You are on page 1of 3


Experimental Chronic Wasting Disease (CWD) in the- Experimental Inoculation:

Develop CWD when injected PrP from deer into cerebrum but do not develop CWD if
PrP given orally-Clinical signs: Polyphagia, somnolence, piloerection, lordosis and
ataxia- Microscopic lesions: Spongiosis of neurophil in basal ganglia, thalamus,
midbrain and pons -Exception: Perivascular PrP aggregates or plaques are absent in
ferrets but present in cervids.

Identification of Group 1 Coronavirus Antigen in Multisystemic Granulomatous

Lesions in Ferrets (Mustela putorius furo): Group 1 includes human coronavirus strain
229E, porcine TGE virus, canine coronavirus, porcine epidemic diarrhoea virus, and
ferret enteric coronavirus. Four main types of lesions were observed: diffuse
granulomatous inflammation on serosal surfaces; granulomas with areas of necrosis;
granulomas without necrosis; and granulomas with neutrophils.

Cystic Renal Disease in the Domestic Ferret. Vol 58, No 2.

primary polycystic disease consisting of either polycystic kidney
disease affecting renal tubules or, more commonly, glomerulocystic
kidney disease. Secondary polycystic lesions were identified in 11
ferrets (20%), and 12 ferrets
(22%) exhibited focal or isolated tubular cysts only as an incidental
necropsy finding. Ferrets with secondary renal cysts associated with
other developmental anomalies, mesangial glomerulopathy, or end-
stage kidney disease had hyperphosphatemia and elevated BUN in
comparison with those with primary cystic disease and elevated BUN
compared with those without renal lesions.

High-throughput Immunophenotyping of 43 Ferret Lymphomas Using Tissue

Microarray Technology. Vet Pathol 44:196–203 (2007). The results of this study
confirmed previously published results suggesting specific cross-reactivity of the applied
IHC markers (CD3, CD79a, Ki67) with ferret lymphoma tissue. Other IHC markers
(CD45Ro, bcl2, bcl10, MUM1, CD30, vimentin) were also expressed in subsets of the
included ferret lymphomas. TMA technology was useful for rapid and accurate analysis
of protein expression in large archival cohorts of ferret lymphoma cases.

Myofasciitis in the Domestic Ferret. Vet Pathol 44:25–38 (2007). young ferrets,
Gross lesions -atrophy of skeletal muscle; red and white mottling and dilatation of the
esophagus; and splenomegaly. Histologically-suppurative to pyogranulomatous myositis
in the esophagus, heart, limbs, body wall, head, and lumbar regions. Myeloid hyperplasia
of spleen and/or bone marrow also is a prominent feature. Ultrastructural lesions include
mitochondrial swelling, intracellular edema, disruption of myofibrils and Z bands.

Subcutaneous Neoplasms of the Ventral Abdomen with Features of Adrenocortical

Tumors in Two Ferrets. Vet Pathol 44:951–955 (2007). neoplasms were composed of
islands of polygonal cells separated by interlacing streams of spindloid cells reminiscent
of ferret adrenocortical tumors with smooth muscle proliferation.
immunohistochemically, the polygonal cells demonstrated strong cytoplasmic reactivity
for inhibin and weak cytoplasmic reactivity for pancytokeratin and S-100 protein.
Spindloid cells demonstrated strong cytoplasmic reactivity for alpha smooth muscle
actin, muscle-specific actin, desmin, and glial fibrillary–associated protein.
Ultrastructurally, the polygonal cells contained numerous intracytoplasmic clear
vacuoles, mitochondria, scant rough endoplasmic reticulum, and few intermediate
filaments. suggestive of adrenocortical tumors with smooth muscle proliferation, but
cannot be differentiated from an ovarian gonadal stromal tumor.

Clinicopathologic Features of a Systemic Coronavirus-Associated Disease Resembling Feline

Infectious Peritonitis in the Domestic Ferret Vet Path 2008 Mar: Grossly, whitish nodules on
mesentery, lymph nodes, visceral peritoneum, liver, kidneys, spleen, and lungs. Microscopically,
pyogranulomatous inflammation was seen. IHC positive for coronavirus antigen using monoclonal
antibody FIPV3-70. Two diseases caused by coronaviruses have been described in ferrets: severe acute
respiratory syndrome (SARS) and epizootic catarrhal enteritis (ECE). Wet form like in cats was not seen.

Cytochrome b5 Expression in Gonadectomy-induced Adrenocortical Neoplasms of the Domestic

Ferret (Mustela putorius furo). Vet Pathol 45:439–442 (2008) July. Normal adrenocortical cells
lacked cyt b5, which may account for the low production of adrenal androgens in healthy ferrets.
Other markers characteristic of gonadal somatic cells, such as luteinizing hormone receptor, aromatase, and
GATA4, were coexpressed with cyt b5 in some of the tumors. We concluded that cyt b5 is upregulated
during gonadectomy-induced adrenocortical neoplasia.

Pathology of Experimental SARS Coronavirus Infection in Cats and Ferrets. Vet Pathol 45:551–562
(2008). All infected cats and ferrets had diffuse alveolar damage associated with SARS-CoV antigen
expression. SARS-CoV antigen expression occurred mainly in type I and II pneumocytes and serous cells
of tracheo-bronchial submucosal glands of cats and in type II pneumocytes of ferrets. ACE2 expression
occurred mainly in type I and II pneumocytes, tracheo-bronchial goblet cells, serous epithelial cells of
tracheo-bronchial submucosal glands in cats, and type II pneumocytes and serous epithelial cells of
tracheo-bronchial submucosal glands in ferrets. syncytia and hyaline membranes were not observed.

Laboratory Findings, Histopathology, and Immunophenotype of Lymphoma in Domestic Ferrets.

Vet Pathol 45:663–673 (2008). Tumors involved the viscera of the abdominal cavity, thoracic cavity; the
skin; or the viscera. Microscopically, all tumors had diffuse architecture. Diffuse T-cell lymphoma >
anaplastic large T-cell lymphoma >, anaplastic large B-cell lymphoma > diffuse large B-cell lymphoma >
and Hodgkin-like lymphoma. frequently associated with anemia and, in some cases, may be
chemosensitive, resulting in relatively long survival times.

Naturally occurring influenza infection in a ferret (Mustela putorius furo) colony. J

Vet Diagn Invest 21:527–530 (2009). bronchointerstitial pneumonia with necrotizing
bronchiolitis. Influenza A virus was detected. homology to contemporary reassortant
H1N1 swine influenza viruses.

Bacterial Diskospondylitis Associated with Posterior Paresis/Paralysis in North

American Farmed Mink: Posterior paresis/paralysis in farmed mink is responsible for
significant morbidity and mortality. 32of the 40 affected animals had an isolated vertebral
lesion chr by bone lysis and proliferation centered on an intervertebral disk space in the
midthoracic area with suppurative inflammation and gram-positive cocci. Streptococcus
sp. was commonly isolated from the intervertebral disk. We conclude that posterior
paresis/paralysis in farmed mink is associated with bacterial diskospondylitis, likely
occurring secondary to bacteremia/septic

Detection of Group C Rotavirus in Juvenile Ferrets (Mustela putorius furo) with

Diarrhea by Reverse Transcription Polymerase Chain Reaction: Sequencing and
Analysis of the Complete Coding Region of the VP6 Gene. Vet Pathol 46:985–991
(2009). Histologically, small intestines exhibited acute superficial atrophic enteritis.
Transmission electron microscopy of the small intestine showed rotavirus-like
particles within apical vacuoles. Reverse transcription polymerase chain reaction
(RT-PCR) was negative for group A rotavirus.