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IMMUNOLOGY:

1.T lymphocytes: A) Are not derived from bone marrow precursors. B) Produce antibodies.
C) Secrete lymphokines. D) Undergo maturation in the thymus gland. E) Can be distinguished from B
lymphocytes on routine light microscopy
2.IgE A) Is present in plasma in the same concentration as IgG B) Is increased acutely in an asthmatic
attack C) Crosses the normal placenta D) Is increased in the serum of atopic individuals
E) Is involved in type 2 hypersensitivity
3.Concerning IgG: A) It has a molecular weight of 50,000 kd. B) It is monovalent. C) It comprises the
majority of circulating antibody in serum. D) It differs from other isotypes in not being able to cross the placental
barrier. E) It is the major antibody produced during the primary response
4. Monoclonal antibodies A) produce only light chain immunoglobulin B) are produced by cell fusion
C) can produce anto-idiotypic antibodies D) precipitate in cold E) are important in the aetiology of SLE

5. Deficiency of T-cells found in: A) Wiscott-Aldrich syndrome B) hereditary angio-oedema


C)chronic granulamatous disease D) ataxia telengiectasia E) congenital agammaglobulinaemia

6. Following are true about Fc fragment of immunoglobulins: A) Confers specificity to Immunoglobulins


B) determines the half-life of immunoglobulins C) determines whether the Igs can cross placenta D) are
excreted as Bence Jones proteins in urine E) heavy chains are encoded in chromosome 14.

7. In the immune response to extracellular bacteria: A) Antigen specific cytotoxic T lymphocytes play a
major role. B) T cell help is involved in the induction of high affinity antibodies. C) Helper T cells release
cytokines in response to antigen stimulation. D) T cell recognition of bacterial antigens is independent of MHC
molecules. E) Antigen specific T and B cells need to recognise the same epitopes on bacterial antigens for
effective help to occur.
8. Self tolerance is achieved by: A) Clonal deletion of potentially autoreactive T cells during thymic
development. B) Suppression or anergy of autoreactive T cells in the periphery. C) Absence of germ line T cell
receptor genes which recognise self antigens. D) Presence of cytotoxic T cells in the thymus which
recognise and kill potentially autoreactive T cells. E) Somatic mutation of potentially autoreactive T cell
receptors in the thymus.
9. Treatment with intravenous immunoglobulin is appropriate in the following conditions
A) chronic lymphocytic leukaemia B) nephrotic syndrome C) X-linked hypogammaglobulinaemia
D) acquired immunodeficiency syndrome in a child E) isolated IgA deficiency

10. Natural Killer cells A) are a type of T lymphocyte B) are predominantly found in lymph nodes
C) express cell surface CD-3 D) kill antibody coated cellsM E) release tumour necrosis factor

11. The following are compatible with a diagnosis of auto-immunity:


A) Pernicious anaemia. B) Delayed type hypersensitivity in tuberculosis.C) Juvenile onset diabetes mellitus.
D) Maturity onset diabetes mellitus. E) Thyroid antibodies in a healthy person

12. Interferons: A) contribute to fever and myalgia in viral infections B) exacerbate psoriasis C) may cause
more expression of molecules of the major histocompatibility complex D) decrease tumour cell growth
E) lead to an enhanced desturction of cells infected by Hepatitis B
13. CD4+ T cells: A) Are cytotoxic for virally infected cells. B) Are restricted in antigen recognition by MHC
class II molecules. C) Release cytokines in response to antigen stimulation. D) Are a major target cell for
infection with HIV. E) Are involved in delayed type hypersensitivity.
14.Type 3 hypersensitivity reaction include: A)Farmer’s Lung B) Autoimmunity C) Graft Rejection
D) SLE E) Meningococcal infection.
15.HLA/MHC Associated diseases are: A) Multiple Sclerosis B) Ankylosing Spondilitis C) Rheumatoid
Arthritis D) Sjogren’s Syndrome E)Psoriatic Arthritis.