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STROBE 2007 (v4) checklist of items to be included in reports of observtionl studies in epidemiolo!

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$hecklist for cohort% cse&control% nd cross&sectionl studies (combined)
Section'Topic
(tem
)
Recommendtion
Reported on
p!e )
Title nd bstrct 1 (a) Indícate the study’s desígn wíth a commoníy used term ín the títíe or the abstract
(b) Províde ín the abstract an ínformatíve and baíanced summary of what was done and what
was found
(ntroduction
Background/ratíonaíe 2 Expíaín the scíentíñc background and ratíonaíe for the ínvestígatíon beíng reported
Ob|ectíves 3 State specíñc ob|ectíves, íncíudíng any pre-specíñed hypotheses
*ethods
Study desígn 4 Present key eíements of study desígn earíy ín the paper
Settíng 5 Descríbe the settíng, íocatíons, and reíevant dates, íncíudíng períods of recruítment, exposure,
foííow-up, and data coííectíon
Partícípants 6 (a) Cohort study-Gíve the eíígíbíííty crítería, and the sources and methods of seíectíon of
partícípants. Descríbe methods of foííow-up
Case-control study-Gíve the eíígíbíííty crítería, and the sources and methods of case
ascertaínment and controí seíectíon. Gíve the ratíonaíe for the choíce of cases and controís
Cross-sectional study-Gíve the eíígíbíííty crítería, and the sources and methods of seíectíon of
partícípants
(b) Cohort study-For matched studíes, gíve matchíng crítería and number of exposed and
unexposed
Case-control study-For matched studíes, gíve matchíng crítería and the number of controís
per case
Varíabíes 7 Cíearíy deñne aíí outcomes, exposures, predíctors, potentíaí confounders, and ehect modíñers.
Gíve díagnostíc crítería, íf appíícabíe
Data sources/
measurement
8* For each varíabíe of ínterest, gíve sources of data and detaíís of methods of assessment
(measurement). Descríbe comparabíííty of assessment methods íf there ís more than one group
Bías 9 Descríbe any ehorts to address potentíaí sources of bías
Study síze 10 Expíaín how the study síze was arríved at
Ouantítatíve varíabíes 11 Expíaín how quantítatíve varíabíes were handíed ín the anaíyses. If appíícabíe, descríbe whích
groupíngs were chosen and why
Statístícaí methods 12 (a) Descríbe aíí statístícaí methods, íncíudíng those used to controí for confoundíng
(b) Descríbe any methods used to examíne subgroups and ínteractíons
(c) Expíaín how míssíng data were addressed
(d) Cohort study-If appíícabíe, expíaín how íoss to foííow-up was addressed
Case-control study-If appíícabíe, expíaín how matchíng of cases and controís was addressed
Cross-sectional study-If appíícabíe, descríbe anaíytícaí methods takíng account of sampííng
strategy
(e) Descríbe any sensítívíty anaíyses
Results
Partícípants 13* (a) Report numbers of índívíduaís at each stage of study-eg numbers potentíaííy eíígíbíe,
examíned for eíígíbíííty, conñrmed eíígíbíe, íncíuded ín the study, compíetíng foííow-up, and
anaíysed
(b) Gíve reasons for non-partícípatíon at each stage
(c) Consíder use of a ñow díagram
Descríptíve data 14* (a) Gíve characterístícs of study partícípants (eg demographíc, cíínícaí, socíaí) and ínformatíon
on exposures and potentíaí confounders
(b) Indícate number of partícípants wíth míssíng data for each varíabíe of ínterest
(c) Cohort study-Summaríse foííow-up tíme (eg, average and totaí amount)
Outcome data 15* Cohort study-Report numbers of outcome events or summary measures over tíme
Case-control study—Report numbers ín each exposure category, or summary measures of
exposure
Cross-sectional study—Report numbers of outcome events or summary measures
Maín resuíts 16 (a) Gíve unad|usted estímates and, íf appíícabíe, confounder-ad|usted estímates and theír
precísíon (eg, 95% conñdence íntervaí). Make cíear whích confounders were ad|usted for and
why they were íncíuded
(b) Report category boundaríes when contínuous varíabíes were categorízed
(c) If reíevant, consíder transíatíng estímates of reíatíve rísk ínto absoíute rísk for a meaníngfuí
tíme períod
Other anaíyses 17 Report other anaíyses done-eg anaíyses of subgroups and ínteractíons, and sensítívíty
anaíyses
+iscussion
Key resuíts 18 Summaríse key resuíts wíth reference to study ob|ectíves
Límítatíons 19 Díscuss íímítatíons of the study, takíng ínto account sources of potentíaí bías or ímprecísíon.
Díscuss both dírectíon and magnítude of any potentíaí bías
Interpretatíon 20 Gíve a cautíous overaíí ínterpretatíon of resuíts consíderíng ob|ectíves, íímítatíons, muítípíícíty
of anaíyses, resuíts from símííar studíes, and other reíevant evídence
Generaíísabíííty 21 Díscuss the generaíísabíííty (externaí vaíídíty) of the study resuíts
Other informtion
Fundíng 22 Gíve the source of fundíng and the roíe of the funders for the present study and, íf appíícabíe,
for the orígínaí study on whích the present artícíe ís based
*Gíve ínformatíon separateíy for cases and controís ín case-controí studíes and, íf appíícabíe, for exposed and unexposed groups ín cohort and
cross-sectíonaí studíes.
,ote- An Expíanatíon and Eíaboratíon artícíe díscusses each checkííst ítem and gíves methodoíogícaí background and pubííshed exampíes of
transparent reportíng. The STROBE checkííst ís best used ín con|unctíon wíth thís artícíe (freeíy avaííabíe on the Web sítes of PLoS Medícíne at
http://www.píosmedícíne.org/, Annaís of Internaí Medícíne at http://www.annaís.org/, and Epídemíoíogy at http://www.epídem.com/). Informatíon
on the STROBE Inítíatíve ís avaííabíe at www.strobe-statement.org.