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Removing Uterine Fibroids Laparoscopically

Removing Uterine Fibroids Laparoscopically


By Dr. Herbert A. Goldfarb, MD

Before the advent of laparoscopy, uterine fibroids were often removed by surgical
hysterectomy. The author describes a number of alternative treatments, including GnRH agonists and
laparoscopic coagulation with the Nd:YAG laser and bipolar needles.
Over 80% of women between 30 and 50 years of age have uterine fibroids. Depending on
their size and location, fibroids can be completely asymptomatic or can cause pelvic pain, dyspareunia,
pressure, urinary problems, and recurrent menorrhagia. In general, the larger the fibroid, the
more severe the symptoms. Abnormal bleeding is usually caused by fibroids adjacent to the uterine
cavity. Patients who have smaller serosal fibroids may be completely asymptomatic or report only one
symptom. Less than 1% of fibroids are malignant, and, unless they affect the patient's quality
of life, there's no need for treatment.
Current Approaches
Medical therapy may be the best way to treat fibroids causing symptoms in premenopausal
women. Synthetic gonadotropin-releasing hormone (GnRH) agonists inhibit estrogen production,
causing,the uterine cavity to shrink by 36% within a few months. Fibroids may be reduced by
38% to 90% of their original size. Although these results are impressive, long-term estrogen suppression
can cause bone loss. Also, GnRH agonists cannot be taken orally; a long-acting version of the
drug requires injection. The drug is expensive and there's no guarantee of continued protection
after treatment is stopped. Indeed, fibroids usually return to their original size within 4 months.
Surgical therapy usually involves myomectomy or total abdoininal or vaginal hysterectomy
(Fig. 2). Some investigators, such as Camran Nezhat, MD, Mercer University, Atlanta, and Harry Reich,
MD, The Graduate Hospital, Philadelphia, recommend laparoscopic myomectomy, which requires
advanced pelviscopic skill. Selecting the appropriate treatment is controversial. Abdominal or vaginal
myomectomy is recommended for women under 40 years of age who wish to have children, and total
vaginal or abdominal hysterectomy is suggested for women who have completed their
families.
Fibroid uterus is the most frequent diagnosis leading to hysterectomy; this accounts for 37% to
62% of all US hysterectomies performed annually. Out of the estimated half-million hysterectomies
performed annually in the US, the overall mortality rate is 12 per 10,000. Major complications, often
include wound infection; postoperative bleeding; transfusion; ureteral, bladder, and bowel
injuries.
There are several new operative techniques that don't require major surgery. Laparoscopic
myoma coagulation - myolysis is an alternative to myomectomy. This procedure can be combined with
endometrial ablation for patients who have persistent uterine bleeding. Laparoscopic
myomectomy is another alternative to hysterectomy.
Laparoscopic Coagulation
Laparoscopic coagulation uses the Nd:YAG laser or bipolar needles (Reznik Instrument Co.,
Skokie, Ill., and J.E.M. Davis, Hicksville, N.Y.) to degrade myometrial stroma, denature protein, destroy
vascularity, and substantially shrink fibroids. We use 50 to 70 W of continuous, pure cutting power
with the Nd:YAG laser to repeatedly pierce and coagulate the fibroid, desiccating a cone of
vasculature approximately 3 to 5 mm in diameter around each puncture point. Repeated puncturing
effectively destroys the fibroids. We've tried using monopolar electrodes, but consider bipolar
current safer. Unipolar energy may increase the size of the holes, but it doesn't increase the effciency
of the energy delivered to the fibroids.
Future research may show that this technique may be used in women who want to maintain
fertility, but current experience is based only on women who have completed their families. Anecdotal
evidence suggests that myometrial necrosis is counterproductive to childbearing.
In the hundreds of procedures I've performed, and in those performed in Europe, there have
been no side effects. Compared with hysterectomy, which requires 5 to 6 weeks recovery, patients
are discharged the same day and can return to work within 4 or 5 days. Because the uterus is left intact,
hormonal and sexual function is preserved. After following these patients for up to 8 years, we
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have seen no regrowth of fibroid tumors, This treatment is successful for both serosal and subserosal
fibroids and is recommended for women who have symptomatic fibroids that measure 10 cm or less.

Imaging Techniques for Diagnosis
Hysteroscopy, endovaginal ultrasonography, cornputerized axial tomography, and magnetic
resonance imaging will allow you to visualize the interior of the uterine cavity accurately. By evaluating
the uterine cavity, you can determine the size, shape, and position of any fibroids. If a myoma is
asymptomatic and measures less than 5 cm in diameter, I recommend watchful waiting.
However, when a fibroid measures 5 cm or more and continues to grow, I usually recommend a course of
action.
Treatment Candidates
Before treatment, always perform a pelvic examination including ultrasound examination to
determine the size and location of the fibroid. If it measures 10 cm or less and responds to treatment with
GnRH agonists, you may consider laparoscopic coagalation. Hysteroscopy with endometrial
biopsy wiil help you identify submucosal and intrauterine fibroids, and rule out endometrial
hyperplasia and premalignant or malignant conditions. Because the procedure shrinks the uterine cavity
and may leave adhesions, it should be performed only on women who are no longer interested
in conception.
To maximize fibroid shrinkage before laparoscopic surgery, I suggest pretreating patients with
depot leuprolide acetate, a synthetic pituitary hormone. A monthly injection (3.75 mg) given at
the onset of menses for at least 3 months will reduce estrogen production and promote fibroid atrophy.

