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Daily low-dose aspirin use led to a significant decrease in time to pregnancy among women with prior losses (P = .04) and to a shorter time to clinically confirmed pregnancy among women with a single documented loss at less than 20 weeks during the past year (P = .02). However, differences were not significant in the broader cohort. Table. EAGER Trial Results Treatment Group Positive Pregnancy TestClinically Confirmed Pregnancy Low-dose aspirin (n = 615)402 378 Placebo (n = 613) 374 350
"We found out that in a subset of women, low-dose aspirin seemed to either increase their probability of getting pregnant or decrease their chances of very early losses," said Dr. Silver. "This is really an exploratory finding, and one that we're excited about, but it needs more research. It is not something we would recommend changing clinical care at present." This is really an exploratory finding, and one that were excited about. Dr. Robert Silver
Emmanuel Bujold, MD, from the Universit Laval in Quebec, Canada, told Medscape Medical News earlier this year that most experts believe that aspirin does not improve conception or reduce the risk for miscarriage. "But if it does, the effect is very small," he said. "Overall, in the women in the trial, who had 1 to 2 prior losses, they found no difference in live birth rate between the low-dose aspirin group and the placebo group. It was only when they did a subgroup analysis that it became significant," he pointed out. This is not the first trial to look at the effect of aspirin before conception, Dr. Bujold noted, and "it is likely not effective, as the EAGER study results suggest." This study is funded by the Intramural Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the National Institutes of Health. Dr. Silver and Dr. Bujold report no relevant financial relationships. American Society for Reproductive Medicine (ASRM) 69th Annual Meeting: Abstract 327. Presented October 16, 2013.
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Cite this article: Aspirin May Improve Chance of Pregnancy After Miscarriage. Medscape. Oct 30, 2013.