Executive Director
Audrey Gordon, Esq.
Medical Director
Leslie B. Gordon, MD, PhD
Board of Directors
Carl Alviti, CPA
Karen N. Ballack, Esq.
cott D. Berns, MD, MP!
andra A. Bresnick, Esq.
"a##i !arold Kushner
u$ette Kushner, M
Ki% Paratore
&ohn en'
Elliott C. (ohlner, MD
Board of Advisors
(. )ed Bro*n, MD, PhD
Monica Klein%an, MD
Geor'e M. Martin, MD
"o#ert K. Morrison
Mary +h, MD
(illia% +h, MD
Dr. (illia% ,. chul$
Mel -ucker%an
P. +. Bo. /01/
Pea#ody, MA 234536/01/
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FOR IMMEDIATE RELEASE Contact: Lauren Harris
The Rare Aging Disease, Progeria, Linked to Aging in the General
Study Results Demonstrate Progerin Increases in Blood Vessels as we Age
BOSTO, MA !Septe"#er $, %&'&( – Proeria! also "no#n as Hutchinson-
$il%or& Proeria '(n&rome (H$P')! is a rare! %atal enetic &isease characteri)e& *(
an appearance o% accelerate& ain in chil&ren. +ll chil&ren #ith Proeria &ie o%
the same heart &isease that a,ects millions o% normal ain a&ults
(atherosclerosis)! *ut instea& o% occurrin at 60 or -0 (ears o% ae! these chil&ren
ma( su,er heart attac"s an& stro"es e.en *e%ore ae /0! an& the a.erae ae o%
&eath is /0 (ears. 1in&in treatments an& a cure %or Proeria ma( pro.i&e clues to
pre.entin or treatin heart &isease in the eneral population.
2n +uust 26! 20/0! Arteriosclerosis, Thrombosis, and Vascular Biology
electronicall( pu*lishe&! ahea& o% print! the results o% a stu&( comparin Proeria
an& t(pical car&io.ascular ain! entitle& 3Car&io.ascular Patholo( in Hutchinson-
$il%or& Proeria: Correlation 4ith the 5ascular Patholo( o% +in6. 7he stu&( %oun&
that proerin! the a*normal protein that causes Proeria! is also present in the
.asculature o% the eneral population an& increases #ith ae.
8esearchers e9amine& car&io.ascular autopsies an& proerin &istri*ution in t#o
patients #ith Proeria! alon #ith a roup o% 29 in&i.i&uals #ithout Proeria
*et#een the aes o% one month an& 9- (ears. 8esearchers %oun& that proerin in
in&i.i&uals #ithout Proeria increase& an a.erae o% 0.0 percent per (ear in the
coronar( arteries.
34e %oun& similarities *et#een man( aspects o% car&io.ascular &isease in *oth
Proeria an& the atherosclerosis that a,ects millions o% people throuhout the
#orl&6 sai& :r. Leslie $or&on! senior author o% the stu&( an& ;e&ical :irector o% 7he
Proeria 8esearch 1oun&ation. 34e also %oun& proerin in car&iac *loo& .essels o%
people #ithout Proeria. 7he %act that proerin is present at all tells us that there
ma( *e a tie *et#een the heart &isease o% Proeria an& the heart &isease that
a,ects us all as #e ae. 6
7his stu&( supports the possi*ilit( that proerin is a contri*utor to the ris" o%
atherosclerosis in the eneral population! an& merits e9amination as a potential
ne# element in<uencin .ascular health #ith ain.
3=( e9aminin one o% the rarest &iseases in the #orl&! #e are ainin crucial insiht
into a &isease that a,ects millions o% people #orl&#i&e. 2noin research has the
potential to ha.e a sini>cant impact on our un&erstan&in o% heart &isease an&
ain!6 sai& :r. $or&on
The Progeria Resear)h Foundation !PRF( #as esta*lishe& in /999 to >n& the
cause! treatment an& cure %or Proeria – a rapi& ain &isease that causes chil&ren
to &ie %rom heart &isease or stro"e at an a.erae ae o% /0. ?n the past /0 (ears!
research con&ucte& in partnership #ith P81 has i&enti>e& the ene that causes
Proeria an& possi*le treatments. P81 is no# %un&in > Proeria clinical
&ru trials! currentl( un&er#a( at Chil&ren@s Hospital =oston. 7o learn more a*out
Proeria an& #hat (ou can &o to help! please .isit proeriaresearch.or