Coagulation With Md:YAG Laser
Laser coagulation proceeds as follows: To begin, inject 5 mL to 10 mL of 10% vasopressin
solution directly into the serosa of the uterine fibroid to eliminate hemorraghic diathesis. It is
critical to measure the desired depth of penetration that will thoroughly coagulate the myoma. By placing
the Nd:YAG laser fiber against the fibroid, you will be able to visualize it in relation to the
surrounding tissue. After determining the desired depth of penetration, puncture the fibroid contiguously
using a drillling technique .
To totally coagulate the fibroid, repeat drilling with the bare fiber tip at multiple, concentric
sites. Fluid may bi used to cool the fiber tip. Because each puncture coagulates a diameter of
5 mm surrounding the puncture, it takes ten punctures per diameter, or a total of 50 to 75 punctures, to
totally coagulate a 5-cm fibroid. The coagulation dispersion of the Nd:YAG laser fiber at 5-mm
intervals creates a contiguous core of coagulation.
To protect the rectum, bladder, and uterine blood vessels, it is extremely important to visualize
the fibroid's posterior surface during the entire procedure. A uterine grasper inserted through
the suprapubic puncture will elevate the uterus and help protect against posterior perforation of the rectum.
I suggest a suprapubic steerable laser probe to obtain right-angle punctures for an anterior
fibroid; for a posterior fibroid, you can achieve a horizontal approach by using an operative
laparoscope with a 50-cm guide. The entire procedure takes about 25 to 30 minutes. In my experience,
minimal - if any-bleeding - has occurred and transfasions haven't been necessary. After 4
hours of recovery from anesthesia, the patient is discharged.
We've performed over 800 procedures without any serious complications. One patient
developed symptoms of fibroid degeneration and was treated successfully with analgesics, bed rest, and
tetracycline. We follow up all patients with endovaginal ultrasound. There has been no residual
flbroid exceeding 5 cm, and, since October 1990, no patient has exhibited any fibroid regeneration nor
required a second procedure.
Coagulation with Bipolar Needles
Because many hospitals do not have access to an Nd:YAG laser, we have developed a
bipolar needle instrument. Laparoscopic coagulation of subserosal fibroids using a newly developed bipolar
needle produces the same effects as the Nd:YAG laser. The bipolar instrument has two, 5-cm
steel needles connected to a standard bipolar generator that procluces 70 to 120 W. Two forms of
bipolar needles have been used to puncture uterine myomas and obtain multiple cores of coagulation: a
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30-cm instrument with a 5-mm probe, and a 45-cm probe attached to the operating
laparoscope, which provides a horizontal approach for posterior fibroids. When placed through a 5-mm
suprapubic puncture, the bipolar needles develop a core of coagulation and effectively destroy
the vasculature of the uterine myoma (Figure 4). After the tissues are lavaged, there is minimal bleeding.
Using this technique, a 7-cm myoma can be thoroughly coagulated in 20 minutes. After 18
months, we have seen fibroid reduction comparable with that achieved by laser laparoscopic coagulation.

