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PMID- 15032596

OWN - NLM
STAT- MEDLINE
DA - 20040322
DCOM- 20040802
LR - 20071114
IS - 0732-0582 (Print)
IS - 0732-0582 (Linking)
VI - 22
DP - 2004
TI - Control of T cell viability.
PG - 765-87
AB - The factors affecting T cell viability vary depending on the type and stat
us of
the T cell involved. Naive T cells die via a Bcl-2/Bim dependent route. Th
eir
deaths are prevented in animals by IL-7 and contact with MHC. Activated T
cells
die in many different ways. Among these is a pathway involving signals tha
t come
from outside the T cell and affect it via surface receptors such as Fas.
Activated T cells also die through a pathway driven by signals generated w
ithin
the T cell itself, a cell autonomous route. This pathway involves members
of the
Bcl-2 family, in particular Bcl-2, Bcl-xl, Bim, and probably Bak. The viab
ility
of CD8+ and CD4+ memory T cells is controlled in different ways. CD8+ memo
ry T
cells are maintained by IL-15 and IL-7. The control of CD4+ memory T cells
is
more mysterious, with roles reported for IL-7 and/or contact via the TCR.
AD - Howard Hughes Medical Institute and Integrated Department of Immunology, N
ational
Jewish Medical and Research Center, and Department of Medicine, University
of
Colorado Health Sciences Center, Denver, Colorado 80206, USA. marrackp@njc
.org
FAU - Marrack, Philippa
AU - Marrack P
FAU - Kappler, John
AU - Kappler J
LA - eng
GR - AI-17134/AI/NIAID NIH HHS/United States
GR - AI-18785/AI/NIAID NIH HHS/United States
GR - AI-22295/AI/NIAID NIH HHS/United States
GR - AI-52225/AI/NIAID NIH HHS/United States
PT - Journal Article
PT - Research Support, U.S. Gov't, P.H.S.
PT - Review
PL - United States
TA - Annu Rev Immunol
JT - Annual review of immunology
JID - 8309206
SB - IM
MH - Animals
MH - Cell Death/immunology
MH - Cell Survival/immunology
MH - Humans
MH - Immunologic Memory
MH - Lymphocyte Activation/immunology
MH - Signal Transduction/*immunology
MH - T-Lymphocytes/*physiology
RF - 156
EDAT- 2004/03/23 05:00
MHDA- 2004/08/03 05:00
CRDT- 2004/03/23 05:00
AID - 10.1146/annurev.immunol.22.012703.104554 [doi]
PST - ppublish
SO - Annu Rev Immunol. 2004;22:765-87.
PMID- 16246265
OWN - NLM
STAT- MEDLINE
DA - 20051025
DCOM- 20051201
LR - 20071114
IS - 1001-0602 (Print)
IS - 1001-0602 (Linking)
VI - 15
IP - 10
DP - 2005 Oct
TI - The role of apoptosis in the development and function of T lymphocytes.
PG - 749-69
AB - Apoptosis plays an essential role in T cell biology. Thymocytes expressing
nonfunctional or autoreactive TCRs are eliminated by apoptosis during
development. Apoptosis also leads to the deletion of expanded effector T c
ells
during immune responses. The dysregulation of apoptosis in the immune syst
em
results in autoimmunity, tumorogenesis and immunodeficiency. Two major pat
hways
lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 fa
mily
members and the extrinsic cell death pathway controlled by death receptor
signaling. These two pathways work together to regulate T lymphocyte devel
opment
and function.
AD - Department of Immunology, Duke University Medical Center, Durham, NC 27710
, USA.
FAU - Zhang, Nu
AU - Zhang N
FAU - Hartig, Heather
AU - Hartig H
FAU - Dzhagalov, Ivan
AU - Dzhagalov I
FAU - Draper, David
AU - Draper D
FAU - He, You Wen
AU - He YW
LA - eng
GR - CA92123/CA/NCI NIH HHS/United States
PT - Journal Article
PT - Research Support, N.I.H., Extramural
PT - Research Support, Non-U.S. Gov't
PT - Review
PL - China
TA - Cell Res
JT - Cell research
JID - 9425763
RN - 0 (Proto-Oncogene Proteins c-bcl-2)
RN - 0 (Receptors, Tumor Necrosis Factor)
SB - IM
MH - Animals
MH - *Apoptosis
MH - Mice
MH - Proto-Oncogene Proteins c-bcl-2/metabolism
MH - Receptors, Tumor Necrosis Factor/metabolism
MH - Signal Transduction
MH - T-Lymphocytes/cytology/*immunology
MH - Thymus Gland/cytology/growth & development/immunology
RF - 247
EDAT- 2005/10/26 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/10/26 09:00
AID - 10.1038/sj.cr.7290345 [doi]
PST - ppublish
SO - Cell Res. 2005 Oct;15(10):749-69.