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2 Practicalstatistics
Introductory Biostatistics Maths from Scratch for
CHAP T. LE, Comprehensive Cancer Center, Biologists
University of Minnesota, USA
ALAN J. CANN, University of Leicester, UK
Taking a problems-based approach full of • An accessible, jargon-busting approach to
real-world examples, the text slowly and help readers master basic mathematical,
methodically builds understanding and statistical and data handling techniques in
mastery of the fundamentals of biostatistics. biology
It briefly covers data collection and then
expands on the subjects of descriptive • Numerous end of chapter problems
statistics, statistical inference, probability, • A handy, time saving glossary
and probability models. Such features as • A supplementary website with numerous
“Brief Notes on the Fundamentals,” end-of- problems and self-test exercises
chapter notes on computations using Excel, 0471 49835 1 October 2002 240pp Pbk
and samples of SAS computer programs £17.99 / €29.90
strengthen the reader’s grasp of the background and the concepts of 0471 49834 3 October 2002 240pp Hbk £60.00 / €99.90
biostatistical procedures.
0471 41816 1 May 2003 536pp Hbk £63.50 / €90.50
Statistics for Research
Third Edition
Introductory Biostatistics for SHIRLEY DOWDY, Chesterfield, Missouri, USA, STANLEY WEARDEN and
the Health Sciences DANIEL CHILKO, West Virginia University, USA

Modern Applications Including Featuring:
Bootstrap • Sections on probability, odds ratio and logistic regression
MICHAEL R. CHERNICK, Novo Nordisk • More on regression diagnostics
Pharmaceuticals, Inc., New Jersey, USA and • Further explanation of linear models
ROBERT H. FRIIS, California State University,
USA • Supplementary website offering SAS and data sets
• Discusses Outliers by way of detection 0471 26735 X January 2004 504pp Hbk £60.50 / €85.70
and treatment
• Covers such recent statistical advances as
bootstrapping Analyzing Microarray Gene Expression Data
• Includes helpful exercises throughout GEOFFREY J. MCLACHLAN, The University of Queensland, Australia, KIM-
• Features real-world examples ANH DO, University of Texas, USA
0471 41137 X April 2003 424pp Hbk £60.50 / €85.70 • Emphasis on clustering of data of gene tissues
• Includes new research findings and activities in molecular biology
• Highlights the important general field of bioinformatics and
Biostatistics genomics and discusses the impact of microarray analysis on both
A Methodology for the Health Sciences 0471 22616 5 January 2004 320pp Hbk £60.50 / €85.70

Second Edition
GERALD VAN BELLE The EM Algorithm and Extensions
• Focuses on current techniques and applications Second Edition
• Data sets, tables, additional examples, and solutions to selected GEOFFREY J. MCLACHLAN and THRIYAMBAKAM KRISHNAN
problems will be housed on the web • Features applications in regression, medical imaging, finite mixture
• Additional appendix provides current software packages, web sites, analysis, robust statistical modeling, survival analysis and repeated-
and important data sets measures designs, among others
0471 03185 2 February 2004 992pp Hbk £66.95 / €95.20 • Newly added and updated results on convergence
• Additional discussion of categorical data, numerical differentiation,
and variants of the EM algorithm
Wiley Reference Collection in Biostatistics • Inclusion of interval EM and the EM algorithm in time series
Three Volume Set • Exploration of the relationship between the EM algorithm and the
The Wiley Reference Collection in Biostatistics Gibbs sampler and Markov Chain Monte Carlo methods
provides you with the chance to purchase the 0471 20170 7 April 2004 352pp Hbk £56.95 / €80.90
three spin-off volumes from the Wiley
Encyclopedia of Biostatistics, which present
information in separate articles, arranged
alphabetically and with numerous references to the Microarray Analysis
current literature. The three volumes in this series MARK SCHENA
are: • Provides a working knowledge of
• Encyclopedia of Epidemiologic Methods microarray applications to a broad
• Biostatistics in Clinical Trials spectrum of disciplines
• Biostatistical Genetics and Genetic Epidemiology • Includes coverage of bioinformatics, novel
arrays and applications for clinical studies
Featuring contributions from leading experts in academia,
government and industry, all three volumes have been designed to • Contains commentary on the future
complement existing texts on the subject by providing further impact of microarray technology in
extensive, up-to-date coverage of specialised topics and by medicine
introducing the reader to the research literature. • Presents information on the commercial
By purchasing the Wiley Reference Collection in Biostatistics you can aspects of microarray science
keep yourself up to date with the latest advances in this rapidly evolving 0471 41443 3 January 2003 648pp Hbk
field AND save yourself or your library over £150.00 / €250.00 £60.50 / €99.90
0470 85422 7 2002 2378pp Hbk £595.00 / €922.30

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Biostatistics 3
Exploration and Analysis of DNA Microarray Applied Statistics
and Protein Array Data Analysis of Variance and Regression
Rutgers University, New Jersey, USA OLIVE JEAN DUNN and VIRGINIA A. CLARK, University of California, USA,
• A review of basic molecular biology and a chapter introducing RUTH M. MICKEY, University of Vermont, USA
microarrays and their preparation • Increased discussion of mixed models and random effects
• Chapters on processing scanned images, preprocessing microarray • Greater emphasis on regression and data screening
data, group comparative experiments, and other designs • Includes both graded and challenging exercises.
• Discussions of clustering, protein arrays, and applications for • Liberal computer discussions now supplemented with SAS and
diagnostic tools SPSS.
• Ample exercises 0471 37038 X January 2004 384pp Hbk £60.50 / €85.70
0471 27398 8 October 2003 272pp Hbk £60.50 / €85.70