When patients are treated with depot leuprolide, fibroids are reduced to about 20% to 50% of
pretreatment size. Laparoscopic coagulation reduces fibroid size by another 50%. For example, an 8-cm
myoma reduced to 4 cm before the procedure, typically measures 2 cm at 2 months after myoma
coagulation (Tables 1 and 2). We perform vaginal ultrasound after 6 months, 1 year, and 2
years and have seen no uterine or myoma regrowh.
Endometrial Ablation
A majority of our patients afflicted with fibroids also have persistent uterine bleeding. We treat
these patients with a combination of myoma coagulation and endometrial ablation. Good
candidates for endometrial ablation are women who have persistent abnormal uterine bleeding whose
preoperative uterine size measures between 5 cm and 10 cm. You can use the Nd:YAG laser
for endometrial ablation, but it has a srnall field of focus, requires at least I hour to ablate a small uterus,
and it costs the hospital more than $100,000. Ablation can also be performed with a continuous
flow resectoscope fitted with a roller-bar electrode at 75 to 100 W of coagulating current (some
physicians recommend cutting current). Results with the roller electrode are comparable with those
achieved by the Nd:YAG laser.
To dilate the cervix, insert laminaria tents the night before surgery. This dilation prevents
cervical spasm duririg the procedure, facilitates the insertion of a 27F-continuous flow
resectoscope, and allows fluid to circulate easily, thus preventing excessive intrauterine pressure and fluid
absorption. The loop electrode is used to shave interecavity or submucosal fibroids, Once this
is accomplished, use the roller-bar electrode to coagulate the entire uterine cavity. Combining this
technique witlh myoma coagulation allows you to treat serosal and submucosal fibroids
simultaneously.
The results of endometrial ablation with the Nd:YAG laser or roller-bar electrode show that
uterine hernorrhage is controlled in 95% of patients and uterine size is redueced more than 50%.
Amenorrhea rates vary, depending on the technique used and the size of the uterine cavity. In
patients whose preoperative uterine cavity measures 7 cm or less, amenorrhea rates are about 60%.
This rate decreases to 30% when the uterine cavity measures between 10 cm and 15 cm (Tables 3
and 4). Since October 1990, when we performed the first myoma coagulation procedure in the
US, we have seen no recurrence of abnormal uterine bleeding nor has any patient required a second
procedure.
Although evaluation is necessar to confirm long-term fibroid suppression (more than 2 years),
the immediate benefits of the Nd:YAG laser and bipolar needles include same-day surgery, avoidance
of hysterectomy, and elimination of abnormal bleeding.
Laparoscopic Myomectomy
Abdominal myomectomy is considered a complicated procedure because of technical
difficulties inherent in removing large fibroids from the abdominal cavity, controlling bleeding, and suturing
the unterine defect. GnRIH analogs are used preoperatively to reduce fibroid size and
vascularity, and eliminate the need for transfusion. Laparoscopic myomectomy is a relatively
new technique that treats symptomatic fibroids and avoids the complications associated with laparotomy
and hyster-tomy. This technique should be performed by advanced pelviscopic surgeons who
have mastered techniques of laparoscopic suturing and tissue removal.
When fertility is an issue, we restrict laparoscopic myomectomy to pedunculated and
superficial serosal fibroids, and those in which the uterine cavity is not compressed. Because of
the potentially destructive impact on the uterine cavity, I don't recommend laparoscopic myomectomy for
deep intramural fibroids in women who want to have children. The experience of the operator,
blood loss, and safety are the criteria that determine the appropriateness of the procedure when fertility
isn't an issue.
Before laparoscopic myomectomy, perform an endometral biopsy and a diagnostic
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hysterocopy to evaluate the uterine cavity. Exclude women with malignant or premalignant conditions.
Pretreatment with leuprolide therapy for 3 to 5 months will shrink fibroids by 30% to 50%.

First, inject the fibroid with 5 mL to 10 mL 10% vasopressin solution fo vasoconstirction. We
injject the fluid immediately uder the serosa. We incise the fundus of the uterus in the anterior-posterior
plance, using a knife electrode at 100W of cutting power. A suction lavage instrument helps
evacuate smoke as well as prode adequate lavage. A 1-mm corkscrew is insereted into the
fundus of the the myoma to aid in the dissection process. As soon as a bleeding point is found, we
coagulate it with the knofe electrode, using 100 W cutting power. This power level prvides
effective cutting as well as excellent coagulation.
The combination of the knife electrode, the suction lavage instrument, and the corkscrew allow
adequate dissection of the fibroid. Be careful to keep the knife electrode away from the intestines,
and use caution when cutting. We repeat this dissection procedure until the root of the fibroid is exposed
and can be incised. After the excess blood is suctioned and the tissue thoroughly lavaged, we
coagulate oozing points, and then place the myoma in the cul-de-sac.
Suturing
In the past, we performed suturing intracorporeally by stitching the wound inside the
abdominal cavity. Because this was time consuming and awkward, we now use an extracorporeal suturing
technique, which.shortens the procedure considerably.
Using a .00 PDS CT.2 needle placed through a 10-mm trocar, we position the needle inside
the abdomen with the help of two needle-holders. One needle-holder (Wolf Castroviejo) is placed through
the 10-mm trocar and is used to grasp the needle; the other needle-holder is used for
manipulation. After suturing, we withdraw the needle through the 10-rnm trocar. We tie the knots
extracorporeally in a double surgeon's knot and use a knot-pusher to secure them. Three
knots are made for each suture before cutting. This process is repeated as often as necessary to
adequately close the uterine defect. Bleeding is minimal and there has been no need for
transfusion. The area is then thoroughly lavaged.
Removing the Myoma
To remove the myoma from the abdominal cavity, we expand the trocar to 20 mm, using the
Semm tissue removal system. The procedure requires 30 to 40 minutes for a large myoma, and
is analternative to colpotomy, which is also an effective method of removal. Once the myoma is completely
removed, tissues are thoroughly lavaged with 2,000 mL to 8,000 mL of warm lactated Ringer's
solution. Another 1,500 mL of Ringer's irrigation are left in the pelvic cavity for hydroflotation and adhesion
prevention. It is very irnportant to close the fascia and peritoneal surfaces of the trocar sites of
10 mm or more so that a loop of intestine cannot isolate itself. This entire procedure can be
successfully completed in approximately 2 hours and provides an excellent, but highly technical, alternative
to open abdominal surgery.
Hysterectomy Unacceptable
The use of hysterectomy to treat myomatous conditions in post-reproductive women is no
longer acceptable to increasing numbers of patients. Learning these alternative laparoscopic options
requires diligence and dedication, but allows us to provide patients with alternatives to major
surgery.

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