ethers 2 ; Acetals Ether

Weak bases electrophiles

Strong acid nucleophile reducing agents

ALCOHOLS

2 , ; 2 4 ; 2 3

Electrophile bases ;Oxidation

HX (X is a nucleophile)

PHENOLS

Bases, weak electrophile

Attack by electrophile on ring

*P.G= protecting group;

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Alcohols have acidic protons that can interfere with strongly basic species, such as a Grignard reagent. Protection of the alcohol involves replacing the hydrogen with some groups that can later be removed (ROH ROPG). A variety of protective groups are available for alcohols, including ethers, esters, and acetals.

Protection of Alcohols
Ether protective groups for Alcohols

An ether is a very stable functional group that generally resists reactions with nucleophiles, bases, and oxidizing agents. In fact, ethers are so unreactive that many are unsuitable as protective groups, since it would be nearly impossible to deprotect and get rid of the ether once it is created! A variety of special ethers with simple deprotection strategies have been developed and are regularly used in synthesis. For example, the benzyl ether protective group (CH2Ph, or Bn) is useful since it is very stable to most reaction conditions but it can be removed by catalytic hydrogenation (H2, Pd). The highly reactive benzylic carbon can be reduced, thus deprotecting the alcohol

Similarly, the p-methoxybenzyl ether (CH2C6H4OCH3, abbreviated as PMB or MPM for methoxyphenylmethyl) is simple to put on and can be removed by oxidation of the benzylic position (usually with 2,3-dichloro-5,6dicyanobenzoquinone, or DDQ).

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The triphenylmethyl, or trityl, ether (CPh3, or Tr) can be cleaved by reduction or with acid, via the stabilized trityl carbocation. Derivatives of the trityl group are widely used as protective groups in the laboratory synthesis of oligonucleotides (DNA).

Silyl ethers are widely used protective groups because they also have a convenient method of deprotection: treatment with tetrabutylammonium fluoride (n-Bu4NF or TBAF, pronounced t-baff). The reaction of an alcohol (ROH) with trimethylsilyl chloride (Me 3SiCl or TMSCl) and base makes the protected trimethylsilyl ether (ROTMS). Variation of the alkyl groups on the silicon (e.g., triisopropylsilyl TIPS, or t-butyldimethylsilyl TBDMS/TBS) increases the silyl ethers stability,

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especially toward acidic conditions, and also allows for selective protection of less hindered alcohols.

Ester protecting group for Alcohols

Esters (ROCOR) can be easily prepared by reacting an alcohol (ROH) with an acid chloride (RCOCl) and base. Deprotection is generally accomplished by basic hydrolysis or alcoholysis of the ester. Commonly used ester groups include acetate (COCH3, or Ac) and benzoate (COPh, or Bz). The pivaloate ester (COt-Bu, or Pv) is useful for selective acylation of a primary alcohol in the presence of more hindered secondary or tertiary alcohols.

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Acetal protective group of Alcohols

Since an acetal is produced by the reaction of a carbonyl with a diol, an acetal can serve as a protective group for either functional group. Deprotection is accomplished as usual by treatment with acid and water; hydrolysis of the acetal regenerates both the carbonyl and the diol. Both 1,2- and 1,3-Diols can be protected by reaction with acetone and acid. The resulting cyclic acetal (called an acetonide) is widely used in carbohydrate chemistry to selectively mask pairs of hydroxyl groups in sugars.

The methoxymethyl (CH3OCH2 or MOM) and tetrahydropyranyl (THP) groups are called ether groups (e.g., the hydroxyl group was protected to give the MOM ether), but they are actually examples of acetals that are cleaved by acidic hydrolysis. The MOM group is introduced by treatment of the alcohol with the very reactive chloromethyl methyl ether (CH3OCH2Cl, or MOMCl) and base (less toxic reagents are also available). The THP group is formed by reaction of an alcohol with dihydropyran (DHP).

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Protection of carboxylic acids

Carboxylic acids have acidic protons that can interfere with any basic species, including amines. Carboxylic acids are usually protected as esters. A methyl ester (RCO2CH3) can be prepared in a variety of ways, including reaction of an acid chloride with methanol (nucleophilic acyl substitution), reaction of a carboxylate nucleophile with methyl iodide (SN2), or treatment of the carboxylic acid with diazomethane (CH2N2). Deprotection involves hydrolysis, usually under basic conditions (saponification). Bulky esters that inhibit nucleophilic attack of the carbonyl and esters with unique deprotection strategies are also commonly used. Examples include t-butyl esters (RCO2CMe3), which are stable to base but can be removed with trifluoroacetic acid (TFA), and benzyl esters (RCO2CH2Ph) that can be removed by catalytic hydrogenation.

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Protection of amines

Amines are good bases and strong nucleophiles. Protection of amines, typically as an amide or a carbamate, works by introducing a carbonyl that can delocalize the nitrogens lone pair of electrons by resonance, thus rendering the nitrogen much less reactive.

Amide protective groups of amines

ORGANIC SYNTHESIS

Like esters, amides (RNHCOR) can be easily prepared by reacting an amine (RNH2) with an acid chloride (RCOCl) and base. Commonly used acyl groups include acetyl (COCH3, or Ac) and benzoyl (COPh, or Bz). Amide protective groups are generally removed by hydrolysis, but removal is often difficult since amides are fairly unreactive and stable.

Carbamate Protective Groups for Amines

Carbamate protective groups (RNHCO2R) are more widely used in the protection of amines, especially for amino acids and in the synthesis of peptides. The t-butoxycarbonyl (CO2t-Bu, or BOC) group is added using di-t-butyl dicarbonate (BOC2O) and base, and is readily removed with acidic hydrolysis. The carboxybenzyl (CO2CH2Ph, or Cbz or Z) group is introduced by treatment of the amine with benzyl chloroformate (BnOCOCl) and base; it can be removed by catalytic hydrogenation.

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ORGANIC SYNTHESIS

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SYNTHETIC TOOLBOX: OVERVIEW OF ORGANIC TRANSFORMATIONS

Nucleophile and Electrophile

Metal stabilized nuleophile

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Resonance Stabilized Nucleophile

Common electrophiles

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OXIDATION AND REDUCTION REACTION

ORGANIC SYNTHESIS

Organic Synthesis: An disconnection approach by stuart warren ; wileys pub.. Organic Synthesis Vol 2 by Jagdamba Singh Organic Chemistry by Stuart Warren, Wothers Wikipedia ACS publication Comprehensive Organic Transformation by Richard Larock

BIBLOGRAPHY

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