Bayesian Approaches to
Quantitative Methods in Population Health Clinical Trials and Health-
Extensions of Ordinary Regression Care Evaluation
MARI PALTA, University of Wisconsin-Madison, USA DAVID SPIEGELHALTER, MRC Biostatistics Unit,
• First chapter includes a SAS refresher Cambridge, UK, KEITH R. ABRAMS, University
of Leicester, UK, JONATHAN MYLES, Cancer
• Each topic starts with an explanation of the theoretical background Research UK, London, UK
• Explanations are designed to assume as little background in • Illustrated throughout by case studies
mathematics and statistical theory as possible and worked examples
• SAS commands are provided for applying the methods. (PROC • Suitable for those with a limited
REG, PROC MIXED, and PROC GENMOD) statistical background
• All sections contain real life examples • Accompanied by a Web site featuring
0471 45505 9 September 2003 336pp Hbk £60.50 / €85.70 data sets and worked examples in
0471 49975 7 March 2004 340pp Hbk £45.00 / €69.80

Statistical Methods for Applied Bayesian Modelling
Rates and Proportions PETER CONGDON, Queen Mary, University of
Third Edition London, UK
JOSEPH L. FLEISS, BRUCE LEVIN and • Describes a variety of model assessment
MYUNGHEE CHO PAIK, Columbia University, methods and the flexibility of Bayesian
USA prior specifications.
• Includes a new chapter on logistic • Covers many application areas,
regression. including panel data models, structural
• Discusses the design and analysis of equation and other multivariate
random trials. structure models, spatial analysis,
• Explores the latest applications of survival analysis and epidemiology.
sample size tables. • Provides detailed worked examples in
• Contains a new section on binomial WINBUGS to illustrate the practical
distribution. application of the techniques described.
0471 52629 0 September 2003 776pp Hbk £63.50 / €90.50 • All WINBUGS programs are available from an ftp site.
0471 48695 7 March 2003 478pp Hbk £55.00 / €85.30

Applied Spatial Analysis of Public Disease Mapping with WINBUGS & MLwiN
Health Data ANDREW B. LAWSON, University of South Carolina, USA,
LANCE A. WALLER, Emory University, Georgia, USA, CAROL A. GOTWAY WILLIAM J. BROWNE, University of Nottingham, UK and
CRAWFORD, National Center for Environmental Health, Center for Disease CARMEN L. VIDAL-RODEIRO, University of South Carolina, USA
Control/Prevention, Georgia, USA • Provides an introduction to Bayesian and multilevel modelling in
• Touches upon some advanced topics, such as random effects,
4,073,067 disease mapping.
hierarchical models and spatial point processes • Adopts a practical approach, with many detailed worked examples.
• Includes lavish use of figures/illustrations throughout the volume • Includes introductory material on WinBUGS and MLwiN.
as well as analyses of several data sets (in the form2,787,843
of “data breaks”) • Discusses three applications in detail relative risk estimation,
• Exercises based on data analyses reinforce concepts 4,659,711 focused clustering, and ecological analysis.
0471 38771 1 March 2004 416pp Hbk £60.50 / €85.70
2,490,300 • Supported by a Website featuring data sets and WinBUGS and
MLwiN programs.
4,073,067 0470 85604 1 September 2003 256pp Hbk £45.00 / €69.80
4,073,067 4,677,677
3,334,791 2,426,877
2,787,843 3,334,791
4,659,711 2,426,877
2,490,300 3,334,791
4,073,067 2,787,843
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4 Biostatistics
Handbook of Dictionary of Bioinformatics
Statistical Genetics JOHN M. HANCOCK, Medical Research Council (MRC), Mammalian Genetics Unit,
Second Edition Harwell, UK, MARKETA J. ZVELEBIL, Ludwig Institute for Cancer Research, University
College London, UK
Two Volume Set • Provides concise and accurate definitions of over 600 terms
D. J. BALDING, Imperial College,
London, UK, M. BISHOP, UK HGMP • Entries point to additional reading and Internet links
Resource Centre, Cambridge, UK, • Cross-referencing is incorporated throughout
C. CANNINGS, University of
Sheffield, UK • Includes an index by sub-speciality topics
“This magnificent book 0471 43622 4 February 2004 416pp Hbk £66.95 / €95.20
attempts to catalogue and
introduce all aspects of
modern statistical genetics...I Protein Bioinformatics
can thoroughly recommend it.” An Algorithmic Approach to Sequence and Structure Analysis
Bergen, Norway and WILLIAM R. TAYLOR, National Institute for Medical Research, UK
Offering comprehensive coverage of a thriving area of
research, this new edition contains new articles, and updated • Provides a comprehensive introduction to the analysis of protein sequence
articles from the previous edition. New features include: and structure analysis.
• Glossary of Terms • Takes an algorithmic approach, relying on computational methods rather
than theoretical.
• Reference Author list
• Provides an integrated presentation of theory, examples, exercises and
• List of contributors applications.
• Comprehensive Subject Index • Includes coverage of both protein structure, and sequence, analysis.
0470 84829 4 August 2003 1250pp 2 Volume Set Hbk
• Supported by a Web site featuring exercises, solutions, images, and
PRE-PUBLICATION PRICE £195.00 / €302.30.. computer programs.
Price on Publication £225.00 / €340.00
0470 84839 1 February 2004 368pp Hbk £45.00 / €69.80

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